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Research Articles

Vitamin U prevents valproic acid-induced liver injury through supporting enzymatic antioxidant system and increasing hepatocyte proliferation triggered by inflammation and apoptosis

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Pages 600-608 | Received 10 May 2021, Accepted 08 Jun 2021, Published online: 22 Aug 2021

References

  • Aebi H. 1984. Catalase in vitro. Methods Enzymol. 105:121–126.
  • Aires CCP, Soveral G, Luís PBM, ten Brink HJ, de Almeida IT, Duran M, Wanders RJA, Silva MFB. 2008. Pyruvate uptake is inhibited by valproic acid and metabolites in mitochondrial membranes. FEBS Lett. 582(23–24):3359–3366.
  • Akpolat M, Oz ZS, Gulle K, Hamamcioglu AC, Bakkal BH, Kececi M. 2020. X irradiation induced colonic mucosal injury and the detection of apoptosis through PARP-1/p53 regulatory pathway. Biomed Pharmacother. 127:110134.
  • Al-Rouby NM, Gawish SM. 2013. Histological study on the possible protective effect of nigella sativa oil on experimentally induced hepatotoxicity in albino rats treated with sodium valproate. Global Adv Res J Med Sci. 2(4):90–99.
  • Asconapé JJ. 2018. Pharmacokinetic considerations with the use of antiepileptic drugs in patients with HIV and organ transplants. Curr Neurol Neurosci Rep. 18(12):89.
  • Bédry R, Parrot F. 2004. Severe valproate poisoning. Reanimation. 13(5):324–333.
  • Bergmann A, Steller H. 2010. Apoptosis, stem cells, and tissue regeneration. Sci Signal. 3(145):re8.
  • Beutler E. 1971. Red cell metabolism. A manual of biochemical methods. London: Academic Press. p. 12.
  • Bolkent Ş, Öztay F, Gezginci Oktayoğlu S, Sancar Baş S, Karatuğ A. 2016. A matter of regeneration and repair: caspases as the key molecules. Turk J Biol. 40(2):333–352.
  • Chang TK, Abbott FS. 2006. Oxidative stress as a mechanism of valproic acid-associated hepatotoxicity. Drug Metab Rev. 38(4):627–639.
  • El-Mowafy AM, Katary MM, Pye C, Ibrahim AS, Elmarakby AA. 2016. Novel molecular triggers underlie valproate-induced liver injury and its alleviation by the omega-3 fatty acid DHA: role of inflammation and apoptosis. Heliyon. 2(7):e00130.
  • Galluzzi L, Vitale I, Abrams JM, Alnemri ES, Baehrecke EH, Blagosklonny MV, Dawson TM, Dawson VL, El-Deiry WS, Fulda S, et al. 2012. Molecular definitions of cell death subroutines: recommendations of the nomenclature committee on cell death. Cell Death Differ. 19(1):107–120.
  • Gezginci-Oktayoglu S, Tunali S, Yanardag R, Bolkent S. 2008. Effects of Z-FA.FMK on d-galactosamine/tumor necrosis factor-alpha-induced kidney injury and oxidative stress in mice: effects of Z-FA.FMK on TNF-alpha-mediated kidney injury. Mol Cell Biochem. 309(1–2):9–20.
  • Gezginci-Oktayoglu S, Turkyilmaz IB, Ercin M, Yanardag R, Bolkent S. 2016. Vitamin U has a protective effect on valproic acid-induced renal damage due to its anti-oxidant, anti-inflammatory, and anti-fibrotic properties. Protoplasma. 253(1):127–135.
  • Gurtner GC, Werner S, Barrandon Y, Longaker MT. 2008. Wound repair and regeneration. Nature. 453(7193):314–321.
  • Ilhan A, Gurel A, Armutcu F, Kamisli S, Iraz M. 2005. Antiepileptogenic and antioxidant effects of Nigella sativa oil against pentylenetetrazol-induced kindling in mice. Neuropharmacology. 49(4):456–464.
  • Jafarian I, Eskandari MR, Mashayekhi V, Ahadpour M, Hosseini MJ. 2013. Toxicity of valproic acid in isolated rat liver mitochondria. Toxicol Mech Methods. 23(8):617–623.
  • Kim WS, Yang YJ, Min HG, Song MG, Lee JS, Park KY, Kim JJ, Sung JH, Choi JS, Cha HJ. 2010. Accelerated wound healing by S-methylmethionine sulfonium: evidence of dermal fibroblast activation via the ERK1/2 pathway. Pharmacology. 85(2):68–76.
  • Kim WS, Kim WK, Choi N, Suh W, Lee J, Kim DD, Kim I, Sung J-H. 2018. Development of S-methylmethionine sulfonium derivatives and their skin-protective effect against ultraviolet exposure. Biomol Ther. 26(3):306–312.
  • Komulainen T, Lodge T, Hinttala R, Bolszak M, Pietilä M, Koivunen P, Hakkola J, Poulton J, Morten KJ, Uusimaa J, et al. 2015. Sodium valproate induces mitochondrial respiration dysfunction in HepG2 in vitro cell model. Toxicology. 331:47–56.
  • Lavrik IN, Golks A, Krammer PH. 2005. Caspases: pharmacological manipulation of cell death. J Clin Invest. 115(10):2665–2672.
  • Liu M, Chen P. 2017. Proliferation inhibiting pathways in liver regeneration. Mol. Med. Rep. 6:23–35.
  • Mcllwain DR, Berger T, Mak TW. 2013. Caspase functions in cell death and disease. Cold Spring Harb Perspect Biol. 5(4):a008656.
