The chemical disruption of human metabolism

References

• Afrin LB. 2016. Mast cell activation disease and the modern epidemic of chronic inflammatory disease. Transl Res. 174:33–59.
   PubMed Web of Science ®Google Scholar
• Aguilar-Garduno C, Lacasana M, Blanco-Munoz J, Rodriguez-Barranco M, Hernandez AF, Bassol S, Bassol S, González-Alzaga B, Cebrián ME. 2013. Changes in male hormone profile after occupational organophosphate exposure. A longitudinal study. Toxicology. 307:55–65.
   PubMed Web of Science ®Google Scholar
• Al-Mousa F, Michelangeli F. 2012. Some commonly used brominated flame retardants cause Ca2+-ATPase inhibition, beta-amyloid peptide release and apoptosis in SH-SY5Y neuronal cells. PLoS One. 7:e33059.
   PubMed Web of Science ®Google Scholar
• Al-Mousa F, Michelangeli F. 2014. The sarcoplasmic-endoplasmic reticulum Ca(2+)-ATPase (SERCA) is the likely molecular target for the acute toxicity of the brominated flame retardant hexabromocyclododecane (HBCD). Chem Biol Interact. 207:1–6.
   PubMed Web of Science ®Google Scholar
• Anway MD, Skinner MK. 2008. Epigenetic programming of the germ line: effects of endocrine disruptors on the development of transgenerational disease. Reprod Biomed Online. 16:23–25.
   PubMed Web of Science ®Google Scholar
• Anyanwu EC, Campbell AW, Vojdani A. 2003. Neurophysiological effects of chronic indoor environmental toxic mold exposure on children. Sci World J. 3:281–290.
   Google Scholar
• Arakawa O, Nakahiro M, Narahashi T. 1991. Mercury modulation of GABA-activated chloride channels and non-specific cation channels in rat dorsal root ganglion neurons. Brain Res. 551:58–63.
   PubMed Web of Science ®Google Scholar
• Arican O, Kurutas EB. 2008. Oxidative stress in the blood of patients with active localized vitiligo. Acta Dermatovenerol Alp Pannonica Adriat. 17:12–16.
   PubMedGoogle Scholar
• Arrieta MC, Stiemsma LT, Amenyogbe N, Brown EM, Finlay B. 2014. The intestinal microbiome in early life: health and disease. Front Immunol. 5:427.
   PubMed Web of Science ®Google Scholar
• Ashby J, Houthoff E, Kennedy SJ, Stevens J, Bars R, Jekat FW, Campbell P, Van Miller J, Carpanini FM, Randall GL, et al. 1997. The challenge posed by endocrine-disrupting chemicals. Environ Health Perspect. 105:164–169.
   PubMed Web of Science ®Google Scholar
• Bagga HS, Chi T, Miller J, Stoller ML. 2013. New insights into the pathogenesis of renal calculi. Urol Clin North Am. 40:1–12.
   PubMed Web of Science ®Google Scholar
• Baker SM. 2003. Detoxification and healing: the key to optimal health. New York: McGraw-Hill Education.
   Google Scholar
• Balthazart J. 2011. Minireview: hormones and human sexual orientation. Endocrinology. 152(8):2937–2947.
   PubMed Web of Science ®Google Scholar
• Bandara SB, Eubig PA, Sadowski RN, Schantz SL. 2016. Developmental PCB exposure increases audiogenic seizures and decreases glutamic acid decarboxylase in the inferior colliculus. Toxicol Sci. 149:335–345.
   PubMed Web of Science ®Google Scholar
• Baquero F, Nombela C. 2012. The microbiome as a human organ. Clin Microbiol Infect. 18(Suppl 4):2–4.
   PubMed Web of Science ®Google Scholar
• Belpomme D, Campagnac C, Irigaray P. 2015. Reliable disease biomarkers characterizing and identifying electrohypersensitivity and multiple chemical sensitivity as two etiopathogenic aspects of a unique pathological disorder. Rev Environ Health. 30:251–271.
   PubMed Web of Science ®Google Scholar
• Bernhoft RA. Cadmium toxicity and treatment. Sci World J. 2013;2013:394652.
   Web of Science ®Google Scholar
• Betts KS. 2011. A study in balance: how microbiomes are changing the shape of environmental health. Environ Health Perspect. 119:A340–A346.
   PubMedGoogle Scholar
• Birnbaum LS. 1994. Endocrine effects of prenatal exposure to PCBs, dioxins, and other xenobiotics: implications for policy and future research. Environ Health Perspect. 102:676–679.
   PubMed Web of Science ®Google Scholar
• Bitto A, Pizzino G, Irrera N, Galfo F, Squadrito F. 2014. Epigenetic modifications due to heavy metals exposure in children living in polluted areas. Curr Genomics. 15:464–468.
   PubMed Web of Science ®Google Scholar
• Blossom SJ, Pumford NR, Gilbert KM. 2004. Activation and attenuation of apoptosis of CD4+ T cells following in vivo exposure to two common environmental toxicants, trichloroacetaldehyde hydrate and trichloroacetic acid. J Autoimmun. 23:211–220.
   PubMed Web of Science ®Google Scholar
• Bodin J, Stene LC, Nygaard UC. 2015. Can exposure to environmental chemicals increase the risk of diabetes type 1 development? Biomed Res Int. 2015;208947.
   PubMed Web of Science ®Google Scholar
• Boeckxstaens G. 2015. Mast cells and inflammatory bowel disease. Curr Opin Pharmacol. 25:45–49.
   PubMed Web of Science ®Google Scholar
• Bonomini F, Tengattini S, Fabiano A, Bianchi R, Rezzani R. 2008. Atherosclerosis and oxidative stress. Histol Histopathol. 23:381–390.
   PubMed Web of Science ®Google Scholar
• Bottiglieri T. 2013. Folate, vitamin B(1)(2), and S-adenosylmethionine. Psychiatr Clin North Am. 36:1–13.
   PubMed Web of Science ®Google Scholar
• Brenner PF, Goebelsmann U, Stanczyk FZ, Mishell DR, Jr. 1980. Serum levels of ethinylestradiol following its ingestion alone or in oral contraceptive formulations. Contraception. 22:85–95.
   PubMed Web of Science ®Google Scholar
• Brent GA. 2010. Environmental exposures and autoimmune thyroid disease. Thyroid. 20:755–761.
   PubMed Web of Science ®Google Scholar
• Breton J, Massart S, Vandamme P, De Brandt E, Pot B, Foligne B. 2013. Ecotoxicology inside the gut: impact of heavy metals on the mouse microbiome. BMC Pharmacol Toxicol. 14:62.
   PubMed Web of Science ®Google Scholar
• Brown JM, Pfau JC, Pershouse MA, Holian A. 2005. Silica, apoptosis, and autoimmunity. J Immunotoxicol. 1:177–187.
   PubMedGoogle Scholar
• Cai P, Konig R, Boor PJ, Kondraganti S, Kaphalia BS, Khan MF, Ansari GAS. 2008. Chronic exposure to trichloroethene causes early onset of SLE-like disease in female MRL +/+ mice. Toxicol Appl Pharmacol. 228:68–75.
   PubMed Web of Science ®Google Scholar
• Calcerrada P, Peluffo G, Radi R. 2011. Nitric oxide-derived oxidants with a focus on peroxynitrite: molecular targets, cellular responses and therapeutic implications. Curr Pharm Des. 17:3905–3932.
   PubMed Web of Science ®Google Scholar
• Camacho L, Latendresse JR, Muskhelishvili L, Patton R, Bowyer JF, Thomas M, Doerge DR. 2012. Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats. Toxicology Lett. 211:135–143.
   PubMed Web of Science ®Google Scholar
• Canfield RL, Henderson CR Jr., Cory-Slechta DA, Cox C, Jusko TA, Lanphear BP. 2003. Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. N Engl J Med. 348:1517–1526.
   PubMed Web of Science ®Google Scholar
• Cascio G, Schiera G, Di Liegro I. 2012. Dietary fatty acids in metabolic syndrome, diabetes and cardiovascular diseases. Curr Diabetes Rev. 8:2–17.
   PubMedGoogle Scholar
• Centers for Disease Control and Prevention: Department of Health and Human Services. 2013. Fourth National Report on Human Exposure to Environmental Chemicals. Atlanta: Georgia. Updated Tables. Available from: [http://www.cdc.gov/exposurereport/pdf/FourthReport_UpdatedTables_Mar2013.pdf
   Google Scholar
• Chavan H, Krishnamurthy P. 2012. Polycyclic aromatic hydrocarbons (PAHs) mediate transcriptional activation of the ATP binding cassette transporter ABCB6 gene via the aryl hydrocarbon receptor (AhR). J Biol Chem. 287:32054–32068.
   PubMed Web of Science ®Google Scholar
• Chen S, Melchior WB, Jr., Guo L. 2014. Endoplasmic reticulum stress in drug- and environmental toxicant-induced liver toxicity. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 32:83–104.
   PubMed Web of Science ®Google Scholar
• Chevrier J, Harley KG, Bradman A, Gharbi M, Sjodin A, Eskenazi B. 2010. Polybrominated diphenyl ether (PBDE) flame retardants and thyroid hormone during pregnancy. Environ Health Perspect. 118:1444–1449.
