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Invited review

Molecular parameters involved in aminoglycoside nephrotoxicity

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Pages 263-300 | Received 12 Apr 1994, Accepted 20 Jul 1994, Published online: 20 Oct 2009

References

  • Alexander , A. M. , Gonda , I. , Harpur , E. S. and Kayes , J. B. 1979 . Interaction of aminoglycoside antibiotics with phospholipid liposomes studies by microelectrophoresis . J. Antibiot. (Tokyo) , 32 : 504 – 510 .
  • Allen , T. M. and Cleland , L. C. 1980 . Serum‐induced leakage of liposome contents . Biochim. Biophys. Acta , 597 : 418 – 426 .
  • Aramaki , Y. and Tsuchiya , S. 1989 . Interactions between aminoglycosides and phospholipids using liposomes: A possible mechanism of nephrotoxicity . Pharmacol. Res. , 6 : 362 – 366 .
  • Aubert‐Tulkens , C. , Van Hoof , F. and Tulkens , P. 1979 . Centamicin‐induced lysosomal phospholipidosis in cultured rat fibroblasts . Lab. Invest. , 40 : 481 – 493 .
  • Auslander , D. E. , Felmeister , A. and Sciarrone , B. J. 1975 . Drug‐biomolecule interactions: Interaction of gentamicin with lipid monomolecular films . J. Pharm. Sci. , 64 : 516 – 519 .
  • Bachmann , L. and Schmitt , W. W. 1971 . Improved cryofixation applicable to freeze etching . Proc. Natl Acad. Sci. USA , 68 : 2149 – 2152 .
  • Batenburg , A. M. , Bougis , P. E. , Rochat , H. , Verkleij , A. J. and de Kruijff , B. 1985 . Penetration of a car‐diotoxin into cardiolipin model membranes and its implications on lipid organization . Biochemistry , 24 : 7101 – 7110 .
  • Batenburg , A. M. , Von Esch , J. H. , Leunissen‐Bijvelt , A. J. , Verkleij , A. J. and de Kruijff , B. 1987 . Interaction of mellitin with negatively‐charged phospholipids: Consequences for lipid organization . FEBS Lett. , 223 : 148 – 154 .
  • Beauchamp , D. , Laurent , C. , Maldague , P. and Tulkens , P. M. 1986 . Reduction of gentamicin nephrotoxicity by the concomitant administration of poly‐L‐aspartic acid and poly‐L‐asparagine in rats . Arch. Toxicol. Suppl. , 9 : 306 – 309 .
  • Beauchamp , D. , Laurent , C. , Maldague , P. , Abid , S. , Kishore , B. K. and Tulkens , P. M. 1990 . Protection against gentamicin‐induced early renal alterations (phospholipidosis, increased DNA synthesis) by co‐administration of poly‐L‐aspartic acid . J. Pharmacol. Exp. Ther. , 255 : 858 – 866 .
  • Benameur , H. , De Cand , C. , Brasseur , R. , Van Vooren , J. P. and Legros , F. J. 1993 . Liposomes‐incor‐porated dexamethasone palmitate: Chemical and physical properties . Int. J. Pharm. , 89 : 157 – 167 .
  • Berden , J. A. , Barker , R. W. and Radda , G. K. 1975 . NMR studies on phospholipid bilayers. Some factors affecting lipid distribution . Biochim. Biophys. Acta , 375 : 186 – 208 .
  • Borchardt , K. , Heber , D. , Klingmuller , M. , Mohr , K. and Müller , B. 1991 . The ability of cationic amphiphilic compounds to depress the transition temperature of dipalmitoylphosphatidic acid liposomes depends on the spatial arrangement of the lipophilic moiety . Biochem. Pharmacol. , 42 : 561 – 565 .
  • Brasseur , R. 1988 . Calculation of the three‐dimensional structure of Saccharomyces cerevisiae cytochrome fa inserted in a lipid matrix . J. Biol. Chem. , 263 : 12571 – 12575 .
  • Brasseur , R. 1990 . “ TAMMO: Theoretical analysis of membrane molecular organization ” . In Molecular description of biological membrane components by computer‐aided conformational analysis , Edited by: Brasseur , R. vol. 1/1 , A.6 203 – 219 . Boca Raton, Fla. : CRC Press .
  • Brasseur , R. 1991 . Differentiation of lipid‐associating helices by use of three‐dimensional molecular hydrophobicity potential calculations . J. Biol. Chem. , 266 : 16120 – 16127 .
  • Brasseur , R. , Deleers , M. , Malaisse , W. J. and Ruysschaert , J. M. 1982 . Conformational analysis of the calcium‐A23187 complex at a lipid‐water interface . Proc. Natl Acad. Sci. USA , 79 : 2895 – 2897 .
  • Brasseur , R. , Vandenbosch , C. , Van Den Bossche , H. and Ruysschaert , J. M. 1983 . Mode of insertion of miconazole, ketoconazole and deacylated ketoconazole in lipid layers. A conformational analysis . Biochem. Pharmacol. , 32 : 2175 – 2180 .
  • Brasseur , R. , Laurent , C , Ruysschaert , J. M. and Tulkens , P. 1984 . Interactions of aminoglycoside antibiotics with negatively‐charged lipid layers. Biochemical and conformational studies . Biochem. Pharmacol. , 33 : 629 – 637 .
  • Brasseur , R. , Carlier , M. B. , Laurent , G. , Claes , P. J. , Vanderhaeghe , H. J. , Tulkens , P. M. and Ruysschaert , J. M. 1985a . Interactions of streptomycin and streptomycylamine derivatives with negatively charged lipid layers: Correlation between binding, conformation of complexes and inhibition of phospholipase activities . Biochem. Pharmacol. , 34 : 1035 – 1047 .
