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Research Articles

The potential pharmacological mechanism of prunetin against osteoporosis: transcriptome analysis, molecular docking, and experimental approaches

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Pages 46-56 | Received 20 Jul 2023, Accepted 25 Aug 2023, Published online: 04 Sep 2023

References

  • An Y, Zhang H, Wang C, Jiao F, Xu H, Wang X, Luan W, Ma F, Ni L, Tang X, et al. 2019. Activation of ROS/MAPKs/NF-κB/NLRP3 and inhibition of efferocytosis in osteoclast-mediated diabetic osteoporosis. Faseb J. 33(11):12515–12527. doi: 10.1096/fj.201802805RR.
  • Bhargavan B, Gautam AK, Singh D, Kumar A, Chaurasia S, Tyagi AM, Yadav DK, Mishra JS, Singh AB, Sanyal S, et al. 2009. Methoxylated isoflavones, cajanin and isoformononetin, have non-estrogenic bone forming effect via differential mitogen activated protein kinase (MAPK) signaling. J Cell Biochem. 108(2):388–399. doi: 10.1002/jcb.22264.
  • Compston JE, McClung MR, Leslie WD. 2019. Osteoporosis. Lancet. 393(10169):364–376. doi: 10.1016/S0140-6736(18)32112-3.
  • Dong C, Fang Y, Shi J, Wang X, Liu Y, Zhao J, Gao X. 2021. Experimental study on prevention and treatment of postmenopausal osteoporosis by antioxidant stress of Mongolian medicine blue thorn regulating FoxO/Wnt/β-catenin pathway. Panminerva Med. doi: 10.23736/S0031-0808.21.04476-1.
  • Einhorn TA, Bogdan Y, Tornetta P. 3rd. 2014. Bisphosphonate-associated fractures of the femur: pathophysiology and treatment. J Orthop Trauma. 28(7):433–438. doi: 10.1097/BOT.0000000000000023.
  • Eisenhardt S, Fleckenstein J. 2016. Traditional Chinese medicine valuably augments therapeutic options in the treatment of climacteric syndrome. Arch Gynecol Obstet. 294(1):193–200. doi: 10.1007/s00404-016-4078-x.
  • Farias-Cisneros E, Hidalgo-Bravo A, Miranda-Duarte A, Casas-Ávila L, Rozental TD, Velázquez-Cruz R, Valdés-Flores M. 2020. COL1A1, CCDC170, and ESR1 single nucleotide polymorphisms associated with distal radius fracture in postmenopausal Mexican women. Climacteric. 23(1):65–74. doi: 10.1080/13697137.2019.1627313.
  • Garcia-Martinez R, Caraceni P, Bernardi M, Gines P, Arroyo V, Jalan R. 2013. Albumin: pathophysiologic basis of its role in the treatment of cirrhosis and its complications. Hepatology. 58(5):1836–1846. doi: 10.1002/hep.26338.
  • Gautam AK, Bhargavan B, Tyagi AM, Srivastava K, Yadav DK, Kumar M, Singh A, Mishra JS, Singh AB, Sanyal S, et al. 2011. Differential effects of formononetin and cladrin on osteoblast function, peak bone mass achievement and bioavailability in rats. J Nutr Biochem. 22(4):318–327. doi: 10.1016/j.jnutbio.2010.02.010.
  • Gupta A, Upadhyaya S, Cha T, Schwab J, Bono C, Hershman S. 2019. Serum albumin levels predict which patients are at increased risk for complications following surgical management of acute osteoporotic vertebral compression fractures. Spine J. 19(11):1796–1802. doi: 10.1016/j.spinee.2019.06.023.
  • Jing Z, Wang C, Yang Q, Wei X, Jin Y, Meng Q, Liu Q, Liu Z, Ma X, Liu K, et al. 2019. Luteolin attenuates glucocorticoid-induced osteoporosis by regulating ERK/Lrp-5/GSK-3β signaling pathway in vivo and in vitro. J Cell Physiol. 234(4):4472–4490. doi: 10.1002/jcp.27252.
  • Khan K, Pal S, Yadav M, Maurya R, Trivedi AK, Sanyal S, Chattopadhyay N. 2015. Prunetin signals via G-protein-coupled receptor, GPR30(GPER1): Stimulation of adenylyl cyclase and cAMP-mediated activation of MAPK signaling induces Runx2 expression in osteoblasts to promote bone regeneration. J Nutr Biochem. 26(12):1491–1501. doi: 10.1016/j.jnutbio.2015.07.021.
  • Khan K, Sharan K, Swarnkar G, Chakravarti B, Mittal M, Barbhuyan TK, China SP, Khan MP, Nagar GK, Yadav D, et al. 2013. Positive skeletal effects of cladrin, a naturally occurring dimethoxydaidzein, in osteopenic rats that were maintained after treatment discontinuation. Osteoporos Int. 24(4):1455–1470. doi: 10.1007/s00198-012-2121-8.