   PubMed Web of Science ®Google Scholar
• Chin-Chan M, Navarro-Yepes J, Quintanilla-Vega B. 2015. Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases. Front Cell Neurosci. 9:124.
   PubMed Web of Science ®Google Scholar
• Chinta SJ, Rane A, Poksay KS, Bredesen DE, Andersen JK, Rao RV. 2008. Coupling endoplasmic reticulum stress to the cell death program in dopaminergic cells: effect of paraquat. Neuromolecular Med. 10:333–342.
   PubMed Web of Science ®Google Scholar
• City of Ottawa. 2015. Lemieux Island Water Purification Plant. 2015 Drinking Water Quality physical, microbiological, chemical, & radiological test results. Available from: http://documents.ottawa.ca/sites/documents.ottawa.ca/files/documents/2015_WQSummaryTable_Lemieux_en.pdf
   Google Scholar
• Cobb CO, Sahmarani K, Eissenberg T, Shihadeh A. 2012. Acute toxicant exposure and cardiac autonomic dysfunction from smoking a single narghile waterpipe with tobacco and with a "healthy" tobacco-free alternative. Toxicol Lett. 215:70–75.
   PubMed Web of Science ®Google Scholar
• Coghlan S, Horder J, Inkster B, Mendez MA, Murphy DG, Nutt DJ. 2012. GABA system dysfunction in autism and related disorders: from synapse to symptoms. Neurosci Biobehav Rev. 36:2044–2055.
   PubMed Web of Science ®Google Scholar
• Colon I, Caro D, Bourdony CJ, Rosario O. 2000. Identification of phthalate esters in the serum of young Puerto Rican girls with premature breast development. Environ Health Perspect. 108:895–900.
   PubMed Web of Science ®Google Scholar
• Commandeur JN, Stijntjes GJ, Vermeulen NP. 1995. Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics. Pharmacol Rev. 47:271–330.
   PubMed Web of Science ®Google Scholar
• Conti P, Kempuraj D. 2016. Important role of mast cells in multiple sclerosis. Mult Scler Relat Disord. 5:77–80.
   PubMed Web of Science ®Google Scholar
• Crofton KM. 2008. Thyroid disrupting chemicals: mechanisms and mixtures. Int J Androl. 31:209–223.
   PubMedGoogle Scholar
• Crone HD. 2004. Paracelsus: the man who defied medicine: his real contribution to medicine. Melbourne: Albarello Press; p. 1–183.
   Google Scholar
• Cucchiara S, Iebba V, Conte MP, Schippa S. 2009. The microbiota in inflammatory bowel disease in different age groups. Dig Dis. 27:252–258.
   PubMed Web of Science ®Google Scholar
• Cui Y, Chen X, Zhou Z, Lei Y, Ma M, Cao R, Sun T, Xu J, Huo M, Cao R, et al. 2014. Prenatal exposure to nanoparticulate titanium dioxide enhances depressive-like behaviors in adult rats. Chemosphere. 96:99–104.
   PubMed Web of Science ®Google Scholar
• Dagda RK, Das Banerjee T, Janda E. 2013. How Parkinsonian toxins dysregulate the autophagy machinery. Int J Mol Sci. 14:22163–22189.
   PubMed Web of Science ®Google Scholar
• Dahlgren J, Takhar H, Anderson-Mahoney P, Kotlerman J, Tarr J, Warshaw R. 2007. Cluster of systemic lupus erythematosus (SLE) associated with an oil field waste site: a cross sectional study. Environ Health. 6:8.
   PubMed Web of Science ®Google Scholar
• Dammann RH, Kirsch S, Schagdarsurengin U, Dansranjavin T, Gradhand E, Schmitt WD, Hauptmann S. 2010. Frequent aberrant methylation of the imprinted IGF2/H19 locus and LINE1 hypomethylation in ovarian carcinoma. Int J Oncol. 36:171–179.
   PubMed Web of Science ®Google Scholar
• Dardiotis E, Xiromerisiou G, Hadjichristodoulou C, Tsatsakis AM, Wilks MF, Hadjigeorgiou GM. 2013. The interplay between environmental and genetic factors in Parkinson's disease susceptibility: the evidence for pesticides. Toxicology. 307:17–23.
   PubMed Web of Science ®Google Scholar
• De Luca C, Scordo MG, Cesareo E, Pastore S, Mariani S, Maiani G, Stancato A, Loreti B, Valacchi G, Lubrano C, et al. 2010. Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes. Toxicol Appl Pharmacol. 248:285–292.
   PubMed Web of Science ®Google Scholar
• Dheer R, Patterson J, Dudash M, Stachler EN, Bibby KJ, Stolz DB, Shiva S, Wang Z, Hazen SL, Barchowsky A, et al. 2015. Arsenic induces structural and compositional colonic microbiome change and promotes host nitrogen and amino acid metabolism. Toxicol Appl Pharmacol. 289:397–408.
   PubMed Web of Science ®Google Scholar
• Di Renzo GC, Conry JA, Blake J, DeFrancesco MS, DeNicola N, Martin JN, Jr., McCue KA, Richmond D, Shah A, Sutton P, et al. 2015. International federation of gynecology and obstetrics opinion on reproductive health impacts of exposure to toxic environmental chemicals. Int J Gynaecol Obstet. 131:219–225.
   PubMed Web of Science ®Google Scholar
• Dijkers MP. 2009. The value of traditional reviews in the era of systematic reviewing. Am J Phys Med Rehabil. 88:423–430.
   PubMed Web of Science ®Google Scholar
• Doi K, Uetsuka K. 2011. Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways. Int J Mol Sci. 12:5213–5237.
   PubMed Web of Science ®Google Scholar
• Dynacare-Gamma Laboratory Partnership. 2016. Estradiol. Available from: https://www.dynacare.ca/specialpages/secondarynav/find-a-test/nat/estradiol.aspx?sr=ont&st=estradiol&
   Google Scholar
• Eggar C, Hamon CG, Morar C, Al-Salihi F, Blair JA, Barford PA. 1986. The effect of lead on tetrahydrobiopterin metabolism. A possible mechanism for neurotoxicity. Clin Chim Acta. 161:103–109.
   PubMed Web of Science ®Google Scholar
• Engelmann J, Janke V, Volk J, Leyhausen G, von Neuhoff N, Schlegelberger B, Geurtsen W. 2004. Effects of BisGMA on glutathione metabolism and apoptosis in human gingival fibroblasts in vitro. Biomaterials. 25:4573–4580.
   PubMed Web of Science ®Google Scholar
• Environmental Working Group. 2005. Body burden: the pollution in newborns: A benchmark investigation of industrial chemicals, pollutants and pesticides in umbilical cord blood. (Executive Summary); July 14. Available from: http://ewg.org/reports/bodyburden2/execsumm.php
   Google Scholar
• Ezendam J, Vos JG, Pieters R. 2005. Research articles mechanisms of hexachlorobenzene-induced adverse immune effects in brown norway rats. J Immunotoxicol. 1:167–175.
   PubMedGoogle Scholar
• Farooq SM, Boppana NB, Devarajan A, Sekaran SD, Shankar EM, Li C, Gopal K, Bakar SA, Karthik HS, Ebrahim AS, et al. 2014. C-phycocyanin confers protection against oxalate-mediated oxidative stress and mitochondrial dysfunctions in MDCK cells. PLoS One. 9:e93056.
   PubMed Web of Science ®Google Scholar
• Final amended report on the safety assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in cosmetic products. Int J Toxicol. 2008;27(Suppl 4):1–82.
   PubMed Web of Science ®Google Scholar
• Folino AF, Scapellato ML, Canova C, Maestrelli P, Bertorelli G, Simonato L, Iliceto S, Lotti M. 2009. Individual exposure to particulate matter and the short-term arrhythmic and autonomic profiles in patients with myocardial infarction. Eur Heart J. 30:1614–1620. doi: 10.1093/eurheartj/ehp136.
   PubMed Web of Science ®Google Scholar
• Frenzel L, Hermine O. 2013. Mast cells and inflammation. Joint Bone Spine. 80:141–145.
   PubMed Web of Science ®Google Scholar
• Frisbee SJ, Shankar A, Knox SS, Steenland K, Savitz DA, Fletcher T, Ducatman AM. 2010. Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project. Arch Pediatr Adolesc Med. 164:860–869.
   PubMed Web of Science ®Google Scholar
• Frizzell C, Ndossi D, Kalayou S, Eriksen GS, Verhaegen S, Sorlie M, Elliott CT, Ropstad E, Connolly L. 2013a. An in vitro investigation of endocrine disrupting effects of the mycotoxin alternariol. Toxicol Appl Pharmacol. 271:64–71.
   PubMed Web of Science ®Google Scholar
• Frizzell C, Verhaegen S, Ropstad E, Elliott CT, Connolly L. 2013b. Endocrine disrupting effects of ochratoxin A at the level of nuclear receptor activation and steroidogenesis. Toxicol Lett. 217:243–250.
   PubMed Web of Science ®Google Scholar
• Ganesan K, Raza SK, Vijayaraghavan R. 2010. Chemical warfare agents. J Pharm Bioallied Sci. 2:166–178.
   PubMedGoogle Scholar
• Garcia-Arenas G, Claudio L, Perez-Severiano F, Rios C. 1999. Lead acetate exposure inhibits nitric oxide synthase activity in capillary and synaptosomal fractions of mouse brain. Toxicol Sci. 50:244–248.