  • Brasseur , R. , Chatelain , P. , Goormaghtigh , E. and Ruysschaert , J. M. 1985b . Interactions of N‐alkanols with dipalmitoylphosphatidylcholine: A semi‐empirical conformational analysis . Biochim. Biophys. Acta , 814 : 227 – 236 .
  • Brasseur , R. , Ruysschaert , J. M. and Châtelain , P. 1985c . Semi‐empirical conformational analysis of propanolol interacting with dipalmitoylphosphatidylcholine . Biochim. Biophys. Acta , 815 : 341 – 350 .
  • Brasseur , R. , Cabiaux , V. , Falmagne , P. and Ruysschaert , J. M. 1986 . pH Dependent insertion of a diph‐teria toxin B fragment peptide into the lipid membrane: A conformational analysis . Biochem. Biophys. Res. Commun. , 136 : 160 – 168 .
  • Brasseur , R. , Killian , J. A. , De Kruijff , B. and Ruysschaert , J. M. 1987 . Conformational analysis of gramicidin‐gramicidin interactions at the air water interface suggests that gramicidin aggregates into tube‐like structures similar as found in the gramicidin‐induced hexagonal H”; phase . Biochim. Biophys. Acta , 903 : 11 – 17 .
  • Brasseur , R. , Cornet , B. , Burny , A. , Vandenbranden , M. and Ruysschaert , J. M. 1988 . Mode of insertion into lipid membrane of the N‐terminus HIV gp 41 peptide segment . AIDS Res. Hum. Retrov. , 4 : 83 – 90 .
  • Brasseur , R. , Vandenbranden , M. , Cornet , B. , Burny , A. and Ruysschaert , J. M. 1990 . Orientation into the lipid bilayer of an asymmetric amphipathic helical peptide located at the N‐terminus of viral fusion proteins . Biochim. Biophys. Acta , 1029 : 267 – 273 .
  • Brasseur , R. , Lins , L. , Vanloo , B. , Ruysschaert , J. M. and Rosseneu , M. 1992 . Molecular modelling of the amphipathic helices of the plasma apolipoproteins . Proteins , 13 : 246 – 257 .
  • Carlier , M. B. , Laurent , G. , Claes , P. J. , Vanderhaeghe , H. J. and Tulkens , P. M. 1983 . Inhibition of lysosomal phospholipases by aminoglycoside antibiotics: Comparative studies in vitro . Antimicrob. Agents Chemother. , 23 : 440 – 449 .
  • Carlier , M. B. , Brasseur , R. , Laurent , G. , Mingeot‐Leclercq , M. P. , Ruysschaert , J. M. and Tulkens , P. M. 1986 . Use of an in vitro model to assess aminoglycoside‐phospholipid interactions in relation with their nephrotoxicity . Food Chem. Toxicol. , 24 : 815 – 816 .
  • Carlier , M. B. , Laurent , G. and Tulkens , P. M. Reduction of aminoglycoside‐induced renal alterations in rats by co‐administration of piperacillin at clinically relevant doses . 15th Int. Congr. Chemotherapy . Istanbul, Turkey. abstr. 883
  • Carlier , M. B. , Brasseur , R. , Ruysschaert , J. M. and Tulkens , P. M. 1988 . In vitro study and conformational analysis of 1‐N‐aminohydroxybutyryl derivatives of aminoglycosides in correlation with their inhibitory potency towards lysosomal phospholipases . Arch. Toxicol. , 12 ( Suppl. ) : 186 – 189 .
  • Carrier , D. and Pezolet , M. 1986 . Investigation of polylysine‐dipalmitoylphosphatidylglycerol. Interactions in model membranes . Biochemistry , 25 : 4167 – 4174 .
  • Carruthers , A. and Melchior , D. L. 1983 . Studies of the relationship between bilayer water permeability and bilayer physical state . Biochemistry , 22 : 5797 – 5807 .
  • Cater , B. R. , Chapman , D. , Hawes , S. M. and Saville , J. 1974 . Lipid phase transitions and drug interactions . Biochim. Biophys. Acta , 363 : 54 – 69 .
  • Chatelain , P. and Brasseur , R. 1990 . “ Conformational analysis of cardiovascular drug‐lipid interactions: Propanolol and amiodarone ” . In Molecular description of biological membranes by computer aided conformational analysis , Edited by: Brasseur , R. 43 – 62 . Boca Raton, Fla. : CRC Press .
  • Chung , L. , Kaloyanides , C. , McDaniel , R. , McLaughin , A. and McLaughin , S. 1985 . Interaction of gen‐tamicin and spermine with bilayer membranes containing negatively‐charged phospholipids . Biochemistry , 24 : 442 – 452 .
  • Craig , W. A. , Leggett , J. , Totsuka , K. and Vogelman , B. 1988 . Key pharmacokinetic parameters of antibiotic efficacy in experimental animal infections . J. Drug. Dev. , 1 (Suppl. 3) : 7 – 15 .
  • Cullis , P. R. and De Kruijff , B. 1976 . 31P‐NMR studies of unsonicated aqueous dispersion of neutral and acidic phospholipids. Effects of phase transitions, p2H and divalent cations on the motion in the phosphate region of the polar head group . Biochim. Biophys. Acta , 436 : 523 – 540 .
  • Cullis , P. R. and de Kruijff , B. 1978a . Polymorphic phase behaviour of lipid mixtures as detected by 31P NMR. Evidence that cholesterol may destabilize bilayer structure in membrane systems containing phosphatidylethanolamine . Biochim. Biophys. Acta , 507 : 207 – 218 .
  • Cullis , P. R. and De Kruijff , B. 1978b . The polymorphic phase behaviour of phosphatidylethalonamines of natural and synthetic origin. A 31P NMR study, Biochim . Biophys. Acta , 513 : 31 – 42 .
