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Review Article

Role of Smoking-Mediated molecular events in the genesis of oral cancers

& ORCID Icon
Pages 665-685 | Received 17 May 2019, Accepted 14 Jul 2019, Published online: 03 Sep 2019

References

  • Abadi LIG, Dehaghi BF, Boazar M. 2015. Bioassay of environmental exposure of children to polycyclic aromatic hydrocarbons using 1-hydroxypyrene. Jundishapur J Health Sci. 7(2):20–24.
  • Acharya S, Kale J, Hallikeri K, Anehosur V, Arnold D. 2018. Clinical significance of preoperative serum C-reactive protein in oral squamous cell carcinoma. Int J Oral Maxillofac Surg. 47(1):16–23.
  • Adeyemi DB, Abimbola DO, Kolude DB. 2019. A comparative study of oral health status in diabetic and non-diabetic patients. Oral Surg Oral Med Oral Pathol Oral Radiol. 128(1):e68–e69.
  • Adhami N, Starck SR, Flores C, Green MM. 2016. A health threat to bystanders living in the homes of smokers: how smoke toxins deposited on surfaces can cause insulin resistance. PloS One. 11(3):e0149510.
  • Aditya A, Lele S. 2015. Association between psychosocial disorders and oral health. J Dent Allied Sci. 4(2):84–88.
  • Aggarwal BB, Gehlot P. 2009. Inflammation and cancer: how friendly is the relationship for cancer patients? Curr Opin Pharmacol. 9(4):351–369.
  • Airoldi M, Garzaro M, Raimondo L, Pecorari G, Giordano C, Varetto A, Caldera P, Torta R. 2011. Functional and psychological evaluation after flap reconstruction plus radiotherapy in oral cancer. Head Neck. 33(4):458–468.
  • Aizenbud D, Aizenbud I, Reznick AZ, Avezov K. 2016. Acrolein-an α,β-unsaturated aldehyde: a review of oral cavity exposure and oral pathology effects. Rambam Maimonides Med J. 7(3):e0024.
  • Alam MS, Perween R, Siddiqui SA. 2017. Epidemiological profile of head and neck cancer patients in Western Utter Pradesh and analysis of distributions of risk factors in relation to site of tumor. J Can Res Ther. 4:47.
  • Albano GD, Bonanno A, Riccobono L, Gagliardo R, Pieper M, Gjomarkaj M, Profita M. 2015. Cigarette smoke extract (CSE) promotes acetylcholine (ACh) mediated inflammation and oxidative stress by PEBP1/Raf-mediated MEK and ERK pathway in human bronchial epithelial cells. Eur Respirat J. 46(suppl 59):PA1015.
  • Al-Hebshi NN, Nasher AT, Speicher DJ, Shaikh MH, Johnson NW. 2016. Possible interaction between tobacco use and EBV in oral squamous cell carcinoma. Oral Oncol. 59:e4–e5.
  • Ali‐Khan N, Zuo X, Speicher DW. 2002. Overview of proteome analysis. Curr Protocol Prot Sci. 30(1):22.21. 21–22.21. 19.
  • Al-Shareef H, Matsuoka Y, Kogo M, Nakahara H. 2019. Effects of decreased Rac activity and malignant state on oral squamous cell carcinoma. bioRxiv:540591.
  • Anderson L. 2005. Candidate-based proteomics in the search for biomarkers of cardiovascular disease . J Physiol (Lond). 563(Pt 1):23–60.
  • Anderson NL, Anderson NG. 2002. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics. 1(11):845–867.
  • Andreotti G, Freedman ND, Silverman DT, Lerro CC, Koutros S, Hartge P, Alavanja MC, Sandler DP, Beane Freeman L. 2016. Tobacco use and cancer risk in the Agricultural Health Study. Cancer Epidemiol Biomarkers Prev. 26(5):769–778.
  • Anvar SY, Allard G, Tseng E, Sheynkman GM, de Klerk E, Vermaat M, Yin RH, Johansson HE, Ariyurek Y, den Dunnen JT, et al. 2018. Full-length mRNA sequencing uncovers a widespread coupling between transcription initiation and mRNA processing. Genome Biol. 19(1):46.
  • Anwar SL, Wulaningsih W, Lehmann U. 2017. Transposable elements in human cancer: causes and consequences of deregulation. Int J Mol Sci. 18(5):974.
  • Aral M, Ekerbicer HC, Celik M, Ciragil P,. #3, N, Gul M. 2006. Comparison of effects of smoking and smokeless tobacco “Maras Powder” use on humoral immune system parameters. Mediat Inflamm. 2006:85019.
  • Arbabi-Kalati F, Salimi S, Nabavi S, Rigi S, Miri-Moghaddam M. 2017. Effects of tobacco on salivary antioxidative and immunologic systems. Asian Pac J Cancer Prev. 18(5):1215–1218.
  • Arimilli S, Madahian B, Chen P, Marano K, Prasad GL. 2017. Gene expression profiles associated with cigarette smoking and moist snuff consumption. BMC Genomics. 18(1):156.
  • Arowojolu MO, Fawole OI, Dosumu EB, Opeodu OI. 2013. A comparative study of the oral hygiene status of smokers and non-smokers in Ibadan, Oyo state. Niger Med J. 54(4):240–243.
  • Barbieri SS, Zacchi E, Amadio P, Gianellini S, Mussoni L, Weksler BB, Tremoli E. 2011. Cytokines present in smokers' serum interact with smoke components to enhance endothelial dysfunction. Cardiovasc Res. 90(3):475–483.
  • Bastide A, David A. 2018. Interaction of rRNA with mRNA and tRNA in translating mammalian ribosome: functional implications in health and disease. Biomolecules. 8(4):100.
  • Batsakis JG. 2003. Clinical pathology of oral cancer. In: Shah JP, Johnson NW, and Batsakis JG, editors. Oral Cancer. Stuttgart, Germany: Thieme. p. 77–129.
  • Beaudoing E, Freier S, Wyatt JR, Claverie JM, Gautheret D. 2000. Patterns of variant polyadenylation signal usage in human genes. Genome Res. 10(7):1001–1010.
  • Benowitz NL, Renner CC, Lanier AP, Tyndale RF, Hatsukami DK, Lindgren B, Stepanov I, Watson CH, Sosnoff CS, Jacob P. 2012. Exposure to nicotine and carcinogens among Southwestern Alaskan Native cigarette smokers and smokeless tobacco users. Cancer Epidemiol Prev Biomark. 21(6):934–942.
  • Benowitz NL, Hukkanen J, Jacob P. III 2009. Nicotine chemistry, metabolism, kinetics and biomarkers. Handb Exp Pharmacol. 192:29–60.
  • Bhat MY, Advani J, Rajagopalan P, Patel K, Nanjappa V, Solanki HS, Patil AH, Bhat FA, Mathur PP, Nair B, et al. 2018. Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes. Sci Rep. 8(1):7040.
  • Bhat SN, Varsha VK, Girish HC, Murgod S, Savita JK, Umapathy T. 2015. Micronuclei assay in smokers v/s non smokers-gaining genomic insight. IJOCR. 3(9):35–41.
  • Biancotto A, McCoy JP. 2013. Studying the human immunome: the complexity of comprehensive leukocyte immunophenotyping. Curr Top Microbiol Immunol. 377:23–60.
  • Bijanzadeh M. 2017. The recurrence risk of genetic complex diseases. J Res Med Sci. 22(1):32.
  • Bonassi S, Neri M, Lando C, Ceppi M, Lin Y-P, Chang WP, Holland N, Kirsch-Volders M, Zeiger E, Fenech M. 2003. Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project. Mutat Res. 543(2):155–166.
  • Bornemisza P, Suciu I. 1980. Effect of cigarette smoking on the blood glucose level in normals and diabetics. Med Interne. 18(4):353–356.
  • Bourdon J-C, Fernandes K, Murray-Zmijewski F, Liu G, Diot A, Xirodimas DP, Saville MK, Lane DP. 2005. p53 isoforms can regulate p53 transcriptional activity. Gene Dev. 19(18):2122–2137.
  • Boyle JO, Gümüs ZH, Kacker A, Choksi VL, Bocker JM, Zhou XK, Yantiss RK, Hughes DB, Du B, Judson BL, et al. 2010. Effects of cigarette smoke on the human oral mucosal transcriptome. Cancer Prevent Res (Philadelphia, Pa). 3(3):266–278.
  • Brahmbhatt B, Vora H, Shah B. 2016. Infiltration of T cell subsets during oral carcinogenesis. Indian J Oral Sci. 7(1):28–41.
  • Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. 2018. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68(6):394–424.
  • Bray F, Ren J-S, Masuyer E, Ferlay J. 2013. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer. 132(5):1133–1145.
  • Burzlaff JB, Bohrer PL, Paiva RL, Visioli F, Sant'Ana Filho M, da Silva VD, Rados PV. 2007. Exposure to alcohol or tobacco affects the pattern of maturation in oral mucosal cells: a cytohistological study. Cytopathology. 18(6):367–375.
