2,122
Views
25
CrossRef citations to date
0
Altmetric
Review Articles

IQOS – a heat-not-burn (HnB) tobacco product – chemical composition and possible impact on oxidative stress and inflammatory response. A systematic review

&
Pages 81-87 | Received 14 Jun 2019, Accepted 25 Aug 2019, Published online: 02 Oct 2019

References

  • Adriaens K, Gucht DV, Baeyens F. 2018. IQOSTM vs. e-cigarette vs. tobacco cigarette: a direct comparison of short-term effects after overnight-abstinence. Int J Env Res Pub Health. 15(12):2902.
  • Bekki K, Inaba Y, Uchiyama S, Kunugita N. 2017. Comparison of chemicals in mainstream smoke in heat-not-burn tobacco and combustion cigarettes. J UOEH. 39(3):201–207.
  • Cai H, Wang C. 2017. Graphical review: the redox dark side of e-cigarettes; exposure to oxidants and public health concerns. Redox Biol. 13:402–406.
  • Davis B, Williams M, Talbot P. 2019. iQOS: evidence of pyrolysis and release of a toxicant from plastic. Tob Control. 28(1):34–41.
  • Elias J, Dutra LM, St. Helen G, Ling PM. 2018. Revolution or redux? Assessing IQOS through a precursor product. Tob Control. 27(1):s102–s110.
  • Farsalinos KE, Yannovits N, Sarri T, Voudris V, Poulas K. 2018. Nicotine delivery to the aerosol of a heat-not-burn tobacco product: comparison with a tobacco cigarette and E-cigarettes. Nicotine Tob. Res. 20(8):1004–1009.
  • Farsalinos KE, Yannovits N, Sarri T, Voudris V, Poulas K, Leischow SJ. 2018. Carbonyl emissions from a novel heated tobacco product (IQOS): comparison with an e-cigarette and a tobacco cigarette: carbonyl emissions in heated tobacco product. Addiction. 113(11):2099–2106.
  • Gale N, McEwan M, Eldridge AC, Fearon IM, Sherwood N, Bowen E, McDermott S, Holmes E, Hedge A, Hossack S, et al. 2018. Changes in biomarkers of exposure on switching from a conventional cigarette to tobacco heating products: a randomized, controlled study in healthy Japanese subjects. Nicotine Tob. Res. 29(9):1220–1227.
  • Glantz SA. 2018. PMI’s own in vivo clinical data on biomarkers of potential harm in Americans show that IQOS is not detectably different from conventional cigarettes. Tob Control. 27(1):s9–s12.
  • Gometz ED. 2011. Health effects of smoking and the benefits of quitting. Virtual Mentor. 13(1):31.
  • Harris JE. 1996. Cigarette smoke components and disease: cigarette smoke is more than a triad of tar, nicotine, and carbon monoxide. Smok Tob Control Monogr. 7:59–75.
  • Kaur G, Muthumalage T, Rahman I. 2018. Mechanisms of toxicity and biomarkers of flavoring and flavor enhancing chemicals in emerging tobacco and non-tobacco products. Toxicol. Lett. 288:143–155.
  • Lauterstein D, Tijerina P, Corbett K, Akgol Oksuz B, Shen S, Gordon T, Klein C, Zelikoff J. 2016. Frontal cortex transcriptome analysis of mice exposed to electronic cigarettes during early life stages. Int J Env Res Pub Health. 13(4):417.
  • Lee PN. 2013. The effect of reducing the number of cigarettes smoked on risk of lung cancer, COPD, cardiovascular disease and FEV1 – A review. Regul Toxicol Pharmacol. 67(3):372–381.
  • Lee PN, Djurdjevic S, Weitkunat R, Baker G. 2018. Estimating the population health impact of introducing a reduced-risk tobacco product into Japan. The effect of differing assumptions, and some comparisons with the U.S. Regul Toxicol Pharmacol. 100:92–104.
  • Leigh NJ, Palumbo MN, Marino AM, O’Connor RJ, Goniewicz ML. 2018. Tobacco-specific nitrosamines (TSNA) in heated tobacco product IQOS. Tob Control. 27(1):s37–s38.
  • Leigh NJ, Tran PL, O’Connor RJ, Goniewicz ML. 2018. Cytotoxic effects of heated tobacco products (HTP) on human bronchial epithelial cells. Tob Control. 27(1):s26–s29.
  • Li X, Luo Y, Jiang X, Zhang H, Zhu F, Hu S, Hou H, Hu Q, Pang Y. 2019. Chemical analysis and simulated pyrolysis of tobacco heating system 2.2 compared to conventional cigarettes. Nicotine Tob. Res. Off. J. Soc. Res. Nicotine Tob. 21(1):111–118.