  • Cullis , P. R. , Verkleij , A. J. and Ververgaert , P. H. J. 1978 . Polymorphic phase behaviour of cardiolipin as detected by 31P NMR and freeze‐fracture techniques. Effects of calcium, dibucaine and chlorpro‐mazine . Biochim. Biophys. Acta , 513 : 11 – 20 .
  • Cullis , P. R. , de Kruijff , B. , Hope , M. J. , Verkleij , A. J. , Nayar , R. , Farren , S. and Bally , M. B. 1983 . “ Structural properties of lipids and their functional roles in biological membranes ” . In Membrane fluidity in biology , Edited by: Aloia , R. C. vol. 1 , 39 – 81 . New York : Academic Press .
  • Cuppage , F. E. , Setter , K. , Sullivan , P. , Reitzes , E. J. and Melnykovych , A. O. 1977 . Centamicin nephrotoxicity. II. Physiological, biochemical and morphological effects of prolonged administration to rats . Virchows Arch. B , 24 : 121 – 138 .
  • Curtis , M. T. , Gilfor , D. and Farber , J. L. 1984 . Lipid peroxydation increases the molecular order of microsomal membranes . Arch. Biochem. Biophys. , 235 : 644 – 649 .
  • De Broe , M. E. , Paulus , G. J. , Verpooten , G. A. , Roels , F. , Buyssens , N. , Wedeen , R. and Tulkens , P. M. 1984 . Early effects of gentamicin, tobramycin and amikacin on the human kidney . Kidney Int. , 25 : 643 – 652 .
  • de Duve , C. and Wattiaux , R. 1966 . Functions of lysosomes . Annu. Rev. Physiol. , 28 : 435 – 492 .
  • De Kruijff , B. , Cullis , P. R. and Radda , G. K. 1975 . Differential scanning calorimetry and 31P NMR studies on sonicated and unsonicated phosphatidylcholine liposomes . Biochim. Biophys. Acta , 406 : 6 – 20 .
  • Deleers , M. and Brasseur , R. 1990 . “ Transformation of ionophores at the lipid/water interface ” . In Molecular description of biological membranes by computer aided conformational analysis. Part 2. Mode of insertion of amphiphilic components into the lipid membrane , Edited by: Brasseur , R. 17 – 26 . Boca Raton, Fla. : CRC Press .
  • Deleers , M. , Ruysschaert , J. M. and Brasseur , R. 1990 . “ Molecular conformations of phorbol esters in a simulated lipid/water interface ” . In Molecular description of biological membranes by computer aided conformational analysis. Part I. Lipids structures and organizations , Edited by: Brasseur , R. 221 – 230 . Boca Raton, Fla. : CRC Press .
  • Di Virgilio , F. , Steinberg , T. H. , Swanson , J. A. and Silverstein , S. C. 1988 . Fura‐2 secretion and sequestration in macrophages. A blocker or organic anion transport reveals that these processes occur via a membrane transport system for organic anion . J. Immunol. , 140 : 915 – 920 .
  • Ellens , H. , Siegel , D. P. , Alford , D. , Yeagle , P. L. , Boni , L. , Lis , L. J. and Bentz , J. 1989 . Membrane fusion and inverted phases . Biochemistry , 28 : 3692 – 3703 .
  • Epand , R. M. 1990 . Relationship of phospholipid hexagonal phases to biological phenomena . Biochem. Cell Biol. , 68 : 17 – 23 .
  • Epand , R. M. , Epand , R. F. and McKenzie , R. C. 1987 . Effects of viral chemotherapeutic agents on membrane properties . J. Biol. Chem. , 262 : 1526 – 1529 .
  • Esko , J. D. and Raetz , C. R. H. 1983 . “ Synthesis of phospholipids in animal cells ” . In The enzymes—Lipid enzymology , Edited by: Bayer , P. D. vol. 16 , 208 – 253 . New York : Academic Press .
  • Calla , H. J. and Sackmann , E. 1975 . Chemically‐induced lipid phase separation in model membranes containing charged lipids: A spin label study . Biochim. Biophys. Acta , 301 : 509 – 529 .
  • Ganesan , M. C. , Weiner , N. D. and Schacht , J. 1983 . Effects of calcium and neomycin on phase behavior of phospholipid bilayers . J. Pharm. Sci. , 72 : 1465 – 1467 .
  • Gilbert , D. N. , Woods , C. A. , Kohlhepp , S. J. , Kohnen , P. W. , Houghton , D. C. , Finkbeiner , H. C. and Bennett , W. M. 1989 . Polyaspartic acid prevents experimental aminoglycoside nephrotoxicity . J. Infect. Dis. , 159 : 945 – 953 .
  • Girke , S. , Mohr , K. and Schrape , S. 1989 . Comparison between the activities of cationic amphiphilic drugs to affect phospholipid‐membranes and to depress cardiac function . Biochem. Pharmacol. , 38 : 2487 – 2496 .
  • Girotti , A. W. and Thomas , J. P. 1984 . Damaging effects of oxygen radicals on resealed erythrocyte ghosts . J. Biol. Chem. , 259 : 1744 – 1752 .
  • Giurgea‐Marion , L and Tulkens , P. M. 1986 . “ Effect of hydroxylation of the 2’,6’ diaminohexose moiety on the intrarenal accumulation of aminoglycoside antibiotics: Comparison between kanamycin B, tobramycin, dibekacin and gentamicin ” . In Recent advances in chemotherapy , Edited by: Ishigami , J. 2679 – 2680 . Tokyo : University of Tokyo Press .
  • Giurgea‐Marion , L. , Toubeau , G. , Laurent , G. , Heuson‐Stiennon , J. and Tulkens , P. M. 1986 . Impairment of lysosome‐pinocytic vesicle fusion in rat kidney proximal tubules after treatment with gentamicin at low doses . Toxicol. Appl. Pharm. , 86 : 271 – 285 .
