L-ascorbic acid and α-tocopherol attenuate arsenic trioxide-induced toxicity in H9c2 cardiomyocytes by the activation of Nrf2 and Bcl2 transcription factors

References

• Aravind L, Dixit VM, Koonin EV. 2001. Apoptotic molecular machinery: vastly increased complexity in vertebrates revealed by genome comparisons. Science. 291:1279–1284.
   PubMed Web of Science ®Google Scholar
• Brand MD, Affourtit C, Esteves TC, Green K, Lambert AJ, Miwa S, Pakay JL, Parker N. 2004. Mitochondrial superoxide: production, biological effects, and activation of uncoupling proteins. Free Radic Biol Med. 37:755–767.
   PubMed Web of Science ®Google Scholar
• Christen WG, Gaziano JM, Hennekens CH. 2000. Design of Physicians' Health Study II—a randomized trial of beta-carotene, vitamins E and C, and multivitamins, in prevention of cancer, cardiovascular disease, and eye disease, and review of results of completed trials. Ann Epidemiol. 10:125–134.
   PubMed Web of Science ®Google Scholar
• Danial NN, Korsmeyer SJ. 2004. Cell death: critical control points. Cell. 116:205–219.
   PubMed Web of Science ®Google Scholar
• Ermak G, Davies KJ. 2002. Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol. 38:713–721.
   PubMed Web of Science ®Google Scholar
• Ficker E, Kuryshev YA, Dennis AT, Obejero-Paz C, Wang L, Hawryluk P, Wible BA, Brown AM. 2004. Mechanisms of arsenic-induced prolongation of cardiac repolarization. Mol Pharmacol. 66:33–44.
   PubMed Web of Science ®Google Scholar
• Flora SJ. 2009. Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure. Oxid Med Cell Longev. 2:191–206.
   PubMed Web of Science ®Google Scholar
• Frenkel K, Gleichauf C. 1991. Hydrogen peroxide formation by cells treated with a tumor promoter. Free Radic Res Commun. 13:783–794.
   Web of Science ®Google Scholar
• Garcia-Closas R, Berenguer A, José Tormo M, José Sánchez M, Quirós JR, Navarro C, Arnaud R, Dorronsoro M, Dolores Chirlaque M, Barricarte A, et al. 2004. Dietary sources of vitamin C, vitamin E and specific carotenoids in Spain. Br J Nutr. 91:1005–1011.
   PubMed Web of Science ®Google Scholar
• Gousul Azam SMG, Afrin S, Naz S. 2017. Arsenic in cereals, their relation with human health risk, and possible mitigation strategies. Food Rev Int. 33:620–643.
   Google Scholar
• Halestrap AP, Pasdois P. 2009. The role of the mitochondrial permeability transition pore in heart disease. Biochim Biophys Acta. 1787:1402–1415.
   PubMed Web of Science ®Google Scholar
• Higgins LG, Kelleher MO, Eggleston IM, Itoh K, Yamamoto M, Hayes JD. 2009. Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. Toxicol Appl Pharmacol. 237:267–280.
   PubMed Web of Science ®Google Scholar
• Huigsloot M, Tijdens IB, Mulder GJ, van de Water B. 2002. Differential regulation of doxorubicin-induced mitochondrial dysfunction and apoptosis by Bcl-2 in mammary adenocarcinoma (MTLn3) cells. J Biol Chem. 277:35869–35879.
   PubMed Web of Science ®Google Scholar
• Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, Bannai S, Yamamoto M. 2000. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem. 275:16023–16029.
   PubMed Web of Science ®Google Scholar
• Kalender S, Kalender Y, Ogutcu A, Uzunhisarcikli M, Durak D, Açikgoz F. 2004. Endosulfan-induced cardiotoxicity and free radical metabolism in rats: the protective effect of vitamin E. Toxicology. 202:227–235.
   PubMed Web of Science ®Google Scholar
• Kirkinezos IG, Moraes CT. 2001. Reactive oxygen species and mitochondrial diseases. Semin Cell Dev Biol. 12: 449–457.
   PubMed Web of Science ®Google Scholar
• Low ICC, Chen ZX, Pervaiz S. 2010. Bcl-2 modulates resveratrol-induced ROS production by regulating mitochondrial respiration in tumor cells. Antioxid Redox Signal. 13:807–819.
   PubMed Web of Science ®Google Scholar
• Lutsenko EA, Carcamo JM, Golde DW. 2002. Vitamin C prevents DNA mutation induced by oxidative stress. J Biol Chem. 277:16895–16899.
   PubMed Web of Science ®Google Scholar
• Mandal BK, Suzuki KT. 2002. Arsenic round the world: a review. Talanta. 58:201–235.