   PubMed Web of Science ®Google Scholar
• Garry VF, Schreinemachers D, Harkins ME, Griffith J. 1996. Pesticide appliers, biocides, and birth defects in rural Minnesota. Environ Health Perspect. 104:394–399.
   PubMed Web of Science ®Google Scholar
• Gebel T, Marchan R, Hengstler JG. 2013. The nanotoxicology revolution. Arch Toxicol. 87:2057–2062.
   PubMed Web of Science ®Google Scholar
• Genuis S. 2005. Back to the future of healthcare: aetiology-centred medicine. NZ Med J. 118:U1467.
   PubMedGoogle Scholar
• Genuis SJ, Birkholz D, Rodushkin I, Beesoon S. 2010. Blood, Urine, and Sweat (BUS) study: monitoring and elimination of bioaccumulated toxic elements. Arch Environ Contam Toxicol. 61:344–357.
   PubMed Web of Science ®Google Scholar
• Genuis SJ, Liu H, Genuis QIT, Martin JW. 2014. Phlebotomy treatment for elimination of perfluoroalkyl acids in a highly exposed family: a retrospective case-series. PLoS One. 9:e114295.
   PubMed Web of Science ®Google Scholar
• Genuis SJ, Sears ME, Schwalfenberg G, Hope J, Bernhoft R. 2013. Clinical detoxification: elimination of persistent toxicants from the human body. Sci World J. 2013:238347.
   Web of Science ®Google Scholar
• Genuis SJ. 2008. Our genes are not our destiny: incorporating molecular medicine into clinical practice. J Eval Clin Pract. 14:94–102.
   PubMed Web of Science ®Google Scholar
• Genuis SJ. 2008. Toxic causes of mental illness are overlooked. Neurotoxicology. 29(6):1147–1149.
   PubMed Web of Science ®Google Scholar
• Genuis SJ. 2010. Sensitivity-related illness: the escalating pandemic of allergy, food intolerance and chemical sensitivity. Sci Total Environ. 408:6047–6061.
   PubMed Web of Science ®Google Scholar
• Genuis SJ. 2011. Elimination of persistent toxicants from the human body. Hum Exp Toxicol. 30:3–18.
   PubMed Web of Science ®Google Scholar
• Genuis SJ. 2012. What's out there making us sick? J Environ Public Health. 2012:605137.
   PubMedGoogle Scholar
• Genuis SJ. 2013. Chemical sensitivity: pathophysiology or pathopsychology? Clin Ther. 35:572–577.
   PubMed Web of Science ®Google Scholar
• Gilbert KM, Pumford NR, Blossom SJ. 2006. Environmental contaminant trichloroethylene promotes autoimmune disease and inhibits T-cell apoptosis in MRL(+/+) mice. J Immunotoxicol. 3:263–267.
   PubMedGoogle Scholar
• Giordano G, Kavanagh TJ, Costa LG. 2008. Neurotoxicity of a polybrominated diphenyl ether mixture (DE-71) in mouse neurons and astrocytes is modulated by intracellular glutathione levels. Toxicol Appl Pharmacol. 232:161–168.
   PubMed Web of Science ®Google Scholar
• Gomez-Arroyo S, Diaz-Sanchez Y, Meneses-Perez MA, Villalobos-Pietrini R, De Leon-Rodriguez J. 2000. Cytogenetic biomonitoring in a Mexican floriculture worker group exposed to pesticides. Mutat Res. 466:117–24.
   PubMed Web of Science ®Google Scholar
• Goulet O. 2015. Potential role of the intestinal microbiota in programming health and disease. Nutr Rev. 73(Suppl 1):32–40.
   PubMed Web of Science ®Google Scholar
• Grandjean P, Poulsen LK, Heilmann C, Steuerwald U, Weihe P. 2010. Allergy and sensitization during childhood associated with prenatal and lactational exposure to marine pollutants. Environ Health Perspect. 118:1429–1433.
   PubMed Web of Science ®Google Scholar
• Gravina S, Vijg J. 2010. Epigenetic factors in aging and longevity. Pflugers Arch. 459:247–258.
   PubMed Web of Science ®Google Scholar
• Gray LE, Jr., Wolf C, Lambright C, Mann P, Price M, Cooper RL, Ostby J. 1999. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat. Toxicol Ind Health. 15:94–118.
   PubMed Web of Science ®Google Scholar
• Grover P, Danadevi K, Mahboob M, Rozati R, Banu BS, Rahman MF. 2003. Evaluation of genetic damage in workers employed in pesticide production utilizing the Comet assay. Mutagenesis. 18:201–205.
   PubMed Web of Science ®Google Scholar
• Gu X, Manautou JE. 2012. Molecular mechanisms underlying chemical liver injury. Expert Rev Mol Med. 14:e4.
   PubMed Web of Science ®Google Scholar
• Guengerich FP. 2001. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem Res Toxicol. 14:611–650.
   PubMed Web of Science ®Google Scholar
• Guerrero-Bosagna C, Skinner MK. 2012. Environmentally induced epigenetic transgenerational inheritance of phenotype and disease. Mol Cell Endocrinol. 354:3–8.
   PubMed Web of Science ®Google Scholar
• Guerrero-Bosagna CM, Skinner MK. 2012. Environmental epigenetics and phytoestrogen/phytochemical exposures. J Steroid Biochem Mol Biol. 139:270–276.
   PubMed Web of Science ®Google Scholar
• Haberzettl P, O'Toole TE, Bhatnagar A, Conklin DJ. 2016. Exposure to fine particulate air pollution causes vascular insulin resistance by inducing pulmonary oxidative stress. Environ Health Perspect. 124:1830–1839.
   PubMed Web of Science ®Google Scholar
• Hakk H, Letcher RJ. 2003. Metabolism in the toxicokinetics and fate of brominated flame retardants–a review. Environ Int. 29:801–828.
   PubMed Web of Science ®Google Scholar
• Han SJ, Ha KH, Jeon JY, Kim HJ, Lee KW, Kim DJ. 2015. Impact of cadmium exposure on the association between lipopolysaccharide and metabolic syndrome. Int J Environ Res Public Health. 12:11396–11409.
   PubMed Web of Science ®Google Scholar
• Hauser R, Williams P, Altshul L, Calafat AM. 2005. Evidence of interaction between polychlorinated biphenyls and phthalates in relation to human sperm motility. Environ Health Perspect. 113:425–430.
   PubMed Web of Science ®Google Scholar
• Havarinasab S, Johansson U, Pollard KM, Hultman P. 2007. Gold causes genetically determined autoimmune and immunostimulatory responses in mice. Clin Exp Immunol. 150:179–188.
   PubMed Web of Science ®Google Scholar
• Health Canada. 2013. Canadian Helath Measures Survey. Second report on human biomonitoring of environmental chemicals in Canada. Available from: http://www.hc-sc.gc.ca/ewh-semt/contaminants/human-humaine/chms-ecms-eng.php
   Google Scholar
• Hendriks HS, Antunes Fernandes EC, Bergman A, van den Berg M, Westerink RH. 2010. PCB-47, PBDE-47, and 6-OH-PBDE-47 differentially modulate human GABAA and alpha4beta2 nicotinic acetylcholine receptors. Toxicol Sci. 118:635–642.
   PubMed Web of Science ®Google Scholar
• Heo Y, Lee BK, Ahn KD, Lawrence DA. 2004. Serum IgE elevation correlates with blood lead levels in battery manufacturing workers. Hum Exp Toxicol. 23:209–213.
   PubMed Web of Science ®Google Scholar
• Homolya L, Varadi A, Sarkadi B. 2003. Multidrug resistance-associated proteins: Export pumps for conjugates with glutathione, glucuronate or sulfate. Biofactors. 17:103–114.
   PubMed Web of Science ®Google Scholar
• Hood E. 2005. Are EDCs blurring issues of gender? Environ Health Perspect. 113:A670–A677.
   PubMed Web of Science ®Google Scholar
• Hooper DC, Scott GS, Zborek A, Mikheeva T, Kean RB, Koprowski H, Spitsin SV. 2000. Uric acid, a peroxynitrite scavenger, inhibits CNS inflammation, blood-CNS barrier permeability changes, and tissue damage in a mouse model of multiple sclerosis. FASEB J. 14:691–698.
   PubMed Web of Science ®Google Scholar
• Horton R. 2005. The neglected epidemic of chronic disease. Lancet. 366:1514.
   PubMed Web of Science ®Google Scholar
• Hossain MM, Richardson JR. 2011. Mechanism of pyrethroid pesticide-induced apoptosis: role of calpain and the ER stress pathway. Toxicol Sci. 122:512–525.
   PubMed Web of Science ®Google Scholar
• Hou L, Zhang X, Wang D, Baccarelli A. 2012. Environmental chemical exposures and human epigenetics. International journal of epidemiology. 41:79–105.
   PubMed Web of Science ®Google Scholar
• Huff MO, Todd SL, Smith AL, Elpers JT, Smith AP, Murphy RD, Bleser-Shartzer AS, Hoerter JE, Radde BN, Klinge CM, et al. 2016. Arsenite and cadmium activate MAPK/ERK via membrane estrogen receptors and G-protein coupled estrogen receptor signaling in human lung adenocarcinoma cells. Toxicol Sci. 152:62–71. doi: 10.1093/toxsci/kfw064.
