Chitosan and solid lipid nanoparticles enhance the efficiency of alpha-lipoic acid against experimental neurotoxicity

References

• Abd-Ella EMM, El-Sisy SF, El-Dash H-H. 2016. Protective effects of alpha lipoic acid (α-LA) against lead neuro-toxicity in albino rats. Int J Pharm Sci Invent. 5(2):5–13.
   Google Scholar
• Abdel-Salam OM, Hamdy SM, Seadawy SAM, Galal AF, Abouelfadl DM, Atrees SS. 2016. Effect of piracetam, vincamine, vinpocetine, and donepezil on oxidative stress and neurodegeneration induced by aluminum chloride in rats. Comp Clin Pathol. 25(2):305–318.
   Google Scholar
• Abdel-Salam OM, Youness ER, Morsy FA, Mahfouz MM, Kenawy SA. 2015. Study of the effect of antidepressant drugs and donepezil on aluminum-induced memory impairment and biochemical alterations in rats. Comp Clin Pathol. 24(4):847–860.
   Google Scholar
• Abdel-Wahab B, Metwally M. 2014. Protective effect of alpha lipoic acid against lead-induced hippocampal neurotoxicity and neuronal oxidative stress in rats. Austin J Pharmacol Ther. 2(11):8.
   Google Scholar
• Al-Otaibi SS, Arafah MM, Sharma B, Alhomida AS, Siddiqi NJ. 2018. Synergistic effect of quercetin and α-lipoic acid on aluminium chloride induced neurotoxicity in rats. J Toxicol. 2018:2817036.
   PubMed Web of Science ®Google Scholar
• Auti ST, Kulkarni YA. 2019. Neuroprotective effect of cardamom oil against aluminum induced neurotoxicity in rats. Front Neurol. 10:399.
   PubMed Web of Science ®Google Scholar
• Aziza SAH, El-Haggar M, Abo-Zaid OA, Hassanien MR, El-Shawarb R. 2013. Fatty acids composition abnormalities of rats sciatic nerve in streptozotocin-induced diabetic neuropathy. Asian J Biochem. 9(1):1–15.
   Google Scholar
• Balgoon MJ, Raouf GA, Qusti SY, Ali SS. 2015. ATR-IR study of the mechanism of aluminum chloride induced Alzheimer’s disease; curative and protective effect of Lipidium sativum water extract on hippocampus rats brain tissue. Int J Med. 9(11):782–792.
   Google Scholar
• Baluchnejadmojarad T, Roghani M, Kamran M, Karimi N. 2012. The effect of Alpha-lipoic acid on learning and memory deficit in a rat model of temporal lobe epilepsy. Basic Clin Neurosci. 3(3):58–66.
   Google Scholar
• Beutler E, Duron O, Kelly BM. 1963. Improved method for the determination of blood glutathione. J Lab Clin Med. 61:882–888.
   PubMed Web of Science ®Google Scholar
• Borai IH, Ezz MK, Rizk MZ, Aly HF, El-Sherbiny M, Matloub AA, Fouad GI. 2017. Therapeutic impact of grape leaves polyphenols on certain biochemical and neurological markers in AlCl3-induced Alzheimer’s disease. Biomed Pharmacother. 93:837–851.
   PubMed Web of Science ®Google Scholar
• Davies S, Contri RV, Guterres SS, Pohlmann AR, Guerreiro ICK. 2020. Simultaneous nanoencapsulation of lipoic acid and resveratrol with improved antioxidant properties for the skin. Colloids Surf B Biointerfaces. 192:111023.
   PubMed Web of Science ®Google Scholar
• Dhaundiyal A, Jena SK, Samal SK, Sonvane B, Chand M, Sangamwar AT. 2016. Alpha-lipoic acid-stearylamine conjugate-based solid lipid nanoparticles for tamoxifen delivery: formulation, optimization, in-vivo pharmacokinetic and hepatotoxicity study. J Pharm Pharmacol. 68(12):1535–1550.
   PubMed Web of Science ®Google Scholar
• El-Feki M, Amin H, Abdalla A, Fesal M. 2016. Immunomodulatory and anti-oxidant effects of Alpha-lipoic acid and vitamin E on lipopolysaccharide-induced liver injury in rats. Middle East J Appl Sci. 6(03):460–467.
