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Case Reports

The Enigma of Low-Dose Ketamine for Treatment of Opioid-Induced Hyperalgesia in the Setting of Psychosocial Suffering and Cancer-Associated Pain

Pages 248-255 | Received 17 Nov 2018, Accepted 25 Apr 2019, Published online: 24 May 2019

References

  • van den Beuken-van Everdingen MH, de Rijke JM, Kessels AG, et al. Prevalence of pain in patients with cancer: a systematic review of the past 40 years. Ann Oncol. 2007;18(9):1437–1449. doi:10.1093/annonc/mdm056.
  • Chu LF, Angst MS, Clark D. Opioid-induced hyperalgesia in humans: molecular mechanisms and clinical considerations. Clin J Pain. 2008;24(6):479–496. doi:10.1097/AJP.0b013e31816b2f43.
  • Lee M, Silverman SM, Hansen H, Patel VB, Manchikanti L. A comprehensive review of opioid-induced hyperalgesia. Pain Physician 2011;14(2):145–161.
  • Juba KM, Wahler RG, Daron SM. Morphine and hydromorphone-induced hyperalgesia in a hospice patient. J Palliat Med. 2013;16(7):809–812. doi:10.1089/jpm.2011.0502.
  • Roeckel LA, Utard V, Reiss D, et al. Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide. Sci Rep 2017;7:10406.
  • Santonocito C, Noto A, Crimi C, Sanfilippo F. Remifentanil-induced postoperative hyperalgesia: current perspectives on mechanisms and therapeutic strategies. Lra. 2018;11:15–23. doi:10.2147/LRA.S143618.
  • Kalaydjian A, Farah F, Cheng Y, Acquadro MA, Gerges FJ. Opioid induced hyperalgesia with intrathecal infusion of high dose fentanyl. Pain Pract 2018;19:222–223.
  • Lyons PJ, Rivosecchi RM, Nery JP, Kane-Gill SL. Fentanyl-induced hyperalgesia in acute pain management. J Pain Palliat Care Pharmacother. 2015;29(2):153–160. doi:10.3109/15360288.2015.1035835.
  • Yi P, Pryzbylkowski P. Opioid induced hyperalgesia. Pain Med. 2015;16 Suppl 1:S32–S6. doi:10.1111/pme.12914.
  • McPherson ML, Walker KA, Davis MP, et al. Safe and appropriate use of methadone in hospice and palliative care: expert consensus white paper. J Pain Symptom Manage 2018;57(3):635–645.
  • Fine PG. Low-dose ketamine in the management of opioid nonresponsive terminal cancer pain. J Pain Symptom Manage 1999;17(4):296–300.
  • Lauretti GR, Lima IC, Reis MP, Prado WA, Pereira NL. Oral ketamine and transdermal nitroglycerin as analgesic adjuvants to oral morphine therapy for cancer pain management. Anesthesiology 1999;90(6):1528–1533.
  • Javery KB, Ussery TW, Steger HG, Colclough GW. Comparison of morphine and morphine with ketamine for postoperative analgesia. Can J Anaesth 1996;43(3):212–215. doi:10.1007/BF03011736.
  • Bell RF, Dahl JB, Moore RA, Kalso E. Perioperative ketamine for acute postoperative pain. Cochrane Database Syst Rev 2006; (3):CD004603.
  • Joachimsson PO, Hedstrand U, Eklund A. Low-dose ketamine infusion for analgesia during postoperative ventilator treatment. Acta Anaesthesiol Scand.1986;30(8):697–702. doi:10.1111/j.1399-6576.1986.tb02505.x.
  • Stubhaug A, Breivik H, Eide PK, Kreunen M, Foss A. Mapping of punctuate hyperalgesia around a surgical incision demonstrates that ketamine is a powerful suppressor of central sensitization to pain following surgery. Acta Anaesthesiol Scand 1997;41(9):1124–1132.