   PubMed Web of Science ®Google Scholar
• Hultman P, Bell LJ, Enestrom S, Pollard KM. 1992. Murine susceptibility to mercury. I. Autoantibody profiles and systemic immune deposits in inbred, congenic, and intra-H-2 recombinant strains. Clin Immunol Immunopathol. 65:98–109.
   PubMedGoogle Scholar
• Hwang O. 2013. Role of oxidative stress in Parkinson's disease. Exp Neurobiol. 22:11–17.
   PubMedGoogle Scholar
• Ichihara M, Sobue S, Ito M, Ito M, Hirayama M, Ohno K. 2015. Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles. Med Gas Res. 5:12.
   PubMed Web of Science ®Google Scholar
• Islam BU, Habib S, Ahmad P, Allarakha S, Moinuddin, Ali A. 2015. Pathophysiological role of peroxynitrite induced DNA damage in human diseases: a special focus on poly(ADP-ribose) Polymerase (PARP). Indian J Clin Biochem. 30:368–385.
   PubMedGoogle Scholar
• Islam LN, Nabi AH, Rahman MM, Zahid MS. 2007. Association of respiratory complications and elevated serum immunoglobulins with drinking water arsenic toxicity in human. J Environ Sci Health. 42:1807–1814.
   Web of Science ®Google Scholar
• Jadiya P, Nazir A. 2012. Environmental toxicants as extrinsic epigenetic factors for parkinsonism: studies employing transgenic C. elegans model. CNS Neurol Disord Drug Targets. 11:976–983.
   PubMed Web of Science ®Google Scholar
• Jakoby WB, Ziegler DM. 1990. The enzymes of detoxication. J Biol Chem. 265:20715–20718.
   PubMed Web of Science ®Google Scholar
• James SJ, Cutler P, Melnyk S, Jernigan S, Janak L, Gaylor DW, Neubrander JA. 2004. Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. Am J Clin Nutr. 80:1611–1617.
   PubMed Web of Science ®Google Scholar
• Jandacek RJ, Anderson N, Liu M, Zheng S, Yang Q, Tso P. 2005. Effects of yo-yo diet, caloric restriction, and olestra on tissue distribution of hexachlorobenzene. Am J Physiol. 288:G292–G299.
   PubMed Web of Science ®Google Scholar
• Jandacek RJ, Genuis SJ. 2013. An assessment of the intestinal lumen as a site for intervention in reducing body burdens of organochlorine compounds. Sci World J. 2013:205621.
   Web of Science ®Google Scholar
• Jedrychowski W, Galas A, Pac A, Flak E, Camman D, Rauh V, Perera F. 2005. Prenatal ambient air exposure to polycyclic aromatic hydrocarbons and the occurrence of respiratory symptoms over the first year of life. Eur J Epidemiol. 20:775–782.
   PubMed Web of Science ®Google Scholar
• Jedrychowski W, Perera F, Maugeri U, Miller RL, Rembiasz M, Flak E, Mroz E, Majewska R, Zembala M. 2011. Intrauterine exposure to lead may enhance sensitization to common inhalant allergens in early childhood: a prospective prebirth cohort study. Environ Res. 111:119–124.
   PubMed Web of Science ®Google Scholar
• Jensen AA, Leffers H. 2008. Emerging endocrine disrupters: perfluoroalkylated substances. Int J Androl. 31:161–169.
   PubMed Web of Science ®Google Scholar
• Johansson U, Hansson-Georgiadis H, Hultman P. 1997. Murine silver-induced autoimmunity: silver shares induction of antinucleolar antibodies with mercury, but causes less activation of the immune system. Int Arch Allergy Immunol. 113:432–443.
   PubMed Web of Science ®Google Scholar
• Johnson CH, Patterson AD, Idle JR, Gonzalez FJ. 2012. Xenobiotic metabolomics: major impact on the metabolome. Annu Rev Pharmacol Toxicol. 52:37–56.
   PubMed Web of Science ®Google Scholar
• Jomova K, Valko M. 2011. Advances in metal-induced oxidative stress and human disease. Toxicology. 283:65–87.
   PubMed Web of Science ®Google Scholar
• Jomova K, Vondrakova D, Lawson M, Valko M. 2010. Metals, oxidative stress and neurodegenerative disorders. Mol Cell Biochem. 345:91–104.
   PubMed Web of Science ®Google Scholar
• Jonassen JA, Cao LC, Honeyman T, Scheid CR. 2003. Mechanisms mediating oxalate-induced alterations in renal cell functions. Crit Rev Eukaryot Gene Expr. 13:55–72.
   PubMed Web of Science ®Google Scholar
• Joseph N, Zhang-James Y, Perl A, Faraone SV. 2015. Oxidative stress and ADHD: a meta-analysis. J Atten Disord. 19:915–924.
   PubMed Web of Science ®Google Scholar
• Kabir ER, Rahman MS, Rahman I. 2015. A review on endocrine disruptors and their possible impacts on human health. Environ Toxicol Pharmacol. 40:241–258.
   PubMed Web of Science ®Google Scholar
• Kass GE, Nicotera P, Orrenius S. 1990. Effects of xenobiotics on signal transduction and Ca2+ mediated processes in mammalian cells. Princess Takamatsu Symp. 21:213–226.
   PubMedGoogle Scholar
• Katsnelson BA, Minigaliyeva IA, Degtyareva TD, Privalova LI, Beresneva TA. 2014. Does a concomitant exposure to lead influence unfavorably the naphthalene subchronic toxicity and toxicokinetics? Environ Toxicol Chem. 33:152–157.
   PubMed Web of Science ®Google Scholar
• Kempuraj D, Asadi S, Zhang B, Manola A, Hogan J, Peterson E, Theoharides TC. 2010. Mercury induces inflammatory mediator release from human mast cells. J Neuroinflammation. 7:20.
   PubMed Web of Science ®Google Scholar
• Kenna TJ, Brown MA. 2013. The role of IL-17-secreting mast cells in inflammatory joint disease. Nat Rev Rheumatol. 9:375–379.
   PubMed Web of Science ®Google Scholar
• Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJ. 2005. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med. 39:584–589.
   PubMed Web of Science ®Google Scholar
• Kern JK, Geier DA, Audhya T, King PG, Sykes LK, Geier MR. 2012. Evidence of parallels between mercury intoxication and the brain pathology in autism. Acta Neurobiol Exp (Wars). 72:113–153.
   PubMed Web of Science ®Google Scholar
• Kerr JF, Wyllie AH, Currie AR. 1972. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer. 26:239–257.
   PubMed Web of Science ®Google Scholar
• Khattak S, Moghtader GK, McMartin K, Barrera M, Kennedy D, Koren G. 1999. Pregnancy outcome following gestational exposure to organic solvents: a prospective controlled study. JAMA. 281:1106–1109.
   PubMed Web of Science ®Google Scholar
• Kim HS, Kim YJ, Seo YR. 2015. An overview of carcinogenic heavy metal: molecular toxicity mechanism and prevention. J Cancer Prev. 20(4):232–240.
   PubMedGoogle Scholar
• Kitamura M, Hiramatsu N. 2010. The oxidative stress: endoplasmic reticulum stress axis in cadmium toxicity. Biometals. 23:941–950.
   PubMed Web of Science ®Google Scholar
• Kjellstrom T. 1992. Mechanism and epidemiology of bone effects of cadmium. IARC Sci Publ. 301–310.
   PubMedGoogle Scholar
• Klaunig JE, Kamendulis LM. 2004. The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol. 44:239–267.
   PubMed Web of Science ®Google Scholar
• Knox EG. 2005. Childhood cancers and atmospheric carcinogens. J Epidemiol Community Health. 59:101–105.
   PubMed Web of Science ®Google Scholar
• Konstantynowicz J, Porowski T, Zoch-Zwierz W, Wasilewska J, Kadziela-Olech H, Kulak W, Owens SC, Piotrowska-Jastrzebska J, Kaczmarski M. 2012. A potential pathogenic role of oxalate in autism. Eur J Paediatr Neurol. 16:485–491.
   PubMed Web of Science ®Google Scholar
• Kortenkamp A. 2011. Are cadmium and other heavy metal compounds acting as endocrine disrupters? Met Ions Life Sci. 8:305–317.
   PubMedGoogle Scholar
• Kovacova-Hanuskova E, Buday T, Gavliakova S, Plevkova J. 2015. Histamine, histamine intoxication and intolerance. Allergol Immunopathol (Madr). 43:498–506.
   PubMed Web of Science ®Google Scholar
• Kumar R, Ansari KM, Chaudhari BP, Dhawan A, Dwivedi PD, Jain SK, Das M. 2012. Topical application of ochratoxin A causes DNA damage and tumor initiation in mouse skin. PLoS One. 7:e47280.
   PubMed Web of Science ®Google Scholar
• Lander BF, Knudsen LE, Gamborg MO, Jarventaus H, Norppa H. 2000. Chromosome aberrations in pesticide-exposed greenhouse workers. Scand J Work Environ Health. 26:436–442.
   PubMed Web of Science ®Google Scholar
• Langie SA, Koppen G, Desaulniers D, Al-Mulla F, Al-Temaimi R, Amedei A, Azqueta A, Bisson WH, Brown D, Brunborg G, et al. 2015. Causes of genome instability: the effect of low dose chemical exposures in modern society. Carcinogenesis. 36(Suppl 1):S61–S88.
