The Effect of Concurrent Use of Opioids and Gabapentin on Fall Risk in Older Adults

References

• Newgard CD, Lin A, Caughey AB, Eckstrom E, Bulger EM, Staudenmayer K, Maughan B, Malveau S, Griffiths D, McConnell KJ. The cost of a fall among older adults requiring emergency services. J Am Geriatr Soc. 2021;69(2):389–98.
   PubMed Web of Science ®Google Scholar
• CDC. Older Adult Fall Prevention. CDC; 2023. https://www.cdc.gov/falls/data-research/facts-stats/index.html.
   Google Scholar
• Florence CS, Bergen G, Atherly A, Burns E, Stevens J, Drake C. Medical costs of fatal and nonfatal falls in older adults. J Am Geriatr Soc. 2018;66(4):693–8. doi:10.1111/jgs.15304.
   PubMed Web of Science ®Google Scholar
• Huang AR, Mallet L, Rochefort CM, Eguale T, Buckeridge DL, Tamblyn R. Medication-related falls in the elderly. Drugs Aging. 2012;29(5):359–76. doi:10.2165/11599460-000000000-00000.
   PubMed Web of Science ®Google Scholar
• Naples JG, Gellad WF, Hanlon JT. The role of opioid analgesics in geriatric pain management. Clin Geriatr Med. 2016;32(4):725–35. doi:10.1016/j.cger.2016.06.006.
   PubMed Web of Science ®Google Scholar
• Fleet JL, Dixon SN, Kuwornu PJ, Dev VK, Montero-Odasso M, Burneo J, Garg AX. Gabapentin dose and the 30-day risk of altered mental status in older adults: a retrospective population-based study. PLoS One. 2018;13(3):e0193134. doi:10.1371/journal.pone.0193134.
   PubMed Web of Science ®Google Scholar
• Ishida JH, McCulloch CE, Steinman MA, Grimes BA, Johansen KL. Gabapentin and pregabalin use and association with adverse outcomes among hemodialysis patients. J Am Soc Nephrol. 2018;29(7):1970–8. doi:10.1681/ASN.2018010096.
   PubMed Web of Science ®Google Scholar
• American Geriatrics Society 2023 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2023;71(7):2052–81.
   PubMed Web of Science ®Google Scholar
• Shah R, Raji MA, Westra J, Kuo YF. Association of co-prescribing of opioid and benzodiazepine substitutes with incident falls and fractures among older adults: a cohort study. BMJ Open. 2021;11(12):e052057. doi:10.1136/bmjopen-2021-052057.
   PubMed Web of Science ®Google Scholar
• McPherson, ML (Eds.). Demystifying opioid conversion calculations. 2nd ed. Bethesda (MD): American Society of Health-System Pharmacists; 2018. doi:10.37573/9781585284306.
   Google Scholar
• Banerjee G, Edelman EJ, Barry DT, Crystal S, Gordon KS, Gordon AJ, Gaither JR, Green TC, Kerns RD, Manhapra A, et al. High-dose prescribed opioids are associated with increased risk of heroin use among United States military veterans. Pain. 2019;160(9):2126–35. doi:10.1097/j.pain.0000000000001606.
   PubMed Web of Science ®Google Scholar
• Liacos M, Page AT, Etherton-Beer C. Deprescribing in older people. Aust Prescr. 2020;43(4):114–20. doi:10.18773/austprescr.2020.033.
   PubMed Web of Science ®Google Scholar
• Ailabouni N, Mangin D, Nishtala PS. DEFEAT-polypharmacy: deprescribing anticholinergic and sedative medicines feasibility trial in residential aged care facilities. Int J Clin Pharm. 2019;41(1):167–78. doi:10.1007/s11096-019-00784-9.
   PubMed Web of Science ®Google Scholar
• Langford AV, Lin CC, Bero L, Blyth FM, Doctor J, Holliday S, Jeon Y-H, Moullin J, Murnion B, Nielsen S, et al. Clinical practice guideline for deprescribing opioid analgesics: summary of recommendations. Med J Aust. 2023;219(2):80–9. doi:10.5694/mja2.52002.