  • Goormaghtigh , E. , Brasseur , R. and Ruysschaert , J. M. 1982 . Adriamycin inactivates cytochrome c‐oxi‐dase by exclusion of the enzyme from its cardiolipin essential environment . Biochem. Biophys. Res. Commun. , 104 : 314 – 320 .
  • Goormaghtigh , E. , Huart , P. , Praet , M. , Brasseur , R. and Ruysschaert , J. M. 1990 . “ Adriamycin‐mito‐chondrial membrane interactions and cardiotoxicity ” . In Molecular description of membranes by computer aided conformational analysis. Part 2. Mode of insertion of amphiphilic components into the lipid membrane , Edited by: Brasseur , R. 95 – 112 . Boca Raton, Fla. : CRC Press .
  • Grynkiewicz , G. , Poenie , M. and Tsien , R. Y. 1985 . A new generation of Ca2+ indicators with greatly improved fluorescence properties . J. Biol. Chem. , 260 (6) : 3440 – 3450 .
  • Hanpft , R. and Mohr , K. 1985 . Influence of cationic amphiphilic drug on the phase‐transition temperature of phospholipids with different polar headgroups . Biochim. Biophys. Acta , 814 : 156 – 162 .
  • Hartmann , W. , Galla , H. J. and Sackmann , E. 1977 . Direct evidence of charge induced lipid domain structure in model membranes . FEBS Lett. , 78 : 169 – 172 .
  • Haydon , D. A. and Elliott , J. R. 1986 . Surface potential changes in lipid monolayers and the “cut‐off”; in anaesthetic effects of N‐alkanols . Biochem. Biophys. Acta , 863 : 337 – 340 .
  • Hein , L. , Lullmann‐Rauch , R. and Mohr , K. 1990 . Human accumulation potential of xenobiotics: Potential of catamphiphilic drugs to promote their accumulation via inducing lipidosis or mucopoly‐saccharidosis . Xenobiotica , 20 : 1259 – 1267 .
  • Herbette , L. , Katz , A. M. and Sturtevant , J. M. 1983 . Comparisons of the interaction of propanolol and timolol with model and biological membrane systems . Mol. Pharmacol. , 24 : 259 – 269 .
  • Hoekstra , D. , de Boer , T. , Klappe , K. and Wilschut , J. 1984 . Fluorescence method for measuring the kinetics of fusion between biological membranes . Biochemistry , 23 : 5675 – 5681 .
  • Hope , M. J. , Bally , M. B. , Webb , G. and Cullis , P. R. 1985 . Production of large unilamellar vesicles by a rapid extrusion procedure. Characterization of size distribution, trapped volume and ability to maintain a membrane potential . Biochim. Biophys. Acta , 812 : 55 – 65 .
  • Hostetler , K. Y. and Hall , L. B. 1982 . Inhibition of kidney lysosomal phospholipases A and C by aminoglycoside antibiotics: Possible mechanism of aminoglycoside toxicity . Proc. Natl Acad. Sci. USA , 79 : 1663 – 1667 .
  • Hostetler , K. Y. and Jellison , E. J. 1990 . Inhibition of kidney phospholipase A1 by aminoglycosides is a novel variant of substrate depletion inhibition . J. Pharmacol. Exp. Ther. , 254 : 188 – 191 .
  • Hottendorf , C. H. and Cordon , L. 1980 . Comparative low‐dose nephrotoxicities of gentamicin, tobramycin and amikacin . Antimicrob. Agents Chemother. , 18 : 176 – 181 .
  • Houghton , D. C. , Lee , D. , Gilbert , D. N. and Bennett , W. M. 1986 . Chronic gentamicin nephrotoxicity. Continued tubular injury with preserved glomerular filtration function . Am. J. Pathol. , 123 : 183 – 194 .
  • Hui , S. W. , Boni , T. , Stewart , T. P. and Isac , T. 1983 . Identification of phosphatidylserine and phos‐phatidylcholine in calcium‐induced phase separated domains . Biochemistry , 22 : 3511 – 3516 .
  • Ibrahim , S. , Kishore , B. K. , Lambricht , P. , Laurent , C. and Tulkens , P. M. Effect of aminoglycosides and of coadministration of poly‐L‐aspartic acid on urinary phospholipids excretion in rats: A comparative study . 4th Int. Nephrotoxicity Symp. Guildford, U.K.. Abstract 25
  • In't Veld , G. , Driessen , A. J. M. and Konings , W. N. 1992 . Effect of the unsaturation of phospholipid acyl chains on leucine transport of Lactococcus lactis and membrane permeability . Biochem. Biophys. Acta , 1108 : 31 – 39 .
  • Kahlmeter , G. and Dahlager , J. I. 1984 . Aminoglycoside toxicity: A review of clinical studies published between 1975 and 1982 . J. Antimicrob. Chemother. , 13 : 9 – 22 .
  • Kaloyanides , G. J. 1984a . Aminoglycoside‐induced functional and biochemical defects in the renal cortex . Fundam. Appl. Toxicol. , 4 : 930 – 943 .
  • Kaloyanides , G. J. 1984b . Renal pharmacology of aminoglycoside antibiotics . Contrib. Nephrol. , 42 : 148 – 167 .
  • Kirschbaum , B. B. 1984 . Interactions between renal brush border membranes and polyamines . J. Pharmacol. Exp. Ther. , 229 : 409 – 416 .
  • Kishore , B. K. , Kallay , Z. , Lambricht , P. , Laurent , G. and Tulkens , P. M. 1990a . Mechanism of protection afforded by polyaspartic acid against gentamicin‐induced phospholipidosis. I. Polyaspartic acid binds and displaces gentamicin from negatively‐charged phospholipid layers . J. Pharmacol. Exp. Ther. , 255 : 867 – 874 .