  • Cameron Goertzen HM, Laliberte C, Meirson T, Eymael D, Gil-Henn H, Magalhaes M. 2018. Oral inflammation promotes oral squamous cell carcinoma invasion. Oncotarget. 9(49):29047.
  • Cardellach F, Alonso JR, Lopez S, Casademont J, Miro O. 2003. Effect of smoking cessation on mitochondrial respiratory chain function. J Toxicol Clin Toxicol. 41(3):223–228.
  • Carta CFL, Oliveira Alves MG, de Barros PP, Campos MS, Scholz J, Jorge AOC, Nunes FD, Almeida JD. 2018. Screening methylation of DNA repair genes in the oral mucosa of chronic smokers. Arch Oral Biol. 92:83–87.
  • Castagnola M, Scarano E, Passali GC, Messana I, Cabras T, Iavarone F, Di Cintio G, Fiorita A, De Corso E, Paludetti G. 2017. Salivary biomarkers and proteomics: future diagnostic and clinical utilities. [Biomarkers e proteomica salivari: prospettive future cliniche e diagnostiche]. Acta Otorhinolaryngol Ital. 37(2):94–101.
  • Castañeda-Yslas IJ, Arellano-García ME, García-Zarate MA, Ruíz-Ruíz B, Zavala-Cerna MG, Torres-Bugarín O. 2016. Biomonitoring with micronuclei test in buccal cells of female farmers and children exposed to pesticides of Maneadero Agricultural Valley, Baja California, Mexico. J Toxicol. 2016:7934257.
  • Cervino G, Fiorillo L, Herford AS, Romeo U, Bianchi A, Crimi S,. #X, Amico C, De Stefano R, Troiano G, Santoro R, et al. 2019. Molecular biomarkers related to oral carcinoma: clinical trial outcome evaluation in a literature review. Disease Markers. 2019:1.
  • Chakraborty P, Karmakar T, Arora N, Mukherjee G. 2018. Immune and genomic signatures in oral (head and neck) cancer. Heliyon. 4(10):e00880.
  • Chang SS, Jiang WW, Smith I, Glazer C, Sun W-Y, Mithani S, Califano JA. 2010. Chronic cigarette smoke extract treatment selects for apoptotic dysfunction and mitochondrial mutations in minimally transformed oral keratinocytes. Int J Cancer. 126(1):19–27.
  • Charlesworth JC, Curran JE, Johnson MP, Göring HHH, Dyer TD, Diego VP, Kent JW, Mahaney MC, Almasy L, MacCluer JW, et al. 2010. Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes. BMC Med Genomics. 3(1):29.
  • Chattopadhyay E, De Sarkar N, Singh R, Ray A, Roy R, Paul RR, Pal M, Ghose S, Ghosh S, Kabiraj D, et al. 2016. Genome-wide mitochondrial DNA sequence variations and lower expression of OXPHOS genes predict mitochondrial dysfunction in oral cancer tissue. Tumour Biol. 37(9):11861–11871.
  • Chaudhuri S, Dey S, Awasthi A. 2017. Epidemiological hazards of tobacco and its manifestations in oral health of a screened population in Northern India. J Cancer Policy. 12:1–6.
  • Chen AM, Chao KSC. 2012. Chapter 18: Head and neck cancer. In: Levitt SH, Purdy JA, Perez CA and Poortmans P, editors. Technical basis of radiation therapy: practical clinical applications. Berlin, Heidelberg: Springer-Verlag. p. 601–640.
  • Chen HH, Chen IH, Liao CT, Wei FC, Lee LY, Huang SF. 2011. Preoperative circulating C-reactive protein levels predict pathological aggressiveness in oral squamous cell carcinoma: a retrospective clinical study. Clin Otolaryngol. 36(2):147–153.
  • Chen Y, Pan Y, Ji Y, Sheng L, Du X. 2018. Network analysis of differentially expressed smoking-associated mRNAs, lncRNAs and miRNAs reveals key regulators in smoking-associated lung cancer. Exp Ther Med. 16(6):4991–5002.
  • Chiolero A, Faeh D, Paccaud F, Cornuz J. 2008. Consequences of smoking for body weight, body fat distribution, and insulin resistance. Am J Clin Nutr. 87(4):801–809.
  • Clapp P, Lavrich K, Reidel B, van Heusden C, Kesimer M, Lazarowski E, Carson J, Jaspers I. 2018. The e-cigarette flavoring cinnamaldehyde suppresses mitochondrial function and transiently impairs cilia beat frequency in human bronchial epithelial cells. D110 Epithelial function in health and disease: American Thoracic Society. Am J Respirat Crit Care Med. 197:A7626.
  • Comhair SAA, Gaston BM, Ricci KS, Hammel J, Dweik RA, Teague WG, Meyers D, Ampleford EJ, Bleecker ER, Busse WW, et al. 2011. Detrimental effects of environmental tobacco smoke in relation to asthma severity. PloS One. 6(5):e18574.
  • Couch ET, Chaffee BW, Gansky SA, Walsh MM. 2016. The changing tobacco landscape: what dental professionals need to know. J Am Dent Assoc. 147(7):561–569.
  • Crick F. 1970. Central dogma of molecular biology. Nature. 227(5258):561–563.
  • Cruchley AT, Bergmeier LA. 2018. Structure and functions of the oral mucosa. In: Bergmeier LA, editor. Oral mucosa in health and disease: a concise handbook. Cham: Springer International Publishing. p 1–18.
  • Cruz IB, Snijders PJ, Meijer CJ, Braakhuis BJ, Snow GB, Walboomers JM, van der Waal I. 1998. p53 expression above the basal cell layer in oral mucosa is an early event of malignant transformation and has predictive value for developing oral squamous cell carcinoma. J Pathol. 184(4):360–368.
  • Csősz É, Lábiscsák P, Kalló G, Márkus B, Emri M, Szabó A, Tar I, Tőzsér J, Kiss C, Márton I. 2017. Proteomics investigation of OSCC-specific salivary biomarkers in a Hungarian population highlights the importance of identification of population-tailored biomarkers. Plos One. 12(5):e0177282.
  • Cui X-B, Zhang S-M, Xu Y-X, Dang H-W, Liu C-X, Wang L-H, Yang L, Hu J-M, Liang W-H, Jiang J-F, et al. 2016. PFN2, a novel marker of unfavorable prognosis, is a potential therapeutic target involved in esophageal squamous cell carcinoma. J Transl Med. 14(1):137.
  • Dadgostar A. 2015. Lesions in the posterior oral cavity and oropharynx: variations of normal and when to investigate. Oral Health. 2015.
  • Dallongeville J, Marécaux N, Fruchart JC, Amouyel P. 1998. Cigarette smoking is associated with unhealthy patterns of nutrient intake: a meta-analysis. J Nutr. 128(9):1450–1457.
  • de Geus JL, Wambier LM, Bortoluzzi MC, Loguercio AD, Kossatz S, Reis A. 2018. Does smoking habit increase the micronuclei frequency in the oral mucosa of adults compared to non-smokers? A systematic review and meta-analysis Clin Oral Investig. 22(1):81–91.
  • Debnath KC, Uddin MS, Goswami S, Herrera-Ca O, Kabir MT, Hasan MF, Lucky KN, Khanum S, Abdel-Daim MM. 2017. Impact of tobacco smoking, betel quid chewing and alcohol consumption habits in patients with oral cavity cancer in Bangladesh. J Med Sci. 17(1):46–52.
  • Deshpande A. 2017. Successful use of oral acitretin in oral lichen planus. Indian J Drugs Dermatol. 3(1):24–27.
  • Dhillon VS, Thomas P, Fenech M. 2004. Comparison of DNA damage and repair following radiation challenge in buccal cells and lymphocytes using single-cell gel electrophoresis. Int J Radiat Biol. 80(7):517–528.
  • Donadelli M. 2017. The cancer secretome and secreted biomarkers. Semin Cell Dev Biol. 78:1–2.
  • Dong Y, Wu W. 2018. Downregulation of lncRNA CASC2 promotes the postoperative local recurrence of early oral squamous cell carcinoma. Eur Arch Otorhinolaryngol. 276:605–610.
  • Doorbar J, Egawa N, Griffin H, Kranjec C, Murakami I. 2015. Human papillomavirus molecular biology and disease association. Rev Med Virol. 25(Suppl 1):2–23.
  • Elbehairy AF, Faisal A, Ciavaglia CE, Kwok C, Reid K, Vincent SG, Domnik NJ, Neder JA, O’Donnell DE. 2018. Severe exertional dyspnea in an ex-smoker with a large apical bulla. Ann Am Thorac Soc. 15(10):1221–1228.
  • Erales J, Marchand V, Panthu B, Gillot S, Belin S, Ghayad SE, Garcia M, Laforets F, Marcel V, Baudin-Baillieu A, et al. 2017. Evidence for rRNA 2'-O-methylation plasticity: control of intrinsic translational capabilities of human ribosomes. Proc Natl Acad Sci USA. 114(49):12934–12939.
  • Established list 2012. US Food and Drug Administration. Harmful and Potentially Harmful Constituents in Tobacco Products and Tobacco Smoke. Available from: wwwfdagov/TobaccoProducts/GuidanceComplianceRegulatoryInformation/ucm297786htm (accessed 7th July, 2017).
