Social and Behavioral Challenges of HIV Vaccines: Implications for Social Work and Social Science

REFERENCES

• AIDS Vaccine Advocacy Coalition . ( 2008, March 26 ). A call for accuracy, a call for respect. Retrieved August 4, 2009, from http://www.avac.org/pdf/summit_commentary_mar2008.pdf
   Google Scholar
• Allen , M. , & Lau , C.-Y. ( 2008 ). Social impact of preventive HIV vaccine clinical trial participation: A model of prevention, assessment and intervention . Social Science & Medicine , 66 ( 4 ), 945 – 951 . doi:10.1016/j.socscimed.2007.10.019
   PubMed Web of Science ®Google Scholar
• Bartholow , B. N. , Buchbinder , S. , Celum , C. , Goli , V. , Koblin , B. , et al. . ( 2005 ). HIV sexual risk behavior over 36 months of follow-up in the world's first HIV vaccine efficacy trial . Journal of Acquired Immune Deficiency Syndromes , 39 , 90 – 101 .
   PubMed Web of Science ®Google Scholar
• Belshe , R. B. , Clements , M. L. , Keefer , M. C. , Graham , B. S. , Corey , L. , et al. . ( 1994 ). Interpreting HIV serodiagnostic test results in the 1990's: Social risks of HIV vaccine studies in uninfected volunteers . Annals of Internal Medicine , 121 , 584 – 589 .
   PubMed Web of Science ®Google Scholar
• Buchbinder , S. , Mehrotra , D. , Duerr , A. , Fitzgerald , D. , Mogg , R. , et al. . ( 2008 ). Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the step study): A double-blind, randomised, placebo-controlled, test-of-concept trial . Lancet , 372 ( 9653 ), 1881 – 1893 .
   PubMed Web of Science ®Google Scholar
• Buchbinder , S. P. , Metch , B. , Holte , S. E. , Scheer , S. , Coletti , A. , & Vittinghoff , E. ( 2004 ). Determinants of enrollment in a preventive HIV vaccine trial . Journal of Acquired Immune Deficiency Syndromes , 36 , 604 – 612 .
   PubMed Web of Science ®Google Scholar
• Cassell , M. M. , Halperin , D. T. , Shelton , J. D. , & Stanton , D. ( 2006 ). Risk compensation: The Achilles' heel of innovations in HIV prevention ? British Medical Journal , 332 , 605 – 607 .
   PubMed Web of Science ®Google Scholar
• Centers for Disease Control and Prevention . ( 2006 ). HIV/AIDS Surveillance Report: Cases of HIV infection and AIDS in the United States and dependent areas . Retrieved August 4, 2009, from http://www.cdc.gov/hiv/topics/surveillance/resources/reports/2006report/pdf/2006SurveillanceReport.pdf
   Google Scholar
• Chesney , M. A. , Chambers , D. B. , & Kahn , J. O. ( 1997 ). Risk behavior for HIV infection in participants in preventive HIV vaccine trials: A cautionary note . Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology , 16 ( 4 ), 266 – 271 .
   PubMedGoogle Scholar
• Chesney , M. A. , Lurie , P. , & Coates , T. J. (1995). Strategies for addressing the social and behavioral challenges of prophylactic HIV vaccine trials. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology , 9(1), 30–35.
   PubMedGoogle Scholar
• Choopanya , K. , Des Jarlais , D. C. , Vanichseni , S. , Kitayaporn , D. , Mock , P. A. , et al. . ( 2002 ). Incarceration and risk for HIV infection among rejection drug users in Bangkok . Journal of Acquired Immune Deficiency Syndromes , 29 ( 1 ), 86 – 94 .
   PubMed Web of Science ®Google Scholar
• Chua , A. , Ford , N. , Wilson , D. , & Cawthorne , P. ( 2005 ). The Tenofovir pre-exposure prophylaxis trial in Thailand: Researchers should show more openness in their engagement with the community . Public Library of Science: Medicine , 2 ( 10 ), e346 .