  • Kim B, Jo C, Choi HY, Lee K. 2018. Prunetin relaxed isolated rat aortic rings by blocking calcium channels. Molecules. 23(9):2372. doi: 10.3390/molecules23092372.
  • Kuete V, Nono EC, Mkounga P, Marat K, Hultin PG, Nkengfack AE. 2011. Antimicrobial activities of the CH2Cl2-CH3OH (1:1) extracts and compounds from the roots and fruits of Pycnanthus angolensis (Myristicaceae). Nat Prod Res. 25(4):432–443. doi: 10.1080/14786419.2010.522577.
  • Lane JM, Russell L, Khan SN. 2000. Osteoporosis. Clin Orthop Relat Res. 372(372):139–150. doi: 10.1097/00003086-200003000-00016.
  • Lemmon MA, Schlessinger J. 2010. Cell signaling by receptor tyrosine kinases. Cell. 141(7):1117–1134. doi: 10.1016/j.cell.2010.06.011.
  • Li M, Yu Y, Xue K, Li J, Son G, Wang J, Qian W, Wang S, Zheng J, Yang C, et al. 2023. Genistein mitigates senescence of bone marrow mesenchymal stem cells via ERRα-mediated mitochondrial biogenesis and mitophagy in ovariectomized rats. Redox Biol. 61:102649. doi: 10.1016/j.redox.2023.102649.
  • Lin X, Xiong D, Peng YQ, Sheng ZF, Wu XY, Wu XP, Wu F, Yuan LQ, Liao EY. 2015. Epidemiology and management of osteoporosis in the People’s Republic of China: current perspectives. Clin Interv Aging. 10:1017–1033. doi: 10.2147/CIA.S54613.
  • Liu J, Liu J, Tong X, Peng W, Wei S, Sun T, Wang Y, Zhang B, Li W. 2021. Network pharmacology prediction and molecular docking-based strategy to discover the potential pharmacological mechanism of huai hua san against ulcerative colitis. Drug Des Devel Ther. 15:3255–3276. doi: 10.2147/DDDT.S319786.
  • Liu WJ, Jiang ZM, Chen Y, Xiao PT, Wang ZY, Huang TQ, Liu EH. 2020. Network pharmacology approach to elucidate possible action mechanisms of Sinomenii Caulis for treating osteoporosis. J Ethnopharmacol. 257:112871. doi: 10.1016/j.jep.2020.112871.
  • Lu LY, Loi F, Nathan K, Lin TH, Pajarinen J, Gibon E, Nabeshima A, Cordova L, Jämsen E, Yao Z, et al. 2017. Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway. J Orthop Res. 35(11):2378–2385. doi: 10.1002/jor.23553.
  • Mondockova V, Adamkovicova M, Lukacova M, Grosskopf B, Babosova R, Galbavy D, Martiniakova M, Omelka R. 2018. The estrogen receptor 1 gene affects bone mineral density and osteoporosis treatment efficiency in Slovak postmenopausal women. BMC Med Genet. 19(1):174. doi: 10.1186/s12881-018-0684-8.
  • Muñoz M, Robinson K, Shibli-Rahhal A. 2020. Bone health and osteoporosis prevention and treatment. Clin Obstet Gynecol. 63(4):770–787. doi: 10.1097/GRF.0000000000000572.
  • Nogales C, Mamdouh ZM, List M, Kiel C, Casas AI, Schmidt H. 2022. Network pharmacology: curing causal mechanisms instead of treating symptoms. Trends Pharmacol Sci. 43(2):136–150. doi: 10.1016/j.tips.2021.11.004.
  • Nogués X, Martinez-Laguna D. 2018. Update on osteoporosis treatment. Med Clin (Barc). 150(12):479–486. doi: 10.1016/j.medcli.2017.10.019.
  • Ornitz DM. 2005. FGF signaling in the developing endochondral skeleton. Cytokine Growth Factor Rev. 16(2):205–213. doi: 10.1016/j.cytogfr.2005.02.003.
  • Ou L, Kang W, Liang Z, Gao F, Dong T, Wei P, Li M. 2021. Investigation of anti-osteoporosis mechanisms of rehmanniae radix preparata based on network pharmacology and experimental verification. J Orthop Surg Res. 16(1):599. doi: 10.1186/s13018-021-02751-5.
  • Patel K, Patel DK. 2022. The potential therapeutic properties of prunetin against human health complications: a review of medicinal importance and pharmacological activities. Drug Metab Bioanal Lett. 15(3):166–177. doi: 10.2174/2949681015666220912104743.
  • Rizzoli R, Reginster JY, Boonen S, Bréart G, Diez-Perez A, Felsenberg D, Kaufman JM, Kanis JA, Cooper C. 2011. Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis. Calcif Tissue Int. 89(2):91–104. doi: 10.1007/s00223-011-9499-8.
  • Roscioli T, Flanagan S, Kumar P, Masel J, Gattas M, Hyland VJ, Glass IA. 2000. Clinical findings in a patient with FGFR1 P252R mutation and comparison with the literature. Am J Med Genet. 93(1):22–28. doi: 10.1002/1096-8628(20000703)93:1<22::AID-AJMG5>3.0.CO;2-U.