  • Falsafi P, Nasrabadi ET, Nasrabadi HT, Khiyavi RK, Eslami H. 2016. Comparison of total antioxidant capacity and vitamin C in smokers and non-smokers. Biomed Pharmacol J. 9(1):299–304.
  • Feller L, Altini M, Lemmer J. 2013a. Inflammation in the context of oral cancer. Oral Oncol. 49(9):887–892.
  • Feller L, Chandran R, Khammissa R, Meyerov R, Lemmer J. 2013b. Alcohol and oral squamous cell carcinoma: clinical review. South Afr Dental J. 68(4):176–180.
  • Ferlay J, Colombet M, Soerjomataram I, Mathers C, Parkin DM, Piñeros M, Znaor A, Bray F. 2018. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods. Int J Cancer. 144(8):1941–1953.
  • Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M, Parkin DM, Forman D, Bray F. 2015. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 136(5):E359–E386.
  • Ferlay JE, Lam F, Colombet M, Mery L, Piñeros M, Znaor A, Soerjomataram I, Bray F. 2018. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. Available from: https://gco.iarc.fr/today, accessed [13/02/2019].
  • Field JK, Youngson JH. 2002. The Liverpool Lung Project: a molecular epidemiological study of early lung cancer detection. Eur Respir J. 20(2):464–479.
  • Foy J-P, Bertolus C, Ortiz-Cuaran S, Albaret M-A, Williams WN, Lang W, Destandau S, Souza GD, Sohier E, Kielbassa J, et al. 2018. Immunological and classical subtypes of oral premalignant lesions. Oncoimmunology. 7(12):e1496880.
  • Froogh G, Pinto JT, Le Y, Kandhi S, Aleligne Y, Huang A, Sun D. 2017. Chymase-dependent production of angiotensin II: an old enzyme in old hearts. Am J Physiol Heart Circ Physiol. 312(2):H223–H231.
  • Gao H, Prasad GL, Zacharias W. 2013. Differential cell-specific cytotoxic responses of oral cavity cells to tobacco preparations. Toxicol In Vitro. 27(1):282–291.
  • Gatenby RA, Gillies RJ. 2004. Why do cancers have high aerobic glycolysis? Nat Rev Cancer. 4(11):891.
  • Gatoo MA, Dar AM, Siddiqui M. 2018. Correlation of p53 expression with different histological grades in oral squamous cell carcinoma patients from Northern India. Am J Cancer Sci. 6(1):1–14.
  • Ghosh SK, McCormick TS, Weinberg A. 2019. Human beta defensins and cancer: contradictions and common ground. Front Oncol. 9:341.
  • Gibb EA, Enfield KSS, Stewart GL, Lonergan KM, Chari R, Ng RT, Zhang L, MacAulay CE, Rosin MP, Lam WL. 2011. Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions. Oral Oncol. 47(11):1055–1061.
  • Glick J, Xiong W, Lin Y, Noronha AM, Wilds CJ, Vouros P. 2009. The influence of cytosine methylation on the chemoselectivity of benzo[a]pyrene diol epoxide-oligonucleotide adducts determined using nanoLC/MS/MS. J Mass Spectrom. 44(8):1241–1248.
  • Goerlitz DS, Han D, Tan D, Seillier-Moiseiwitsch F, Chen J, Goldman R, Dumitrescu RG, Orden RA, Spernak SM, Shields PG. 2008. Associations between cigarette smoking and mitochondrial DNA abnormalities in buccal cells. Carcinogenesis. 29(6):1170–1177.
  • Gonçalves PSP, Mendez DAC, Santos P, Damante JH, Rios D, Cruvinel T. 2017. The diagnosis and treatment of multiple factitious oral ulcers in a 6-year-old boy. Case Rep Dentistry. 2017:1986834.
  • Grando SA. 2014. Connections of nicotine to cancer. Nat Rev Cancer. 14(6):419–429.
  • Graves PR, Haystead T. 2002. Molecular biologist's guide to proteomics. Microbiol Mol Biol Rev. 66(1):39–63.
  • Gray H. 1918. Anatomy of the Human Body, 20th edn, Philadelphia: LEA and FEBIGER. Online version, New York (2000) Available from: http://www Bartleby com.
  • Hage FG. 2014. C-reactive protein and hypertension. J Hum Hypertens. 28(7):410.
  • Hagiwara N, Mechanic LE, Trivers GE, Cawley HL, Taga M, Bowman ED, Kumamoto K, He P, Bernard M, Doja S, et al. 2006. Quantitative detection of p53 mutations in plasma DNA from tobacco smokers. Cancer Res. 66(16):8309.
  • Haj Mouhamed D, Ezzaher A, Neffati F, Douki W, Gaha L, Najjar MF. 2016. Effect of cigarette smoking on insulin resistance risk. Ann Cardiol Angeiol (Paris). 65(1):21–25.
  • Hamdoon Z. 2013. The clinical application of optical coherence tomography for head and neck premalignant/malignant lesions. Doctoral thesis. UCL (University College London).
  • Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: the next generation. Cell. 144(5):646–674.
  • Hang B. 2010. Formation and repair of tobacco carcinogen-derived bulky DNA adducts. J Nucleic Acids. 2010:709521.
  • Hanna BE, Hamed JM, Touhala LM. 2008. Serum uric acid in smokers. Oman Med J. 23(4):269–274.
  • Harris CC. 2018. Tobacco smoking, E-cigarettes, and nicotine harm. Proc Natl Acad Sci USA. 115(7):1406–1407.
  • Harty LC, Caporaso NE, Hayes RB, Winn DM, Bravo-Otero E, Blot WJ, Kleinman DV, Brown LM, Armenian HK, Fraumeni JF, Jr, et al. 1997. Alcohol dehydrogenase 3 genotype and risk of oral cavity and pharyngeal cancers. J Natl Cancer Institute. 89(22):1698–1705.
  • Hayashi Y, Mitsudo K, Sakuma K, Iida M, Iwai T, Nakashima H, Okamoto Y, Koizumi T, Oguri S, Hirota M, et al. 2017. Clinical outcomes of retrograde intra-arterial chemotherapy concurrent with radiotherapy for elderly oral squamous cell carcinoma patients aged over 80 years old. Radiat Oncol. 12(1):112.
  • Hecht SS. 2003. Tobacco carcinogens, their biomarkers and tobacco-induced cancer. Nat Rev Cancer. 3(10):733–744.
  • Hecht SS. 2017. Oral cell DNA adducts as potential biomarkers for lung cancer susceptibility in cigarette smokers. Chem Res Toxicol. 30(1):367–375.
  • Heindel JJ, Blumberg B, Cave M, Machtinger R, Mantovani A, Mendez MA, Nadal A, Palanza P, Panzica G, Sargis R, et al. 2017. Metabolism disrupting chemicals and metabolic disorders. Reprod Toxicol. 68:3–33.
  • Hellewell AL, Adams JC. 2016. Insider trading: extracellular matrix proteins and their non-canonical intracellular roles . Bioessays. 38(1):77–88.
  • Hershkovich O, Oliva J, Nagler RM. 2004. Lethal synergistic effect of cigarette smoke and saliva in an in vitro model: does saliva have a role in the development of oral cancer? Eur J Cancer. 40(11):1760–1767.
  • Heyn J, Luchting B, Azad SC. 2018. Smoking associated T-cell imbalance in patients with chronic pain. Nicotine Tobacco Res.
  • Hu W-W, Tang C-H, Sun Y, Lu T-T, Jiang P, Wu Y-M, Wang C-Q, Yang S-F, Su C-M. 2017. Correlation between resistin gene polymorphism and clinical aspects of lung cancer. Medicine. 96(52):e9485.
  • Huang B, Zhang R. 2014. Regulatory non-coding RNAs: revolutionizing the RNA world. Mol Biol Rep. 41(6):3915–3923.
  • Hussain SR, Naqvi H, Gupta S, Mahdi AA, Kumari P, Waseem M, Ahmad MK. 2015. A study on oncogenic role of leptin and leptin receptor in oral squamous cell. Tumour Biol. 36(8):6515–6523.
  • IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. 2012. A review of human carcinogens. Part E: personal habits and indoor combustions. IARC Monogr Eval Carcinog Risks Hum. 100:43–214.
  • Igwo-Ezikpe M. 2016. Urinary 1-hydroxypyrene concentration and toxicity biomarkers in active and passive male smokers from Lagos Metropolis, Nigeria. UNILAG J Med Sci Technol. 4(1):18.
  • Irimie A, Braicu C, Cojocneanu R, Magdo L, Onaciu A, Ciocan C, Mehterov N, Dudea D, Buduru S, Berindan-Neagoe I. 2018. Differential effect of smoking on gene expression in head and neck cancer patients. Int J Environ Res Public Health. 15(7):1558.
  • Iwasaki YW, Siomi MC, Siomi H. 2015. PIWI-interacting RNA: its biogenesis and functions. Annu Rev Biochem. 84(1):405–433.
