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Research Articles

Quercetin induces ferroptosis by inactivating mTOR/S6KP70 pathway in oral squamous cell carcinoma

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Pages 669-675 | Received 07 Dec 2023, Accepted 27 Feb 2024, Published online: 12 May 2024

References

  • Bayeva M, Khechaduri A, Puig S, Chang HC, Patial S, Blackshear PJ, Ardehali H. 2012. mTOR regulates cellular iron homeostasis through tristetraprolin. Cell Metab. 16(5):645–657. doi: 10.1016/j.cmet.2012.10.001.
  • Brown CW, Amante JJ, Chhoy P, Elaimy AL, Liu H, Zhu LJ, Baer CE, Dixon SJ, Mercurio AM. 2019. Prominin2 drives ferroptosis resistance by stimulating iron export. Dev Cell. 51(5):575–586.e4. doi: 10.1016/j.devcel.2019.10.007.
  • Bruning A. 2013. Inhibition of mTOR signaling by quercetin in cancer treatment and prevention. Anticancer Agents Med Chem. 13(7):1025–1031. doi: 10.2174/18715206113139990114.
  • Chamoli A, Gosavi AS, Shirwadkar UP, Wangdale KV, Behera SK, Kurrey NK, Kalia K, Mandoli A. 2021. Overview of oral cavity squamous cell carcinoma: risk factors, mechanisms, and diagnostics. Oral Oncol. 121:105451. doi: 10.1016/j.oraloncology.2021.105451.
  • Chen L, Xia JS, Wu JH, Chen YG, Qiu CJ. 2021. Quercetin suppresses cell survival and invasion in oral squamous cell carcinoma via the miR-1254/CD36 cascade in vitro. Hum Exp Toxicol. 40(9):1413–1421. doi: 10.1177/0960327121991912.
  • Cruz-Gregorio A, Aranda-Rivera AK. 2023. Quercetin and Ferroptosis. Life. 13(8):1730. doi: 10.3390/life13081730.
  • Dey S, Singh AK, Singh AK, Rawat K, Banerjee J, Agnihotri V, Upadhaya D. 2022. Critical pathways of oral squamous cell carcinoma: molecular biomarker and therapeutic intervention. Med Oncol. 39(3):30. doi: 10.1007/s12032-021-01633-4.
  • Droguett D, Castillo C, Leiva E, Theoduloz C, Schmeda-Hirschmann G, Kemmerling U. 2015. Efficacy of quercetin against chemically induced murine oral squamous cell carcinoma. Oncol Lett. 10(4):2432–2438. doi: 10.3892/ol.2015.3598.
  • Fadhil M, Singh R, Havas T, Jacobson I. 2022. Systematic review of head and neck lymphedema assessment. Head Neck. 44(10):2301–2315. doi: 10.1002/hed.27136.
  • Ghafouri-Fard S, Shoorei H, Khanbabapour Sasi A, Taheri M, Ayatollahi SA. 2021. The impact of the phytotherapeutic agent quercetin on expression of genes and activity of signaling pathways. Biomed Pharmacother. 141:111847. doi: 10.1016/j.biopha.2021.111847.
  • Hu M, Song HY, Chen L. 2023. Quercetin acts via the G3BP1/YWHAZ axis to inhibit glycolysis and proliferation in oral squamous cell carcinoma. Toxicol Mech Methods. 33(2):141–150. doi: 10.1080/15376516.2022.2103480.
  • Huang CF, Liu SH, Ho TJ, Lee KI, Fang KM, Lo WC, Liu JM, Wu CC, Su CC. 2022. Quercetin induces tongue squamous cell carcinoma cell apoptosis via the JNK activation-regulated ERK/GSK-3α/β-mediated mitochondria-dependent apoptotic signaling pathway. Oncol Lett. 23(3):78. doi: 10.3892/ol.2022.13198.
  • Jiang X, Stockwell BR, Conrad M. 2021. Ferroptosis: mechanisms, biology and role in disease. Nat Rev Mol Cell Biol. 22(4):266–282. doi: 10.1038/s41580-020-00324-8.
  • Koppula P, Zhuang L, Gan B. 2021. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy. Protein Cell. 12(8):599–620. doi: 10.1007/s13238-020-00789-5.
  • Lei G, Zhuang L, Gan B. 2022. Targeting ferroptosis as a vulnerability in cancer. Nat Rev Cancer. 22(7):381–396. doi: 10.1038/s41568-022-00459-0.