   Google Scholar
• Ciaranello , A. L. , Walensky , R. P. , Sax , P. E. , Chang , Y. , Freedberg , K. A. , & Weissman , J. S. ( 2009 ). Access to medications and medical care after participation in HIV clinical trials: A systematic review of trial protocols and informed consent documents . HIV Clinical Trials , 10 ( 1 ), 13 – 24 .
   PubMed Web of Science ®Google Scholar
• Cohen , J. ( 2003 ). HIV/AIDS. Vaccine results lose significance under scrutiny . Science , 299 ( 5612 ), 1495 .
   PubMed Web of Science ®Google Scholar
• Crepaz , N. , Hart , T. A. , & Marks , G. ( 2004 ). Highly active antiretroviral therapy and sexual risk behavior: A meta-analytic review . Journal of the American Medical Association , 292 ( 2 ), 224 – 236 .
   PubMed Web of Science ®Google Scholar
• Diaz , T. , Chu , S. Y. , Buehler , J. W. , Boyd , D. , Checko , P. J. , & et al. . ( 1994 ). Socioeconomic differences among people with AIDS: Results from a multistate surveillance project . American Journal of Preventive Medicine , 10 , 217 – 222 .
   PubMed Web of Science ®Google Scholar
• Dickert , N. , Emanuel , E. , & Grady , C. ( 2002 ). Paying research subjects: An analysis of current policies . Annals of Internal Medicine , 136 , 368 – 373 .
   PubMed Web of Science ®Google Scholar
• Dickert , N. , & Sugarman , J. ( 2005 ). Ethical goals of community consultation in research . American Journal of Public Health , 95 ( 7 ), 1123 – 1127 .
   PubMed Web of Science ®Google Scholar
• Epstein , S. ( 1995 ). The construction of lay expertise: AIDS activism and the forging of credibility in the reform of clinical trials . Science, Technology & Human Values , 20 ( 4 ), 408 – 437 .
   PubMed Web of Science ®Google Scholar
• Esparza , J. , Osmanov , S. , Pattou-Markovic , C. , Touré , C. , Chang , M.-L. , & Nixon , S. ( 2002 ). Past, present and future of HIV vaccine trials in developing countries . Vaccine , 20 , 1897 – 1898 .
   PubMed Web of Science ®Google Scholar
• Excler , J.-L. ( 2003 ). HIV vaccine development in Asia . Journal of Health Management , 5 ( 2 ), 327 – 341 .
   Google Scholar
• Fauci , A. S. , Johnston , M. I. , Dieffenbach , C. W. , Burton , D. R. , Hammer , S. M. , et al. . ( 2008 ). HIV vaccine research: The way forward . Science , 321 , 530 – 532 .
   PubMed Web of Science ®Google Scholar
• Fee , E. , & Krieger , N. ( 1993 ). Understanding AIDS: Historical interpretations and the limits of biomedical individualism . American Journal of Public Health , 83 , 1477 – 1486 .
   PubMed Web of Science ®Google Scholar
• Flory , J. , & Emanuel , E. ( 2004 ). Interventions to improve research participants’ understanding in informed consent for research: A systematic review . Journal of the American Medical Association , 292 , 1593 – 1601 .
   PubMed Web of Science ®Google Scholar
• Francis , D. P. , Heyward , W. L. , Popovic , V. , Orozo-Cronin , P. , Orelind , K. , et al. . ( 2003 ). Candidate HIV/AIDS vaccines: Lessons learned from the world's first phase III efficacy trials . AIDS , 17 , 147 – 156 .
   PubMed Web of Science ®Google Scholar
• Gifford , A. L. , Cunningham , W. E. , Heslin , K. C. , Anderson , R. M. , Nakazono , T. , et al.. (2002). Participation in research and access to experimental treatments by HIV-infected patients. New England Journal of Medicine , 346(18), 1373–1382.