  • Jahanshahi G, Shirani S. 2015. Detection of Candida albicans in oral squamous cell carcinoma by fluorescence staining technique. Dent Res J (Isfahan). 12(2):115–120.
  • Jessen WJ, Borgerding MF, Prasad GL. 2018. Global methylation profiles in buccal cells of long-term smokers and moist snuff consumers. Biomarkers. 23(7):625–639.
  • Jessie K, Pang WW, Haji Z, Rahim A, Hashim OH. 2010. Proteomic analysis of whole human saliva detects enhanced expression of interleukin-1 receptor antagonist, thioredoxin and lipocalin-1 in cigarette smokers compared to non-smokers. Int J Mol Sci. 11(11):4488–4505.
  • Ji EH, Sun B, Zhao T, Shu S, Chang CH, Messadi D, Xia T, Zhu Y, Hu S. 2016. Characterization of electronic cigarette aerosol and its induction of oxidative stress response in oral keratinocytes. Plos One. 11(5):e0154447.
  • Jin PS, Dong KK, Seung ‐S, Il Jeong HY, Young KG, Ah KH. 2014. Association of oral health behaviors and status with depression: results from the Korean National Health and Nutrition Examination Survey, 2010. J Public Health Dent. 74(2):127–138.
  • Jo D-W, Kim Y-K, Yun P-Y. 2016. The influence of p53 mutation status on the anti-cancer effect of cisplatin in oral squamous cell carcinoma cell lines. J Korean Assoc Oral Maxillofac Surg. 42(6):337–344.
  • Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T, Elks CE, Aslibekyan S, et al. 2016. Epigenetic signatures of cigarette smoking. Circ Cardiovasc Genet. 9(5):436–447.
  • Johnson NW, Gupta B, Ariyawardana A, Amarasinghe H. 2017. Epidemiology and Site-specific risk factors for oral cancer. In: Kuriakose M, (editor). Contemporary Oral Oncology. Cham: Springer. p 103–153.
  • Kampman E, Thompson R, Wiseman M, Mitrou G, Allen K. 2018. PO-087 The wcrf/aicr third expert report on diet, nutrition, physical activity and cancer: updated recommendations. ESMO Open. 3 p. A260.
  • Kanojia D, Vaidya MM. 2006. 4-nitroquinoline-1-oxide induced experimental oral carcinogenesis. Oral Oncol. 42(7):655–667.
  • Kesarwala AH, Krishna MC, Mitchell JB. 2016. Oxidative stress in oral diseases. Oral Dis. 22(1):9–18.
  • Khan S, Shreedhar B, Kamboj M. 2016. Ultrastructural analysis of oral exfoliated epithelial cells of tobacco smokers and betel nut chewers: a scanning electron microscopy study. Dent Res J (Isfahan). 13(6):521–526.
  • Khan Y, Lalchandani A, Gupta AC, Khadanga S, Kumar S. 2018. Prevalence of metabolic syndrome crossing 40% in Northern India: time to act fast before it runs out of proportions. J Family Med Prim Care. 7(1):118.
  • Khowal S, Jain SK, Wajid S. 2018. A potential association between mutations in the iNOS cDNA 3′ stretch and oral squamous cell carcinoma - A preliminary study. Meta Gene. 16:189–195.
  • Khowal S, Naqvi SH, Monga S, Jain SK, Wajid S. 2018. Assessment of cellular and serum proteome from tongue squamous cell carcinoma patient lacking addictive proclivities for tobacco, betel nut, and alcohol: case study. J Cell Biochem. 119(7):5186–5221.
  • Khowal S, Jain SK, Wajid S. 2019. Prevalence of human papillomavirus Type 16 in persistent oral lesions arising in patients with tobacco, areca nut, and alcohol habits. Oral Sci Int. doi:10.1002/osi2.1022
  • Kim MM, Clinger JD, Masayesva BG, Ha PK, Zahurak ML, Westra WH, Califano JA. 2004. Mitochondrial DNA quantity increases with histopathologic grade in premalignant and malignant head and neck lesions. Clin Cancer Res. 10(24):8512.
  • Kim MS, Huang Y, Lee J, Zhong X, Jiang W-W, Ratovitski EA, Sidransky D. 2010. Cellular transformation by cigarette smoke extract involves alteration of glycolysis and mitochondrial function in esophageal epithelial cells. Int J Cancer. 127(2):269–281.
  • Kim SM. 2016. Human papilloma virus in oral cancer. J Korean Assoc Oral Maxillofac Surg. 42(6):327–336.
  • Kirimura K, Takai S, Jin D, Muramatsu M, Kishi K, Yoshikawa K, Nakabayashi M, Mino Y, Miyazaki M. 2005. Role of chymase-dependent angiotensin II formation in regulating blood pressure in spontaneously hypertensive rats. Hypertens Res. 28(5):457–464.
  • Ko HR, Chang YS, Park WS, Ahn J-Y. 2016. Opposing roles of the two isoforms of ErbB3 binding protein 1 in human cancer cells. Int J Cancer. 139(6):1202–1208.
  • Krishna Rao SV, Mejia G, Roberts-Thomson K, Logan R. 2013. Epidemiology of oral cancer in Asia in the past decade-an update (2000-2012)). Asian Pac J Cancer Prev. 14(10):5567–5577.
  • Krishnan AR, Korrapati A, Zou AE, Qu Y, Wang XQ, Califano JA, Wang-Rodriguez J, Lippman SM, Hovell MF, Ongkeko WM. 2017. Smoking status regulates a novel panel of PIWI-interacting RNAs in head and neck squamous cell carcinoma. Oral Oncology. 65:68–75.
  • Krishnan AR, Qu Y, Li PX, Zou AE, Califano JA, Wang-Rodriguez J, Ongkeko WM. 2017b. Computational methods reveal novel functionalities of PIWI-interacting RNAs in human papillomavirus-induced head and neck squamous cell carcinoma. Oncotarget. 9(4):4614–4624.
  • Krishnan R, Thayalan DK, Padmanaban R, Ramadas R, Annasamy RK, Anandan N. 2014. Association of serum and salivary tumor necrosis factor-α with histological grading in oral cancer and its role in differentiating premalignant and malignant oral disease . Asian Pac J Cancer Prev. 15(17):7141–7148.
  • Kubota K, Moriyama M, Furukawa S, Rafiul HASM, Maruse Y, Jinno T, Tanaka A, Ohta M, Ishiguro N, Yamauchi M, et al. 2017. CD163+ CD204+ tumor-associated macrophages contribute to T cell regulation via interleukin-10 and PD-L1 production in oral squamous cell carcinoma. Sci Rep. 7(1):1755.
  • Kumar J, Teoh SL, Das S, Mahakknaukrauh P. 2017. Oxidative stress in oral diseases: understanding its relation with other systemic diseases. Front Physiol. 8:693–693.
  • Kumar M, Nanavati R, Modi T, Dobariya C. 2016. Oral cancer: etiology and risk factors: a review. J Cancer Res Ther. 12(2):458–463.
  • Kumar PS, Matthews CR, Joshi V, de Jager M, Aspiras M. 2011. Tobacco smoking affects bacterial acquisition and colonization in oral biofilms. Infect Immun. 79(11):4730–4738.
  • Kundu JK, Surh Y-J. 2008. Inflammation: gearing the journey to cancer. Mutat Res. 659(1-2):15–30.
  • Lachenmeier DW, Przybylski MC, Rehm J. 2012. Comparative risk assessment of carcinogens in alcoholic beverages using the margin of exposure approach. Int J Cancer. 131(6):E995–E1003.
  • Larramendy ML, Knuutila S. 1991. Increased frequency of micronuclei in B and T8 lymphocytes from smokers. Mutat Res. 259(2):189–195.
  • Lasisi TJ, Oluwasola AO, Lasisi OA, Akang EE. 2013. Association between langerhans cells population and histological grade of oral squamous cell carcinoma. J Oral Maxillofac Pathol. 17(3):329.
  • Lee CH, Chang JS, Syu SH, Wong TS, Chan JY, Tang YC, Yang ZP, Yang WC, Chen CT, Lu SC, et al. 2015. IL-1β promotes malignant transformation and tumor aggressiveness in oral cancer. J Cell Physiol. 230(4):875–884.
  • Leon ME, Peruga A, McNeill A, Kralikova E, Guha N, Minozzi S, Espina C, Schuz J. 2015. European code against cancer, 4th Edition: tobacco and cancer. Cancer Epidemiol. 39 Suppl 1:S20–S33.
  • Li MD. 2018. DNA methylation analysis reveals a strong connection between tobacco smoking and cancer pathogenesis. Tobacco smoking addiction: epidemiology, genetics, mechanisms, and treatment. Singapore: Springer Singapore. p 303–317.
  • Li Y, Elashoff D, Oh M, Sinha U, St John MAR, Zhou X, Abemayor E, Wong DT. 2006. Serum circulating human mRNA profiling and its utility for oral cancer detection. J Clin Oncol. 24(11):1754–1760.
