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Articles

Evaluation of aromatase inhibitor on radiation induced pulmonary fibrosis via TGF- β/Smad 3 and TGF- β/PDGF pathways in rats

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Pages 538-545 | Received 11 Mar 2021, Accepted 20 May 2021, Published online: 21 Jun 2021

References

  • Abdollahi A, Li M, Ping G, Plathow C, Domhan S, Kiessling F, Lee LB, McMahon G, Grone HJ, Lipson KE, et al. 2005. Inhibition of platelet-derived growth factor signaling attenuates pulmonary fibrosis. J Exp Med. 201(6):925–935.
  • Altinok AY, Yildirim S, Altug T, Sut N, Ober A, Ozsahin EM, Azria D, Bese NS. 2016. Aromatase inhibitors decrease radiation-induced lung fibrosis: results of an experimental study. Breast. 28:174–177.
  • Anscher MS. 2005. The irreversibility of radiation-induced fibrosis: fact or folklore? J Clin Oncol. 23(34):8551–8552.
  • Anscher MS, Kong F-M, Andrews K, Clough R, Marks LB, Bentel G, Jirtle RL. 1998. Plasma transforming growth factor beta 1 as a predictor or radiation pneumonitis. Int J Radiat Oncol Biol Phys. 41(5):1029e35–1021035.
  • Azzam EI, Jay-Gerin JP, Pain D. 2012. Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury. Cancer Lett. 327(1–2):48–60.
  • Bae YS, Oh H, Rhee SG, Yoo YD. 2011. Regulation of reactive oxygen species generation in cell signaling. Mol Cells. 32(6):491–509.
  • Bancroft JD, Stevens A, Turner DR. 2013. Theory and practice of histological techniques, 4th ed. Edinburgh, London, Melbourne, New York: Churchill Livingstone
  • Barnes JL, Gorin Y. 2011. Myofibroblast differentiation during fibrosis: role of NAD(P)H oxidases. Kidney Int. 79(9):944–956.
  • Bartsch H, Nair J. 2002. Potential role of lipid peroxidation derived DNA damage in human colon carcinogenesis: studies on exocyclic base adduct as stable oxidative stress markers. Cancer Detect Prev. 26(4):308–312.
  • Bese NS, Umay C, Yildirim S. 2006. The effects of tamoxifen on radiation-induced pulmonary fibrosis in Wistar albino rats: results of an experimental study. Breast. 15(3):456–460.
  • Bickelhaupt S, Erbel C, Timke C, Wirkner U, Dadrich M, Flechsig P, Tietz A, Pfohler J, Gross W, Peschke P. 2017. Effects of CTGF blockade on attenuation and reversal of radiation-induced pulmonary fibrosis. J Natl Cancer Inst. 109(8). doi:https://doi.org/10.1093/jnci/djw339.
  • Biernacka A, Dobaczewski M, Frangogiannis NG. 2011. TGF-β signaling in fibrosis. Growth Factors. 29(5):196–202.
  • Buege JA, Aust SD. 1978. Microsomal lipid peroxidation. Methods Enzymol. 52:302–310.
  • Chen P-J, Huang C, Meng X-M, Li J. 2015. Epigenetic modifications by histone deacetylases: biological implications and therapeutic potential in liver fibrosis. Biochimie. 116:61–69.
  • Chen Z, Wu Z, Ning W. 2019. Advances in molecular mechanisms and treatment of radiation-induced pulmonary fibrosis. Transl Oncol. 12(1):162–169.
  • Cherupally NKK, Parida Dillip K, Nomura T. 2001. Radioprotectors in radiotherapy. J Radiat Res. 42:21–37.
  • Coates AS, Keshaviah A, Thürlimann B, Mouridsen H, Mauriac L, Forbes JF, Paridaens R, Castiglione-Gertsch M, Gelber RD, Colleoni M, et al. 2007. Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98. J Clin Oncol. 25(5):486–486492.
  • Dinarello CA. 1997. Interleukin-1. Cytokine Growth Factor Rev. 8(4):253–265.
  • Dowsett M, Cuzick J, Ingle J, Coates A, Forbes J, Bliss J, Buyse M, Baum M, Buzdar A, Colleoni M, et al. 2010. Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. JCO. 28(3):509–518.