   PubMed Web of Science ®Google Scholar
• Dowell D, Ragan KR, Jones CM, Baldwin GT, Chou R. CDC clinical practice guideline for prescribing opioids for pain—United States, 2022. MMWR Recomm Rep. 2022;71(3):1–95. doi:10.15585/mmwr.rr7103a1.
   PubMed Web of Science ®Google Scholar
• Frank JW, Lovejoy TI, Becker WC, Morasco BJ, Koenig CJ, Hoffecker L, Dischinger HR, Dobscha SK, Krebs EE. Patient outcomes in dose reduction or discontinuation of long-term opioid therapy. Ann Intern Med. 2017;167(3):181–91. doi:10.7326/M17-0598.
   PubMed Web of Science ®Google Scholar
• Pollard EM, Lamer TJ, Moeschler SM, Gazelka HM, Hooten WM, Bendel MA, et al. The effect of spinal cord stimulation on pain medication reduction in intractable spine and limb pain: a systematic review of randomized controlled trials and meta-analysis. J Pain Res. 2019;12:1311–24.
   PubMed Web of Science ®Google Scholar
• Hassan S, Zheng Q, Rizzolo E, Tezcanli E, Bhardwaj S, Cooley K. Does integrative medicine reduce prescribed opioid use for chronic pain? A systematic literature review. Pain Med. 2020;21(4):836–59. doi:10.1093/pm/pnz291.
   PubMed Web of Science ®Google Scholar
• Shropshire M, Stapleton S, Jin Kim M, Dyck M, Mallory C. Older people’s use of non-pharmacological interventions for chronic, non-cancer pain and comfort. Nurs Older People. 2019;31(6):33–9. doi:10.7748/nop.2019.e1110.
   PubMedGoogle Scholar
• Qaseem A, McLean RM, O’Gurek D, Batur P, Lin K, Kansagara DL, et al. Nonpharmacologic and pharmacologic management of acute pain from non–low back, musculoskeletal injuries in adults: a clinical guideline from the American College of Physicians and American Academy of Family Physicians. Ann Intern Med. 2020;173(9):739–48. doi:10.7326/M19-3602.
   PubMed Web of Science ®Google Scholar
• Qaseem A, Wilt TJ, McLean RM, Forciea MA, Denberg TD, Barry MJ, Boyd C, Chow RD, Fitterman N, Harris RP, Clinical Guidelines Committee of the American College of Physicians., et al. Noninvasive treatments for acute, subacute, and chronic low back pain: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2017;166(7):514–30. doi:10.7326/M16-2367.
   PubMed Web of Science ®Google Scholar
• Krebs EE, Gravely A, Nugent S, Jensen AC, DeRonne B, Goldsmith ES, Kroenke K, Bair MJ, Noorbaloochi S. Effect of opioid vs nonopioid medications on pain-related function in patients with chronic back pain or hip or knee osteoarthritis pain. JAMA. 2018;319(9):872–82. doi:10.1001/jama.2018.0899.
   PubMed Web of Science ®Google Scholar
• Fick D, Selma T, Steinman M, Beizer J, Brandt N, Dombrowski R. American Geriatrics Society 2019 updated AGS Beers Criteria® for potentially inappropriate medication use in older adults. J Am Geriatr Soc. 2019;67(4):674–94.
   PubMed Web of Science ®Google Scholar
• Ali A, Arif AW, Bhan C, Kumar D, Malik MB, Sayyed Z, Akhtar KH, Ahmad MQ. Managing chronic pain in the elderly: an overview of the recent therapeutic advancements. Cureus. 2018;10(9):e3293. doi:10.7759/cureus.3293.
   PubMed Web of Science ®Google Scholar
• Montero-Odasso M, van der Velde N, Martin FC, Petrovic M, Tan MP, Ryg J, Aguilar-Navarro S, Alexander NB, Becker C, Blain H, et al. World guidelines for falls prevention and management for older adults: a global initiative. Age Ageing. 2022;51(9):1–36.
   Web of Science ®Google Scholar
• Resnick B, Boltz M. Optimizing function and physical activity in hospitalized older adults to prevent functional decline and falls. Clin Geriatr Med. 2019;35(2):237–51. doi:10.1016/j.cger.2019.01.003.
   PubMed Web of Science ®Google Scholar