  • Li Y, Zhang J. 2015. Expression of mutant p53 in oral squamous cell carcinoma is correlated with the effectiveness of intra-arterial chemotherapy. Oncol Lett. 10(5):2883–2887.
  • Lin Y, Elowitz MB. 2016. Central dogma goes digital. Mol Cell. 61(6):791–792.
  • Lisanti MP, Martinez-Outschoorn UE, Lin Z, Pavlides S, Whitaker-Menezes D, Pestell RG, Howell A, Sotgia F. 2011. Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs “ "fertilizer". Cell Cycle. 10(15):2440–2449.
  • Liu C-J, Chang W-J, Chen C-Y, Sun F-J, Cheng H-W, Chen T-Y, Lin S-C, Li W-C. 2015. Dynamic cellular and molecular modulations of diabetes mediated head and neck carcinogenesis. Oncotarget. 6(30):29268–29284.
  • Liu J, Wu Y, Wang Q, Liu X, Liao X, Pan J. 2018. Bioinformatic analysis of PFN2 dysregulation and its prognostic value in head and neck squamous carcinoma. Future Oncol. 14(5):449–459.
  • Liu W, Zeng L, Li N, Wang F, Jiang C, Guo F, Chen X, Su T, Xu C, Zhang S, et al. 2016. Quantitative proteomic analysis for novel biomarkers of buccal squamous cell carcinoma arising in background of oral submucous fibrosis. BMC Cancer. 16(1):584.
  • Loaiza N, Demaria M. 2016. Cellular senescence and tumor promotion: is aging the key? Biochim Biophys Acta. 1865(2):155–167.
  • Lu L-M, Zavitz CCJ, Chen B, Kianpour S, Wan Y, Stämpfli MR. 2007. Cigarette smoke impairs NK cell-dependent tumor immune surveillance. J Immunol. 178(2):936.
  • Lu T, Liu H, You G. 2018. Long non-coding RNA C5orf66-AS1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis. Int J Mol Med. 42(6):3291–3299.
  • Ma H-L, Yu C, Liu Y, Tan Y-R, Qiao J-K, Yang X, Wang L-Z, Li J, Chen Q, Chen F-X, et al. 2015. Decreased expression of glutathione S-transferase pi correlates with poorly differentiated grade in patients with oral squamous cell carcinoma. J Oral Pathol Med. 44(3):193–200.
  • Ma Y, Hu X, Shang C, Zhong M, Guo Y. 2017. Silencing of long non-coding RNA CCAT2 depressed malignancy of oral squamous cell carcinoma via Wnt/β-catenin pathway. Tumour Biol. 39(7):1010428317717670.
  • Macari F, El-Houfi Y, Boldina G, Xu H, Khoury-Hanna S, Ollier J, Yazdani L, Zheng G, Bieche I, Legrand N, et al. 2016. TRM6/61 connects PKCα with translational control through tRNAi(Met) stabilization: impact on tumorigenesis. Oncogene. 35(14):1785–1796.
  • Madankumar A, Tamilarasi S, Premkumar T, Gopikrishnan M, Nagabhishek N, Devaki T. 2017. Geraniol attenuates 4NQO-induced tongue carcinogenesis through downregulating the activation of NF-κB in rats. Mol Cell Biochem. 434(1-2):7–15.
  • Malvezzi S, Farnung L, Aloisi CMN, Angelov T, Cramer P, Sturla SJ. 2017. Mechanism of RNA polymerase II stalling by DNA alkylation. Proc Natl Acad Sci USA. 114(46):12172.
  • Matsushima-Otsuka S, Fujiwara-Tani R, Sasaki T, Ohmori H, Nakashima C, Kishi S, Nishiguchi Y, Fujii K, Luo Y, Kuniyasu H. 2018. Significance of intranuclear angiotensin-II type 2 receptor in oral squamous cell carcinoma. Oncotarget. 9(93):36561.
  • Matthews JB, Chen FM, Milward MR, Wright HJ, Carter K, McDonagh A, Chapple IL. 2011. Effect of nicotine, cotinine and cigarette smoke extract on the neutrophil respiratory burst. J Clin Periodontol. 38(3):208–218.
  • Maza M, Schocken CM, Bergman KL, Randall TC, Cremer ML. 2017. Cervical precancer treatment in low- and middle-income countries: a technology overview. J Glob Oncol. 3(4):400–408.
  • McCullough MJ, Farah CS. 2008. The role of alcohol in oral carcinogenesis with particular reference to alcohol-containing mouthwashes. Aust Dent J. 53(4):302–305.
  • Melo SLS, Li Z, Kamburoğlu K, Scarfe WC. 2018. The upper airway. In: Scarfe WC, Angelopoulos C, editors. Maxillofacial cone beam computed tomography: principles, techniques and clinical applications. Cham: Springer International Publishing. p 399–413.
  • Mendes SF, Ramos GO, Rivero ERC, Modolo F, Grando LJ, Meurer MI. 2011. Techniques for precancerous lesion diagnosis. J Oncology. 2011:326094.
  • Miki K, Orita Y, Gion Y, Takao S, Ohno K, Takeuchi M, Ito T, Minoura A, Tachibana T, Marunaka H, et al. 2017. Tumor-associated macrophages in the development of 4-nitroquinoline-1-oxide-induced tongue squamous cell carcinoma in a mouse model. Oncology. 93 (3):204.
  • Mishra R, Palve V, Kannan S, Pawar S, Teni T. 2015. High expression of survivin and its splice variants survivin ΔEx3 and survivin 2 B in oral cancers. Oral Surg Oral Med Oral Pathol Oral Radiol. 120(4):497–507.
  • Mohd Bakri M, Mohd Hussaini H, Rachel Holmes A, David Cannon R, Mary Rich A. 2010. Revisiting the association between candidal infection and carcinoma, particularly oral squamous cell carcinoma. J Oral Microbiol. 2 (1):5780.
  • National Cancer Institute. 2018. Oral cavity. National Cancer Institute Dictionary of Cancer Terms (NIH; United States). Available from: https://www.cancer.gov/publications/dictionaries/cancer-terms/def/oral-cavity.
  • Na H-K, Kim M, Chang S-S, Kim S-Y, Park JY, Chung MW, Yang M. 2015. Tobacco smoking-response genes in blood and buccal cells. Toxicol Lett. 232(2):429–437.
  • Nagamatsu T, Sakoda A, Kataoka T, Ono T, Yamaoka K. 2011. An assessment of radioactivity levels of 210Pb and 40K in tobacco and radiation exposure from smoking. Acta Med Okayama. 65(2):91–95.
  • Nakamoto T, Wagner M, Melvin JE, Bogdanffy MS. 2005. Vinyl acetate induces intracellular acidification in mouse oral buccal epithelial cells. Toxicol Lett. 158(2):116–121.
  • Nieh S. 2017. Abstract 4333: The role of cancer-associated fibroblast-induced chemokine ligand 11 in tumor microenvironment contributes to the progression of oral cancer. Cancer Res. 77:4333.
  • Niklander S, Crane H, Lambert D, Hunter K. 2017. Interleukin 1 receptor antagonist (IL-1RA) expression is progressively lost in oral dysplasia and oral squamous cell carcinoma but the phenotypic consequences are not clear. 24-28 OVAL RD, London, England: Academic Press Ltd-Elsevier Science Ltd. p 185.
  • Niranjan VR, Ranpise SG. 2017. Evaluating the epidemiology and needs of oral cancer patients from Aurangabad district, Maharashtra, India. Int J Res Med Sci. 5 (7):2905.
  • Nunes NA. 2018. The influence of the electronic cigarette on the buccal mucosa. EC Dental Sci. 17:1113–1122.
  • Nwanaji-Enwerem JC, Cardenas A, Chai PR, Weisskopf MG, Baccarelli AA, Boyer EW. 2018. Relationships of long-term smoking and moist snuff consumption with a DNA methylation age relevant smoking index: an analysis in buccal cells. Nicotine Tobacco Res.
  • Ogden G. 2018. Alcohol and mouth cancer. Br Dent J. 225(9):880.
  • Ozata DM, Gainetdinov I, Zoch A, O'Carroll D, Zamore PD. 2019. PIWI-interacting RNAs: small RNAs with big functions. Nat Rev Genet. 20(2):89–108.
  • Paiva RL, Sant'Ana Filho M, Bohrer PL, Lauxen Ida S, Rados PV. 2004. AgNOR quantification in cells of normal oral mucosa exposed to smoking and alcohol. A cytopathologic study. Anal Quant Cytol Histol. 26(3):175–180.
  • Palanichamy JK, Tran TM, Howard JM, Contreras JR, Fernando TR, Sterne-Weiler T, Katzman S, Toloue M, Yan W, Basso G, et al. 2016. RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation. J Clin Invest. 126(4):1495–1511.
  • Papastefanou C. 2009. Radioactivity of tobacco leaves and radiation dose induced from smoking. Int J Environ Res Public Health. 6(2):558–567.
  • Patil P, Savalagi A. 2015. Psychosomatic disorders of the oral cavity - A review. Am J Oral Med Radiol. 2(2):96–102.