  • Waldfogel JM, Nesbit S, Cohen SP, Dy SM. Successful treatment of opioid-refractory cancer pain with short-course, low-dose ketamine. J Pain Palliat Care Pharmacother. 2016;30(4):294–297. doi:10.1080/15360288.2016.1231732.
  • Ballard ED, Ionescu DF, Vande Voort JL, et al. Improvement in suicidal ideation after ketamine infusion: relationship to reductions in depression and anxiety. J Psychiatr Res. 2014;58:161–166. doi:10.1016/j.jpsychires.2014.07.027.
  • Berman RM, Cappiello A, Anand A, et al. Antidepressant effects of ketamine in depressed patients. Biol Psychiatry 2000;47(4):351–354.
  • Irwin SA, Iglewicz A. Oral ketamine for the rapid treatment of depression and anxiety in patients receiving hospice care. J Palliat Med. 2010;13(7):903–908. doi:10.1089/jpm.2010.9808.
  • Zarate CA, Jr., Singh J, Manji HK. Cellular plasticity cascades: targets for the development of novel therapeutics for bipolar disorder. Biol Psychiatry.2006;59(11):1006–1020. doi:10.1016/j.biopsych.2005.10.021.
  • Vanderah TW, Gardell LR, Burgess SE, et al. Dynorphin promotes abnormal pain and spinal opioid antinociceptive tolerance. J Neurosci. 2000;20(18):7074–7079. doi:10.1523/JNEUROSCI.20-18-07074.2000.
  • Hutchinson MR, Zhang Y, Shridhar M, et al. Evidence that opioids may have toll-like receptor 4 and MD-2 effects. Brain Behav Immun. 2010;24(1):83–95. doi:10.1016/j.bbi.2009.08.004.
  • Lutz BM, Nia S, Xiong M, Tao YX, Bekker A. mTOR, a new potential target for chronic pain and opioid-induced tolerance and hyperalgesia. Mol Pain. 2015;11:32. doi:10.1186/s12990-015-0030-5.
  • Li X, Angst MS, Clark JD. A murine model of opioid-induced hyperalgesia. Brain Res Mol Brain Res 2001;86(1–2):56–62.
  • Roeckel LA, Le Coz GM, Gaveriaux-Ruff C, Simonin F. Opioid-induced hyperalgesia: Cellular and molecular mechanisms. Neuroscience 2016;338:160–182. doi:10.1016/j.neuroscience.2016.06.029.
  • Seeburg PH, Burnashev N, Kohr G, et al. The NMDA receptor channel: molecular design of a coincidence detector. Recent Prog Horm Res 1995;50:19–34.
  • Petrenko AB, Yamakura T, Baba H, Shimoji K. The role of N-methyl-D-aspartate (NMDA) receptors in pain: a review. Anesth Analg 2003;97(4):1108–1116.
  • Bartlett SE, Cramond T, Smith MT. The excitatory effects of morphine-3-glucuronide are attenuated by LY274614, a competitive NMDA receptor antagonist, and by midazolam, an agonist at the benzodiazepine site on the GABAA receptor complex. Life Sci 1994;54(10):687–694.
  • Zhao YL, Chen SR, Chen H, Pan HL. Chronic opioid potentiates presynaptic but impairs postsynaptic N-methyl-D-aspartic acid receptor activity in spinal cords: implications for opioid hyperalgesia and tolerance. J Biol Chem. 2012;287(30):25073–25085. doi:10.1074/jbc.M112.378737.
  • Rodriguez-Munoz M, Sanchez-Blazquez P, Vicente-Sanchez A, Berrocoso E, Garzon J. The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control. Neuropsychopharmacol. 2012;37:338–349. doi:10.1038/npp.2011.155.
  • Celerier E, Rivat C, Jun Y, et al. Long-lasting hyperalgesia induced by fentanyl in rats: preventive effect of ketamine. Anesthesiology 2000;92:465–472. doi:10.1097/00000542-200002000-00029.
  • Larcher A, Laulin JP, Celerier E, Le Moal M, Simonnet G. Acute tolerance associated with a single opiate administration: involvement of N-methyl-D-aspartate-dependent pain facilitatory systems. Neuroscience 1998;84(2):583–589.