  • Ellman GL. 1959. Tissue sulfhydryl groups. Arch Biochem Biophys. 17:214–226.
  • Flechsig P, Dadrich M, Bickelhaupt S, Jenne J, Hauser K, Timke C, Peschke P, Hahn EW, Grone HJ, Yingling J, et al. 2012. LY2109761 attenuates radiation-induced pulmonary murine fibrosis via reversal of TGF-β and BMP-associated proinflammatory and proangiogenic signals. Clin Cancer Res. 18(13):3616–3627.
  • Fleckenstein K, Zgonjanin L, Chen L, Rabbani Z, Jackson IL, Thrasher B, Kirkpatrick J, Foster WM, Vujaskovic Z. 2007. Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. Int J Radiat Oncol Biol Phys. 68(1):196–204.
  • Forbes JF, Cuzick J, Buzdar A. 2008. Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial. Lancet Oncol. 9(1):45e53.
  • Graves PR, Siddiqui F, Anscher MS, Movsas B. 2010. Radiation pulmonary toxicity: from mechanisms to management. Semin Radiat Oncol. 20(3):201–207.
  • He Y, Thummuri D, Zheng G, Okunieff P, Citrin DE, Vujaskovic Z, Zhou D. 2019. Cellular senescence and radiation-induced pulmonary fibrosis. Transl Res. 209:14–21.
  • Ignarro L, Buga G, Wood K, Byrns RE, Chaudhuri G. 1987. Endothelium-derived relaxing factor produced and released from artery and veins is nitric oxide. Proc Nat Acad Sci. 84(24):9265–9269.
  • Irifuku T, Doi S, Sasaki K, Doi T, Nakashima A, Ueno T, Yamada K, Arihiro K, Kohno N, Masaki T. 2016. Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression. Kidney Int. 89(1):147–157.
  • Johnston CJ, Piedboeuf B, Rubin P, Williams JP, Baggs R, Finkelstein JN. 1996. Early and persistent alterations in the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor alpha mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiat Res. 145(6):762–767.
  • Kang SK, Rabbani ZN, Folz RJ, Golson ML, Huang H, Yu D, Samulski TS, Dewhirst MW, Anscher MS, Vujaskovic Z. 2003. Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. Int J Radiat Oncol Biol Phys. 57(4):1056–1066.
  • Kelly L. Walton, Katharine E. Johnson and Craig A. Harrison. 2017. Targeting T GF-β mediated SMAD signaling for the prevention of fibrosis. Front Pharmacol. 8. Article 461.
  • KŁuciński PI, Mazur BO, Kaufman JO, Hrycek AN, Cieślik PA, Martirosian GA. 2005. Assessment of blood serum immunoglobulin and C-reactive protein concentrations in workers of X-ray diagnostics units. Int J Occup Med Environ Health. 18:327–330.
  • Kolb M, Margetts PJ, Anthony DC, Pitossi F, Gauldie J. 2001. Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. J Clin Invest. 107(12):1529–1536.
  • Liu R-M, Vayalil PK, Ballinger C, Dickinson DA, Huang W-T, Wang S, Kavanagh TJ, Matthews QL, Postlethwait EM. 2012. Transforming growth factor β suppresses glutamate-cysteine ligase gene expression and induces oxidative stress in a lung fibrosis model. Free Radic Biol Med. 53(3):554–563.
  • Liu R-M, Desai LP. 2015. Reciprocal regulation of TGF-β and reactive oxygen species: a perverse cycle for fibrosis. Redox Biol. 6:565–577.
  • Mansour SZ, Moawed FSM, Badawy MMM, Mohamed HE. 2020. Boswellic acid synergizes with low-level ionizing radiation to modulate bisphenol induced-lung toxicity in rats by inhibiting jNK/ERK/c-Fos pathway. Dose Response. 18(4):155932582096959.
  • Matsunami T, Sato Y, Yukawa M. 2010. Oxidative stress and gene expression of antioxidant enzymes in the streptozotocin-induced diabetic rats under hyperbaric oxygen exposure. Int J Clin Exp Pathol. 3(2):177–188.
  • Minami M, Yoshikawa HA. 1979. Simplified assay method of superoxide dismutase activity for clinical use. Clin Chim Acta. 92:337–342.
