Development of an acute, short-term exposure model for phosgene

References

• Baggett RK, Simpkins BK. 2018. Chapter 6, Critical infrastructure threats and hazards. In: Homeland security and critical infrastructure protection. 2nd ed. Santa Barbara, Denver: Praeger, ABC-CLIO, LLC; p. 146–170.
   Google Scholar
• Bast CB, Glass-Mattie DF. 2015. Chapter 25, Phosgene. In: Gupta RC, editor. Handbook of toxicology of chemical warfare agents. 2nd ed. New York, San Francisco, London: Academic Press, Inc.; p. 327–335.
   Google Scholar
• Belkebir E, Rousselle C, Duboudin C, Bodin L, Bonvallot N. 2011. Haber’s rule duration adjustments should not be used systematically for risk assessment in public health decision-making. Toxicol Lett. 204:148–155.
   PubMed Web of Science ®Google Scholar
• Borak J, Diller WF. 2001. Phosgene exposure: mechanisms of injury and treatment strategies. J Occup Environ Med. 43:110–119.
   PubMed Web of Science ®Google Scholar
• Chen HL, Bai H, Xi MM, Liu R, Qin XJ, Liang X, Zhang W, Zhang XD, Li WL, Hai CX. 2013. Ethyl pyruvate protects rats from phosgene-induced pulmonary edema by inhibiting cyclooxygenase2 and inducible nitric oxide synthase expression. J Appl Toxicol. 33:71–77.
   PubMed Web of Science ®Google Scholar
• Diller WF. 1985. Pathogenesis of phosgene poisoning. Toxicol Ind Health. 1:7–15.
   PubMedGoogle Scholar
• Fentener van Vlissingen JM, Borrens M, Girod A, Lelovas P, Morrison F, Torres YS. 2015. The reporting of clinical signs in laboratory animals: FELASA Working Group Report. Lab Anim. 49:267–283.
   PubMed Web of Science ®Google Scholar
• Filipczak PT, Senft AP, Seagrave J, Weber W, Kuehl PJ, Fredenburgh LE, McDonald JD, Baron RM. 2015. NOS-2 inhibition in phosgene-induced acute lung injury. Toxicol Sci. 146:89–100.
   PubMed Web of Science ®Google Scholar
• Finney DJ. 1952. Probit analysis. 2nd ed. New York (NY): Cambridge University Press.
   Google Scholar
• Ghio AJ, Kennedy TP, Hatch GE, Tepper JS. 1991. Reduction of neutrophil influx diminishes lung injury and mortality following phosgene inhalation. J Appl Physiol. 71:657–665.
   PubMed Web of Science ®Google Scholar
• Grainge C, Brown R, Jugg BJ, Smith AJ, Mann TM, Jenner J, Rice P, Parkhouse DA. 2009. Early treatment with nebulised salbutamol worsens physiological measures and does not improve survival following phosgene induced acute lung injury. J R Army Med Corps. 155:105–109.
   PubMedGoogle Scholar
• Grainge C, Jugg BJ, Smith AJ, Brown RF, Jenner J, Parkhouse DA, Rice P. 2010. Delayed low-dose supplemental oxygen improves survival following phosgene-induced acute lung injury. Inhal Toxicol. 22:552–560.
   PubMed Web of Science ®Google Scholar
• Grainge C, Rice P. 2010. Management of phosgene-induced acute lung injury. Clin Toxicol (Phila). 48:497–508.
   PubMed Web of Science ®Google Scholar
• Grainge C, Smith AJ, Jugg BJ, Fairhall SJ, Mann T, Perrott R, Jenner J, Millar T, Rice P. 2010. Furosemide in the treatment of phosgene induced acute lung injury. J R Army Med Corps. 156:245–250.
   PubMedGoogle Scholar
• Haber F. 1924. Zur geschichte des gaskrieges [On the history of gas warfare]. In: Fünf Vorträge aus den Jahren 1920–1923 [Five Lectures from the Years 1920–1923]. Berlin: Springer; p. 76–92.
   Google Scholar
• He DK, Shao YR, Zhang L, Shen J, Zhong ZY, Wang J, Xu G. 2014 . Adenovirus-delivered angiopoietin-1 suppresses NF-κB and p38 MAPK and attenuates inflammatory responses in phosgene-induced acute lung injury. Inhal Toxicol. 26:185–192.
   PubMed Web of Science ®Google Scholar
• Krishna G, Goel S. 2015. Chapter 45, Alternative animal toxicity testing of chemical warfare agents. In: Gupta RC, editor. Handbook of toxicology of chemical warfare agents. 2nd ed. New York, San Francisco, London: Academic Press, Inc.; p. 657–673.
   Google Scholar
• Li W, Pauluhn J. 2014. Chapter 19, Mechanisms involved in the inhalation toxicity of phosgene. In: Salem H, Katz SA, editors. Inhalation toxicology. 3rd ed. Boca Raton (FL): CRC Press; p. 459–483.
   Google Scholar
• Miller FJ, Schlosser PM, Janszen DB. 2000. Haber’s rule: a special case in a family of curves relating concentration and duration of exposure to a fixed level of response for a given endpoint. Toxicology. 149:21–34.
   PubMed Web of Science ®Google Scholar
• Mioduszewski R, Manthei J, Way R, Burnett D, Gaviola B, Muse W, Thomson S, Sommerville D, Crosier R. 2002. Interaction of exposure concentration and duration in determining acute toxic effects of sarin vapor in rats. Toxicol Sci. 66:176–184.