  • Ohnesorge H, Feng Z, Zitta K, et al. Influence of clonidine and ketamine on m-RNA expression in a model of opioid-induced hyperalgesia in mice. PLoS One. 2013;8(11):e79567 doi:10.1371/journal.pone.0079567.
  • Arout CA, Caldwell M, Rossi G, Kest B. Spinal and supraspinal N-methyl-D-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia. Physiol Behav. 2015;147:364–372. doi:10.1016/j.physbeh.2015.05.006.
  • Allen CA, Ivester JR. Jr., Low-dose ketamine for postoperative pain management. J Perianesth Nurs. 2018;33(4):389–398. doi:10.1016/j.jopan.2016.12.009.
  • Bell RF, Eccleston C, Kalso EA. Ketamine as an adjuvant to opioids for cancer pain. Cochrane Database Syst Rev 2017;6:CD003351.
  • De Conno F, Groff L, Brunelli C, et al. Clinical experience with oral methadone administration in the treatment of pain in 196 advanced cancer patients. Jco. 1996;14(10):2836–2842. doi:10.1200/JCO.1996.14.10.2836.
  • De Kock M, Lavand'homme P, Waterloos H. Balanced analgesia' in the perioperative period: is there a place for ketamine? Pain 2001;92(3):373–380.
  • Gardner-Nix JS. Oral methadone for managing chronic nonmalignant pain. J Pain Symptom Manage 1996;11(5):321–328.
  • Maher DP, Chen L, Mao J. Intravenous ketamine infusions for neuropathic pain management: a promising therapy in need of optimization. Anesth Analg. 2017;124(2):661–674. doi:10.1213/ANE.0000000000001787.
  • Bosma RL, Cheng JC, Rogachov A, et al. Brain dynamics and temporal summation of pain predicts neuropathic pain relief from ketamine infusion. Anesthesiology 2018;129(5):1015–1024. doi:10.1097/ALN.0000000000002417.
  • Davis MP, Walsh D. Methadone for relief of cancer pain: a review of pharmacokinetics, pharmacodynamics, drug interactions and protocols of administration. Support Care Cancer. 2001;9(2):73–83. doi:10.1007/s005200000180.
  • Eap CB, Buclin T, Baumann P. Interindividual variability of the clinical pharmacokinetics of methadone: implications for the treatment of opioid dependence. Clin Pharmacokinet. 2002;41(14):1153–1193. doi:10.2165/00003088-200241140-00003.
  • Peltoniemi MA, Hagelberg NM, Olkkola KT, Saari TI. Ketamine: a review of clinical pharmacokinetics and pharmacodynamics in anesthesia and pain therapy. Clin Pharmacokinet. 2016;55(9):1059–1077. doi:10.1007/s40262-016-0383-6.
  • Engelhardt T, Zaarour C, Naser B, et al. Intraoperative low-dose ketamine does not prevent a remifentanil-induced increase in morphine requirement after pediatric scoliosis surgery. Anesth Analg.2008;107(4):1170–1175. doi:10.1213/ane.0b013e318183919e.
  • Joly V, Richebe P, Guignard B, et al. Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine. Anesthesiology 2005;103(1):147–155. doi:10.1097/00000542-200507000-00022.
  • Luginbuhl M, Gerber A, Schnider TW, et al. Modulation of remifentanil-induced analgesia, hyperalgesia, and tolerance by small-dose ketamine in humans. Anesth Analg 2003;96:726–732. table of contents.
  • Forero M, Chan PS, Restrepo-Garces CE. Successful reversal of hyperalgesia/myoclonus complex with low-dose ketamine infusion. Pain Pract.2012;12(2):154–158. doi:10.1111/j.1533-2500.2011.00475.x.
  • Winegarden J, Carr DB, Bradshaw YS. Intravenous ketamine for rapid opioid dose reduction, reversal of opioid-induced neurotoxicity, and pain control in terminal care: case report and literature review. Pain Med 2016;17:644–649.
