Development and Validation of an ELISA Method for Detection of Growth Arrest Specific 6 (GAS6) Protein in Human Plasma

REFERENCES

• Schneider , C. , King , R. M. and Philipson , L. 1988 . Genes specifically expressed at growth arrest of mammalian cells . Cell , 54 ( 6 ) : 787 – 793 .
   PubMed Web of Science ®Google Scholar
• Manfioletti , G. , Brancolini , C. , Avanzi , G. C. and Schneider , C. 1993 . The protein encoded by a growth arrest‐specific gene (gas6) is a new member of the vitamin K‐dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade . Mol. Cell. Biol. , 13 ( 8 ) : 4976 – 4985 .
   PubMedGoogle Scholar
• Saccone , S. , Marcandalli , P. , Gostissa , M. , Schneider , C. and Della Valle , G. 1995 . Assignment of the human GAS6 gene to chromosome 13q34 by fluorescence in situ hybridization . Genomics , 30 ( 1 ) : 129 – 131 .
   Google Scholar
• Mark , M. R. , Chen , J. , Hammonds , R. G. , Sadick , M. and Godowsk , P. J. 1996 . Characterization of Gas6, a member of the superfamily of G domain‐containing proteins, as a ligand for Rse and Axl . J. Biol. Chem. , 271 ( 16 ) : 9785 – 9789 .
   Google Scholar
• Avanzi , G. C. , Gallicchio , M. , Bottarel , F. , Gammaitoni , L. , Cavalloni , G. , Buonfiglio , D. , Bragardo , M. , Bellomo , G. , Albano , E. , Fantozzi , R. , Garbarino , G. , Varnum , B. , Aglietta , M. , Saglio , G. , Dianzani , U. and Dianzani , C. 1998 . GAS6 inhibits granulocyte adhesion to endothelial cells . Blood , 91 ( 7 ) : 2334 – 2340 .
   Google Scholar
• Nakano , T. , Kawamoto , K. , Higashino , K. and Arita , H. 1996 . Prevention of growth arrest‐induced cell death of vascular smooth muscle cells by a product of growth arrest‐specific gene, gas6 . FEBS Lett. , 387 ( 1 ) : 78 – 80 .
   Google Scholar
• Neubauer , A. , Fiebeler , A. , Graham , D. K. , O'Bryan , J. P. , Schmidt , C. A. , Barckow , P. , Serke , S. , Siegert , W. , Snodgrass , H. R. and Huhn , D. 1994 . Expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis . Blood , 84 ( 6 ) : 1931 – 1941 .
   PubMed Web of Science ®Google Scholar
• Prieto , A. L. , Weber , J. L. , Tracy , S. , Heeb , M. J. and Lai , C. 1999 . Gas6, a ligand for the receptor protein‐tyrosine kinase Tyro‐3, is widely expressed in the central nervous system . Brain Res. , 816 ( 2 ) : 646 – 661 .
   Google Scholar
• Chan , M. C. , Mather , J. P. , McCray , G. and Lee , W. M. 2000 . Identification and regulation of receptor tyrosine kinases Rse and Mer and their ligand Gas6 in testicular somatic cells . J. Androl. , 21 ( 2 ) : 291 – 302 .
   Google Scholar
• Goruppi , S. , Ruaro , E. and Schneider , C. 1996 . Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts . Oncogene , 12 ( 3 ) : 471 – 480 .
   PubMed Web of Science ®Google Scholar
• Chen , W. S. , Kung , H. J. , Yang , W. K. and Lin , W. 1999 . Comparative tyrosine‐kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa . Intl. J. Cancer , 83 ( 5 ) : 579 – 584 .
   Google Scholar
• Craven , R. J. , Xu , L. H. , Weiner , T. M. , Fridell , Y. W. , Dent , G. A. , Srivastava , S. , Varnum , B. , Liu , E. T. and Cance , W. G. 1995 . Receptor tyrosine kinases expressed in metastatic colon cancer . Intl. J. Cancer , 60 ( 6 ) : 791 – 797 .
   Google Scholar
• Sainaghi , P. P. , Castello , L. , Bergamasco , L. , Galletti , M. , Bellosta , P. and Avanzi , G. C. 2005 . Gas6 induces proliferation in prostate carcinoma cell lines expressing the Axl receptor . J. Cell. Physiol. , 204 ( 1 ) : 36 – 44 .
   PubMed Web of Science ®Google Scholar
• Nakano , T. , Kawamoto , K. , Kishino , J. , Nomura , K. , Higashino , K. and Arita , H. 1997 . Requirement of gamma‐carboxyglutamic acid residues for the biological activity of Gas6: contribution of endogenous Gas6 to the proliferation of vascular smooth muscle cells . Biochem. J. , 323 ( 2 ) : 387 – 392 .