  • Li J, Li M, Li L, Ma J, Yao C, Yao S. 2022. Hydrogen sulfide attenuates ferroptosis and stimulates autophagy by blocking mTOR signaling in sepsis-induced acute lung injury. Mol Immunol. 141:318–327. doi: 10.1016/j.molimm.2021.12.003.
  • Niedzwiecki A, Roomi MW, Kalinovsky T, Rath M. 2016. Anticancer efficacy of polyphenols and their combinations. Nutrients. 8(9):552. doi: 10.3390/nu8090552.
  • Rauf A, Imran M, Khan IA, Ur-Rehman M, Gilani SA, Mehmood Z, Mubarak MS. 2018. Anticancer potential of quercetin: a comprehensive review. Phytother Res. 32(11):2109–2130. doi: 10.1002/ptr.6155.
  • Reyes-Farias M, Carrasco-Pozo C. 2019. The anti-cancer effect of quercetin: molecular implications in cancer metabolism. Int J Mol Sci. 20(13):3177. doi: 10.3390/ijms20133177.
  • Sekhar KR, Hanna DN, Cyr S, Baechle JJ, Kuravi S, Balusu R, Rathmell K, Baregamian N. 2022. Glutathione peroxidase 4 inhibition induces ferroptosis and mTOR pathway suppression in thyroid cancer. Sci Rep. 12(1):19396. doi: 10.1038/s41598-022-23906-2.
  • Shafabakhsh R, Asemi Z. 2019. Quercetin: a natural compound for ovarian cancer treatment. J Ovarian Res. 12(1):55. doi: 10.1186/s13048-019-0530-4.
  • Son HK, Kim D. 2023. Quercetin induces cell cycle arrest and apoptosis in YD10B and YD38 oral squamous cell carcinoma cells. Asian Pac J Cancer Prev. 24(1):283–289. doi: 10.31557/APJCP.2023.24.1.283.
  • Song X, Zhu S, Chen P, Hou W, Wen Q, Liu J, Xie Y, Liu J, Klionsky DJ, Kroemer G, et al. 2018. AMPK-mediated BECN1 phosphorylation promotes ferroptosis by directly blocking system Xc- activity. Curr Biol. 28(15):2388–2399.e5. doi: 10.1016/j.cub.2018.05.094.
  • Sun J, Pan Y, Li X, Wang L, Liu M, Tu P, Wu C, Xiao J, Han Q, Da W, et al. 2022. Quercetin attenuates osteoporosis in orchiectomy mice by regulating glucose and lipid metabolism via the GPRC6A/AMPK/mTOR signaling pathway. Front Endocrinol (Lausanne). 13:849544. doi: 10.3389/fendo.2022.849544.
  • Tan QL, Zhang MX, Yao DH, Yan Y, Yang XF, Qin ZH, Gong Y, Meng Q. 2023. TIGAR protects against adenine-induced ferroptosis in human proximal tubular epithelial cells by activating the mTOR/S6KP70 axis. Nutr Cancer. 4:1–9.
  • Wang L, Liu Y, Du T, Yang H, Lei L, Guo M, Ding HF, Zhang J, Wang H, Chen X, et al. 2020. ATF3 promotes erastin-induced ferroptosis by suppressing system Xc. Cell Death Differ. 27(2):662–675. doi: 10.1038/s41418-019-0380-z.
  • Xu D, Hu MJ, Wang YQ, Cui YL. 2019. Antioxidant activities of quercetin and its complexes for medicinal application. Molecules. 24(6):1123. doi: 10.3390/molecules24061123.
  • Xu H, Shen L, Chen X, Ding Y, He J, Zhu J, Wang Y, Liu X. 2016. mTOR/P70S6K promotes spermatogonia proliferation and spermatogenesis in Sprague Dawley rats. Reprod Biomed Online. 32(2):207–217. doi: 10.1016/j.rbmo.2015.11.007.
  • Yang Y, Chen D, Liu H, Yang K. 2019. Increased expression of lncRNA CASC9 promotes tumor progression by suppressing autophagy-mediated cell apoptosis via the AKT/mTOR pathway in oral squamous cell carcinoma. Cell Death Dis. 10(2):41. doi: 10.1038/s41419-018-1280-8.
  • Zhang C, Hao Y, Sun Y, Liu P. 2019. Quercetin suppresses the tumorigenesis of oral squamous cell carcinoma by regulating microRNA-22/WNT1/β-catenin axis. J Pharmacol Sci. 140(2):128–136. doi: 10.1016/j.jphs.2019.03.005.
  • Zhang L, Liu W, Liu F, Wang Q, Song M, Yu Q, Tang K, Teng T, Wu D, Wang X, et al. 2020. IMCA induces ferroptosis mediated by SLC7A11 through the AMPK/mTOR pathway in colorectal cancer. Oxid Med Cell Longev. 2020:1675613–1675612. doi: 10.1155/2020/1675613.

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