   PubMed Web of Science ®Google Scholar
• Guenter , D. , Esparza , J. , & Macklin , R. ( 2000 ). Ethical considerations in international HIV vaccine trials: Summary of a consultative process conducted by the Joint United Nations Programme on HIV/AIDS (UNAIDS) . Journal of Medical Ethics , 26 , 37 – 43 .
   PubMed Web of Science ®Google Scholar
• Gust , D. A. , Wiegand , R. E. , Para , M. , Chen , R. T. , & Bartholow , B. N. ( 2009 ). HIV testing outside of the study among men who have sex with men participating in an HIV vaccine efficacy trial . Journal of Acquired Immune Deficiency Syndromes , Epub ahead of print .
   Google Scholar
• Hall , H. I. , Song , R. , Rhodes , P. , Prejean , J. , An , Q. , et al. . ( 2008 ). Estimation of HIV incidence in the United States . Journal of the American Medical Association , 300 ( 5 ), 520 – 529 .
   PubMed Web of Science ®Google Scholar
• Haynes , B. ( 1993 ). Scientific and social issues of human immunodeficiency virus vaccine development . Science , 260 , 1279 – 1286 .
   PubMed Web of Science ®Google Scholar
• Herek , G. M. , Capitanio , J. P. , & Widaman , K. F. ( 2003 ). Stigma, social risk, and health policy: Public attitudes toward HIV surveillance policies and the social construction of illness . Health Psychology , 22 ( 5 ), 533 – 540 .
   PubMed Web of Science ®Google Scholar
• Hu , D. J. , Vitek , C. R. , Bartholow , B. , & Mastro , T. D. ( 2003 ). Key issues for a potential human immunodeficiency virus vaccine . Clinical Infectious Diseases , 36 , 638 – 644 .
   Google Scholar
• Institute of Medicine . ( 2008 ). Methodological challenges in biomedical HIV prevention trials . Washington , DC : The National Academies Press .
   Google Scholar
• International AIDS Vaccine Initiative . ( 2009 ). IAVI Database of AIDS vaccines in human trials. Special Features. Retrieved September 3, 2009, from http://www.iavireport.org/trialsdb/
   Google Scholar
• Irvine , J. M. ( 2002 ). Talk about sex: The battles over sex education in the United States . Berkeley , CA : University of California Press .
   Google Scholar
• Johnston , M. I. , & Fauci , A. S. ( 2008 ). An HIV vaccine—challenges and prospects . New England Journal of Medicine , 359 ( 9 ), 888 – 890 .
   PubMed Web of Science ®Google Scholar
• Kahnlou , H. , & Weinstein , M. ( 2008 ). Enough is enough: Instead of continuing to squander hundreds of millions of dollars on a futile quest for an HIV vaccine, focus AIDS spending on prevention, testing and treatment . AIDS Healthcare Foundation . Retrieved August 3, 2009, from http://www.aidshealth.org/news/in-the-media/enough-is-enough.html
   Google Scholar
• Kirby , D. , Laris , B. , & Rolleri , L. ( 2007 ). Sex and HIV education programs: Their impact on sexual behaviors of young people throughout the world . Journal of Adolescent Health , 40 ( 3 ), 206 – 217 .
   PubMed Web of Science ®Google Scholar
• Kuehn , B. M. ( 2006 ). Routine male circumcision could prevent millions of HIV infections in Africa . Journal of the American Medical Association , 296 ( 7 ), 755 .
   Web of Science ®Google Scholar
• Lederman , D. ( 2009 ). NIH appropriations: One-man peer review. Inside Higher Ed. Retrieved August 5, 2009, from http://www.insidehighered.com/news/2009/07/28/issa
   Google Scholar
• Lindegger , G. , Milford , C. , Slack , C. , Quayle , M. , Xaba , X. , & Vards , E. (2006). Beyond the checklist: Assessing understanding for HIV vaccine trial participation in South Africa. Journal of Acquired Immune Deficiency Syndromes , 43(5), 560–566.
   PubMed Web of Science ®Google Scholar
• Lurie , P. , & Drucker , E. ( 1997 ). An opportunity lost: HIV infections associated with lack of national needle-exchange programme in the USA . Lancet , 349 ( 9052 ), 604 – 608 .
