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Data Note

Fifteen day repeat air: liquid Interface air-only exposures can cause respiratory epithelium injury in MucilAir nasal respiratory epithelial cells that parallels chemically induced cytotoxicity

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Received 01 Apr 2024, Accepted 16 Jul 2024, Published online: 30 Jul 2024

References

  • Braakhuis HM, Gremmer ER, Bannuscher A, Drasler B, Keshavan S, Rothen-Rutishauser B, Birk B, Verlohner A, Landsiedel R, Meldrum K, et al. 2023. Transferability and reproducibility of exposed air-liquid interface co-culture lung models. NanoImpact. 31:100466. doi:10.1016/j.impact.2023.100466.
  • Cao X, Coyle JP, Xiong R, Wang Y, Heflich RH, Ren B, Gwinn WM, Hayden P, Rojanasakul L. 2021. Invited review: human air-liquid-interface organotypic airway tissue models derived from primary tracheobronchial epithelial cells-overview and perspectives. In Vitro Cell Dev Biol Anim. 57(2):104–132. doi:10.1007/s11626-020-00517-7.
  • Dixon D, Herbert RA, Kissling GE, Brix AE, Miller RA, Maronpot RR. 2008. Apr Summary of chemically induced pulmonary lesions in the National Toxicology Program (NTP) toxicology and carcinogenesis studies. Toxicol Pathol. 36(3):428–439. doi:10.1177/0192623308315360.
  • Hargrove MM, Parr-Dobrzanski B, Li L, Constant S, Wallace J, Hinderliter P, Wolf DC, Charlton A. 2021. Use of the Mucilair airway assay, a new approach methodology, for evaluating the safety and inhalation risk of agrochemicals. Appl In Vitro Toxicol. 7(2):50–60. doi:10.1089/aivt.2021.0005.
  • Hayes A, Bakand S. 2010. Inhalation toxicology. In: Luch A, editor. Molecular, clinical, and environmental toxicology: volume 2: clinical toxicology. Basel: Birkhäuser Basel; p. 461–488.
  • Holmström M, Wilhelmsson B, Hellquist H. 1989. Histological changes in the nasal mucosa in rats after long-term exposure to formaldehyde and wood dust. Acta Otolaryngol. 108(3–4):274–283.
  • Leikauf GD. 2015. Chapter 15: “Toxic responses of the respiratory system”. In: Klaassen CD, WatkinsIIIJB, editors. Casarett & Doull’s essentials of toxicology. 3rd ed. New York: McGraw Hill.
  • Meyerholz DK, Suarez CJ, Dintzis AM, Frevert CW. 2017. In: Respiratory system” comparative anatomy and histology a mouse, rat, and human atlas. 2nd ed. Treuting PM, Dintzis SM, Montine KS, editors. New York: Academic Press.
  • Monticello T M, Morgan KT, Uraih L. 1990. Nonneoplastic nasal lesions in rats and mice. Environ Health Perspect. 85:249–274.
  • Moreau M, Fisher J, Andersen ME, Barnwell A, Corzine S, Ranade A, McMullen PD, Slattery SD. 2022. NAM-based prediction of point-of-contact toxicity in the lung: a case example with 1,3-dichloropropene. Toxicology. 481:153340.
  • Moura JA, Meldrum K, Doak SH, Clift MJD. 2023. Alternative lung cell model systems for toxicology testing strategies: current knowledge and future outlook. Semin Cell Dev Biol. 147:70–82. doi:10.1016/j.semcdb.2022.12.006.
  • National Academies of Sciences, Engineering, and Medicine. 2022. New approach methods (NAMs) for human health risk assessment: proceedings of a workshop–in brief. Washington, DC: The National Academies Press. doi:10.17226/26496.
  • National Research Council. 2007. Toxicity testing in the 21st century: a vision and a strategy. Washington, DC: The National Academies Press.
  • OECD. 2018. Test no. 408: repeated dose 90-day oral toxicity study in rodents, OECD guidelines for the testing of chemicals, Section 4. Paris: OECD Publishing.
  • Patel VS, Amin K, Wahab A, Marimoutou M, Ukishima L, Alvarez J, Battle K, Stucki AO, Clippinger AJ, Behrsing HP. 2023. Cryopreserved human precision-cut lung slices provide an immune competent pulmonary test system for "on-demand" use and long-term cultures. Toxicol Sci. 191(2):253–265. PMID: 36617185; PMCID: PMC9936202. doi:10.1093/toxsci/kfac136.
  • Paudel I, Barutcu AR, Samuel R, Moreau M, Slattery SD, Scaglione J, Recio L. 2023. Increasing confidence in new approach methodologies for inhalation risk assessment with multiple end point assays using 5-day repeated exposure to 1,3-dichloropropene. Toxicology. 499:153642. doi:10.1016/j.tox.2023.153642.
  • Ramanarayanan T, Szarka A, Flack S, Hinderliter P, Corley R, Charlton A, Pyles S, Wolf D. 2022. Application of a new approach method (NAM) for inhalation risk assessment. Regul Toxicol Pharmacol. 133:105216. doi:10.1016/j.yrtph.2022.105216.
  • Schmeisser S, Miccoli A, von Bergen M, Berggren E, Braeuning A, Busch W, Desaintes C, Gourmelon A, Grafström R, Harrill J, et al. 2023. New approach methodologies in human regulatory toxicology - not if, but how and when!. Environ Int. 178:108082. Epub 2023 Jul 4. PMID: 37422975; PMCID: PMC10858683. doi:10.1016/j.envint.2023.108082.
  • Singh AV, Romeo A, Scott K, Wagener S, Leibrock L, Laux P, Luch A, Kerkar P, Balakrishnan S, Dakua SP, et al. 2021. Emerging technologies for in vitro inhalation toxicology. Adv Healthcare Mater. 10(18):2100633. doi:10.1002/adhm.202100633.
  • Stucki AO, Barton-Maclaren TS, Bhuller Y, Henriquez JE, Henry TR, Hirn C, Miller-Holt J, Nagy EG, Perron MM, Ratzlaff DE, et al. 2022. Use of new approach methodologies (NAMs) to meet regulatory requirements for the assessment of industrial chemicals and pesticides for effects on human health. Front Toxicol. 4:964553. doi:10.3389/ftox.2022.964553.
  • US EPA. 2023. Trifluoro(trifluoromethyl)oxirane order under section 4 of the toxic substances control act (TSCA) January 4, 2023. In vitro respiratory tract epithelial toxicity in primary human cell culture (see Appendix E).
  • Vitucci ECM, Simmons AE, Martin EM, McCullough SD. 2024. Epithelial MAPK signaling directs endothelial NRF2 signaling and IL-8 secretion in a tri-culture model of the alveolar-microvascular interface following diesel exhaust particulate (DEP) exposure. Part Fibre Toxicol. 21(1):15. doi:10.1186/s12989-024-00576-8.