   Google Scholar
• El-Khayat Z, El-Matty DA, Rasheed W, Hussein J, Shaker O, Raafat J. 2013. Role of cell membrane fatty acids in insulin sensitivity in diabetic rats treated with flaxseed oil. Int J Pharm Pharm Sci. 5(2):146–151.
   Google Scholar
• Ellman GL, Courtney KD, Andres V, Feather-Stone RM. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol. 7(2):88–95.
   PubMed Web of Science ®Google Scholar
• Farr SA, Poon HF, Dogrukol-Ak D, Drake J, Banks WA, Eyerman E, Butterfield DA, Morley JE. 2003. The antioxidants alpha-lipoic acid and N-acetylcysteine reverse memory impairment and brain oxidative stress in aged SAMP8 mice. J Neurochem. 84(5):1173–1183.
   PubMed Web of Science ®Google Scholar
• Furtado D, Björnmalm M, Ayton S, Bush AI, Kempe K, Caruso F. 2018. Overcoming the blood–brain barrier: the role of nanomaterials in treating neurological diseases. Adv Mater. 30(46):1801362.
   PubMed Web of Science ®Google Scholar
• Garud A, Singh D, Garud N. 2012. Solid lipid nanoparticles (SLN): method, characterization and applications. Int Curr Pharm J. 1(11):384–393.
   Google Scholar
• Giacobbo BL, Doorduin J, Klein HC, Dierckx RA, Bromberg E, de Vries EF. 2019. Brain-derived neurotrophic factor in brain disorders: focus on neuroinflammation. Mol Neurobiol. 56(5):3295–3312.
   PubMed Web of Science ®Google Scholar
• Gogoi P, Dutta A, Ramteke A, Maji TK. 2020. Preparation, characterization and cytotoxic applications of curcumin-(±) α-lipoic acid coloaded phosphorylated chitosan nanoparticles in MDA MB 231 breast cancer cell line. Polym Adv Technol. 31(11):2827–2841.
   Web of Science ®Google Scholar
• Guvenc M, Yİlmaz O, Tuzcu M, Ozsahİn A. 2009. Contribution of vitamin C and α-lipoic acid and their combination on the products level of desaturase enzymes in the lung and muscle tissues of poorly controlled experimental diabetic rats. Res J Biol Sci. 4(6):710–715.
   Google Scholar
• Hussein J, Refaat E, Morsy S, Medhat D, Oraby F. 2013. Green tea attenuates experimental hepatitis in context of oxidative stress. J Appl Pharm Sci. 3(12):124.
   Google Scholar
• Hussein JS, El-bana MA, El-Naggar ME, Abdel-Latif Y, El-Sayed SM, Medhat D. 2021. Prophylactic effect of probiotics fortified with Aloe vera pulp nanoemulsion against ethanol-induced gastric ulcer. Toxicology Mech Methods. 31: 699–710.
   Google Scholar
• Jain V, Baitharu I, Prasad D, Ilavazhagan G. 2013. Enriched environment prevents hypobaric hypoxia induced memory impairment and neurodegeneration: role of BDNF/PI3K/GSK3β pathway coupled with CREB activation. PLoS One. 8(5):e62235.
   PubMed Web of Science ®Google Scholar
• Jamor P, Ahmadvand H, Birjandi M, Sharafabad BE. 2018. Activity of serum paraoxonase 1, lipid profile and atherogenic indexes in diabetic induced rats treated with alpha lipoic acid. J Nephropathol. 7(4):241–247.
   Google Scholar
• Kamarudin MNA, Raflee NAM, Hussein SSS, Lo JY, Supriady H, Kadir HA. 2014. (R)-(+)-α-lipoic acid protected NG108-15 cells against H2O2-induced cell death through PI3K-Akt/GSK-3β pathway and suppression of NF-κβ-cytokines. Drug Des Devel Ther. 8:1765–1780.
   PubMed Web of Science ®Google Scholar
• Khafaga AF. 2017. Exogenous phosphatidylcholine supplementation retrieve aluminum-induced toxicity in male albino rats. Environ Sci Pollut Res Int. 24(18):15589–15598.
   PubMed Web of Science ®Google Scholar
• Khan A, Ali T, Rehman SU, Khan MS, Alam SI, Ikram M, Muhammad T, Saeed K, Badshah H, Kim MO. 2018. Neuroprotective effect of quercetin against the detrimental effects of LPS in the adult mouse brain. Front Pharmacol. 9:1383.