  • Kishore , B. K. , Lambricht , P. , Laurent , G. , Maldague , P. , Wagner , R. and Tulkens , P. M. 1990b . Mechanism of protection afforded by polyaspartic acid against gentamicin‐induced phospholipidosis. II. Comparative in vitro and in vivo studies with poly‐L‐aspartic, poly‐L‐glutamic and poly‐D‐glumatic acids . J. Pharmacol. Exp. Ther. , 255 : 875 – 885 .
  • Kishore , B. K. , Ibrahim , S. , Lambricht , P. , Laurent , G. , Maldague , P. and Tulkens , P. M. 1992 . Comparative assessment of poly‐L‐aspartic and poly‐L‐glutamic acids against gentamicin‐induced renal lysosomal phospholipidosis, phospholipiduria and cell proliferation in rats . J. Pharmacol. Exp. Ther. , 262 : 424 – 432 .
  • Kosek , J. C. , Mazze , R. I. and Cousins , M. J. 1974 . Nephrotoxicity of gentamicin . Lab. Invest. , 30 : 48 – 57 .
  • Kouaouci , R. , Silvius , J. R. , Graham , I. and Pézolet , M. 1985 . Calcium‐induced lateral phase separations in phosphatidylcholine‐phosphatidic acid mixtures. A Raman spectroscopic study . Biochemistry , 24 : 7132 – 7140 .
  • Kubo , M. , Gardner , M. F. and Hostetler , K. Y. 1986 . Binding of propranolol and gentamicin to small unilamellar phospholipid vesicles. Contribution of ionic and hydrophobic forces . Biochem. Pharmacol. , 35 : 3761 – 3765 .
  • Kursch , B. , Lullmann , H. and Mohr , K. 1983 . Influence of various cationic amphiphilic drugs on the phase‐transition temperature of phosphatidylcholine liposomes . Biochem. Pharmacol. , 32 : 2589 – 2594 .
  • Lakhdar‐Ghazal , F. , Vigroux , A. , Willson , M. , Tocanne , J. F. , Pri , J. and Fayes , J. C. 1991 . Interactions between trypanocidal drugs and membrane phospholipids. A surface pressure, surface potential and electrophoretic mobility study . Biochem. Pharmacol. , 42 : 2099 – 2105 .
  • Laroche , G. , Carrier , D. and Pézolet , M. 1988 . Study of the effect of poly (L‐lysine) on phosphatidic acid and phosphatidylcholine/phosphatidic acid bilayers by Raman spectroscopy . Biochemistry , 27 : 6220 – 6228 .
  • Laurent , G. and Tulkens , P. M. 1987 . Aminoglycoside nephrotoxicity: Cellular and molecular aspects . ISI atlas of science/pharmacology , 1 : 40 – 44 .
  • Laurent , G. , Carlier , M. B. , Rollman , B. , Van Hoof , F. and Tulkens , P. 1982 . Mechanism of aminogly‐coside‐induced lysosomal phospholipidosis: In vitro and in vivo studies with gentamicin and amikacin . Biochem. Pharmacol. , 31 : 3861 – 3870 .
  • Laurent , G. , Maldague , P. , Carlier , M. B. and Tulkens , P. 1983 . Increased renal DNA synthesis in vivo after administration of low doses of gentamicin to rats . Antimicrob. Agents Chemother. , 24 : 586 – 593 .
  • Laurent , G. , Maldague , P. , Toubeau , G. , Heuson‐Stiennon , J. A. and Tulkens , P. M. 1988 . Kidney tissue repair after nephrotoxic injury: Biochemical and morphological characterization . CRC Crit. Rev Toxicol. , 19 : 147 – 183 .
  • Laurent , G. , Kishore , B. K. and Tulkens , P. M. 1990 . Aminoglycoside‐induced phospholipidosis and nephrotoxicity (Commentary) . Biochem. Pharmacol. , 40 : 2383 – 2392 .
  • Lee , A. G. 1976 . Model for action of local anaesthetics . Nature (Lond.) , 262 : 545 – 548 .
  • Lietman , P. S. 1985 . “ Aminoglycosides and spectinomycin: Aminocyclitols ” . In Principles and practice of infectious diseases , Edited by: Mandell , G. L. , Douglas , R. G. and Bennet , J. E. 192 – 206 . New York : John Wiley & Sons .
  • Lipsky , J. J. and Lietman , P. S. 1982 . Aminoglycoside inhibition of a renal phosphatidylinositol phospho‐lipase C . J. Pharmacol. Exp. Ther. , 220 : 287 – 292 .
  • Lohdi , S. , Weiner , N. D. and Schacht , J. 1976 . Interactions of neomycin and calcium in synaptosomal membranes and polyphosphoinositide monolayers . Biochim. Biophys. Acta , 426 : 781 – 785 .
  • Lüllmann , H. and Vollmer , B. 1982 . An interaction of aminoglycoside antibiotics with Ca binding to lipid monolayers and to biomembranes . Biochem. Pharmacol. , 31 : 3769 – 3773 .
  • Lüllmann , H. , Ltillmann‐Rauch , R. and Wassermann , O. 1975 . Drug‐induced phospholipidosis . CRC Crit. Rev. Toxicol. , 4 : 185 – 218 .
  • Lüllmann‐Rauch , R. 1979 . “ Drug‐induced lysosomal storage disorders ” . In Lysosomes in applied biology and therapeutics Edited by: Dingle , J. T. , Jacques , P. J. and Shaw , H. I. vol. 6 , 49 – 130 . Amsterdam, North Holland
  • Luxnat , M. and Galla , H. J. 1986 . Partition of chlorpromazine into lipid bilayer membranes: The effect of membrane structure and composition . Biochim. Biophys. Acta , 856 : 274 – 282 .
  • Marichal , P. , Vanden Bossche , H. , Moereels , H. and Brasseur , R. 1990 . “ Mode of insertion of azole anti‐fungals and sterols in biological membranes ” . In Molecular description of biological membranes by computer aided conformational analysis. Part 2; Mode of insertion of amphiphilic components into the lipid membrane , Edited by: Brasseur , R. 27 – 42 . Boca Raton, Fla. : CRC Press .