   PubMed Web of Science ®Google Scholar
• Masenior , N. F. , & Beyrer , C. ( 2007 ). The US Anti-Prostitution Pledge: First amendment challenges and public health priorities . Public Library of Science: Medicine , 4 ( 7 ), 1158 – 1161 .
   Google Scholar
• Mills , E. , Cooper , C. , Guyatt , G. , Gilchrist , A. , Rachlis , B. , et al. . ( 2004 ). Barriers to participating in an HIV vaccine trial: A systematic review . AIDS , 18 , 2235 – 2242 .
   PubMed Web of Science ®Google Scholar
• Mills , E. J. , & Singh , S. ( 2007 ). Health, human rights, and the conduct of clinical research within oppressed populations . Globalization and Health , 3 ( 10 ), doi:10.1186/1744-8603-3-10. Retrieved July 30, 2009, from http://www.globalizationandhealth.com/content/3/1/10
   PubMedGoogle Scholar
• Murphy , D. A. , Hoffman , D. , Seage , G. R. , 3rd , Belzer , M. , Xu , J. , et al. . ( 2007 ). Improving comprehension for HIV vaccine trial information among adolescents at risk of HIV . AIDS Care , 19 ( 1 ), 42 – 51 .
   PubMed Web of Science ®Google Scholar
• National Institute of Allergy and Infectious Diseases . ( 2007 ). Immunizations are discontinued in two HIV vaccine trials. NIH News. Retrieved August 3, 2009, from http://www3.niaid.nih.gov/news/newsreleases/2007/step_statement.htm
   Google Scholar
• Newman , P. A. ( 2006 ). Towards a science of community engagement . Lancet , 367 , 302 .
   PubMed Web of Science ®Google Scholar
• Newman , P. A. , Chakrapani , V. , Cook , C. , Shunmugam , M. , & Kakinami , L. ( 2008 ). Correlates of paid sex among men who have sex with men in Chennai, India . Sexually Transmitted Infections , 84 , 434 – 438 .
   PubMed Web of Science ®Google Scholar
• Newman , P. A. , Daley , A. , Halpenny , R. , & Loutfy , M. ( 2008 ). Community heroes or ‘high-risk’ pariahs? Reasons for declining to enroll in an HIV vaccine trial . Vaccine , 26 , 1091 – 1097 .
   PubMed Web of Science ®Google Scholar
• Newman , P. A. , Duan , N. , Kakinami , L. , & Roberts , K. ( 2008 ). What can HIV vaccine trials teach us about future HIV vaccine dissemination? Vaccine , 26 ( 20 ), 2528 – 2536 .
   PubMed Web of Science ®Google Scholar
• Newman , P. A. , Duan , N. , Rudy , E. T. , & Anton , P. A. ( 2004 ). Challenges for HIV vaccine dissemination and clinical trial recruitment: If we build it, will they come? AIDS Patient Care & STDs , 18 ( 12 ), 691 – 701 .
   PubMed Web of Science ®Google Scholar
• Newman , P. A. , Lee , S. J. , Duan , N. , Duan , E. , Nakazono , T. K. , et al. . ( 2009 ). HIV vaccine acceptability among a random sample of adults in Los Angeles (L.A. VOICES) . Health Services Research , 44 ( 6 ), 2167 – 2179 .
   PubMed Web of Science ®Google Scholar
• Newman , P. A. , Seiden , D. , Roberts , K. , Kakinami , L. , & Duan , N. ( 2009 ). A small dose of HIV? HIV vaccine mental models and risk communication . Health Education & Behavior , 36 ( 2 ), 321 – 333 .
   PubMed Web of Science ®Google Scholar
• Pace , C. , Grady , C. , Wendler , D. , Bebchuk , J. D. , Tavel , J. A. , et al. . ( 2006 ). Post-trial access to tested interventions: The views of IRB/REC chair, investigators, and research participants in a multinational HIV/AIDS study . AIDS Research and Human Retroviruses , 22 , 837 – 841 .