  • Patil S, Subbannayya T, Mohan SV, Babu N, Advani J, Sathe G, Rajagopalan P, Patel K, Bhandi S, Solanki H, et al. 2019. Proteomic changes in oral keratinocytes chronically exposed to shisha (Water Pipe). Omics. 23(2):86–97.
  • Pellicioli ACA, Bingle L, Farthing P, Lopes MA, Martins MD, Vargas PA. 2017. Immunosurveillance profile of oral squamous cell carcinoma and oral epithelial dysplasia through dendritic and T cells analysis. J Oral Pathol Med. 46(10):928–933.
  • Peng X, Li W, Johnson WD, Torres KEO, McCormick DL. 2015. Overexpression of lipocalins and pro-inflammatory chemokines and altered methylation of PTGS2 and APC2 in oral squamous cell carcinomas induced in rats by 4-nitroquinoline-1-oxide. PloS One. 10(1):e0116285.
  • Perera M, Al-Hebshi NN, Speicher DJ, Perera I, Johnson NW. 2016. Emerging role of bacteria in oral carcinogenesis: a review with special reference to perio-pathogenic bacteria. J Oral Microbiol. 8(1):32762.
  • Peters ES, McClean MD, Liu M, Eisen EA, Mueller N, Kelsey KT. 2005. The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use. Cancer Epidemiol Biomarkers Prev. 14(2):476–482.
  • Petruzzi M, Cherubini K, Salum FG, de Figueiredo M. 2017. Role of tumour-associated macrophages in oral squamous cells carcinoma progression: an update on current knowledge. Diagn Pathol. 12(1):32.
  • Pfeifer GP, Denissenko MF, Olivier M, Tretyakova N, Hecht SS, Hainaut P. 2002. Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers. Oncogene. 21(48):7435.
  • Phillips DH, Venitt S. 2012. DNA and protein adducts in human tissues resulting from exposure to tobacco smoke. Int J Cancer. 131(12):2733–2753.
  • Pineda JMB, Bradley RK. 2018. Most human introns are recognized via multiple and tissue-specific branchpoints. Genes Dev. 32(7-8):577–591.
  • Puttipanyalears C, Subbalekha K, Mutirangura A, Kitkumthorn N. 2013. Alu hypomethylation in smoke-exposed epithelia and oral squamous carcinoma. Asian Pac J Cancer Prev. 14(9):5495–5501.
  • Qian Y, Wang X, Gao Y, Duan N, Huang X, Sun F, Han X, Wang W. 2015. Cigarette smoke modulates NOD1 signal pathway and human ß defensins expression in human oral mucosa. Cell Physiol Biochem. 36(2):457–473.
  • Qiu F, Liang C-L, Liu H, Zeng Y-Q, Hou S, Huang S, Lai X, Dai Z. 2017. Impacts of cigarette smoking on immune responsiveness: up and down or upside down? Oncotarget. 8(1):268–284.
  • Radoi L, Paget-Bailly S, Cyr D, Papadopoulos A, Guida F, Schmaus A, Cenee S, Menvielle G, Carton M, Lapotre-Ledoux B, et al. 2013. Tobacco smoking, alcohol drinking and risk of oral cavity cancer by subsite: results of a French population-based case-control study, the ICARE study. Eur J Cancer Prev. 22(3):268–276.
  • Rajagopalan P, Nanjappa V, Patel K, Jain AP, Mangalaparthi KK, Patil AH, Nair B, Mathur PP, Keshava Prasad TS, Califano JA, et al. 2018. Role of protein kinase N2 (PKN2) in cigarette smoke-mediated oncogenic transformation of oral cells. J Cell Commun Signal. 12(4):709–721.
  • Rajagopalan P, Patel K, Jain AP, Nanjappa V, Datta KK, Subbannayya T, Mangalaparthi KK, Kumari A, Manoharan M, Coral K, et al. 2018b. Molecular alterations associated with chronic exposure to cigarette smoke and chewing tobacco in normal oral keratinocytes. Cancer Biol Ther. 19(9):773–785.
  • Ralhan R, DeSouza LV, Matta A, Chandra Tripathi S, Ghanny S, DattaGupta S, Thakar A, Chauhan SS, Siu K. 2009. iTRAQ-multidimensional liquid chromatography and tandem mass spectrometry-based identification of potential biomarkers of oral epithelial dysplasia and novel networks between inflammation and premalignancy. J Proteome Res. 8(1):300–309.
  • Ramos DM, Chen B, Regezi J, Zardi L, Pytela R. 1998. Tenascin-C matrix assembly in oral squamous cell carcinoma. Int J Cancer. 75(5):680–687.
  • Ramya AS, Uppala D, Majumdar S, Surekha C, Deepak K. 2015. Are salivary amylase and pH – Prognostic indicators of cancers? J Oral Biol Craniofacial Res. 5(2):81–85.
  • Rayburn ER, Ezell SJ, Zhang R. 2009. Anti-inflammatory agents for cancer therapy. Mol Cell Pharmacol. 1(1):29.
  • Rengaswamy Sankaranarayanan KR, Amarasinghe H, Subramanian S, Johnson N. 2015. Chapter 5. Oral cancer: prevention, early detection, and treatment. In: Gelband H, Jha P, Sankaranarayanan R, Horton S, editors. Cancer: disease control priorities, Third Edition (Volume 3). Washington (DC): The International Bank for Reconstruction and Development/The World Bank (c) 2015 International Bank for Reconstruction and Development/The World Bank.
  • Ribeiro IP, Barroso L, Marques F, Melo JB, Carreira IM. 2016. Early detection and personalized treatment in oral cancer: the impact of omics approaches. Mol Cytogenet. 9:85.
  • Ryan BM, Faupel-Badger JM. 2016. The hallmarks of premalignant conditions: a molecular basis for cancer prevention. Semin Oncol. 43(1):22–35.
  • Sabharwal R, Verma P, Syed MA, Sharma T, Subudhi SK, Mohanty S, Gupta S. 2015. Emergence of micronuclei as a genomic biomarker. Indian J Med Paediatr Oncol. 36(4):212–218.
  • Salaspuro V, Salaspuro M. 2004. Synergistic effect of alcohol drinking and smoking on in vivo acetaldehyde concentration in saliva. Int J Cancer. 111(4):480–483.
  • Salem LM. 2016. Multidisciplinary treatment craniofacial anomalies and its effects on children's oral cavity, psychology, and speech. Boston University Theses & Dissertations Boston University, School of Medicine.
  • Salzberg SL. 2018. Open questions: how many genes do we have? BMC Biol. 16(1):94.
  • Samburova V, Bhattarai C, Strickland M, Darrow L, Angermann J, Son Y, Khlystov A. 2018. Aldehydes in exhaled breath during E-cigarette vaping: pilot study results. Toxics. 6(3):46.
  • San-Cristobal R, Navas-Carretero S, Milagro FI, Riezu-Boj JI, Guruceaga E, Celis-Morales C, Livingstone KM, Brennan L, Lovegrove JA, Daniel H, et al. 2016. Gene methylation parallelisms between peripheral blood cells and oral mucosa samples in relation to overweight. J Physiol Biochem. 73(3):465–474.
  • Sanner T, Grimsrud TK. 2015. Nicotine: carcinogenicity and effects on response to cancer treatment–a review. Front Oncol. 5:196.
  • Sari MI, Sari N, Darlan DM, Prasetya RJ. 2018. Cigarette smoking and hyperglycaemia in diabetic patients. Open Access Maced J Med Sci. 6(4):634–637.
  • Sarmiento Varon L, De Rosa J, Machicote A, Billordo LA, Baz P, Fernández PM, Kaimen Maciel I, Blanco A, Arana EI. 2017. Characterization of tonsillar IL10 secreting B cells and their role in the pathophysiology of tonsillar hypertrophy. Sci Rep. 7(1):11077.
  • Sathiyasekar AC, Chandrasekar P, Pakash A, Kumar KUG, Jaishlal MS. 2016. Overview of immunology of oral squamous cell carcinoma. J Pharm Bioallied Sci. 8(Suppl 1):S8–S12.
  • Savidou A, Kehagia K, Eleftheriadis K. 2006. Concentration levels of 210Pb and 210Po in dry tobacco leaves in Greece. J Environ Radioact. 85(1):94–102.
  • Scheidt JHG, Yurgel LS, Cherubini K, Figueiredo M, Salum FG. 2012. Characteristics of oral squamous cell carcinoma in users or non users of tobacco and alcohol. Rev Odonto Ciênc. 27(1):69–73.
  • Schierl M, Patel D, Ding W, Kochhar A, Adhami K, Zhou XK, Dannenberg AJ, Granstein RD. 2014. Tobacco smoke-induced immunologic changes may contribute to oral carcinogenesis. J Investig Med. 62(2):316–323.
  • Seifi S, Feizi F, Mehdizadeh M, Khafri S, Ahmadi B. 2014. Evaluation of cytological alterations of oral mucosa in smokers and waterpipe users. Cell Journal (Yakhteh). 15(4):302.
  • Shah G, Chaturvedi P, Vaishampayan S. 2012. Arecanut as an emerging etiology of oral cancers in India. Indian J Med Paediatr Oncol. 33(2):71.