  • Mazer , N. A. , Carey , M. C. , Kwasnick , R. F. and Benedek , G. B. 1979 . Quasielastic light scattering studies of aqueous biliary lipid systems. Size, shape and thermodynamics of bile salt micelles . Biochemistry , 18 : 3064 – 3075 .
  • McGilvery , R. W. 1979 . Biochemistry: A functional approach , 206 Philadelphia : W. B. Saunders .
  • McLaughlin , A. C. , Cullis , P. R. , Hemminga , M. A. , Hoult , D. I. , Radda , G. K. , Ritchie , G. A. and Richards , R. E. 1977 . Application of 31P NMR to model and biological membrane systems . FEBS Lett. , 57 : 213 – 218 .
  • Mingeot‐Leclercq , M. P. , Laurent , G. and Tulkens , P. M. 1988 . Biochemical mechanism of aminoglycoside‐induced inhibition of phosphatidylcholine hydrolysis by lysosomal phospholipases . Biochem. Pharmacol. , 37 : 591 – 599 .
  • Mingeot‐Leclercq , M. P. , Schanck , A. , Ronveaux‐Dupal , M. F. , Deleers , M. , Brasseur , R. , Ruysschaert , J. M. and Tulkens , P. M. 1989 . Ultrastructural, physico‐chemical and conformational study of the interactions of gentamicin and bis(beta‐diethylaminoethylether)hexestrol with negatively charged phospholipid bilayers . Biochem. Pharmacol. , 38 : 729 – 741 .
  • Mingeot‐Leclercq , M. P. , Piret , J. , Brasseur , R. and Tulkens , P. M. 1990a . Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics. I. Biochemical analysis . Biochem. Pharmacol. , 40 : 489 – 497 .
  • Mingeot‐Leclercq , M. P. , Piret , J. , Tulkens , P. M. and Brasseur , R. 1990b . Effect of acidic phospholipids on the activity of lysosomal phospholipases and on their inhibition by aminoglycoside antibiotics. II. Conformational analysis . Biochem. Pharmacol. , 40 : 499 – 506 .
  • Mingeot‐Leclercq , M. P. , Laurent , G. , Kishore , B. K. and Tulkens , P. M. 1991a . Aminoglycosides nephrotoxicity . Life Sci. Adv. (Biochem. Pharmacol.) , 10 : 113 – 141 .
  • Mingeot‐Leclercq , M. P. , Van Schepdael , A. , Brasseur , R. , Busson , R. , Vanderhaeghe , H. J. , ‐, Claes , P. J. and Tulkens , P. M. 1991b . New derivatives of Kanamycin B obtained by modifications and substitutions in position 6”;. II. In vitro and computer‐aided toxicological evaluation, with respect to interactions with phosphatidylinositol . J. Med. Chem. , 34 : 1476 – 1482 .
  • Moor , H. , Muhlethaler , K. , Waldner , H. and Frey‐Wyssling , A. 1961 . A new freezing‐ultramicrotome . J. Biophys. Biochem. Cytol. , 10 : 1 – 13 .
  • Nagabhushan , T. L. , Miller , G. H. and Weinstein , M. J. 1982 . “ Structure‐activity relationships in amino‐glycoside‐aminocyclitol antibiotics ” . In The aminoglycosides: Microbiology, clinical use and toxicology , Edited by: Whelton , A. and Neu , H. C. 3 – 27 . New York : Marcel Dekker .
  • Nicolay , K. , Sautereau , A. M. , Tocanne , J. F. , Brasseur , R. , Huart , P. , Ruysschaert , J. M. and de Kruijff , B. 1988 . A comparative model membrane study on structural effects of membrane‐active positively charged anti‐tumor drugs . Biochim. Biophys. Acta , 940 : 197 – 208 .
  • Ohkuma , S. and Poole , B. 1978 . Fluorescence probe measurement of the intralysosomal pH in living cells and the perturbation of pH by various agents . Proc. Natl. Acad. Sci. USA , 75 : 3327 – 3331 .
  • Ohyashiki , T. , Ohtsuka , T. and Mohri , T. 1986 . A change in the lipid fluidity of the porcine intestinal brush‐border membranes by lipid peroxydation. Studies using pyrene and fluorescent stearic acid derivatives . Biochem. Biophys. Acta , 861 : 311 – 318 .
  • Papahadjopoulos , D. , Jacobson , K. , Nir , S. and Isac , T. 1973 . Phase transitions in phospholipid vesicles. Fluorescence polarization and permeability measurements concerning the effect of temperature and cholesterol . Biochim. Biophys. Acta , 311 : 330 – 348 .
  • Papahadjopoulos , D. , Jacobson , K. , Poste , G. and Shepherd , G. 1975 . Effects of local anaesthetics on membrane properties. I. Changes in the fluidity of phospholipid bilayers . Biochim. Biophys. Acta , 394 : 504 – 519 .
  • Parker , R. A. , Gilbert , D. N. , Houghton , D. C. , Porter , G. A. and Bennett , W. M. 1980 . Comparative nephrotoxicities of high‐dose netilmicin and tobramycin in rats . Antimicrob. Agents Chemother. , 18 : 346 – 348 .
  • Piret , J. , Kishore , B. K. and Tulkens , P. M. 1992 . Effect of substrate organization on the activity and on the mechanism of gentamicin‐induced inhibition of rat liver lysosomal phospholipase AI . Biochem. Pharmacol. , 43 : 895 – 898 .
  • Ramaswami , V. , Haaseth , R. C. , Matsunaga , T. O. , Hruby , V. J. and O'Brien , D. F. 1992 . Opioid pep‐tide interactions with lipid bilayer membranes . Biochim. Biophys. Acta , 1109 : 195 – 202 .