   Google Scholar
• Fisher , P. W. , Brigham‐Burke , M. , Wu , S. J. , Luo , J. , Carton , J. , Staquet , K. , Gao , W. , Jackson , S. , Bethea , D. , Chen , C. , Hu , B. , Giles‐Komar , J. and Yang , J. 2005 . A novel site contributing to growth‐arrest‐specific gene 6 binding to its receptors as revealed by a human monoclonal antibody . Biochem. J. , 387 ( 3 ) : 727 – 735 .
   Google Scholar
• Angelillo‐Scherrer , A. , de Frutos , P. , Aparicio , C. , Melis , E. , Savi , P. , Lupu , F. , Arnout , J. , Dewerchin , M. , Hoylaerts , M. , Herbert , J. , Collen , D. , Dahlback , B. and Carmeliet , P. 2001 . Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis . Nat. Med. , 7 ( 2 ) : 215 – 221 .
   PubMed Web of Science ®Google Scholar
• Angelillo‐Scherrer , A. , Burnier , L. , Flores , N. , Savi , P. , DeMol , M. , Schaeffer , P. , Herbert , J. M. , Lemke , G. , Goff , S. P. , Matsushima , G. K. , Earp , H. S. , Vesin , C. , Hoylaerts , M. F. , Plaisance , S. , Collen , D. , Conway , E. M. , Wehrle‐Haller , B. and Carmeliet , P. 2005 . Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy . J. Clin. Invest. , 115 ( 2 ) : 237 – 246 .
   PubMed Web of Science ®Google Scholar
• Fridell , Y. W. , Villa , J. , Attar , E. C. and Liu , E. T. 1998 . GAS6 induces Axl‐mediated chemotaxis of vascular smooth muscle cells . J. Biol. Chem. , 273 ( 12 ) : 7123 – 7126 .
   PubMed Web of Science ®Google Scholar
• Lu , Q. and Lemke , G. 2001 . Homeostatic regulation of the immune system by receptor tyrosine kinases of the Tyro 3 family . Science , 293 ( 5528 ) : 306 – 311 .
   PubMed Web of Science ®Google Scholar
• Gallicchio , M. , Mitola , S. , Valdembri , D. , Fantozzi , R. , Varnum , B. , Avanzi , G. C. and Bussolino , F. 2005 . Inhibition of vascular endothelial growth factor receptor 2‐mediated endothelial cell activation by Axl tyrosine kinase receptor . Blood , 105 ( 5 ) : 1970 – 1976 .
   PubMed Web of Science ®Google Scholar
• Guidance for Industry: Bioanalytical Method Validation . 2001 . : 1 – 20 . U.S. Department of Health and Human Services; Food and Drug Administration; Center for Drug Evaluation and Research (CDER); Center for Veterinary Medicine (CVM)
   Google Scholar
• Balogh , I. , Hafizi , S. , Stenhoff , J. , Hansson , K. and Dahlback , B. 2005 . Analysis of Gas6 in human platelets and plasma . Arterioscler. Thromb. Vasc. Biol. , 25 ( 6 ) : 1280 – 1286 .
   Google Scholar
• Maple , L. , Lathrop , R. , Bozich , S. , Harman , W. , Tacey , R. , Kelley , M. and Danilkovitch‐Miagkova , A. 2004 . Development and validation of ELISA for herceptin detection in human serum . J. Immunol. Meth. , 295 ( 1–2 ) : 169 – 182 .
   PubMedGoogle Scholar
• Kricka , L. J. 1999 . Human anti‐animal antibody interferences in immunological assays . Clin. Chem. , 45 ( 7 ) : 942 – 956 .
   PubMed Web of Science ®Google Scholar
• Budagian , V. , Bulanova , E. , Orinska , Z. , Duitman , E. , Brandt , K. , Ludwig , A. , Hartmann , D. , Lemke , G. , Saftig , P. and Bulfone‐Paus , S. 2005 . Soluble Axl is generated by ADAM10‐dependent cleavage and associates with Gas6 in mouse serum . Mol. Cell. Biol. , 25 ( 21 ) : 9324 – 9339 .
   PubMedGoogle Scholar
• Findlay , J. W. , Smith , W. C. , Lee , J. W. , Nordblom , G. D. , Das , I. , DeSilva , B. S. , Khan , M. N. and Bowsher , R. R. 2000 . Validation of immunoassays for bioanalysis: a pharmaceutical industry perspective . J. Pharm. Biomed. Anal. , 21 ( 6 ) : 1249 – 1273 .
   PubMed Web of Science ®Google Scholar
• Borgel , D. , Clauser , S. , Bornstain , C. , Bieche , I. , Bissery , A. , Remones , V. , Fagon , J. Y. , Aiach , M. and Diehl , J. L. 2006 . Elevated growth‐arrest‐specific protein 6 plasma levels in patients with severe sepsis . Crit. Care Med. , 34 ( 1 ) : 219 – 222 .
   Google Scholar