   PubMed Web of Science ®Google Scholar
• Kumar V, Bal A, Gill KD. 2009. Aluminium-induced oxidative DNA damage recognition and cell-cycle disruption in different regions of rat brain. Toxicology. 264(3):137–144.
   PubMed Web of Science ®Google Scholar
• Kumar V, Gill KD. 2009. Aluminium neurotoxicity: neurobehavioural and oxidative aspects. Arch Toxicol. 83(11):965–978.
   PubMed Web of Science ®Google Scholar
• Kumar A, Mallik SB, Rijal S, Changdar N, Mudgal J, Shenoy RR. 2019. Dietary oils ameliorate aluminum chloride-induced memory deficit in wistar rats. Phcog Mag. 15(60):36.
   Google Scholar
• Kumar A, Prakash A, Dogra S. 2011. Neuroprotective effect of carvedilol against aluminium induced toxicity: possible behavioral and biochemical alterations in rats. Pharmacol Rep. 63(4):915–923.
   PubMed Web of Science ®Google Scholar
• Li G, Fu J, Zhao Y, Ji K, Luan T, Zang B. 2015. Alpha-lipoic acid exerts anti-inflammatory effects on lipopolysaccharide-stimulated rat mesangial cells via inhibition of nuclear factor kappa B (NF-κB) signaling pathway. Inflammation. 38(2):510–519.
   PubMed Web of Science ®Google Scholar
• Mahdy K, Shaker O, Wafay H, Nassar Y, Hassan H, Hussein A. 2012. Effect of some medicinal plant extracts on the oxidative stress status in Alzheimer’s disease induced in rats. Eur Rev Med Pharmacol Sci. 16(3):31–42.
   PubMedGoogle Scholar
• Manolescu BN, Berteanu M, Cintezã D. 2013. Effect of the nutritional supplement ALAnerv® on the serum PON1 activity in post-acute stroke patients. Pharmacol Rep. 65(3):743–750.
   PubMed Web of Science ®Google Scholar
• Maya S, Prakash T, Madhu KD, Goli D. 2016. Multifaceted effects of aluminium in neurodegenerative diseases: a review. Biomed Pharmacother. 83:746–754.
   PubMed Web of Science ®Google Scholar
• Montgomery H, Dymock JF. 1961. Determination of nitrite in water. Science Park, Milton RD, Cambridge: Royal Soc Chemistry Thomas Graham House; p. 414–414.
   Google Scholar
• Mohamed HK, Meligy FY. 2018. The possible protective effects of alfa lipoic acid on diethanolamine-induced renal toxicity in adult male albino rats: a histological and immunohistochemical study. Egypt J Histol. 41(4):431–444.
   Google Scholar
• Prema A, Thenmozhi AJ, Manivasagam T, Essa MM, Akbar MD, Akbar M. 2016. Fenugreek seed powder nullified aluminium chloride induced memory loss, biochemical changes, Aβ burden and apoptosis via regulating Akt/GSK3β signaling pathway. PLoS One. 11(11):e0165955.
   PubMed Web of Science ®Google Scholar
• Rageh MM, El-Gebaly RH. 2019. Antioxidant activities of α-lipoic acid free and nano-capsule inhibit the growth of Ehrlich carcinoma. Mol Biol Rep. 46(3):3141–3148.
   PubMed Web of Science ®Google Scholar
• Rocamonde B, Paradells S, Barcia J, Barcia C, Verdugo JG, Miranda M, Gómez FR, Soria J. 2012. Neuroprotection of lipoic acid treatment promotes angiogenesis and reduces the glial scar formation after brain injury. Neuroscience. 224:102–115.
   PubMed Web of Science ®Google Scholar
• Ruiz-Larrea MB, Leal AM, Liza M, Lacort M, de Groot H. 1994. Antioxidant effects of estradiol and 2-hydroxyestradiol on iron-induced lipid peroxidation of rat liver microsomes. Steroids. 59(6):383–388.
   PubMed Web of Science ®Google Scholar
• Ruktanonchai U, Bejrapha P, Sakulkhu U, Opanasopit P, Bunyapraphatsara N, Junyaprasert V, Puttipipatkhachorn S. 2009. Physicochemical characteristics, cytotoxicity, and antioxidant activity of three lipid nanoparticulate formulations of alpha-lipoic acid. AAPS Pharmscitech. 10(1):227–234.
