Mitochondrial DNA in Tumors

References

• Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich, D. P., Roe, B. A., Sanger, F., Schreier, P. H., Smith, A. J., Staden, R., and Young, I. G. 1981. Sequence and organization of the human mitochondrial genome. Nature 290:457–465.
   PubMed Web of Science ®Google Scholar
• Amuthan, G., Biswas, G., Ananadatheerthavarada, H. K., Vijayasarathy, C., Shephard, H. M., and Avadhani, N. G. 2002. Mitochondrial stress-induced calcium signaling, phenotypic changes and invasive behavior in human lung carcinoma A549 cells. Oncogene 21:7839–7849.
   PubMedGoogle Scholar
• Baysal, B. E., Ferrell, R. E., Willett-Brozick, J. E., Lawrence, E. C., Myssiorek, D., Bosch, A., van der Mey, A., Taschner, P. E., Rubinstein, W.S., Myers, E.N., Richard, C. W., Cornelisse, C. J., Devilee, P., and Devlin, B. 2000. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 287:848–851.
   PubMed Web of Science ®Google Scholar
• Carelli, V., Giordano, C., and d’Amati, G. 2003. Pathogenic expression of homoplasmic mtDNA mutations needs a complex nuclear-mitochondrial interaction. Trends Genet. 19:257–262.
   PubMed Web of Science ®Google Scholar
• Carew, J. S., and Huang, P. 2002. Mitochondrial defects in cancer. Mol. Cancer 1:9.
   Google Scholar
• Cavalli, L. R., Varella-Garcia, M., and Liang, B. C. 1997. Diminished tumorigenic phenotype after depletion of mitochondrial DNA. Cell Growth Differ. 8:1189–1198.
   PubMedGoogle Scholar
• Chester, K. A., Robson, L., Begent, R. H., Pringle, H., Primrose, L., Talbot, I. C., Macpherson, A. J., Owen, S. L., Boxer, G., and Malcolm, A. D. 1990. In situ and slot hybridization analysis of RNA in colorectal tumours and normal colon shows distinct distributions of mitochondrial sequences. J. Pathol. 162:309–315.
   PubMed Web of Science ®Google Scholar
• Chinnery, P. F., Howell, N., Lightowlers, R. N., and Turnbull, D. M. 1997. Molecular pathology of MELAS and MERRF: the relationship between mutation load and clinical phenotypes. Brain 120:1713–1721.
   PubMedGoogle Scholar
• Chomyn, A., and Attardi, G. 2003. MtDNA mutations in aging and apoptosis. Biochem. Biophys. Res. Commun. 304:519–529.
   PubMed Web of Science ®Google Scholar
• Coller, H. A., Khrapko, K., Bodyak, N. D., Nekhaeva, E., Herrero-Jimenez, P., and Thilly, W. G. 2001. High frequency of homoplasmic mitochondrial DNA mutations in human tumors can be explained without selection. Nat. Genet. 28:147–150.
   PubMed Web of Science ®Google Scholar
• Fliss, M. S., Usadel, H., Caballero, O. L., Wu, L., Buta, M. R., Eleff, S. M., Jen, J., and Sidransky, D. 2000. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids. Science 287:2017–2019.
   PubMed Web of Science ®Google Scholar
• Gimm, O., Armanios, M., Dziema, H., Neumann, H. P., and Eng, C. 2000. Somatic and occult germ-line mutations in SDHD, a mitochondrial complex II gene, in nonfamilial pheochromocytoma. Cancer Res. 60:6822–6825.
   PubMed Web of Science ®Google Scholar
• Goto, Y., Tojo, M., Tohyama, J., Horai, S., and Nonaka, I. 1992. A novel point mutation in the mitochondrial tRNALeu(UUR) gene in a family with mitochondrial myopathy. Ann. Neurol. 31:672–675.
   PubMedGoogle Scholar
• Habano, W., Sugai, T., Yoshida, T., and Nakamura, S. 1999. Mitochondrial gene mutation, but not large-scale deletion, is a feature of colorectal carcinomas with mitochondrial microsatellite instability. Int. J. Cancer 83:625–629.