  • Ramsammy , L. and Kaloyanides , G. J. 1985 . Gentamicin alters the physical properties of phosphatidylinositol liposomes . Fed. Proc. , 44 : 1351 A
  • Ramsammy , L. S. and Kaloyanides , G. J. 1987 . Effect of gentamicin on the transition temperature and permeability to glycerol of phosphatidylinositol‐containing liposomes . Biochem. Pharmacol. , 36 : 1179 – 1181 .
  • Ramsammy , L. S. , Josepovitz , C. , Lane , B. P. and Kaloyanides , G. J. 1989 . Polyaspartic acid protects against gentamicin nephrotoxicity in the rat . J. Pharmacol. Exp. Ther. , 250 : 149 – 153 .
  • Ramsammy , L , Josepovitz , C. , Lane , B. and Kaloyanides , G. J. 1990 . Polyaspartic acid inhibits gentamicin‐induced perturbation of phospholipid metabolism . Am. J. Physiol. , 258 : C1141 – C1149 .
  • Reijngoud , D. J. and Tager , J. M. 1977 . The permeability of the lysosomal membrane . Biochim. Biophys. Acta , 472 : 419 – 449 .
  • Sande , M. A. and Mandell , G. L. 1990 . “ Antimicrobial agents: the aminoglycosides ” . In The pharmacological basis of therapeutics , 8th ed. , Edited by: Goodman‐Gilman , A. , Rall , T. W. , Nies , A. S. and Taylor , P. 1098 – 1116 . New York : Pergamon .
  • Schanck , A. , Brasseur , R. , Mingeot‐Leclercq , M. P. and Tulkens , P. M. 1992a . Interactions of aminoglycosides with phosphatidylinositol: A 15N nuclear magnetic resonance study . Magn. Reson. Chem. , 30 : 11 – 15 .
  • Schanck , A. , Mingeot‐Leclercq , M. P. , Tulkens , P. M. , Carrier , D. , Smith , I. C. P. and Jarrel , H. C. 1992b . Interactions of aminoglycosides with phospholipids. A deuterium nuclear magnetic resonance study . Chem. Phys. Lipids , 62 : 153 – 163 .
  • Schwertz , D. W. , Kreisberg , J. I. and Venkatachalam , M. A. 1984 . Effects of aminoglycosides on proximal tubule brush border membrane phosphatidylinositol‐specific phospholipase C . J. Pharmacol. Exp. Ther. , 231 : 48 – 55 .
  • Shinitzky , M. and Barenholz , Y. 1974 . Dynamics of the hydrocarbon layer in liposomes of lecithin and sphingomyelin containing dicethylphosphate . J. Biol. Chem. , 249 : 2652 – 2657 .
  • Silvius , J. R. 1990 . Calcium‐induced lipid phase separations and interactions of phosphatidylcholine/‐anionic phospholipid vesicles. Fluorescence studies using carbazole‐labeled and brominated phos‐pholipids . Biochemistry , 29 : 2930 – 2938 .
  • Smith , R. and Cornell , B. A. 1985 . Myelin basic protein induces hexagonal phase formation in dispersion of diacylphosphatidic acid . Biochem. Biophys. Acta , 818 : 275 – 279 .
  • Struck , D. K. , Hoekstra , D. and Pagano , R. E. 1981 . Use of resonance energy transfer to monitor membrane fusion . Biochemistry , 20 : 4093 – 4099 .
  • Taraschi , T. F. , de Kruijff , B. , Verkleij , A. and Van Echteid , C. J. 1982 . Effect of glycophorin on lipid polymorphism. A 31P‐NMR study . Biochem. Biophys. Acta , 685 : 153 – 161 .
  • Thomas , P. C. and Verkleij , A. J. 1990 . The dissimilar interactions of the calcium antagonist flunarizine with different phospholipidd classes and molecular species: A differential scanning calorimetry study . Biochim. Biophys. Acta , 1030 : 211 – 222 .
  • Toubeau , C. , Laurent , C. , Carlier , M. B. , Abid , S. , Maldague , P. , Heuson‐Stiennon , J. and Tulkens , P. M. 1986 . Tissue repair in rat kidney cortex during short treatment with aminoglycosides at low doses: A comparative biochemical and morphometric study . Lab Invest. , 54 : 385 – 393 .
  • Tournois , H. , Fabrie , C. H. J. , Burger , K. N. J. , Mandersloot , J. , Hilgers , P. , van Dalen , H. and de Kruijff , B. 1990 . Gramicidin A induced fusion of large unilamellar dioleoylphosphatidylcholine vesicles and its relation to the induction of type II nonbilayer structures . Biochemistry , 29 : 8297 – 8307 .
  • Tulkens , P. M. 1986 . Experimental studies on nephrotoxicity of aminoglycosides at low doses: Mechanisms and perspectives . Am. J. Med. , 80 (6B) : 105 – 114 .
  • Tulkens , P. M. 1989 . Nephrotoxicity of aminoglycosides . Toxicol. Lett. , 46 : 107 – 123 .
  • Tulkens , P. M. 1991a . Efficacy and safety of aminoglycosides once‐a‐day: Experimental and clinical data . Scand. J. Infect. Dis. Suppl. , 74 : 249 – 257 .
  • Tulkens , P. M. 1991b . Pharmacokinetic and toxicological evaluation of the once‐a‐day regimen versus conventional schedules of netilmicin and amikacin . J. Antimicrob. Chemother. , 27 (C) : 49 – 61 .
  • Tulkens , P. M. , De Broe , M. E. , Maldague , P. and Heuson‐Stiennon , J. 1984 . “ The role of lysosomes in aminoglycoside‐induced nephrotoxicity ” . In Acute renal failure: Correlations between morphology and (unction , Edited by: Solez , K. and Whelton , A. 299 – 327 . New York : Marcel Dekker .