  • Shang DP, Lian HY, Fu DP, Wu J, Hou SS, Lu JM. 2016. Relationship between estrogen receptor 1 gene polymorphisms and postmenopausal osteoporosis of the spine in Chinese women. Genet Mol Res. 15(2). doi: 10.4238/gmr.15028106.
  • Silverstein WK, Zipursky JS, Shadowitz S. 2021. Closing the osteoporosis care gap: a teachable moment. JAMA Intern Med. 181(12):1635–1636. doi: 10.1001/jamainternmed.2021.5972.
  • Srivastava M, Deal C. 2002. Osteoporosis in elderly: prevention and treatment. Clin Geriatr Med. 18(3):529–555. doi: 10.1016/s0749-0690(02)00022-8.
  • Su N, Jin M, Chen L. 2014. Role of FGF/FGFR signaling in skeletal development and homeostasis: learning from mouse models. Bone Res. 2(1):14003. doi: 10.1038/boneres.2014.3.
  • Sun J, Pan Y, Li X, Wang L, Liu M, Tu P, Wu C, Xiao J, Han Q, Da W, et al. 2022. Quercetin attenuates osteoporosis in orchiectomy mice by regulating glucose and lipid metabolism via the GPRC6A/AMPK/mTOR Signaling Pathway. Front Endocrinol. 13:849544. doi: 10.3389/fendo.2022.849544.
  • Tabatabaei-Malazy O, Salari P, Khashayar P, Larijani B. 2017. New horizons in treatment of osteoporosis. Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 25(1):2. doi: 10.1186/s40199-017-0167-z.
  • Tang Y, Yang P, Jin M, Huang S, Chen H, Chen L, Yang J, Su N. 2023. Fgfr1 deficiency in osteocytes leads to increased bone mass by enhancing Wnt/β-catenin signaling. Bone. 174:116817. doi: 10.1016/j.bone.2023.116817.
  • Vetrivel P, Kim SM, Ha SE, Kim HH, Bhosale PB, Senthil K, Kim GS. 2020. Compound prunetin induces cell death in gastric cancer cell with potent anti-proliferative properties: in vitro assay, molecular docking, dynamics, and ADMET studies. Biomolecules. 10(7):1086. doi: 10.3390/biom10071086.
  • Wu K, Han L, Zhao Y, Xiao Q, Zhang Z, Lin X. 2022. Deciphering the molecular mechanism underlying the effects of epimedium on osteoporosis through system bioinformatic approach. Medicine. 101(32):e29844. doi: 10.1097/MD.0000000000029844.
  • Xiang D, He J, Jiang T. 2018. The correlation between estrogen receptor gene polymorphism and osteoporosis in Han Chinese women. Eur Rev Med Pharmacol Sci. 22(23):8084–8090.
  • Xiao L, Zhong M, Huang Y, Zhu J, Tang W, Li D, Shi J, Lu A, Yang H, Geng D, et al. 2020. Puerarin alleviates osteoporosis in the ovariectomy-induced mice by suppressing osteoclastogenesis via inhibition of TRAF6/ROS-dependent MAPK/NF-κB signaling pathways. Aging. 12(21):21706–21729. doi: 10.18632/aging.103976.
  • Xie B, Wu J, Li Y, Wu X, Zeng Z, Zhou C, Xu D, Wu L. 2019. Geniposide alleviates glucocorticoid-induced inhibition of osteogenic differentiation in MC3T3-E1 cells by ERK pathway. Front Pharmacol. 10:411. doi: 10.3389/fphar.2019.00411.
  • Xie B, Zeng Z, Liao S, Zhou C, Wu L, Xu D. 2021. Kaempferol ameliorates the inhibitory activity of dexamethasone in the osteogenesis of MC3T3-E1 Cells by JNK and p38-MAPK pathways. Front Pharmacol. 12:739326. doi: 10.3389/fphar.2021.739326.
  • Xie Y, Su N, Yang J, Tan Q, Huang S, Jin M, Ni Z, Zhang B, Zhang D, Luo F, et al. 2020. FGF/FGFR signaling in health and disease. Signal Transduct Target Ther. 5(1):181. doi: 10.1038/s41392-020-00222-7.
  • Yang G, Ham I, Choi HY. 2013. Anti-inflammatory effect of prunetin via the suppression of NF-κB pathway. Food Chem Toxicol. 58:124–132. doi: 10.1016/j.fct.2013.03.039.
  • Yu F, Xia W. 2019. The epidemiology of osteoporosis, associated fragility fractures, and management gap in China. Arch Osteoporos. 14(1):32. doi: 10.1007/s11657-018-0549-y.
  • Zhang S, Shen S, Ma P, Fan D. 2022. Biochemical targets and molecular mechanism of ginsenoside compound k in treating osteoporosis based on network pharmacology. Int J Mol Sci. 23(22):13921. doi: 10.3390/ijms232213921.
  • Zhu H, Wang M, Zhao C, Li R, Yang J, Pei G, Ye T, Zuo X, Liu L, Chong Lee Shin OL, et al. 2018. GAG and collagen II attenuate glucocorticoid-induced osteoporosis by regulating NF-κB and MAPK signaling. Am J Trans Res. 10(6):1762–1772.

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