   PubMed Web of Science ®Google Scholar
• Padian , N. C. , Buvé , A. , Balkus , J. , Serwadda , D. , & Cates , W. ( 2008 ). Biomedical interventions to prevent HIV infection: Evidence, challenges, and way forward . Lancet , 372 ( 9638 ), 585 – 599 .
   PubMed Web of Science ®Google Scholar
• Peeters , M. , Toure-Kane , C. , & Nkengasong , J. N. (2003). Genetic diversity of HIV in Africa: Impact on diagnosis, treatment, vaccine development and trials. AIDS , 17, 2547–2560.
   PubMed Web of Science ®Google Scholar
• Quinn , T. C. , & Overbaugh , J. ( 2005 ). HIV/AIDS in women: An expanding epidemic . Science , 308 ( 5728 ), 1582 – 1583 .
   PubMed Web of Science ®Google Scholar
• Roberts , K. J. , Newman , P. A. , Duan , N. , Rudy , E. T. , & Swendeman , D. ( 2005 ). HIV vaccine knowledge and beliefs among communities at elevated risk: Concerns, questions and conspiracies . Journal of the National Medical Association , 97 ( 12 ), 1662 – 1671 .
   PubMedGoogle Scholar
• Robles , A. M. , & Stringer , H. G. ( 2006 ). HIV-AIDS in minorities . Clinics in Chest Medicine , 27 , 511 – 519 .
   Google Scholar
• Sekaly , R.-P. ( 2008 ). The failed HIV Merck vaccine study: A step back or a launching point for future vaccine development ?. Journal of Experimental Medicine , 205 , 7 – 12 .
   PubMed Web of Science ®Google Scholar
• Shaffer , D. N. , Yebei , V. N. , Ballidawa , J. B. , Sidle , J. E. , Greene , J. Y. , et al. . ( 2006 ). Equitable treatment for HIV/AIDS clinical trial participants: A focus group study of patients, clinician researchers, and administrators in Western Kenya . Journal of Medical Ethics , 32 , 55 – 60 .
   PubMed Web of Science ®Google Scholar
• Special Investigations Division, Minority Staff of the Committee on Government Reform . ( 2003 ). Politics and science in the Bush Administration: Prepared for Rep. Henry A. Waxman . Washington , D.C. : United States House of Representatives . Retrieved August 5, 2009, from http://oversight.house.gov/documents/20080130103545.pdf
   Google Scholar
• Singh , J. A. , & Mills , E. J. ( 2005 ). The abandoned trials of pre-exposure prophylaxis for HIV: What went wrong? Public Library of Science: Medicine , 2 ( 9 ), e234 .
   Google Scholar
• Slack , C. , Stobie , M. , Milford , C. , Lindegger , G. , Wassenaar , D. , et al. . ( 2005 ). Provision of HIV treatment in HIV preventive vaccine trials: A developing country perspective . Social Science and Medicine , 60 , 1197 – 1208 .
   PubMed Web of Science ®Google Scholar
• Smith , A. D. , Tapsoba , P. , Peshu , N. , Sanders , E. J. , & Jaffe , H. W. ( 2009 ). Men who have sex with men and HIV/AIDS in sub-Saharan Africa . Lancet , 374 ( 0687 ), 416 – 422 .
   PubMedGoogle Scholar
• Steinbrook , R. ( 2007 ). One step forward, two steps back: Will there ever be an AIDS vaccine? New England Journal of Medicine , 357 , 2653 – 2655 .
   PubMed Web of Science ®Google Scholar
• Stover , J. , Bollinger , L. , Hecht , R. , Williams , C. , & Roca , E. ( 2007 ). The impact of an AIDS vaccine in developing countries: A new model and initial results . Health Affairs , 26 ( 4 ), 1147 – 1158 .