  • Shah SN, Manjunatha BS, Shah VS, Dagrus K, Soni N, Shah S. 2015. Quantitative evaluation of micronuclei in oral squamous cell carcinoma and oral submucous fibrosis patients: a comparative study. Recent Pat Anticancer Drug Discov. 10(2):233–238.
  • Shakhatreh MAK, Khabour OF, Alzoubi KH, Masadeh MM, Hussein EI, Bshara GN. 2018. Alterations in oral microbial flora induced by waterpipe tobacco smoking. Int J Gen Med. 11:47–54.
  • Shao T, Huang J, Zheng Z, Wu Q, Liu T, Lv X. 2018. SCCA, TSGF, and the long non-coding RNA AC007271.3 are effective biomarkers for diagnosing oral squamous cell carcinoma. Cell Physiol Biochem. 47(1):26–38.
  • Sharma V, Salwan R, Sharma PN, Gulati A. 2017. Integrated translatome and proteome: approach for accurate portraying of widespread multifunctional aspects of Trichoderma. Front Microbiol. 8:1602.
  • Shi K, Li N, Yang M, Li W. 2019. Identification of key genes and pathways in female lung cancer patients who never smoked by a bioinformatics analysis. J Cancer. 10(1):51
  • Shield KD, Ferlay J, Jemal A, Sankaranarayanan R, Chaturvedi AK, Bray F, Soerjomataram I. 2017. The global incidence of lip, oral cavity, and pharyngeal cancers by subsite in 2012. CA Cancer J Clin. 67(1):51–64.
  • Shubhra C, Sapna K, Saima W. 2014. In-Silico Scrutiny and Molecular Docking Analysis for Beta Secretase-1 and Presenilin-1. Int J Pharma Biosci. 5(4):274–292.
  • Shwetha S, Reddy V, Sudhir KM, Kumar RK, Srinivasulu G. 2018. Influence of tobacco chewing and smoking on the salivary total antioxidant power - A clinical comparative study. J Clin Diagn Res. 12(6):ZC09–ZC12.
  • Siegel RL, Jacobs EJ, Newton CC, Feskanich D, Freedman ND, Prentice RL, Jemal A. 2015. Deaths due to cigarette smoking for 12 smoking-related cancers in the United States cigarette smoking deaths for smoking-related cancersletters. JAMA Intern Med. 175(9):1574–1576.
  • Solanki HS, Babu N, Jain AP, Bhat MY, Puttamallesh VN, Advani J, Raja R, Mangalaparthi KK, Kumar MM, Prasad TSK, et al. 2018. Cigarette smoke induces mitochondrial metabolic reprogramming in lung cells. Mitochondrion. 40:58–70.
  • Souto GR, Matias MDP, Nunes LFM, Ferreira RC, Mesquita RA. 2018. Mature dendritic cell density is affected by smoking habit, lesion size, and epithelial dysplasia in oral leukoplakia samples. Arch Oral Biol. 95:51–57.
  • Speight PM, Khurram SA, Kujan O. 2017. Oral potentially malignant disorders: risk of progression to malignancy. Oral Surg Oral Med Oral Pathol Oral Radiol. 125:612–627.
  • Squier CA, Kremer MJ. 2001. Biology of oral mucosa and esophagus. JNCI Monographs. 2001(29):7–15.
  • Stohs SJ, Bagchi D, Bagchi M. 1997. Toxicity of trace elements in tobacco smoke. Inhalation Toxicology. 9(9):867–890.
  • Stornetta A, Guidolin V, Balbo S. 2018. Alcohol-derived acetaldehyde exposure in the oral cavity. Cancers. 10(1):20.
  • Su D, Wang X, Campbell MR, Porter DK, Pittman GS, Bennett BD, Wan M, Englert NA, Crowl CL, Gimple RN, et al. 2016. Distinct epigenetic effects of tobacco smoking in whole blood and among leukocyte subtypes. PloS One. 11(12):e0166486.
  • Su Y, Wu H, Pavlosky A, Zou L-L, Deng X, Zhang Z-X, Jevnikar AM. 2016. Regulatory non-coding RNA: new instruments in the orchestration of cell death. Cell Death Dis . 7(8):e2333.
  • Subramanian S, Hoover S, Edwards P. 2016. Barriers to screening, diagnosis, and treatment of oral cancers in India. In: LaBresh KA, editor. Improving outcomes for noncommunicable diseases in low- and middle-income countries. Research Triangle Park, NC: RTI Press. p. 1–10.
  • Subramanian S, Krishnakumar K. 2017. Economics of preventing, screening, and treating oral cancers. In: Kuriakose M, editor. Contemporary Oral Oncology. Cham: Springer. p 283–297.
  • Sumita Y, Yamazaki M, Maruyama S, Abe T, Cheng J, Takagi R, Tanuma JI. 2018. Cytoplasmic expression of SOX9 as a poor prognostic factor for oral squamous cell carcinoma. Oncol Rep. 40(5):2487–2496.
  • Surget S, Khoury MP, Bourdon J-C. 2014. Uncovering the role of p53 splice variants in human malignancy: a clinical perspective. OncoTarget Ther. 7:57.
  • Szalavitz M. 2015. Genetics: no more addictive personality. Nature. 522(7557):S48.
  • Teschendorff AE, Yang Z, Wong A, Pipinikas CP, Jiao Y, Jones A, Anjum S, Hardy R, Salvesen HB, Thirlwell C, et al. 2015. Correlation of smoking-associated DNA methylation changes in buccal cells with DNA methylation changes in epithelial cancer. JAMA Oncol. 1(4):476–485.
  • Thomson P. 2015. Managing oral potentially malignant disorders: a question of risk. FDJ. 6(4):186–191.
  • Thongsroy J, Patchsung M, Mutirangura A. 2017. The association between Alu hypomethylation and severity of type 2 diabetes mellitus. Clin Epigenet. 9(1):93.
  • Tinti F, Soory M. 2013. Oxidative actions of hydrogen peroxide in human gingival and oral periosteal fibroblasts: responses to glutathione and nicotine, relevant to healing in a redox environment. Redox Biol. 2:36–43.
  • Tjalsma H, Bolhuis A, Jongbloed JD, Bron S, van Dijl JM. 2000. Signal peptide-dependent protein transport in Bacillus subtilis: a genome-based survey of the secretome. Microbiol Mol Biol Rev. 64(3):515–547.
  • Tommasi S, Caliri AW, Caceres A, Moreno DE, Li M, Chen Y, Siegmund KD, Besaratinia A. 2019. Deregulation of biologically significant genes and associated molecular pathways in the oral epithelium of electronic cigarette users. Int J Mol Sci. 20(3):738.
  • Tonstad S, Cowan JL. 2009. C-reactive protein as a predictor of disease in smokers and former smokers: a review. Int J Clin Pract. 63(11):1634–1641.
  • Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. 2015. Global cancer statistics, 2012. CA Cancer J Clin. 65(2):87–108.
  • Tremblay S, Pintor dos Reis P, Bradley G, Galloni NN, Perez-Ordonez B, Freeman J, Brown D, Gilbert R, Gullane P, Irish J, Kamel-Reid S. 2006. Young patients with oral squamous cell carcinoma: study of the involvement of GSTP1 and deregulation of the Fanconi anemia genes. Arch Otolaryngol Head Neck Surg. 132(9):958–966.
  • Troiano G, Mastrangelo F, Caponio VCA, Laino L, Cirillo N, Lo Muzio L. 2018. Predictive prognostic value of tissue-based MicroRNA expression in oral squamous cell carcinoma: a systematic review and meta-analysis. J Dent Res. 97(7):759–766.
  • Tuna M, Amos CI, Mills GB. 2019. Genome-wide analysis of head and neck squamous cell carcinomas reveals HPV, TP53, smoking and alcohol-related allele-based acquired uniparental disomy genomic alterations. Neoplasia. 21(2):197–205.
  • Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, et al. 2015. Proteomics. Tissue-based map of the human proteome. Science. 347(6220):1260419.
  • Upadhyay J, Rao N, Upadhyay R. 2012. A comparative analysis of langerhans cell in oral epithelial dysplasia and oral squamous cell carcinoma using antibody CD-1a. J Cancer Res Ther. 8(4):591–597.
  • Upadhyay RB, Upadhyay J, Rao NN, Agrawal P. 2011. The role of Langerhans cells in oral squamous cell carcinoma. Chin -Ger J Clin Oncol. 10(10):606.
  • Uppaluri R, Winkler AE, Lin T, Law JH, Haughey BH, Nussenbaum B, Paniello RC, Rich JT, Diaz JA, Michel LP, et al. 2017. Biomarker and tumor responses of oral cavity squamous cell carcinoma to trametinib: a phase II neoadjuvant window-of-opportunity clinical trial. Clin Cancer Res. 23(9):2186–2194.
  • Vairaktaris E, Spyridonidou S, Goutzanis L, Vylliotis A, Lazaris A, Donta I, Perrea D, Yapijakis C, Patsouris E. 2007. Diabetes and oral oncogenesis. Anticancer Res. 27(6B):4185–4193.