   PubMed Web of Science ®Google Scholar
• Hayashi, J., Takemitsu, M., and Nonaka, I. 1992. Recovery of the missing tumorigenicity in mitochondrial DNA-less HeLa cells by introduction of mitochondrial DNA from normal human cells. Somat. Cell. Mol. Genet. 18:123–129.
   PubMedGoogle Scholar
• Holme, E., Larsson, N. G., Oldfors, A., Tulinius, M., Sahlin, P., and Stenman, G. 1993. Multiple symmetric lipomas with high levels of mtDNA with the tRNALys A-G (8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. Am. J. Hum. Genet. 52:551–556.
   PubMedGoogle Scholar
• Jeronimo, C., Nomoto, S., Caballero, O. L., Usadel, H., Henrique, R., Varzim, G., Oliveira, J., Lopes, C., Fliss, M. S., and Sidransky, D. 2001. Mitochondrial mutations in early stage prostate cancer and bodily fluids. Oncogene 20:5195–5198.
   PubMed Web of Science ®Google Scholar
• Johns, D. R., and Berman, J. 1991. Alternative, simultaneous complex I mitochondrial DNA mutations in Leber’s hereditary optic neuropathy. Biochem. Biophys.Res. Comm. 174:1324–1330.
   PubMed Web of Science ®Google Scholar
• Jones, J. B., Song, J. J., Hempen, P. M., Parmigiani, G., Hruban, R. H., and Kern, S. E. 2001. Detection of mitochondrial DNA mutations in pancreatic cancer offers a “mass”-ive advantage over detection of nuclear DNA mutations. Cancer Res. 61:1299–1304.
   PubMed Web of Science ®Google Scholar
• King, M. P., Koga, Y., Davidson, M., and Schon, E. A. 1992. Defects in mitochondrial protein synthesis and respiratory chain activity segregate with the tRNALeu(UUR) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. Mol. Cell. Biol. 12:480–490.
   PubMed Web of Science ®Google Scholar
• Kirches, E., Krause, G., Warich-Kirches, M., Weis, S., Schneider, T., Meyer-Puttlitz, B., Mawrin, C., and Dietzmann, K. 2001. High frequency of mitochondrial DNA mutations in glioblastoma multiforme identified by direct sequence comparison to blood samples. Int. J. Cancer. 93:534–538.
   PubMed Web of Science ®Google Scholar
• Lightowlers, R. N., Chinnery, P. F., Turnbull, D. M., and Howell, N. 1997. Mammalian mitochondrial genetics: heredity, heteroplasmy and disease. Trends Genet. 13:450–455.
   PubMed Web of Science ®Google Scholar
• Liu, V. W., Shi, H. H., Cheung, A. N., Chiu, P. M., Leung, T. W., Nagley, P., Wong, L. C., and Ngan, H. Y. 2001. High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas. Cancer Res. 61:5998–6001.
   PubMed Web of Science ®Google Scholar
• Lorenc, A., Bryk, J., Golik, P., Kupryjańczyk, J., Ostrowski, J., Pronicki, M., Semczuk, A., Szołkowska, M., and Bartnik, E. 2003. Homoplasmic MELAS A3243G mtDNA mutation in a colon cancer sample. Mitochondrion 2:119–124.
   Google Scholar
• Luciakova, K., and Kuzela, S. 1992. Increased steady-state levels of several mitochondrial and nuclear gene transcripts in rat hepatoma with a low content of mitochondria. Eur. J. Biochem. 205:1187–1193.
   PubMedGoogle Scholar
• Mariotti, C., Tiranti, V., Carrara, F., Dallapiccola, B., DiDonato, S., and Zeviani, M. 1994. Defective respiratory capacity and mitochondrial protein synthesis in transformant cybrids harboring the tRNALeu(UUR) mutation associated with maternally inherited myopathy and cardiomyopathy. J. Clin.învest. 93:1102–1107.