  • Moustakas A, Heldin CH. 2005. Non-Smad TGF-beta signals. J Cell Sci. 118(Pt 16):3573–3584.
  • Najafi M, Fardid R, Takhshid MA, Mosleh-Shirazi MA, Rezaeyan AH, Salajegheh A. 2016. Radiation-induced oxidative stress at out-of-field lung tissues after pelvis irradiation in rats. Cell J. 18(3):340–345.
  • Pang M, Zhuang S. 2010. Histone deacetylase: a potential therapeutic target for fibrotic disorders. J Pharmacol Exp Ther. 335(2):266–272.
  • Phan SH, Kunkel SL. 1992. Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp Lung Res. 18(1):29–43.
  • Piguet PF, Vesin C, Grau GE, Thompson RC. 1993. Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica. Cytokine. 5(1):57–61.
  • Quan T, He T, Shao Y, Lin L, Kang S, Voorhees JJ, Fisher GJ. 2006. Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin. Am J Pathol. 169(2):482–490.
  • Quan T, He T, Voorhees J, Fisher G. 2001. Ultraviolet irradiation blocks cellular responses to transforming growth factor-β by down-regulating its type-II receptor and inducing Smad7. J Biol Chem. 276(28):26349–26356.
  • Quan T, Shao Y, He T, Voorhees JJ, Fisher GJ. 2010. Reduced expression of connective tissue growth factor (CTGF/CCN2) mediates collagen loss in chronologically aged human skin. J Invest Dermatol. 130(2):415–424.
  • Richter K, Kietzmann T. 2016. Reactive oxygen species and fibrosis: further evidence of a significant liaison. Cell Tissue Res. 365(3):591–605.
  • Rube CE, Uthe D, Schmid KW, Richter KD, Wessel J, Schuck A, Willich N, Rube C. 2000. Dose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiation. Int J Radiat Oncol Biol Phys. 47(4):1033–1042.
  • Shi-Wen X, Stanton LA, Kennedy L, Pala D, Chen Y, Howat SL, Renzoni EA, Carter DE, Bou-Gharios G, Stratton RJ, et al. 2006. CCN2 is necessary for adhesive responses to transforming growth factor-beta1 in embryonic fibroblasts. J Biol Chem. 281(16):10715–10726.
  • Shrishrimal S, Kosmacek EA, Oberley-Deegan RE. 2019. Reactive oxygen species drive epigenetic changes in radiation-induced fibrosis. Oxid Med Cell Longev. 2019:4278658.
  • Spitz DR, Azzam EI, Li JJ, Gius D. 2004. Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology. Cancer Metastasis Rev. 23(3–4):311–322.
  • Stone HB, Coleman CN, Anscher MS, McBride WH. 2003. Effects of radiation on normal tissue: consequences and mechanisms. Lancet Oncol. 4(9):529–536.
  • Tada H, Ogushi F, Tani K, Nishioka Y, Miyata JY, Sato K, Asano T, Sone S. 2003. Increased binding and chemotactic capacities of PDGF-BB on fibroblasts in radiation pneumonitis. Radiat Res. 159(6):805–811.
  • Valente M, Denis J, Grenier N, Arvers P, Foucher B, Desangles F, Martigne P, Chaussard H, Drouet M, Abend M, et al. 2015. Revisiting biomarkers of total-body and partial-body exposure in a baboon model of irradiation. PLOS One. 10(7):e0132194.
  • Vujaskovic Z, Marks L, Anscher M. 2000. The physical parameters and molecular events associated with radiation-induced lung toxicity. Semin Radiat Oncol. 10(4):296–296e307.
  • Wynn TA. 2011. Integrating mechanisms of pulmonary fibrosis. J Exp Med. 208(7):1339–1350.
  • Yavas G, Yavas C, Acar H, Toy H, Yuce D, Ata O. 2013. Comparison of the effects of aromatase inhibitors and tamoxifen on radiation-induced lung toxicity: results of an experimental study. Support Care Cancer. 21(3):811–817.
  • Zhang C, Zhao H, Li BL, Fu-GaoLiu H, Cai JM, Zheng M. 2018. CpGoligodeoxynucleotides may be effective for preventing ionizing radiation induced pulmonary fibrosis. Toxicol Lett. 292:181–189.

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