  • van Loon LA, Krieg SR, Davidson CL, Bos JD. 1989. Quantification and distribution of lymphocyte subsets and Langerhans cells in normal human oral mucosa and skin. J Oral Pathol Med. 18(4):197–201.
  • VanderVeen LA, Harris TM, Jen-Jacobson L, Marnett LJ. 2008. Formation of DNA-protein cross-links between gamma-hydroxypropanodeoxyguanosine and EcoRI. Chem Res Toxicol. 21(9):1733–1738.
  • Vassallo R, Tamada K, Lau JS, Kroening PR, Chen L. 2005. Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming. J Immunol. 175(4):2684.
  • Wang T, Han S-X, Zhang S-F, Ning Y-Y, Chen L, Chen Y-J, He G-M, Xu D, An J, Yang T, et al. 2010. Role of chymase in cigarette smoke-induced pulmonary artery remodeling and pulmonary hypertension in hamsters. Respir Res. 11(1):36.
  • Wang X, Jiang W, Duan N, Qian Y, Zhou Q, Ye P, Jiang H, Bai Y, Zhang W, Wang W. 2014. NOD1, RIP2 and Caspase12 are potentially novel biomarkers for oral squamous cell carcinoma development and progression. Int J Clin Exp Pathol. 7(4):1677–1686.
  • Warnakulasuriya S. 2009. Global epidemiology of oral and oropharyngeal cancer. Oral Oncol. 45(4-5):309–316.
  • Wen CP, Tsai SP, Cheng TY, Chen CJ, Levy DT, Yang HJ, Eriksen MP. 2005. Uncovering the relation between betel quid chewing and cigarette smoking in Taiwan. Tobacco Control. 14(suppl_1):i16.
  • Weng M-W, Lee H-W, Park S-H, Hu Y, Wang H-T, Chen L-C, Rom WN, Huang WC, Lepor H, Wu X-R, et al. 2018. Aldehydes are the predominant forces inducing DNA damage and inhibiting DNA repair in tobacco smoke carcinogenesis. Proc Natl Acad Sci USA. 115(27):E6152–E6161.
  • Wreesmann VB, Estilo C, Eisele DW, Singh B, Wang SJ. 2007. Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma. ORL J Otorhinolaryngol Relat Spec. 69(4):218–225.
  • Wu J, Peters BA, Dominianni C, Zhang Y, Pei Z, Yang L, Ma Y, Purdue MP, Jacobs EJ, Gapstur SM, et al. 2016. Cigarette smoking and the oral microbiome in a large study of American adults. ISME J. 10(10):2435.
  • Wyss AB, Hashibe M, Lee Y-C, Chuang S-C, Muscat J, Chen C, Schwartz SM, Smith E, Zhang Z-F, Morgenstern H. 2016. Smokeless tobacco use and the risk of head and neck cancer: pooled analysis of US studies in the INHANCE consortium. Am J Epidemiol. 184(10):703–716.
  • Xue H, Lu B, Lai M. 2008. The cancer secretome: a reservoir of biomarkers. J Transl Med. 6(1):52.
  • Yacoub A, Karmally W. 2017. Nutrition in oral health. In: Rippe JM, editor. Nutrition in lifestyle medicine. Cham: Springer International Publishing. p 193–209.
  • Yan Z, Zhang H, Maher C, Arteaga-Solis E, Champagne FA, Wu L, McDonald JD, Yan B, Schwartz GJ, Miller RL. 2014. Prenatal polycyclic aromatic hydrocarbon, adiposity, peroxisome proliferator-activated receptor (PPAR) γ methylation in offspring, grand-offspring mice. PloS One. 9(10):e110706.
  • Yang G, Ibuki Y. 2018. α,β-unsaturated aldehyde-induced delays in nucleotide excision repair and the contribution of reactive oxygen species . Chem Res Toxicol. 31(2):145–155.
  • Yang W-H, Wang S-J, Chang Y-S, Su C-M, Yang S-F, Tang C-H. 2018. Association of resistin gene polymorphisms with oral squamous cell carcinoma progression and development. BioMed Res Int. 2018:1.
  • Yardimci G, Kutlubay Z, Engin B, Tuzun Y. 2014. Precancerous lesions of oral mucosa. World J Clin Cases. 2(12):866–872.
  • Yeh C-M, Lin C-W, Chuang C-Y, Liu Y-F, Chou C-H, Yang S-F, Chen M-K. 2019. Functional genetic variant of long pentraxin 3 gene is associated with clinical aspects of oral cancer in male patients. Front Oncol. 9:581.
  • Yen AM-F, Boucher BJ, Chiu SY-H, Fann JC-Y, Chen SL-S, Huang K-C, Chen H-H. 2016. Longer duration and earlier age of onset of paternal betel chewing and smoking increase metabolic syndrome risk in human offspring, independently, in a community-based screening program in Taiwan. Circulation. 134(5):392–404.
  • Yenugadhati N, Albalawi AN, Qureshey AT, Qureshey ET, Al-Jahdali H, Jazieh AR, Ahmed AE. 2018. Associated factors for oral health problems in a sample of Saudi cancer patients. Cancer Manag Res. 10:1285.
  • Yin J, Ren WK, Wu XS, Yang G, Wang J, Li TJ, Ding JN, Cai LC, Su DD. 2013. Oxidative stress-mediated signaling pathways: a review. J Food Agric Environ. 11(2):132–139.
  • Yoshida T, Akatsuka T, Imanaka-Yoshida K. 2015. Tenascin-C and integrins in cancer. Cell Adh Migr. 9(1-2):96–104.
  • Yu L-R, Stewart NA, Veenstra TD. 2010. Chapter 8 - proteomics: the deciphering of the functional genome. In: Ginsburg GS, Willard HF, editors. Essentials of genomic and personalized medicine. San Diego: Academic Press. p 89–96.
  • Yu V, Rahimy M, Korrapati A, Xuan Y, Zou AE, Krishnan AR, Tsui T, Aguilera JA, Advani S, Crotty Alexander LE, et al. 2016. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 52:58–65.
  • Yue X, Basting TM, Flanagan TW, Xu J, Lobell TD, Gilpin NW, Gardner JD, Lazartigues E. 2018. Nicotine downregulates the compensatory angiotensin-converting enzyme 2/angiotensin type 2 receptor of the renin-angiotensin system. Ann Am Thorac Soc. 15(Supplement_2):S126–S127.
  • Zaid K, Azar-Maalouf E, Barakat C, Chantiri M. 2018. p53 Overexpression in oral mucosa in relation to shisha smoking in Syria and Lebanon. Asian Pacific J Cancer Prevent. 19(7):1879–1882.
  • Zeidman R, Pettersson L, Sailaja PR, Truedsson E, Fagerström S, Påhlman S, Larsson C. 1999. Novel and classical protein kinase C isoforms have different functions in proliferation, survival and differentiation of neuroblastoma cells. Int J Cancer. 81(3):494–501.
  • Zeilinger S, Kühnel B, Klopp N, Baurecht H, Kleinschmidt A, Gieger C, Weidinger S, Lattka E, Adamski J, Peters A, et al. 2013. Tobacco smoking leads to extensive genome-wide changes in DNA methylation. PloS one. 8:1–14.
  • Zerbino DR, Achuthan P, Akanni W, Amode MR, Barrell D, Bhai J, Billis K, Cummins C, Gall A, Giron CG, et al. 2018. Ensembl 2018. Nucleic Acids Res. 46(D1):D754–D761.
  • Zhang C, Wang M, Shi C, Shi F, Pei C. 2018. Long non-coding RNA Linc00312 modulates the sensitivity of ovarian cancer to cisplatin via the Bcl-2/Caspase-3 signaling pathway. Biosci Trends. 12(3):309–316.
  • Zhang L, Chen J-G, Zhao Q. 2015. Regulatory roles of Alu transcript on gene expression. Exp Cell Res. 338(1):113–118.
  • Zhang S-M, Chen K-M, Aliaga C, Sun Y-W, Lin J-M, Sharma AK, Amin S, El-Bayoumy K. 2011. Identification and quantification of DNA adducts in the oral tissues of mice treated with the environmental carcinogen dibenzo[a,l]pyrene by HPLC-MS/MS. Chem Res Toxicol. 24(8):1297–1303.
  • Zhang W, Huang C, Gong Z, Zhao Y, Tang K, Li X, Fan S, Shi L, Li X, Zhang P, et al. 2013. Expression of LINC00312, a long intergenic non-coding RNA, is negatively correlated with tumor size but positively correlated with lymph node metastasis in nasopharyngeal carcinoma. J Mol Histol. 44(5):545–554.
  • Ziegler YS, Moresco JJ, Tu PG, Yates JR, III, Nardulli AM. 2014. Plasma membrane proteomics of human breast cancer cell lines identifies potential targets for breast cancer diagnosis and treatment. PLoS ONE. 9(7):e102341.
  • Żukowski P, Maciejczyk M, Waszkiel D. 2018. Sources of free radicals and oxidative stress in the oral cavity. Arch Oral Biol. 92:8–17.

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