   PubMedGoogle Scholar
• Maximo, V., Soares, P., Machado, J. C., Seruca, R., and Sobrinho-Simoes, M. 2000. Mitochondrial DNA alteration in gastric cancer. Gastroenterology 119:1808–1809.
   PubMed Web of Science ®Google Scholar
• McClintock, D. S., Santore, M. T., Lee, V. Y., Brunelle, J., Budinger, G. R., Zong, W. X., Thompson, C. B., Hay, N., and Chandel, N. S. 2002. Bcl-2 family members and functional electron transport chain regulate oxygen deprivation- induced cell death. Mol. Cell. Biol. 22:94–104.
   PubMed Web of Science ®Google Scholar
• Mitsui, T., Kawai, H., Nagasawa, M., Kunishige, M., Akaike, M., Kimura, Y., and Saito, S. 1996. Oxidative damage to skeletal muscle DNA from patients with mitochondrial encephalomyopathies. J. Neurol. Sci. 139:111–116.
   PubMedGoogle Scholar
• Modica-Napolitano, J. S., and Aprille, J. R. 2001. Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells. Adv. Drug. Deliv. Rev. 49:63–70.
   PubMed Web of Science ®Google Scholar
• Modica-Napolitano, J. S., and Singh, K. K. 2002. Mitochondria as targets for detection and treatment of cancer. Exp. Rev. Mol. Med. 11 April, http://www-ermm.cbcu.cam.ac.uk/02004453h.htm.
   PubMedGoogle Scholar
• Morais, R., Zinkewich-Peotti, K., Parent, M., Wang, H., Babai, F., and Zollinger, M. 1994. Tumor-forming ability in athymic nude mice of human cell lines devoid of mitochondrial DNA. Cancer Res. 54:3889–3896.
   PubMed Web of Science ®Google Scholar
• Nekhaeva, E., Bodyak, N. D., Kraytsberg, Y., McGrath, S. B., Van Orsouw, N. J., Pluzhnikov, A., Wei, J. Y., Vijg, J., and Khrapko, K. 2002. Clonally expanded mtDNA point mutations are abundant in individual cells of human tissues. Proc. Natl. Acad. Sci. USA 99:5521–5526.
   PubMed Web of Science ®Google Scholar
• Nomoto, S., Yamashita, K., Koshikawa, K., Nakao, A., and Sidransky, D. 2002. Mitochondrial D-loop mutations as clonal markers in multicentric hepatocellular carcinoma and plasma. Clin. Cancer Res. 8:481–487.
   PubMed Web of Science ®Google Scholar
• Parrella, P., Xiao, Y., Fliss, M., Sanchez-Cespedes, M., Mazzarelli, P., Rinaldi, M., Nicol, T., Gabrielson, E., Cuomo, C., Cohen, D., Pandit, S., Spencer, M., Rabitti, C., Fazio, V. M., and Sidransky, D. 2001. Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates. Cancer Res. 61:7623–7626.
   PubMed Web of Science ®Google Scholar
• Polyak, K., Li, Y., Zhu, H., Lengauer, C., Willson, J. K., Markowitz, S. D., Trush, M. A., Kinzler, K. W., and Vogelstein, B. 1998. Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat. Genet. 20:291–293.
   PubMed Web of Science ®Google Scholar
• Pulselli, R., Amadio, L., Fanciulli, M., and Floridi, A. 1996. Effect of lonidamine on the mitochondrial potential in situ in Ehrlich ascites tumor cells. Anticancer Res. 16:419–423.
   PubMedGoogle Scholar
• Sanchez-Cespedes, M., Parrella, P., Nomoto, S., Cohen, D., Xiao, Y., Esteller, M., Jeronimo, C., Jordan, R. C., Nicol, T., Koch, W. M., Schoenberg, M., Mazzarelli, P., Fazio, V. M., and Sidransky, D. 2001. Identification of a mononucleotide repeat as a major target for mitochondrial DNA alterations in human tumors. Cancer Res. 61:7015–7019.
