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Research Article

The effects of rotenone-induced toxicity via the NF-κB–iNOS pathway in rat liver

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Pages 318-325 | Received 17 Oct 2016, Accepted 15 Jan 2017, Published online: 13 Feb 2017

Reference

  • Abdelsalam RM, Safar MM. (2015). Neuroprotective effects of vildagliptin in rat rotenone Parkinson’s disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways. J Neurochem 133:700–7.
  • Ai Q, Jing Y, Jiang R, et al. (2014). Rotenone, a mitochondrial respiratory complex I inhibitor, ameliorates lipopolysaccharide/D-galactosamine-induced fulminant hepatitis in mice. Int Immunopharmacol 21:200–7.
  • Alharbi NO, Imam F, Alharbi MM, et al. (2016). Dexamethasone attenuates LPS-induced acute lung injury through inhibition of NF-κB, COX-2, and pro-inflammatory mediators. Immunol Investigat 45:1–21.
  • Amirtharaj GJ, Natarajan SK, Pulimood A, et al. (2016). Role of oxygen free radicals, nitric oxide and mitochondria in mediating cardiac alterations during liver cirrhosis induced by thioacetamide. Cardiovasc Toxicol [Epub ahead of print]. DOI:10.1007/s12012-016-9371-1
  • Araujo SM, De Paula MT, Poetini MR, et al. (2015). Effectiveness of γ-oryzanol in reducing neuromotor deficits, dopamine depletion and oxidative stress in a Drosophila melanogaster model of Parkinson's disease induced by rotenone. Neurotoxicology 51:96–105.
  • Biehlmaier O, Alam M, Schmidt WJ. (2007). A rat model of Parkinsonism shows depletion of dopamine in the retina. Neurochem Int 50:189–95.
  • Bredt DS. (1999). Endogenous nitric oxide synthesis: biological functions and pathophysiology. Free Rad Res 31:577–96.
  • Cabras P, Caboni P, Cabras M, et al. (2002). Rotenone residues on olives and in olive oil. J Agric Food Chem 50:2576–80.
  • Cavoski I, Caboni P, Sarais G, Miano T. (2008). Degradation and persistence of rotenone in soils and influence of temperature variations. J Agric Food Chem 56:8066–73.
  • Cavoski I, Caboni P, Sarais G, et al. (2007). Photodegradation of rotenone in soils under environmental conditions. J Agric Food Chem 55:7069–74.
  • Cha SM, Cha JD, Jang EJ, Lee KY. (2016). Sophoraflavanone G prevents Streptococcus mutans surface antigen I/II-induced production of NO and PGE2 by inhibiting MAPK-mediated pathways in RAW 264.7 macrophages. Arch Oral Biol 68:97–104.
  • Dhanalakshmi C, Janakiraman U, Manivasagam T, et al. (2016). Vanillin attenuated behavioural impairments, neurochemical defects, oxidative stress and apoptosis against rotenone induced rat model of Parkinson’s disease. Neurochem Res 41:12–1.
  • Ding W, Xu C, Wang B, Zhang M. (2015). Rotenone attenuates renal injury in aldosterone-infused rats by inhibiting oxidative stress, mitochondrial dysfunction, and inflammasome activation. Med Sci Monitor Int Med J Exp Clin Res 21:3136–43.
  • Drolet RE, Cannon JR, Montero L, Greenamyre JT. (2009). Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology. Neurobiol Dis 36:96–102.
  • Du C, Jin M, Hong Y, et al. (2014). Downregulation of cystathionine β-synthase/hydrogen sulfide contributes to rotenone-induced microglia polarization toward M1 type. Biochem Biophys Res Commun 451:239–45.
  • Fasano A, Visanji NP, Liu LW, et al. (2015). Gastrointestinal dysfunction in Parkinson's disease. Lancet Neurol 14:625–39.
  • Galvan A, Wichmann T. (2008). Pathophysiology of parkinsonism. Clin Neurophysiol 119:1459–74.
  • Gao HM, Hong JS, Zhang W, Liu B. (2002). Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci22:782–90.
  • Hseu YC, Wu FY, Wu JJ, et al. (2005). Anti-inflammatory potential of Antrodia Camphorata through inhibition of iNOS, COX-2 and cytokines via the NF-kappaB pathway. Int Immunopharmacol 5:1914–25.
  • Inden M, Kitamura Y, Takeuchi H, et al. (2007). Neurodegeneration of mouse nigrostriatal dopaminergic system induced by repeated oral administration of rotenone is prevented by 4-phenylbutyrate, a chemical chaperone. J Neurochem 101:1491–504.
  • Jiang T, Chang Q, Cai J, et al. (2016). Protective effects of melatonin on retinal inflammation and oxidative stress in experimental diabetic retinopathy. Oxid Med Cell Longev 2016:1–13.