   Web of Science ®Google Scholar
• Streefland , P. H. ( 2003 ). Introduction of a HIV vaccine in developing countries: Social and cultural dimensions . Vaccine , 21 ( 13–14 ), 1304 – 1309 .
   PubMed Web of Science ®Google Scholar
• Sullivan , P. , Rossini , T. , deBruyn , G. , Chiu , Y. , Belshe , R. , et al. . ( 2003 ). Vaccine-induced positive HIV serology results induced by vaccine among participants in 10 clinical trials of Canarypox-vectored HIV vaccine trial units in the US. Poster presented at the 10th Conference on Retroviruses and Opportunistic Infections, Boston, MA .
   Google Scholar
• Swartz , L. , Kafaar , Z. , Smit , J. , Bhana , A. , Gray , G. , et al. . ( 2005 ). Social and behavioral aspects of child and adolescent participation in HIV vaccine trials . Journal of the International Association of Physicians in AIDS Care , 4 ( 4 ), 89 – 92 .
   Google Scholar
• Thapinta , D. , Jenkins , R. A. , Celentano , D. D. , Nitayaphan , S. , Buapunth , P. , et al.. (1999). Evaluation of behavioral and social issues among Thai HIV vaccine trial volunteers. Journal of Acquired Immune Deficiency Syndromes , 20, 308–314.
   Web of Science ®Google Scholar
• UNAIDS (Joint United Nations Programme on HIV/AIDS and World Health Organization). ( 2007a ). AIDS epidemic update, December 2007 . UNAIDS: Geneva .
   Google Scholar
• UNAIDS (Joint United Nations Programme on HIV/AIDS and World Health Organization) . ( 2007b ). Good participatory practice guidelines for biomedical HIV prevention trials. Retrieved August 4, 2009, from http://data.unaids.org/pub/Manual/2007/jc1364_good_participatory_guidelines_en.pdf
   Google Scholar
• United Nations . ( 2008 ). The UN millennium development goals. Retrieved August 4, 2009, from http://www.un.org/millenniumgoals/#
   Google Scholar
• Valdisseri , R. O. ( 2002 ). HIV/AIDS stigma: An impediment to public health . American Journal of Public Health , 92 ( 3 ), 341 – 342 .
   PubMed Web of Science ®Google Scholar
• van Griensven , F. , de Lind van Wijngaarden , J. W. , Baral , S. , & Grulich , A. ( 2009 ). The global epidemic of HIV infection among men who have sex with men . Current Opinion in HIV and AIDS , 4 ( 4 ), 300 – 307 .
   PubMed Web of Science ®Google Scholar
• Weatherall , C. J. , Kelleher , A. D. , & Cooper , D. A. ( 2009 ). Trials and tribulations of HIV vaccines. Future HIV Therapy. Retrieved July 30, 2009, from http://www.medscape.com/viewarticle/589943
   Google Scholar
• Wendler , D. , Kington , R. , Madans , J. , Wye , G. V. , Christ-Schmidt , H. , et al. . ( 2006 ). Are racial and ethnic minorities less willing to participate in health research? Public Library of Science: Medicine , 3 ( 2 ), e19 . doi: 10.1371/journal.pmed.0030019
   Google Scholar
• Westercamp , N. , & Bailey , R. C. ( 2007 ). Acceptability of male circumcision for prevention of HIV/AIDS in sub-Saharan Africa: A review . AIDS and Behavior , 11 , 341 – 355 .
   PubMed Web of Science ®Google Scholar
• Wolffers , I. ( 2000 ). Biomedical and development paradigms in AIDS prevention . Bulletin of the World Health Organization , 78 ( 2 ), 267 – 273 .
   PubMed Web of Science ®Google Scholar
• Xu , F. , Markowitz , L. E. , Sternberg , M. R. , & Aral , S. O. ( 2007 ). Prevalence of circumcision and herpes simplex virus type 2 infection in men in the United States: The National Health and Nutrition Examination Survey (NHANES), 1999–2004 . Sexually Transmitted Diseases , 34 , 479 – 484 .
   PubMed Web of Science ®Google Scholar