  • Tulkens , P. M. , Mingeot‐Leclercq , M. P. , Laurent , C. and Brasseur , R. 1990 . “ Conformational and biochemical analysis of the interactions phospholipids‐aminoglycoside antibiotics in relation with their toxicity ” . In Molecular description of biological membrane components by computer‐aided conformational analysis , Edited by: Brasseur , R. vol. II , 63 – 93 . Boca Raton, Fla. : CRC Press .
  • Vaamonde , C. A. , Laurent , C. , Beauchamp , D. , Carlier , M. B. , Ibrahim , S. , Maldague , P. and Tulkens , P. M. 1986 . Renal phospholipidosis and cellular response of diabetic and control rats to low, non‐toxic doses of gentamicin . Kidney Int. , 29 : 311
  • Van Bambeke , F. , Mingeot‐Leclercq , M. P. , Schanck , A. , Brasseur , R. and Tulkens , P. M. 1993 . Alterations in membrane permeability induced by aminoglycoside antibiotics: Studies on liposomes and cultured cells . Eur. J. Pharmacol. , 247 : 155 – 168 .
  • Van Bambeke , F. , Mingeot‐Leclerq , M.‐P. , Brasseur , R. , Tulkens , P. M. and Schanck , A. “ Aminoglycoside antibiotics prevent the formation of inverted micelles in negatively‐charged membranes ” . Comparative studies using melittin and spermine (submitted)
  • Van Bambeke , F. , Tulkens , P. M. , Brasseur , R. and Mingeot‐Leclercq , M.‐P. “ Aminoglycoside antibiotics induce aggregation but not fusion of negatively‐charged liposomes ” . Comparative studies using melittin and spermine (submitted)
  • Van Dijck , P. W. M. , Ververgaert , P. H. J. , Verkleij , A. J. , Van Deenen , L. L. M. and De Gier , J. 1975 . Influence of Ca2+ and Mg2+ on the thermotropic behaviour and permeability properties of liposomes prepared from dimyristoyl phosphatidylglycerol and mixtures of DMPG and DMPC . Biochim. Biophys. Acta , 406 : 465 – 478 .
  • Van Echteld , C. J. , De Kruijff , B. , Verkleij , A. J. , Leunissen‐Bijvelt , J. and De Gier , J. 1982 . Gramicidin induces the formation of non‐bilayer structures in phosphatidylcholine dispersions in a fatty acid chain length dependent way . Biochim. Biophys. Acta , 692 : 126 – 138 .
  • van Hoogevest , P. , de Gier , J. and de Kruijff , B. 1984 . Determination of the size of the packing defects in dimyristoylphosphatidylcholine bilayers, present at the phase transition temperature . FEBS Lett. , 171 (2) : 160 – 164 .
  • Van Schepdael , A. , Busson , R. , Verbist , L. , Vanderhaeghe , H. J. , Mingeot‐Léclercq , P. M. , Brasseur , R. and Tulkens , P. M. 1991a . Synthesis, antibacterial activity and toxicological evaluation (in vitro and computer‐aided) of 1‐C‐hydroxylmethyl kanamycin B and 1‐C‐hydroxymethyl, 6"‐chlorokanamycin . B. J. Med. Chem. , 34 : 1483 – 1492 .
  • Van Schepdael , A. , Delcourt , J. , Mulier , M. , Busson , R. , Mingeot‐Leclercq , M. P. , Tulkens , P. M. and Claes , P. J. 1991b . New derivatives of kanamycin B obtained by modifications and substitutions in position 6”;. I. Synthesis and microbiological evaluation . J. Med. Chem. , 34 : 1468 – 1475 .
  • Vasilenko , I. , De Kruijff , B. and Verkleij , A. J. 1982 . Polymorphic phase behaviour of cardiolipin from bovine heart and from Bacillus subtilis as detected by 31P‐NMR and freeze‐fracture techniques. Effects of Ca2+, Mg2+, Ba2+ and temperature . Biochim. Biophys. Acta , 684 : 282 – 286 .
  • Verkleij , A. J. 1984 . Lipidic intramembranous particles . Biochim. Biophys. Acta , 779 : 43 – 63 .
  • Verkleij , A. J. , De Maagd , R. and Leunissen‐Bijvelt , J. 1982 . Divalent cations and chlorpromazine can induce non‐bilayer structures in PA containing model membranes . Biochim. Biophys. Acta , 684 : 255 – 262 .
  • Wang , B. M. , Weiner , N. D. , Takada , A. and Schacht , J. 1984 . Characterization of aminoglycoside‐lipid interactions and development of a refined model for ototoxicity testing . Biochem. Pharmacol. , 33 : 3257 – 3262 .
  • Weinstein , J. N. , Yoshikami , S. , Henkart , P. , Blumenthal , R. and Hagins , W. A. 1977 . Liposome‐cell interaction: transfer and intracellular release of a trapped fluorescent marker . Science , 195 : 489 – 491 .
  • Wiener , J. R. , Pal , R. , Barenholz , Y. and Wagner , R. 1985 . Effect of the vesicular stomatitis virus matrix protein on the lateral organization of lipid bilayers containing phosphatidylglycerol: Use of fluorescent phospholipid analogues . Biochemistry , 24 : 7651 – 7658 .
  • Williams , P. D. and Hottendorf , G. H. 1985 . Inhibition of renal membrane binding and nephrotoxicity of gentamicin by polyasparagine and polyaspartic acid in the rat. . Res. Commun. Chem. Pathol. Pharmacol. , 47 : 317 – 320 .
  • Williams , P. D. , Hottendorf , G. H. and Bennett , D. B. 1986 . Inhibition of renal membrane binding and nephrotoxicity of aminoglycosides . A Pharmacol. Exp. Ther. , 237 : 919 – 925 .
  • Yeagle , P. L. 1989 . Lipid regulation of cell membrane structure and function . FASEB J. , 3 : 1833 – 1842 .

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