  • Jansen KL. A review of the nonmedical use of ketamine: use, users and consequences. J Psychoactive Drugs. 2000;32(4):419–433. doi:10.1080/02791072.2000.10400244.
  • Wall J, Chauhan A. A case of opioid-induced hyperalgesia. J Pain Palliat Care Pharmacother.2018:1–3. doi:10.1080/15360288.2018.1546256.
  • Mercadante S, Arcuri E. Hyperalgesia and opioid switching. Am J Hosp Palliat Care. 2005;22(4):291–294. doi:10.1177/104990910502200411.
  • Fine PG. Opioid insights:opioid-induced hyperalgesia and opioid rotation. J Pain Palliat Care Pharmacother.2004;18:75–79. doi:10.1080/J354v18n03_08.
  • Koppert W, Sittl R, Scheuber K, et al. Differential modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by S-ketamine and clonidine in humans. Anesthesiology 2003;99(1):152–159.
  • Patch Iii RK, Eldrige JS, Moeschler SM, Pingree MJ. Dexmedetomidine as part of a multimodal analgesic treatment regimen for opioid induced hyperalgesia in a patient with significant opioid tolerance. Case Rep Anesthesiol. 2017;2017:9876306. doi:10.1155/2017/9876306.
  • Belgrade M, Hall S. Dexmedetomidine infusion for the management of opioid-induced hyperalgesia. Pain Med. 2010;11(12):1819–1826. doi:10.1111/j.1526-4637.2010.00973.x.
  • Yu Z, Wu W, Wu X, et al. Protective effects of dexmedetomidine combined with flurbiprofen axetil on remifentanil-induced hyperalgesia: a randomized controlled trial. Exp Ther Med.2016;12(4):2622–2628. doi:10.3892/etm.2016.3687.
  • Chan AK, Cheung CW, Chong YK. Alpha-2 agonists in acute pain management. Expert Opin Pharmacother. 2010;11(17):2849–2868. doi:10.1517/14656566.2010.511613.
  • Yuan Y, Sun Z, Chen Y, et al. Prevention of remifentanil induced postoperative hyperalgesia by dexmedetomidine via regulating the trafficking and function of spinal nmda receptors as well as PKC and CaMKII level in vivo and in vitro. PLoS One. 2017;12(2):e0171348. doi:10.1371/journal.pone.0171348.
  • Taiwo YO, Levine JD. Prostaglandins inhibit endogenous pain control mechanisms by blocking transmission at spinal noradrenergic synapses. J Neurosci. 1988;8(4):1346–1349. doi:10.1523/JNEUROSCI.08-04-01346.1988.
  • Ito S, Okuda-Ashitaka E, Minami T. Central and peripheral roles of prostaglandins in pain and their interactions with novel neuropeptides nociceptin and nocistatin. Neurosci Res 2001;41(4):299–332.
  • Baba H, Kohno T, Moore KA, Woolf CJ. Direct activation of rat spinal dorsal horn neurons by prostaglandin E2. J Neurosci 2001;21(5):1750–1756.
  • Minami T, Sugatani J, Sakimura K, et al. Absence of prostaglandin E2-induced hyperalgesia in NMDA receptor epsilon subunit knockout mice. Br J Pharmacol. 1997;120(8):1522–1526. doi:10.1038/sj.bjp.0701067.
  • Nishihara I, Minami T, Uda R, et al. Effect of NMDA receptor antagonists on prostaglandin E2-induced hyperalgesia in conscious mice. Brain Res 1995;677(1):138–144.
  • Troster A, Sittl R, Singler B, et al. Modulation of remifentanil-induced analgesia and postinfusion hyperalgesia by parecoxib in humans. Anesthesiology 2006;105(5):1016–1023.
  • Lenz H, Raeder J, Draegni T, et al. Effects of COX inhibition on experimental pain and hyperalgesia during and after remifentanil infusion in humans. Pain 2011;152(6):1289–1297. doi:10.1016/j.pain.2011.02.007.

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