   PubMed Web of Science ®Google Scholar
• Narciso SP, Nadziejko E, Chen LC, Gordon T, Nadziejko C. 2003. Adaptation to stress induced by restraining rats and mice in nose-only inhalation holders. Inhal Toxicol. 15:1133–1143.
   PubMed Web of Science ®Google Scholar
• Parker JC, Townsley MI. 2004. Evaluation of lung injury in rats and mice. Am J Physiol Lung Cell Mol Physiol. 286:L231–L246.
   PubMed Web of Science ®Google Scholar
• Parseghian MH, Hobson ST, Richieri RA. 2016. Targeted heat shock protein 72 for pulmonary cytoprotection. Ann N Y Acad Sci. 1374:78–85.
   PubMed Web of Science ®Google Scholar
• Pauluhn J. 2006a. Acute nose-only exposure of rats to phosgene. Part I: concentration × time dependence of LC50s, nonlethal-threshold concentrations, and analysis of breathing patterns. Inhal Toxicol. 18:423–435.
   PubMed Web of Science ®Google Scholar
• Pauluhn J. 2006b. Acute nose-only exposure of rats to phosgene. Part II. Concentration × time dependence of changes in bronchoalveolar lavage during a follow-up period of 3 months. Inhal Toxicol. 18:595–607.
   PubMed Web of Science ®Google Scholar
• Public Health England. 2016. Phosgene: toxicological overview. Report Number 2014790.
   Google Scholar
• Rozman KK, Doull J. 2000. Dose and time as variables of toxicity. Toxicology. 144:169–178.
   PubMed Web of Science ®Google Scholar
• Russell D, Blain PG, Rice P. 2006. Clinical management of casualties exposed to lung damaging agents: a critical review. Emerg Med J. 23:421–424.
   PubMed Web of Science ®Google Scholar
• Sciuto AM, Cascio MB, Moran TS, Forster JS. 2003. The fate of antioxidant enzymes in bronchoalveolar lavage fluid over 7 days in mice with acute lung injury. Inhal Toxicol. 15:675–685.
   PubMed Web of Science ®Google Scholar
• Sciuto AM, Clapp DL, Hess ZA, Moran TS. 2003. The temporal profile of cytokines in the bronchoalveolar lavage fluid in mice exposed to the industrial gas phosgene. Inhal Toxicol. 15:687–700.
   PubMed Web of Science ®Google Scholar
• Sciuto AM, Hurt HH. 2004. Therapeutic treatments of phosgene-induced lung injury. Inhal Toxicol. 16:565–580.
   PubMed Web of Science ®Google Scholar
• Sciuto AM, Stotts RR, Hurt HH. 1996. Efficacy of ibuprofen and pentoxifylline in the treatment of phosgene-induced acute lung injury. J Appl Toxicol. 16:381–384.
   PubMed Web of Science ®Google Scholar
• Shen J, Gan Z, Zhao J, Zhang L, Xu G. 2014. Ulinastatin reduces pathogenesis of phosgene-induced acute lung injury in rats. Toxicol Ind Health. 30:785–793.
   PubMed Web of Science ®Google Scholar
• Smith A, Brown R, Jugg B, Platt J, Mann T, Masey C, Jenner J, Rice P. 2009. The effect of steroid treatment with inhaled budesonide or intravenous methylprednisolone on phosgene-induced acute lung injury in a porcine model. Mil Med. 174:1287–1294.
   PubMed Web of Science ®Google Scholar
• Spruit HE, Langenberg JP, Trap HC, van der Wiel HJ, Helmich RB, van Helden HP, Benschop HP. 2000. Intravenous and inhalation toxicokinetics of sarin stereoisomers in atropinized guinea pigs. Toxicol Appl Pharmacol. 169:249–254.
   PubMed Web of Science ®Google Scholar
• Summerhill EM, Hoyle GW, Jordt S-E, Jugg BJ, Martin JG, Matalon S, Patterson SE, Prezant DJ, Sciuto AM, Svendsen ER, et al. 2017. An official american thoracic society workshop report: chemical inhalational disasters. Biology of lung injury, development of novel therapeutics, and medical preparedness. Ann Am Thorac Soc. 14:1060–1072.
   PubMed Web of Science ®Google Scholar
• Sweeney LM, Sommerville DR, Channel SR, Sharits BC, Gargas NM, Gut CP Jr. 2015. Evaluating the validity and applicable domain of the toxic load model: impact of concentration vs. time profile on inhalation lethality of hydrogen cyanide. Regul Toxicol Pharmacol. 71:571–584.
   PubMed Web of Science ®Google Scholar
• ten Berge WF, Zwart A, Appelman LM. 1986. Concentration-time mortality response relationship of irritant and systemically acting vapours and gases. J Hazard Mater. 13:301–309.
   Web of Science ®Google Scholar
• Warren E. 1900. On the reaction of Daphnia magna (Straus) to certain changes in its environment. Q J Microsc. 43:199–224.
   Google Scholar
• Weinrich SL, Lawrence AE, Burr JK, Grotte JH, Laviolet LL. 2008. A comparative analysis of toxicity models. Alexandria, Virginia. IDA Paper P-4327.
   Google Scholar
• Worek F, Jenner J, Thiermann H, editors. 2018. Chemical warfare toxicology: volume 2: management of poisoning. London: Royal Society of Chemistry.
   Google Scholar
• Zwart A, Arts JHE, Klokman-Houweling JM, Schoen ED. 1990. Determination of concentration-time-mortality relationships to replace LC50 values. Inhal Toxicol. 2:105–117.
   Google Scholar