   PubMed Web of Science ®Google Scholar
• Maritim AC, Sanders A, Watkins J. 2003. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol. 17:24–38.
   PubMed Web of Science ®Google Scholar
• Mathews VV, Paul MV, Abhilash M, Manju A, Abhilash S, Nair RH. 2013. Myocardial toxicity of acute promyelocytic leukaemia drug-arsenic trioxide. Eur Rev Med Pharmacol Sci. 17:S34–S38.
   PubMed Web of Science ®Google Scholar
• Orrenius S, Zhivotovsky B, Nicotera P. 2003. Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol. 4:552–565.
   PubMed Web of Science ®Google Scholar
• Prieto P, Pineda M, Aguilar M. 1999. Spectrophotometric quantitation of antioxidant capacity through the formation of a phosphomolybdenum complex: specific application to the determination of vitamin E. Anal Biochem. 269:337–341.
   PubMed Web of Science ®Google Scholar
• Quiles JL, Huertas JR, Battino M, Mataix J, Ramírez-Tortosa MC. 2002. Antioxidant nutrients and adriamycin toxicity. Toxicology. 180:79–95.
   PubMed Web of Science ®Google Scholar
• Raghu KG, Yadav GK, Singh R, Prathapan A, Sharma S, Bhadauria S. 2009. Evaluation of adverse cardiac effects induced by arsenic trioxide, a potent anti-APL drug. J Environ Pathol Toxicol Oncol. 28:241.
   PubMed Web of Science ®Google Scholar
• Salonen JT, Nyyssönen K, Salonen R, Lakka HM, Kaikkonen J, Porkkala-Sarataho E, Voutilainen S, Lakka TA, Rissanen T, Leskinen L, et al. 2000. Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) study: a randomized trial of the effect of vitamins E and C on 3‐year progression of carotid atherosclerosis. J Intern Med. 248:377–386.
   PubMed Web of Science ®Google Scholar
• Shen ZY, Shen WY, Chen MH, Shen J, Cai WJ, Zeng Y. 2002. Mitochondria, calcium and nitric oxide in the apoptotic pathway of esophageal carcinoma cells induced by As2O3. Int J Mol Med. 9:385–390.
   PubMed Web of Science ®Google Scholar
• Taguchi K, Motohashi H, Yamamoto M. 2011. Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution. Genes Cells. 16:123–140.
   PubMed Web of Science ®Google Scholar
• Ting CM, Lee YM, Wong CKC, Wong AS, Lung HL, Lung ML, Lo KW, Wong RNS, Mak NK. 2010. 2-Methoxyestradiol induces endoreduplication through the induction of mitochondrial oxidative stress and the activation of MAPK signaling pathways. Biochem Pharmacol. 79:825–841.
   PubMed Web of Science ®Google Scholar
• Unnikrishnan D, Dutcher JP, Varshneya N, Lucariello R, Api M, Garl S, Wiernik PH, Chiaramida S. 2001. Torsades de pointes in 3 patients with leukemia treated with arsenic trioxide. Blood. 97:1514–1516.
   PubMed Web of Science ®Google Scholar
• Varghese MV, Abhilash M, Paul MVS, Alex M, Nair RH. 2017. Omega-3 fatty acid protects against arsenic trioxide-induced cardiotoxicity in vitro and in vivo. Cardiovasc Toxicol. 17:1–11.
   PubMed Web of Science ®Google Scholar
• Villeneuve NF, Lau A, Zhang DD. 2010. Regulation of the Nrf2–Keap1 antioxidant response by the ubiquitin proteasome system: an insight into cullin-ring ubiquitin ligases. Antioxid Redox Signal. 13:1699–1712.
   PubMed Web of Science ®Google Scholar
• Wang Y, Zhao X, Gao X, Nie X, Yang Y, Fan X. 2011. Development of fluorescence imaging-based assay for screening cardioprotective compounds from medicinal plants. Anal Chim Acta. 702:87–94.
   PubMed Web of Science ®Google Scholar
• Ye Z, Song H. 2008. Antioxidant vitamins intake and the risk of coronary heart disease: meta-analysis of cohort studies. Eur J Cardiovasc Prev Rehabil. 15:26–34.
   PubMed Web of Science ®Google Scholar
• Zhao X, Feng T, Chen H, Shan H, Zhang Y, Lu Y, Yang B. 2008. Arsenic trioxide-induced apoptosis in H9c2 cardiomyocytes: implications in cardiotoxicity. Basic Clin Pharmacol Toxicol. 102:419–425.
   PubMed Web of Science ®Google Scholar
• Zhou S, Sun W, Zhang Z, Zheng Y. 2014. The role of Nrf2-mediated pathway in cardiac remodeling and heart failure. Oxid Med Cell Longev. 2014:1.
   Web of Science ®Google Scholar