  • Jing X, Tian ZB, Gao PJ, et al. (2015). Lipopolysaccharide enhances beta2-glycoprotein I activation of nuclear factor κB in liver cancer cells. Clin Lab 61:1239–45.
  • Karin M, Yamamoto Y, Wang QM. (2004). The IKK NF-|[kappa]|B system: a treasure trove for drug development. Dressnat Rev Drug Discov 3:17–26.
  • Liang HL, Whelan HT, Eells JT, Wong-Riley MTT. (2008). Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. Neuroscience 153:963–74.
  • Liu C, Sekine S, Ito K. (2016). Assessment of mitochondrial dysfunction-related, drug-induced hepatotoxicity in primary rat hepatocytes. Toxicol Appl Pharmacol 302:23–30.
  • Manna E, Bank S, Maiti S, et al. (2015). Neutralization by acetyl salicylic acid of the testosterone induced impaired Maspin synthesis stimulated by Estriol in neutrophils through nitric oxide synthesis. Int J Biomed Sci 11:176–84.
  • Mastbergen SC, Lafeber FP, Bijlsma JW. (2002). Selective COX-2 inhibition prevents proinflammatory cytokine-induced cartilage damage. Rheumatology 41:801–8.
  • Mauldin RE, Furcolow CA, Johnston JJ, Kimball BA. (2000). Determination of whole-body rotenone residues in the Brown Tree Snake (Boiga irregularis). J Agric Food Chem48:2240–3.
  • Moustafa GG, Hussein MM. (2016). New insight on using aged garlic extract against toxic impacts of titanium dioxide bulk salt triggers inflammatory and fibrotic cascades in male rats. Biomed Pharmacother 84:687–97.
  • Ojha S, Javed H, Azimullah S, et al. (2015). Neuroprotective potential of ferulic acid in the rotenone model of Parkinson’s disease. Drug Des Devel Ther 9:5499–510.
  • Ojha S, Javed H, Azimullah S, et al. (2016). Glycyrrhizic acid attenuates neuroinflammation and oxidative stress in rotenone model of Parkinson’s disease. Neurotoxic Res 29:1–13.
  • Panmontojo F, Schwarz M, Winkler C, et al. (2012). Environmental toxins trigger PD-like progression via increased alpha-synuclein release from enteric neurons in mice. Sci Rep 2:898.
  • Plaza DM. (2015). Inhibition of mitochondrial complex I leads to decreased motility and membrane integrity related to increased hydrogen peroxide and reduced ATP production, while the inhibition of glycolysis has less impact on sperm motility. PLoS One 10:701–706.
  • Seibert K, Zhang Y, Leahy K, et al. (1994). Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci 91:12013–12017.
  • Sharma N, Jamwal S, Kumar P. (2016). Beneficial effect of antidepressants against rotenone induced Parkinsonism like symptoms in rats. Pathophysiology 23:123–134.
  • Simeone V, Baser N, Perrelli D, et al. (2009). Residues of rotenone, azadirachtin, pyrethrins and copper used to control Bactrocera oleae (Gmel.) in organic olives and oil. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 26:475–81.
  • Singh K, Poteryakhina A, Zheltukhin A, et al. (2015). NLRX1 acts as tumor suppressor by regulating TNF-α induced apoptosis and metabolism in cancer cells. Biochim Biophys Acta 1853:1073–1086.
  • Tang Y, Yin L, Zhang Y, et al. (2016). Study on anti-inflammatory efficacy and correlative ingredients with pharmacodynamics detected in acute inflammation rat model serum from Caulis Lonicerae japonicae. Phytomed Int J Phytother Phytopharmacol 23:597–610.
  • Thakur P, Nehru B. (2013). Anti-inflammatory properties rather than anti-oxidant capability is the major mechanism of neuroprotection by sodium salicylate in a chronic rotenone model of Parkinson’s disease. Neuroscience 231:420–431.
  • Xiong Z, Lang J, Xu G, et al. (2015). Excessive levels of nitric oxide in rat model of Parkinson's disease induced by rotenone. Exp Therapeut Med 9:553–558.
  • Zhang XY, Chen L, Yang Y, et al. (2014). Regulation of rotenone-induced microglial activation by 5-lipoxygenase and cysteinyl leukotriene receptor 1. Brain Res 1572:59–71.
  • Zhou Y, Wang K, Yan C, et al. (2014). Effect of two formulations on the decline curves and residue levels of rotenone in cabbage and soil under field conditions. Ecotoxicol Environ Safe 104:23–27.
  • Zhou Y, Zhang N, Wang K, et al. (2013). Dissipation and residue of rotenone in cabbage and soil under field conditions. Bull Environ Contamin Toxicol 91:251–5.

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