   PubMed Web of Science ®Google Scholar
• Saliq AM, Krishnaswami V, Janakiraman K, Kandasamy R. 2020. α-Lipoic acid nanocapsules fortified cow milk application as a dietary supplement product for anemia. Appl Nanosci. 10(6):2007–2023.
   Web of Science ®Google Scholar
• Satapathy MK, Yen T-L, Jan J-S, Tang R-D, Wang J-Y, Taliyan R, Yang C-H. 2021. Solid Lipid Nanoparticles (SLNs): an advanced drug delivery system targeting brain through BBB. Pharmaceutics. 13(8):1183.
   PubMed Web of Science ®Google Scholar
• Sharma D, Wani W, Sunkaria A, Kandimalla R, Sharma R, Verma D, Bal A, Gill K. 2016. Quercetin attenuates neuronal death against aluminum-induced neurodegeneration in the rat hippocampus. Neuroscience. 324:163–176.
   PubMed Web of Science ®Google Scholar
• Song G, Liu Z, Liu Q, Liu X. 2017. Lipoic acid prevents acrylamide-induced neurotoxicity in CD-1 mice and BV2 microglial cells via maintaining redox homeostasis. J Funct Foods. 35:363–375.
   Web of Science ®Google Scholar
• Taïr K, Kharoubi O, Taïr OA, Hellal N, Benyettou I, Aoues A. 2016. Aluminium-induced acute neurotoxicity in rats: treatment with aqueous extract of Arthrophytum (Hammada scoparia). J Acute Dis. 5(6):470–482.
   Web of Science ®Google Scholar
• Tan SH, Karri V, Tay NWR, Chang KH, Ah HY, Ng PQ, San Ho H, Keh HW, Candasamy M. 2019. Emerging pathways to neurodegeneration: dissecting the critical molecular mechanisms in Alzheimer’s disease, Parkinson’s disease. Biomed Pharmacother. 111:765–777.
   PubMed Web of Science ®Google Scholar
• Velasco-Rodríguez V, Cornejo-Mazón M, Flores-Flores J, Gutiérrez-López G, Hernández-Sánchez H. 2012. Preparation and properties of alpha-lipoic acid-loaded chitosan nanoparticles. Revista mexicana de ingeniería química. 11(1):155–161.
   Web of Science ®Google Scholar
• Verma P. 2018. Effect of alpha-lipoic acid and its Nano-formulation on streptozotocin induced diabetic neuropathy in Rats. Pharma Innov. 7(1):482–485.
   Google Scholar
• Vidovic B, Milasinovic N, Kotur-Stevuljevic J, Dilber S, Kalagasidis-Krusic M, Djordjevic B, Knezevic-Jugovic Z. 2016. Encapsulation of alpha-lipoic acid into chitosan and alginate/gelatin hydrogel microparticles and its in vitro antioxidant activity. Hem Ind. 70(1):49–58.
   Web of Science ®Google Scholar
• Wang K, Zhu X, Yu E, Desai P, Wang H, Zhang C-l, Zhuge Q, Yang J, Hu J. 2020. Therapeutic nanomaterials for neurological diseases and cancer therapy. J Nanomater. 2020:1–18.
   Web of Science ®Google Scholar
• Weerakody R, Fagan P, Kosaraju SL. 2008. Chitosan microspheres for encapsulation of alpha-lipoic acid. Int J Pharm. 357(1–2):213–218.
   PubMedGoogle Scholar
• Wilson B. 2009. Brain targeting PBCA nanoparticles and the blood-brain barrier. Nanomedicine. 4(5):499–502.
   PubMed Web of Science ®Google Scholar
• Wilson B, Samanta MK, Muthu MS, Vinothapooshan G. 2011. Design and evaluation of chitosan nanoparticles as novel drug carrier for the delivery of rivastigmine to treat Alzheimer’s disease. Ther Deliv. 2(5):599–609.
   PubMedGoogle Scholar
• Zaky A, Mohammad B, Moftah M, Kandeel KM, Bassiouny AR. 2013. Apurinic/apyrimidinic endonuclease 1 is a key modulator of aluminum-induced neuroinflammation. BMC Neurosci. 14(1):26–12.
   PubMedGoogle Scholar
• Zhao Y, Dang M, Zhang W, Lei Y, Ramesh T, Veeraraghavan VP, Hou X. 2020. Neuroprotective effects of Syringic acid against aluminium chloride induced oxidative stress mediated neuroinflammation in rat model of Alzheimer's disease. J Funct Foods. 71:104009.
   Web of Science ®Google Scholar