   PubMed Web of Science ®Google Scholar
• Lasley SM, Gilbert ME. 2002. Rat hippocampal glutamate and GABA release exhibit biphasic effects as a function of chronic lead exposure level. Toxicol Sci. 66:139–147.
   PubMed Web of Science ®Google Scholar
• Latar I, Koufany M, Hablot J, Loeuille D, Netter P, Jouzeau JY, Chary-Valckenaere I, Moulin D. 2016. Association between rheumatoid arthritis and systemic mastocytosis: a case report and literature review. Clin Rheumatol. 35:2619–2623.
   PubMed Web of Science ®Google Scholar
• Leeming RJ. 1981. The role of tetrahydrobiopterin in neurological disease: a review. J Ment Defic Res. 25:231–241.
   PubMedGoogle Scholar
• Li Q, Nagahara N, Takahashi H, Takeda K, Okumura K, Minami M. 2002. Organophosphorus pesticides markedly inhibit the activities of natural killer, cytotoxic T lymphocyte and lymphokine-activated killer: a proposed inhibiting mechanism via granzyme inhibition. Toxicology. 172:181–190.
   PubMed Web of Science ®Google Scholar
• Li Z, Dong T, Proschel C, Noble M. 2007. Chemically diverse toxicants converge on Fyn and c-Cbl to disrupt precursor cell function. PLoS Biol. 5:e35.
   PubMed Web of Science ®Google Scholar
• Lin RY, Smith AJ, Hergenroeder P. 1993. High serum albuterol levels and tachycardia in adult asthmatics treated with high-dose continuously aerosolized albuterol. Chest. 103:221–225.
   PubMed Web of Science ®Google Scholar
• Lippmann M. (ed). 2009. Environmental Toxicants: Human Exposures and Their Health Effects. 3rd ed. Hoboken (NJ): John Wiley & Sons.
   Google Scholar
• Liston HL, Markowitz JS, DeVane CL. 2001. Drug glucuronidation in clinical psychopharmacology. J Clin Psychopharmacol. 21:500–515.
   PubMed Web of Science ®Google Scholar
• Liu BH, Wu TS, Yu FY, Su CC. 2007. Induction of oxidative stress response by the mycotoxin patulin in mammalian cells. Toxicol Sci. 95:340–347.
   PubMed Web of Science ®Google Scholar
• Liu D, Perkins JT, Petriello MC, Hennig B. 2015. Exposure to coplanar PCBs induces endothelial cell inflammation through epigenetic regulation of NF-kappaB subunit p65. Toxicol Appl Pharmacol. 289:457–465.
   PubMed Web of Science ®Google Scholar
• Lukes J, Stensvold CR, Jirku-Pomajbikova K, Wegener Parfrey L. 2015. Are human intestinal eukaryotes beneficial or commensals? PLoS Pathog. 11:e1005039.
   PubMed Web of Science ®Google Scholar
• Maintz L, Novak N. 2007. Histamine and histamine intolerance. Am J Clin Nutr. 85:1185–1196.
   PubMed Web of Science ®Google Scholar
• Mak A, Tay SH. 2014. Environmental factors, toxicants and systemic lupus erythematosus. Int J Mol Sci. 15:16043–16056.
   PubMed Web of Science ®Google Scholar
• Malaguarnera G, Cataudella E, Giordano M, Nunnari G, Chisari G, Malaguarnera M. 2012. Toxic hepatitis in occupational exposure to solvents. World J Gastroenterol. 18:2756–2766.
   PubMed Web of Science ®Google Scholar
• Maqbool F, Mostafalou S, Bahadar H, Abdollahi M. 2016. Review of endocrine disorders associated with environmental toxicants and possible involved mechanisms. Life Sci. 145:265–273.
   PubMed Web of Science ®Google Scholar
• Mariussen E, Fonnum F. 2003. The effect of brominated flame retardants on neurotransmitter uptake into rat brain synaptosomes and vesicles. Neurochem Int. 43:533–542.
   PubMed Web of Science ®Google Scholar
• Mariussen E. 2012. Neurotoxic effects of perfluoroalkylated compounds: mechanisms of action and environmental relevance. Arch Toxicol. 86:1349–1367.
   PubMed Web of Science ®Google Scholar
• Markowitz SS, McDonald CJ, Fethiere W, Kerzner MS. 1972. Occupational acroosteolysis. Arch Dermatol. 106:219–223.
   PubMedGoogle Scholar
• Mathur PP, D'Cruz SC. 2011. The effect of environmental contaminants on testicular function. Asian J Androl. 13:585–591.
   PubMed Web of Science ®Google Scholar
• Mathur PP, Huang L, Kashour A, Vaithinathan S, Agarwal A. 2011. Environmental toxicants and testicular apoptosis. Open Reproduct Sci J. 3:114–124.
   Google Scholar
• Mattila E, Uusitalo-Seppala R, Wuorela M, Lehtola L, Nurmi H, Ristikankare M, Moilanen V, Salminen K, Seppälä M, Mattila PS, et al. 2012. Fecal transplantation, through colonoscopy, is effective therapy for recurrent Clostridium difficile infection. Gastroenterology. 142:490–496.
   PubMed Web of Science ®Google Scholar
• Mayo Clinic Laboratories. 2016a. Testosterone, Total, Bioavailable, and Free, Serum. Available from: http://www.mayomedicallaboratories.com/test-catalog/Clinical+and+Interpretive/83686
   Google Scholar
• Mayo Clinic Laboratories. 2016b. Paroxetine, Serum, Clinical Information. Available from: http://www.mayomedicallaboratories.com/interpretive-guide/?alpha=P&unit_code =83731
   Google Scholar
• McClure EA, North CM, Kaminski NE, Goodman JI. 2011. Changes in DNA methylation and gene expression during 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced suppression of the lipopolysaccharide-stimulated IgM response in splenocytes. Toxicol Sci. 120:339–348.
   PubMed Web of Science ®Google Scholar
• Meyer JN, Leung MC, Rooney JP, Sendoel A, Hengartner MO, Kisby GE, Bess AS. 2013. Mitochondria as a target of environmental toxicants. Toxicol Sci. 134:1–17.
   PubMed Web of Science ®Google Scholar
• Miller CS. 1997. Toxicant-induced loss of tolerance–an emerging theory of disease? Environ Health Perspect. 105(Suppl 2):445–453.
   PubMed Web of Science ®Google Scholar
• Miller FW, Alfredsson L, Costenbader KH, Kamen DL, Nelson LM, Norris JM, De Roos AJ. 2012. Epidemiology of environmental exposures and human autoimmune diseases: findings from a National Institute of Environmental Health Sciences Expert Panel Workshop. J Autoimmun. 39:259–271.
   PubMed Web of Science ®Google Scholar
• Mishra PK, Dabadghao S, Modi GK, Desikan P, Jain A, Mittra I, Gupta D, Chauhan C, Jain SK, Maudar KK, et al. 2009. In utero exposure to methyl isocyanate in the Bhopal gas disaster: evidence of persisting hyperactivation of immune system two decades later. Occup Environ Med. 66:279.
   PubMed Web of Science ®Google Scholar
• Miyashita C, Sasaki S, Saijo Y, Washino N, Okada E, Kobayashi S, Konishi K, Kajiwara J, Todaka T, Kishi R, et al. 2011. Effects of prenatal exposure to dioxin-like compounds on allergies and infections during infancy. Environmental Research. 111:551–558.
   PubMed Web of Science ®Google Scholar
• Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y. 2003. Impact of drug transporter studies on drug discovery and development. Pharmacol Rev. 55:425–461.
   PubMed Web of Science ®Google Scholar
• Mnif W, Hassine AI, Bouaziz A, Bartegi A, Thomas O, Roig B. 2011. Effect of endocrine disruptor pesticides: a review. Int J Environ Res Public Health. 8:2265–2303.
   PubMed Web of Science ®Google Scholar
• Moss M. 2007. Drugs as anti-nutrients. J Nutrit Environ Med. 16:149–166.
   Google Scholar
• Mostafalou S, Abdollahi M. 2013. Pesticides and human chronic diseases: evidences, mechanisms, and perspectives. Toxicol Appl Pharmacol. 268:157–177.
   PubMed Web of Science ®Google Scholar
• Moszczynski P, Rutowski J, Slowinski S, Bem S. 1998. Immunological effects of occupational exposure to metallic mercury in the population of T-cells and NK-cells. Analyst. 123:99–103.
   PubMed Web of Science ®Google Scholar
• Nakamura R, Teshima R, Sawada J. 2002. Effect of dialkyl phthalates on the degranulation and Ca2+ response of RBL-2H3 mast cells. Immunol Lett. 80:119–124.
   PubMed Web of Science ®Google Scholar
• National Institute of Environmental Health Sciences. Division of Extramural Research and Training Cellular OaSPB. 2012. Microbiome/Environment Interactions. Available from: http://www.niehs.nih.gov/news/newsletter/2012/3/spotlight-council/file62863.pdf
   Google Scholar
• Naughton C, O'Toole D, Kirik D, Dowd E. 2017. Interaction between subclinical doses of the Parkinson's disease associated gene, α-synuclein, and the pesticide, rotenone, precipitates motor dysfunction and nigrostriatal neurodegeneration in rats. Behav Brain Res. 316:160–168.
