328
Views
12
CrossRef citations to date
0
Altmetric
Original Articles

Neurotoxicity and related mechanisms of flame retardant TCEP exposure in mice

, , , , , ORCID Icon & ORCID Icon show all
Pages 490-496 | Received 24 Jan 2020, Accepted 30 Apr 2020, Published online: 13 May 2020

References

  • An J, Hu J, Shang Y, Zhong Y, Zhang X, Yu Z. 2016. The cytotoxicity of organophosphate flame retardants on HepG2, A549 and Caco-2 cells. J Environ Sci Health A Tox Hazard Subst Environ Eng. 51:980–988.
  • Butt CM, Congleton J, Hoffman K, Fang M, Stapleton HM. 2014. Metabolites of organophosphate flame retardants and 2-ethylhexyl tetrabromobenzoate in urine from paired mothers and toddlers. Environ Sci Technol. 48:10432–10438.
  • Chen G, Jin Y, Wu Y, Liu L, Fu Z. 2015. Exposure of male mice to two kinds of organophosphate flame retardants (OPFRs) induced oxidative stress and endocrine disruption. Environ Toxicol Pharmacol. 40:310–318.
  • Ding JJ, Yang FX. 2017. [Progress in environmental exposure of organophosphate flame retardants]. Zhonghua Yu Fang Yi Xue Za Zhi. 51:570–576.
  • Dishaw LV, Powers CM, Ryde IT, Roberts SC, Seidler FJ, Slotkin TA, Stapleton HM. 2011. Is the PentaBDE replacement, tris (1,3-dichloro-2-propyl) phosphate (TDCPP), a developmental neurotoxicant? Studies in PC12 cells. Toxicol Appl Pharmacol. 256:281–289.
  • Farhat A, Crump D, Chiu S, Williams KL, Letcher RJ, Gauthier LT, Kennedy SW. 2013. In Ovo effects of two organophosphate flame retardants–TCPP and TDCPP–on pipping success, development, mRNA expression, and thyroid hormone levels in chicken embryos. Toxicol Sci. 134:92–102.
  • Fernie KJ, Palace V, Peters LE, Basu N, Letcher RJ, Karouna-Renier NK, Schultz SL, Lazarus RS, Rattner BA. 2015. Investigating endocrine and physiological parameters of captive American kestrels exposed by diet to selected organophosphate flame retardants. Environ Sci Technol. 49:7448–7455.
  • Kim S, Jung J, Lee I, Jung D, Youn H, Choi K. 2015. Thyroid disruption by triphenyl phosphate, an organophosphate flame retardant, in zebrafish (Danio rerio) embryos/larvae, and in GH3 and FRTL-5 cell lines. Aquat Toxicol. 160:188–196.
  • Li L, Jiang S, Li K, Lin B, Wang Z, Zhang Z, Fang Y. 2017. Assessment of tris (1, 3-dichloro-2-propyl) phosphate toxicology in PC12 cells by using digital gene expression profiling. Chemosphere. 183:353–360.
  • Liu X, Cai Y, Wang Y, Xu S, Ji K, Choi K. 2019. Effects of tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP) on sex-dependent alterations of thyroid hormones in adult zebrafish. Ecotoxicol Environ Saf. 170:25–32.
  • Meeker JD, Stapleton HM. 2010. House dust concentrations of organophosphate flame retardants in relation to hormone levels and semen quality parameters. Environ Health Perspect. 118:318–323.
  • Mezzadra R, Sun C, Jae LT, Gomez-Eerland R, de Vries E, Wu W, Logtenberg MEW, Slagter M, Rozeman EA, Hofland I, et al. 2017. Identification of CMTM6 and CMTM4 as PD-L1 protein regulators. Nature. 549:106–110.
  • Moser VC, Phillips PM, Hedge JM, McDaniel KL. 2015. Neurotoxicological and thyroid evaluations of rats developmentally exposed to tris(1,3-dichloro-2-propyl)phosphate (TDCIPP) and tris(2-chloro-2-ethyl)phosphate (TCEP). Neurotoxicol Teratol. 52:236–247.
  • Parsons A, Lange A, Hutchinson TH, Miyagawa S, Iguchi T, Kudoh T, Tyler CR. 2019. Molecular mechanisms and tissue targets of brominated flame retardants, BDE-47 and TBBPA, in embryo-larval life stages of zebrafish (Danio rerio). Aquat Toxicol. 209:99–112.
  • Pi T, Cai L, Jiang J, Zhao X, Wang Y, Wu S, Su L, Tang T. 2016. Toxicity effects of a new flame retardant tris(2-chloroisopropyl) phosphate to zebrafish (Danio rerio). Asian J Ecotoxicol. 11:247–256.
  • Shen Y, Yu C, Kong D-d, Wang R-f, Li J. 2018. Thyroid hormone disrupting effects of organophosphorus flame retardants and its mechanisms of action, take TCPP as an example. China Environ Sci. 38:2337–2344.
  • Tilson HA, Veronesi B, McLamb RL, Matthews HB. 1990. Acute exposure to tris(2-chloroethyl)phosphate produces hippocampal neuronal loss and impairs learning in rats. Toxicol Appl Pharmacol. 106:254–269.
  • Umezu T, Yonemoto J, Soma Y, Suzuki T. 1998. Tris(2-chloroethyl)phosphate increases ambulatory activity in mice: pharmacological analyses of its neurochemical mechanism. Toxicol Appl Pharmacol. 148:109–116.
  • Villanueva I, Alva-Sanchez C, Pacheco-Rosado J. 2013. 2013. The role of thyroid hormones as inductors of oxidative stress and neurodegeneration. Oxid Med Cell Longev. 2013:218145.
  • Wang Q, Liang K, Liu J, Yang L, Guo Y, Liu C, Zhou B. 2013. Exposure of zebrafish embryos/larvae to TDCPP alters concentrations of thyroid hormones and transcriptions of genes involved in the hypothalamic-pituitary-thyroid axis. Aquat Toxicol. 126:207–213.
  • Xu T, Li P, Wu S, Lei L, He D. 2017. Tris(2-chloroethyl) phosphate (TCEP) and tris(2-chloropropyl) phosphate (TCPP) induce locomotor deficits and dopaminergic degeneration in Caenorhabditis elegans. Toxicol Res (Camb). 6:63–72.
  • Yu X, Yin H, Peng H, Lu G, Liu Z, Dang Z. 2019. OPFRs and BFRs induced A549cell apoptosis by caspase-dependent mitochondrial pathway. Chemosphere. 221:693–702.
  • Yuan L, Li J, Zha J, Wang Z. 2016. Targeting neurotrophic factors and their receptors, but not cholinesterase or neurotransmitter, in the neurotoxicity of TDCPP in Chinese rare minnow adults (Gobiocypris rarus). Environ Pollut. 208:670–677.
  • Zhang T, Bai XY, Lu SY, Zhang B, Xie L, Zheng HC, Jiang YC, Zhou MZ, Zhou ZQ, Song SM, et al. 2018. Urinary metabolites of organophosphate flame retardants in China: Health risk from tris(2-chloroethyl) phosphate (TCEP) exposure. Environ Int. 121:1363–1371.
  • Zhao F, Wang J, Fang Y, Ding J, Yang H, Li L, Xi Z, Qiao H. 2016. Effects of tris(1,3-dichloro-2-propyl)phosphate on pathomorphology and gene/protein expression related to thyroid disruption in rats. Toxicol Res (Camb). 5:921–930.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.