  • Liu X, Lugo A, Spizzichino L, Tabuchi T, Pacifici R, Gallus S. 2019. Heat-not-burn tobacco products: concerns from the Italian experience. Tob Control. 28:113–114.
  • McEvoy CT, Spindel ER. 2017. Pulmonary effects of maternal smoking on the fetus and child: effects on lung development, respiratory morbidities, and life long lung health. Paediatr Respir Rev. 21:27–33.
  • McKelvey K, Popova L, Kim M, Chaffee BW, Vijayaraghavan M, Ling P, Halpern-Felsher B. 2018. Heated tobacco products likely appeal to adolescents and young adults. Tob Control. 27(1):s41–s47.
  • McKelvey K, Popova L, Kim M, Lempert LK, Chaffee BW, Vijayaraghavan M, Ling P, Halpern-Felsher B. 2018. IQOS labelling will mislead consumers. Tob Control. 27(1):s48–s54.
  • Moazed F, Chun L, Matthay MA, Calfee CS, Gotts J. 2018. Assessment of industry data on pulmonary and immunosuppressive effects of IQOS. Tob Control. 27(1):s20–s25.
  • Pacitto A, Stabile L, Scungio M, Rizza V, Buonanno G. 2018. Characterization of airborne particles emitted by an electrically heated tobacco smoking system. Environ Pollut. 240:248–254.
  • Popova L, Lempert LK, Glantz SA. 2018. Light and mild redux: heated tobacco products’ reduced exposure claims are likely to be misunderstood as reduced risk claims. Tob Control. 27(1):s87–s95.
  • Protano C, Manigrasso M, Avino P, Sernia S, Vitali M. 2016. Second-hand smoke exposure generated by new electronic devices (IQOS® and e-cigs) and traditional cigarettes: submicron particle behaviour in human respiratory system. Ann Ig Med Prev E Comunita. 28:109–112.
  • Protano C, Manigrasso M, Avino P, Vitali M. 2017. Second-hand smoke generated by combustion and electronic smoking devices used in real scenarios: ultrafine particle pollution and age-related dose assessment. Environ Int. 107:190–195.
  • Salman R, Talih S, El-Hage R, Haddad C, Karaoghlanian N, El-Hellani A, Saliba NA, Shihadeh A. 2019. Free-base and total nicotine, reactive oxygen species, and carbonyl emissions from IQOS, a heated tobacco product. Nicotine Tob Res. 21(9):1285–1288.
  • Schober W, Fembacher L, Frenzen A, Fromme H. 2019. Passive exposure to pollutants from conventional cigarettes and new electronic smoking devices (IQOS, e-cigarette) in passenger cars. Int J Hyg Environ Health. 222(3):486–493.
  • Sharman A, Zhussupov B, Sharman D, Kim I, Yerenchina E. 2018. Lung function in users of a smoke-free electronic device with heat sticks (iQOS) versus smokers of conventional cigarettes: protocol for a longitudinal cohort observational study. JMIR Res Protoc. 7(11):e10006.
  • Sherman CB. 1991. Health effects of cigarette smoking. Clin. Chest Med. 12(4):643–658.
  • Sohal SS, Eapen MS, Naidu VG, Sharma P. 2019. IQOS exposure impairs human airway cell homeostasis: direct comparison with traditional cigarette and e-cigarette. ERJ Open Res. 5(1):00159–2018.
  • Tabuchi, T, Kiyohara, K, Hoshino, T, Bekki, K, Inaba, Y, Kunugita, N. 2016. Awareness and use of electronic cigarettes and heat‐not‐burn tobacco products in Japan. Addiction. 111(4):706–713. 
  • Talhout R, Schulz T, Florek E, van Benthem J, Wester P, Opperhuizen A. 2011. Hazardous compounds in tobacco smoke. Int J Env Res Pub Health. 8(2):613–628.
  • Williams M, Villarreal A, Bozhilov K, Lin S, Talbot P. 2013. Metal and silicate particles including nanoparticles are present in electronic cigarette cartomizer fluid and aerosol. PLoS ONE. 8(3):e57987.
  • World Health Organization. 2013. WHO report on the global tobacco epidemic, 2013: enforcing bans on tobacco advertising, promotion and sponsorship. Geneva (Switzerland): WHO.
  • World Health Organization. 2015. WHO global report on trends in prevalence of tobacco smoking. Geneva (Switzerland): WHO.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.