   PubMed Web of Science ®Google Scholar
• Navarro-Yepes J, Anandhan A, Bradley E, Bohovych I, Yarabe B, de Jong A, Ovaa H, Zhou Y, Khalimonchuk O, Quintanilla-Vega B, et al. 2016. Inhibition of protein ubiquitination by paraquat and 1-Methyl-4-phenylpyridinium impairs ubiquitin-dependent protein degradation pathways. Mol Neurobiol. 53:5229–5251.
   PubMed Web of Science ®Google Scholar
• Nel A, Xia T, Madler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science. 311:622–627.
   PubMed Web of Science ®Google Scholar
• Nemery B. 1996. Late consequences of accidental exposure to inhaled irritants: RADS and the Bhopal disaster. Eur Respir J. 9:1973–1976.
   PubMed Web of Science ®Google Scholar
• NHANES. 2012. Fourth national report on exposure to environmental chemical exposures. Available from: http://www.cdc.gov/exposurereport/pdf/FourthReport.pdf
   Google Scholar
• Nicklisch SC, Rees SD, McGrath AP, Gokirmak T, Bonito LT, Vermeer LM, Cregger C, Loewen G, Sandin S, Chang G, et al. 2016. Global marine pollutants inhibit P-glycoprotein: environmental levels, inhibitory effects, and cocrystal structure. Sci Adv. 2:e1600001.
   PubMed Web of Science ®Google Scholar
• Niide O, Suzuki Y, Yoshimaru T, Inoue T, Takayama T, Ra C. 2006. Fungal metabolite gliotoxin blocks mast cell activation by a calcium- and superoxide-dependent mechanism: implications for immunosuppressive activities. Clin Immunol. 118:108–116.
   PubMed Web of Science ®Google Scholar
• O'Brien E, Dolinoy DC, Mancuso P. 2014. Bisphenol A at concentrations relevant to human exposure enhances histamine and cysteinyl leukotriene release from bone marrow-derived mast cells. J Immunotoxicol. 11:84–89.
   PubMed Web of Science ®Google Scholar
• Office of Genomics and Disease Prevention. 2000. Centers for Disease Control and Prevention. Department of Health and Human S. Gene-Environment Interaction Fact Sheet.
   Google Scholar
• O'Horo JC, Jindai K, Kunzer B, Safdar N. 2014. Treatment of recurrent clostridium difficile infection: a systematic review. Infection. 42:43–59.
   PubMed Web of Science ®Google Scholar
• Ohta S. 2014. Molecular hydrogen as a preventive and therapeutic medical gas: initiation, development and potential of hydrogen medicine. Pharmacol Ther. 144:1–11.
   PubMed Web of Science ®Google Scholar
• Okada E, Sasaki S, Saijo Y, Washino N, Miyashita C, Kobayashi S, Konishi K, Ito YM, Ito R, Nakata A, et al. 2012. Prenatal exposure to perfluorinated chemicals and relationship with allergies and infectious diseases in infants. Environ Res. 112:118–25.
   PubMed Web of Science ®Google Scholar
• Omaye ST. 2002. Metabolic modulation of carbon monoxide toxicity. Toxicology. 180:139–150.
   PubMed Web of Science ®Google Scholar
• Omiecinski CJ, Vanden Heuvel JP, Perdew GH, Peters JM. 2011. Xenobiotic metabolism, disposition, and regulation by receptors: from biochemical phenomenon to predictors of major toxicities. Toxicol Sci. 120(Suppl 1):S49–S75.
   PubMed Web of Science ®Google Scholar
• O'Neill HC, Orlicky DJ, Hendry-Hofer TB, Loader JE, Day BJ, White CW. 2011. Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide. Am J Respir Cell Mol Biol. 45:323–331.
   PubMed Web of Science ®Google Scholar
• Orrenius S, Kaminskyy VO, Zhivotovsky B. 2013. Autophagy in toxicology: cause or consequence? Annu Rev Pharmacol Toxicol. 53:275–297.
   PubMed Web of Science ®Google Scholar
• Orrenius S, Nicotera P, Zhivotovsky B. 2011. Cell death mechanisms and their implications in toxicology. Toxicol Sci. 119:3–19.
   PubMed Web of Science ®Google Scholar
• O'Shaughnessy PJ, Monteiro A, Bhattacharya S, Fowler PA. 2011. Maternal smoking and fetal sex significantly affect metabolic enzyme expression in the human fetal liver. J Clin Endocrinol Metab. 96:2851–2860.
   PubMed Web of Science ®Google Scholar
• Otsuki T, Maeda M, Murakami S, Hayashi H, Miura Y, Kusaka M, Nakano T, Fukuoka K, Kishimoto T, Hyodoh F, et al. 2007. Immunological effects of silica and asbestos. Cell Mol Immunol. 4:261–268.
   PubMed Web of Science ®Google Scholar
• Ottman N, Smidt H, de Vos WM, Belzer C. 2012. The function of our microbiota: who is out there and what do they do? Front Cell Infect Microbiol. 2:104.
   PubMed Web of Science ®Google Scholar
• Pacher P, Beckman JS, Liaudet L. 2007. Nitric oxide and peroxynitrite in health and disease. Physiol Rev. 87:315–424.
   PubMed Web of Science ®Google Scholar
• Parfrey LW, Walters WA, Knight R. 2011. Microbial eukaryotes in the human microbiome: ecology, evolution, and future directions. Front Microbiol. 2:153.
   PubMed Web of Science ®Google Scholar
• Parkin J, Cohen B. 2001. An overview of the immune system. Lancet. 357:1777–1789
   PubMed Web of Science ®Google Scholar
• Parks CG, Conrad K, Cooper GS. 1999. Occupational exposure to crystalline silica and autoimmune disease. Environ Health Perspect. 107(Suppl 5):793–802.
   PubMed Web of Science ®Google Scholar
• Pearson JN, Patel M. 2016. The role of oxidative stress in organophosphate and nerve agent toxicity. Ann NY Acad Sci. 1378:17–24.
   PubMed Web of Science ®Google Scholar
• Perrin JM, Bloom SR, Gortmaker SL. 2007. The increase of childhood chronic conditions in the United States. JAMA. 297:2755–2759.
   PubMed Web of Science ®Google Scholar
• Pesonen M, Pasanen M, Loikkanen J, Naukkarinen A, Hemmila M, Seulanto H, Kuitunen T, Vähäkangas K. 2012. Chloropicrin induces endoplasmic reticulum stress in human retinal pigment epithelial cells. Toxicol Lett. 211:239–245.
   PubMed Web of Science ®Google Scholar
• Pittman RN. 2011. Regulation of tissue oxygenation. Chapter 4. In: Oxygen transport. San Rafael (CA): Morgan & Claypool Life Sciences.
   Google Scholar
• Pohanka M. 2014. Alzheimer s disease and oxidative stress: a review. Curr Med Chem. 21:356–364.
   PubMed Web of Science ®Google Scholar
• Pollard KM, Hultman P, Kono DH. 2010. Toxicology of autoimmune diseases. Chem Res Toxicol. 23:455–466.
   PubMed Web of Science ®Google Scholar
• Pritchard JB. 1979. Toxic substances and cell membrane function. Fed Proc. 38:2220–2225.
   PubMedGoogle Scholar
• Ptak G, Zacchini F, Czernik M, Fidanza A, Palmieri C, Della Salda L, Scapolo PA, Loi P. 2012. A short exposure to polychlorinated biphenyls deregulates cellular autophagy in mammalian blastocyst in vitro. Hum Reprod. 27:1034–1042.
   PubMed Web of Science ®Google Scholar
• Ramond A, Godin-Ribuot D, Ribuot C, Totoson P, Koritchneva I, Cachot S, Levy P, Joyeux-Faure M. 2013. Oxidative stress mediates cardiac infarction aggravation induced by intermittent hypoxia. Fundam Clin Pharmacol. 27:252–261.
   PubMed Web of Science ®Google Scholar
• Ramos KS, Bowes RC, 3rd, Ou X, Weber TJ. 1994. Responses of vascular smooth muscle cells to toxic insult: cellular and molecular perspectives for environmental toxicants. J Toxicol Environ Health. 43:419–440.
   PubMed Web of Science ®Google Scholar
• Rappaport SM, Smith MT. 2010. Epidemiology. Environment and disease risks. Science. 330:460–461.
   PubMed Web of Science ®Google Scholar
• Rat Genome Sequencing Project C. 2004. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature. 428:493–521.
   PubMed Web of Science ®Google Scholar
• Regauer S. 2016. Mast cell activation syndrome in pain syndromes bladder pain syndrome/interstitial cystitis and vulvodynia. Transl Androl Urol. 5:396–397.
   PubMed Web of Science ®Google Scholar
• Reichrtova E, Ciznar P, Prachar V, Palkovicova L, Veningerova M. 1999. Cord serum immunoglobulin E related to the environmental contamination of human placentas with organochlorine compounds. Environ Health Perspect. 107:895–899.
   PubMed Web of Science ®Google Scholar
• Relton CL, Davey Smith G. 2010. Epigenetic epidemiology of common complex disease: prospects for prediction, prevention, and treatment. PLoS medicine. 7:e1000356.