  • Mylroie AA, Collins H, Umbles C, Kyle J. 1986. Erythrocyte superoxide dismutase activity and other parameters of copper status in rats ingesting lead acetate. Toxicol Appl Pharmacol. 82(3):512–520.
  • Nanau RM, Neuman MG. 2013. Adverse drug reactions induced by valproic acid. Clin Biochem. 46(15):1323–1338.
  • Oktay S, Bayrak G, Alev B, Ipekci H, Ustundag UV, Turkyilmaz IB, Pisiriciler R, Emekli-Alturfan E, Tunali-Akbay T, Yanardag R, et al. 2018. The effect of vitamin U on the lung tissue of pentyleneterazole-induced seizures in rats. Naunyn Schmiedebergs Arch Pharmacol. 391(2):177–184.
  • Oztay F, Tunali S, Kayalar O, Yanardag R. 2020. The protective effect of vitamin U on valproic acid-induced lung toxicity in rats via amelioration of oxidative stress. J Biochem Mol Toxicol. 34(12):e22602.
  • Paglia DE, Valentine WN. 1967. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 70(1):158–168.
  • Perucca E. 2002. Pharmacological and therapeutic properties of valproate: a summary after 35 years of clinical experience. CNS Drugs. 16(10):695–714.
  • Pourahmad J, Eskandari MR, Kaghazi A, Shaki F, Shahraki J, Fard JK. 2012. A new approach on valproic acid-induced hepatotoxicity: involvement of lysosomal membrane leakiness and cellular proteolysis. Toxicol In Vitro. 26(4):545–551.
  • Rabinowich L, Shibolet O. 2015. Drug induced steatohepatitis: an uncommon culprit of a common disease. BioMed Res Int. 2015:168905.
  • Rácz I, Páldi E, Szalai G, Janda T, Pál M, Lásztity D. 2008. S-methylmethionine reduces cell membrane damage in higher plants exposed to low-temperature stress. J Plant Physiol. 165(14):1483–1490.
  • Rosenberg G. 2007. The mechanisms of action of valproate in neuropsychiatric disorders: can we see the forest for the trees? Cell Mol Life Sci. 64(16):2090–2103.
  • Sancar-Bas S, Türkyılmaz İB, Bolkent Ş, Yanardağ R. 2016. The influence of vitamin U supplementation on liver injury of amiodarone-administered rats. IUFS J Biol. 75(1):1–10.
  • Shaaban A, El-Agamy DS. 2017. Cytoprotective effects of diallyl trisulfide against valproate-induced hepatotoxicity: new anticonvulsant strategy. Naunyn-Schmiedeberg's Arch Pharmacol. 390(9):919–928.
  • Shalini S, Dorstyn L, Dawar S, Kumar S. 2015. Old, new and emerging functions of caspases. Cell Death Differ. 22(4):526–539.
  • Shen J, Xu S, Zhou H, Liu H, Jiang W, Hao J, Hu Z. 2017. IL-1β induces apoptosis and autophagy via mitochondria pathway in human degenerative nucleus pulposus cells. Sci Rep. 7:41067.
  • Silva MFB, Aires CCP, Luis PBM, Ruiter JPN, IJlst L, Duran M, Wanders RJA, Tavares de Almeida I. 2008. Valproic acid metabolism and its effects on mitochondrial fatty acid oxidation: a review. J Inherit Metab Dis. 31(2):205–216.
  • Sokmen BB, Tunali S, Yanardag R. 2012. Efects of vitamin U (S-methyl methionine sulphonium chloride) on valproic acid induced liver injury in rats. Food Chem Toxicol. 50(10):3562–3566.
  • Szasz G. 1969. A kinetic photometric method for serum γ-glutamyl transpeptidase. Clin Chem. 15(2):124–136.
  • Takeishi T, Hirano K, Kobayashi T, Hasegawa G, Hatakeyama K, Naito M. 1999. The role of Kupffer cells in liver regeneration. Arch Histol Cytol. 62(5):413–422.
  • Tong V, Teng XW, Chang TKH, Abbott FS. 2005. Valproic acid II: effects on oxidative stress, mitochondrial membrane potential, and cytotoxicity in glutathione-depleted rat hepatocytes. Toxicol Sci. 86(2):436–443.
  • Tunali S, Cimen ES, Yanardag R. 2020. The effects of chard on brain damage in valproic acid-induced toxicity. J Food Biochem. 44(10):e13382.
  • Tunali S, Kahraman S, Yanardag R. 2015. Vitamin U, a novel free radical scavenger, prevents lens injury in rats administered with valproic acid. Hum Exp Toxicol. 34(9):904–910.
  • Turkyilmaz IB, Sokmen BB, Yanardag R. 2020. Alpha-lipoic acid prevents brain injury in rats administered with valproic acid. J Biochem Mol Toxicol. 34:e22580.
  • Wendel A. 1981. Glutathione peroxidase. Methods Enzymol. 7:325–333.
  • Witko-Sarsat V, Friedlander M, Capeillère-Blandin C, Nguyen-Khoa T, Nguyen AT, Zingraff J, Jungers P, Descamps-Latscha B. 1996. Advanced oxidation protein products as a novel marker of oxidative stress in uremia. Kidney Int. 49(5):1304–1313.
  • Xu S, Chen Y, Ma Y, Liu T, Zhao M, Wang Z, Zhao L. 2019. Lipidomic profiling reveals disruption of lipid metabolism in valproic acid-induced hepatotoxicity. Front Pharmacol. 10:819.

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