   PubMed Web of Science ®Google Scholar
• Savagner, F., Franc, B., Guyetant, S., Rodien, P., Reynier, P., and Malthiery, Y. 2001. Defective mitochondrial ATP synthesis in oxyphilic thyroid tumors. J. Clin. Endocrinol. Metab. 86:4920–4925.
   PubMed Web of Science ®Google Scholar
• Sharp, M. G., Adams, S. M., Walker, R. A., Brammar, W. J., and Varley, J. M. 1992. Differential expression of the mitochondrial gene cytochrome oxidase II in benign and malignant breast tissue. J. Pathol. 168:163–168.
   PubMed Web of Science ®Google Scholar
• Silvestri, G., Moraes, C.T., Shanske, S., Oh, S. J., and DiMauro, S. 1992. Anew mtDNA mutation in the tRNA(Lys) gene associated with myoclonic epilepsy and ragged-red fibers (MERRF). Am. J. Hum. Genet. 51:1213–1217.
   PubMedGoogle Scholar
• Silvestri, G., Rana, M., DiMuzio, A., Uncini, A., Tonali, P., and Servidei, S. 1998. A late-onset mitochondrial myopathy is associated with a novel mtDNApoint mutation in the tRNA(Trp) gene. Neuromuscul. Disord. 8:291–295.
   PubMed Web of Science ®Google Scholar
• Simonnet, H., Alazard, N., Pfeiffer, K., Gallou, C., Beroud, C., Demont, J., Bouvier, R., Schagger, H., and Godinot, C. 2002. Low mitochondrial respiratory chain content correlates with tumor aggressiveness in renal cell carcinoma. Carcinogenesis 23:759–768.
   PubMed Web of Science ®Google Scholar
• Singh, K. K., Russell, J., Sigala, B., Zhang, Y., Williams, J., and Keshav, K. F. 1999. Mitochondrial DNA determines the cellular response to cancer therapeutic agents. Oncogene 18:6641–6646.
   PubMed Web of Science ®Google Scholar
• Tomlinson, I. P., Alam, N. A., Rowan, A. J., Barclay, E., Jaeger, E. E., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R. R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R. S., Kiuru, M., Lehtonen, R., Karhu, A., Vilkki, S., Laiho, P., Eklund, C., Vierimaa, O., Aittomaki, K., Hietala, M., Sistonen, P., Paetau, A., Salovaara, R., Herva, R., Launonen, V, and Aaltonen, L. A. 2002. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat. Genet. 30:406–410.
   PubMed Web of Science ®Google Scholar
• Warburg, O. 1930. Metabolism of Tumours. London, UK: Arnold Constable.
   Google Scholar
• Warburg, O. 1956. On the origin of cancer cells. Science 123:309–314.
   PubMed Web of Science ®Google Scholar
• Wei, Y. H., Lee, C. F., Lee, H. C., Ma, Y. S., Wang, C. W., Lu, C. Y., and Pang, C. Y. 2001. Increases of mitochondrial mass and mitochondrial genome in association with enhanced oxidative stress in human cells harboring 4,977 BP-deleted mitochondrial DNA. Ann. N.Y. Acad. Sci. 928:97–112.
   PubMed Web of Science ®Google Scholar
• Welter, C., Kovacs, G., Seitz, G., and Blin, N. 1989. Alteration of mitochondrial DNA in human oncocytomas. Genes Chromosomes Cancer 1:79–82.
   PubMed Web of Science ®Google Scholar
• Yeh, J. J., Lunetta, K. L., van Orsouw, N. J., Moore, F. D., Jr., Mutter, G. L., Vijg, J., Dahia, P. L., and Eng, C. 2000. Somatic mitochondrial DNA (mtDNA) mutations in papillary thyroid carcinomas and differential mtDNA sequencevariants incases withthyroidtumours. Oncogene 19:2060–2066.
   PubMed Web of Science ®Google Scholar