   PubMed Web of Science ®Google Scholar
• Rhodes SL, Fitzmaurice AG, Cockburn M, Bronstein JM, Sinsheimer JS, Ritz B. 2013. Pesticides that inhibit the ubiquitin-proteasome system: effect measure modification by genetic variation in SKP1 in Parkinsons disease. Environ Res. 126:1–8.
   PubMed Web of Science ®Google Scholar
• Roberts RA, Smith RA, Safe S, Szabo C, Tjalkens RB, Robertson FM. 2010. Toxicological and pathophysiological roles of reactive oxygen and nitrogen species. Toxicology. 276:85–94.
   PubMed Web of Science ®Google Scholar
• Rodnan GP, Benedek TG, Medsger TA, Jr., Cammarata RJ. 1967. The association of progressive systemic sclerosis (scleroderma) with coal miners' pneumoconiosis and other forms of silicosis. Ann Intern Med. 66:323–334.
   PubMed Web of Science ®Google Scholar
• Ross GH, Sternquist MC. 2012. Methamphetamine exposure and chronic illness in police officers: significant improvement with sauna-based detoxification therapy. Toxicol Ind Health. 28:758–768.
   PubMed Web of Science ®Google Scholar
• Rossignol DA, Frye RE. 2014. Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism. Front Physiol. 5:150.
   PubMed Web of Science ®Google Scholar
• Rubin BS. 2011. Bisphenol A: an endocrine disruptor with widespread exposure and multiple effects. J Steroid Biochem Mol Biol. 127:27–34.
   PubMed Web of Science ®Google Scholar
• Sahnoun Z, Jamoussi K, Zeghal KM. 1997. Free radicals and antioxidants: human physiology, pathology and therapeutic aspects. Therapie. 52:251–270.
   PubMed Web of Science ®Google Scholar
• Sakac V, Sakac M. 2000. Free oxygen radiacals and kidney diseases–part I. Med Pregl. 53:463–474.
   PubMedGoogle Scholar
• Salome M, Campos J, Keeshan K. 2015. TRIB2 and the ubiquitin proteasome system in cancer. Biochemical Society transactions. 43:1089–1094.
   PubMed Web of Science ®Google Scholar
• Samsel ASS. 2013. Glyphosate’s suppression of cytochrome P450 enzymes and amino acid biosynthesis by the gut microbiome: pathways to modern diseases Entropy. 15:1416–1463.
   Web of Science ®Google Scholar
• Santoro A, Ferrante MC, Di Guida F, Pirozzi C, Lama A, Simeoli R, Clausi MT, Monnolo A, Mollica MP, Mattace Raso G, et al. 2015. Polychlorinated Biphenyls (PCB 101, 153, and 180) Impair Murine Macrophage Responsiveness to Lipopolysaccharide: Involvement of NF-kappaB Pathway. Toxicol Sci. 147:255–269.
   PubMed Web of Science ®Google Scholar
• Saxena AK, Singh KP, Nagle SL, Gupta BN, Ray PK, Srivastav RK, Tewari SP, Singh R. 1988. Effect of exposure to toxic gas on the population of Bhopal: part IV–Immunological and chromosomal studies. Indian J Exp Biol. 26:173–176.
   PubMed Web of Science ®Google Scholar
• Schedle A, Samorapoompichit P, Fureder W, Rausch-Fan XH, Franz A, Sperr WR, Sperr W, Slavicek R, Simak S, Klepetko W, et al. 1998. Metal ion-induced toxic histamine release from human basophils and mast cells. J Biomed Mater Res. 39:560–567.
   PubMed Web of Science ®Google Scholar
• Schlichting I, Berendzen J, Chu K, Stock AM, Maves SA, Benson DE, Sweet RM, Ringe D, Petsko GA, Sligar SG, et al. 2000. The catalytic pathway of cytochrome p450cam at atomic resolution. Science. 287:1615–1622.
   PubMed Web of Science ®Google Scholar
• Schober W, Lubitz S, Belloni B, Gebauer G, Lintelmann J, Matuschek G, Weichenmeier I, Eberlein-König B, Buters J, Behrendt H, et al. 2007. Environmental polycyclic aromatic hydrocarbons (PAHs) enhance allergic inflammation by acting on human basophils. Inhal Toxicol. 19(Suppl 1):151–156.
   PubMed Web of Science ®Google Scholar
• Selmi C, Leung PS, Sherr DH, Diaz M, Nyland JF, Monestier M, Rose NR, Gershwin ME. 2012. Mechanisms of environmental influence on human autoimmunity: A national institute of environmental health sciences expert panel workshop. J Autoimmun. 39:272–284.
   PubMed Web of Science ®Google Scholar
• Seyfried TN. 2015. Cancer as a mitochondrial metabolic disease. Front Cell Dev Biol. 3:43.
   PubMed Web of Science ®Google Scholar
• Shen O, Du G, Sun H, Wu W, Jiang Y, Song L, Wang X. 2009. Comparison of in vitro hormone activities of selected phthalates using reporter gene assays. Toxicol Lett. 191:9–14.
   PubMed Web of Science ®Google Scholar
• Shih AR, Deshpande V, Ferry JA, Zukerberg L. 2016. Clinicopathologic characteristics of systemic mastocytosis in the intestine. Histopathology. 69:1021–1027.
   PubMed Web of Science ®Google Scholar
• Shim J, Kennedy RH, Weatherly LM, Hutchinson LM, Pelletier JH, Hashmi HN, Blais K, Velez A, Gosse JA. 2016. Arsenic inhibits mast cell degranulation via suppression of early tyrosine phosphorylation events. J Appl Toxicol. 36:1446–1459.
   PubMed Web of Science ®Google Scholar
• Shrivastava R. 2011. Bhopal gas disaster: review on health effects of methyl isocyanate. Research J Environ Sci. 5:150–156.
   Google Scholar
• Singh N, Dhalla AK, Seneviratne C, Singal PK. 1995. Oxidative stress and heart failure. Mol Cell Biochem. 147:77–81.
   PubMed Web of Science ®Google Scholar
• Skinner MK, Manikkam M, Guerrero-Bosagna C. 2011. Epigenetic transgenerational actions of endocrine disruptors. Reproductive toxicology. 31:337–343.
   PubMed Web of Science ®Google Scholar
• Skinner MK. 2011. Role of epigenetics in developmental biology and transgenerational inheritance. Birth Defects Res C Embryo Today. 93:51–55.
   PubMed Web of Science ®Google Scholar
• Sobel ES, Gianini J, Butfiloski EJ, Croker BP, Schiffenbauer J, Roberts SM. 2005. Acceleration of autoimmunity by organochlorine pesticides in (NZB x NZW)F1 mice. Environ Health Perspect. 113:323–328.
   PubMed Web of Science ®Google Scholar
• Song XY, Li JN, Wu YP, Zhang B, Li BX. 2015. Atrazine causes autophagy- and apoptosis-related neurodegenerative effects in dopaminergic neurons in the rat nigrostriatal dopaminergic system. Int J Mol Sci. 16:13490–13506.
   PubMed Web of Science ®Google Scholar
• Sorrenti V, Di Giacomo C, Acquaviva R, Barbagallo I, Bognanno M, Galvano F. 2013. Toxicity of ochratoxin a and its modulation by antioxidants: a review. Toxins (Basel). 5:1742–1766.
   PubMed Web of Science ®Google Scholar
• Stavenes Andersen I, Voie OA, Fonnum F, Mariussen E. 2009. Effects of methyl mercury in combination with polychlorinated biphenyls and brominated flame retardants on the uptake of glutamate in rat brain synaptosomes: a mathematical approach for the study of mixtures. Toxicol Sci. 112:175–184.
   PubMed Web of Science ®Google Scholar
• Steenland K, Tinker S, Shankar A, Ducatman A. 2010. Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with uric acid among adults with elevated community exposure to PFOA. Environ Health Perspect. 118:229–233.
   PubMed Web of Science ®Google Scholar
• Stefanis L. 2012. Alpha-Synuclein in Parkinson's disease. Cold Spring Harb Perspect Med. 2:a009399.
   PubMed Web of Science ®Google Scholar
• Stolevik SB, Nygaard UC, Namork E, Haugen M, Kvalem HE, Meltzer HM, Alexander J, van Delft JH, Loveren Hv, Løvik M, Granum B. 2011. Prenatal exposure to polychlorinated biphenyls and dioxins is associated with increased risk of wheeze and infections in infants. Food Chem Toxicol. 49:1843–1848.
   PubMed Web of Science ®Google Scholar
• Strolin Benedetti M. 2011. FAD-dependent enzymes involved in the metabolic oxidation of xenobiotics. Ann Pharm Fr. 69:45–52.
   PubMedGoogle Scholar
• Su X, Wellen KE, Rabinowitz JD. 2016. Metabolic control of methylation and acetylation. Curr Opin Chem Biol. 30:52–60.
   PubMed Web of Science ®Google Scholar
• Takiguchi M, Yoshihara S. 2006. New aspects of cadmium as endocrine disruptor. Environ Sci. 13:107–116.
   PubMedGoogle Scholar
• Takser L, Mergler D, Baldwin M, de Grosbois S, Smargiassi A, Lafond J. 2005. Thyroid hormones in pregnancy in relation to environmental exposure to organochlorine compounds and mercury. Environ Health Perspect. 113:1039–1045.
   PubMed Web of Science ®Google Scholar
• The Prague Declaration on Endocrine Disruption. 2005. 126 Signatories. Meeting for international group of scientists convened in Prague. May 1-12.
   Google Scholar
• Thompson PA, Khatami M, Baglole CJ, Sun J, Harris SA, Moon EY, Al-Mulla F, Al-Temaimi R, Brown DG, Colacci AM, et al. 2015. Environmental immune disruptors, inflammation and cancer risk. Carcinogenesis. 36(Suppl 1):S232–S253.
   PubMed Web of Science ®Google Scholar
• Togo F, Takahashi M. 2009. Heart rate variability in occupational health –a systematic review. Ind Health. 47:589–602.
   PubMed Web of Science ®Google Scholar
• Tramutola A, Di Domenico F, Barone E, Perluigi M, Butterfield DA. 2016. It is all about (U)biquitin: role of altered ubiquitin-proteasome system and UCHL1 in Alzheimer disease. Oxid Med Cell Longev. 2016:2756068.
   PubMed Web of Science ®Google Scholar
• Turnbaugh PJ, Ley RE, Hamady M, Fraser-Liggett CM, Knight R, Gordon JI. 2007. The human microbiome project. Nature. 449:804–10.
   PubMed Web of Science ®Google Scholar
• United States Senate Committee on Environment and Public Works: Subcommittee on Superfund Toxics and Environmental Health. 2010. Current science on public exposures to toxic chemicals. Available from: https://www.hsdl.org/?view&did=29623
   Google Scholar
• Upham BL, Wagner JG. 2001. Toxicant-induced oxidative stress in cancer. Toxicol Sci. 64:1–3.
   PubMed Web of Science ®Google Scholar
• Urb M, Pouliot P, Gravelat FN, Olivier M, Sheppard DC. 2009. Aspergillus fumigatus induces immunoglobulin E-independent mast cell degranulation. J Infect Dis. 200:464–472.
   PubMed Web of Science ®Google Scholar
• Ursell LK, Knight R. 2013. Xenobiotics and the human gut microbiome: metatranscriptomics reveal the active players. Cell Metab. 17:317–318.
   PubMed Web of Science ®Google Scholar
• Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. 2007. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 39:44–84.
   PubMed Web of Science ®Google Scholar
• Valko M, Morris H, Cronin MT. 2005. Metals, toxicity and oxidative stress. Curr Med Chem. 12:1161–1208.
   PubMed Web of Science ®Google Scholar
• Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M. 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 160:1–40.
   PubMed Web of Science ®Google Scholar
• Van Houten B, Woshner V, Santos JH. 2006. Role of mitochondrial DNA in toxic responses to oxidative stress. DNA Repair (Amst). 5:145–152.
   PubMed Web of Science ®Google Scholar
• Varaksin AN, Katsnelson BA, Panov VG, Privalova LI, Kireyeva EP, Valamina IE, Beresneva OY. 2014. Some considerations concerning the theory of combined toxicity: a case study of subchronic experimental intoxication with cadmium and lead. Food Chem Toxicol. 64:144–156.
   PubMed Web of Science ®Google Scholar
• Vaziri ND, Ding Y, Ni Z. 1999. Nitric oxide synthase expression in the course of lead-induced hypertension. Hypertension. 34:558–562.
   PubMed Web of Science ®Google Scholar
• Veena CK, Josephine A, Preetha SP, Rajesh NG, Varalakshmi P. 2008. Mitochondrial dysfunction in an animal model of hyperoxaluria: a prophylactic approach with fucoidan. Eur J Pharmacol. 579:330–336.
   PubMed Web of Science ®Google Scholar
• Vetrano AM, Laskin DL, Archer F, Syed K, Gray JP, Laskin JD, Nwebube N, Weinberger B. 2010. Inflammatory effects of phthalates in neonatal neutrophils. Pediatr Res. 68:134–139.
   PubMed Web of Science ®Google Scholar
• Victorino VJ, Pizzatti L, Michelletti P, Panis C. 2014. Oxidative stress, redox signaling and cancer chemoresistance: putting together the pieces of the puzzle. Curr Med Chem. 21:3211–3226.
   PubMed Web of Science ®Google Scholar
• Vuong AM, Webster GM, Romano ME, Braun JM, Zoeller RT, Hoofnagle AN, Sjödin A, Yolton K, Lanphear BP, Chen A, et al. 2015. Maternal Polybrominated Diphenyl Ether (PBDE) exposure and thyroid hormones in maternal and cord sera: the HOME Study, Cincinnati, USA. Environ Health Perspect. 123:1079–1085.
   PubMed Web of Science ®Google Scholar
• Walker ME, Hatfield JK, Brown MA. 2012. New insights into the role of mast cells in autoimmunity: evidence for a common mechanism of action? Biochim Biophys Acta. 1822:57–65.
   PubMed Web of Science ®Google Scholar
• Waseem M, Parvez S. 2013. Mitochondrial dysfunction mediated cisplatin induced toxicity: modulatory role of curcumin. Food Chem Toxicol. 53:334–342.
   PubMed Web of Science ®Google Scholar
• Welshons WV, Thayer KA, Judy BM, Taylor JA, Curran EM, vom Saal FS. 2003. Large effects from small exposures. I. Mechanisms for endocrine-disrupting chemicals with estrogenic activity. Environ Health Perspect. 111:994–1006.
   PubMed Web of Science ®Google Scholar
• Werbach M. 1997. Foundations of nutritional medicine: a sourcebook of clinical research. Tarzana (CA): Third Line Press.
   Google Scholar
• Whalen MM, Loganathan BG, Yamashita N, Saito T. 2003. Immunomodulation of human natural killer cell cytotoxic function by triazine and carbamate pesticides. Chem Biol Interact. 145:311–319.
   PubMed Web of Science ®Google Scholar
• World Health Organization (WHO). 2012. United Nations Environment Program: State of the science of endocrine disrupting chemicals. Available from: http://www.who.int/ceh/publications/endocrine/en/index.html
   Google Scholar
• Wu F, Xu HD, Guan JJ, Hou YS, Gu JH, Zhen XC, Qin Z-H. Rotenone impairs autophagic flux and lysosomal functions in Parkinson's disease. Neuroscience. 2015;284:900–911.
   PubMed Web of Science ®Google Scholar
• Wu S, Powers S, Zhu W, Hannun YA. 2015. Substantial contribution of extrinsic risk factors to cancer development. Nature. 529:43–47.
   PubMed Web of Science ®Google Scholar
• Xu Y, Chen G. 2015. Mast cell and autoimmune diseases. Mediators Inflamm. 2015:246126.
   PubMed Web of Science ®Google Scholar
• Yang SN, Hsieh CC, Kuo HF, Lee MS, Huang MY, Kuo CH, Hung C-H. 2014. The effects of environmental toxins on allergic inflammation. Allergy Asthma Immunol Res. 6:478–484.
   PubMed Web of Science ®Google Scholar
• Yasunaga S, Nishi K, Nishimoto S, Sugahara T. 2015. Methoxychlor enhances degranulation of murine mast cells by regulating FcepsilonRI-mediated signal transduction. J Immunotoxicol. 12:283–289.
   PubMed Web of Science ®Google Scholar
• Yegambaram M, Manivannan B, Beach TG, Halden RU. 2015. Role of environmental contaminants in the etiology of Alzheimer's disease: a review. Curr Alzheimer Res. 12:116–146.
   PubMed Web of Science ®Google Scholar
• Yen YP, Tsai KS, Chen YW, Huang CF, Yang RS, Liu SH. 2012. Arsenic induces apoptosis in myoblasts through a reactive oxygen species-induced endoplasmic reticulum stress and mitochondrial dysfunction pathway. Arch Toxicol. 86:923–933.
   PubMed Web of Science ®Google Scholar
• Yu X, Robinson JF, Sidhu JS, Hong S, Faustman EM. 2010. A system-based comparison of gene expression reveals alterations in oxidative stress, disruption of ubiquitin-proteasome system and altered cell cycle regulation after exposure to cadmium and methylmercury in mouse embryonic fibroblast. Toxicol Sci. 114:356–377.
   PubMed Web of Science ®Google Scholar
• Zeljezic D, Garaj-Vrhovac V. 2002. Sister chromatid exchange and proliferative rate index in the longitudinal risk assessment of occupational exposure to pesticides. Chemosphere. 46:295–303.
   PubMed Web of Science ®Google Scholar
• Zhang S, Jin Y, Zeng Z, Liu Z, Fu Z. 2015. Subchronic exposure of mice to cadmium perturbs their hepatic energy metabolism and gut microbiome. Chem Res Toxicol. 28:2000–2009.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Sun LG, Ye LP, Wang B, Li Y. 2008. Lead-induced stress response in endoplasmic reticulum of astrocytes in CNS. Toxicol Mech Methods. 18:751–757.
   PubMed Web of Science ®Google Scholar
• Zhang Z, Miah M, Culbreth M, Aschner M. 2016. Autophagy in neurodegenerative diseases and metal neurotoxicity. Neurochem Res. 41:409–422.
   PubMed Web of Science ®Google Scholar
• Zmrzljak UP, Rozman D. 2012. Circadian regulation of the hepatic endobiotic and xenobitoic detoxification pathways: the time matters. Chem Res Toxicol. 25:811–824.
   PubMed Web of Science ®Google Scholar