Autocrine IL-8 promotes F-actin polymerization and mediate mesenchymal transition via ELMO1-NF-κB-Snail signaling in glioma

References

• Burke F, Relf M, Negus R, Balkwill F. A cytokine profile of normal and malignant ovary. Cytokine 1996; 8:578–85; PMID:8891439; http://dx.doi.org/10.1006/cyto.1996.0077
   PubMed Web of Science ®Google Scholar
• Auf G, Jabouille A, Delugin M, Guerit S, Pineau R, North S, Platonova N, Maitre M, Favereaux A, Vajkoczy P, et al. High epiregulin expression in human U87 glioma cells relies on IRE1alpha and promotes autocrine growth through EGF receptor. BMC Cancer 2013; 13:597; PMID:24330607; http://dx.doi.org/10.1186/1471-2407-13-597
   PubMed Web of Science ®Google Scholar
• Hoelzinger DB, Demuth T, Berens ME. Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment. J Natl Cancer Inst 2007; 99:1583–93; PMID:17971532; http://dx.doi.org/10.1093/jnci/djm187
   PubMed Web of Science ®Google Scholar
• Tsareva SA, Wagner S, Muller A, Corvinus F, Friedrich K. Cell-cell contacts induce STAT3 activity in colon carcinoma cells through an autocrine stimulation loop. J Cancer Res Clin Oncol 2011; 137:857–63; PMID:20830487; http://dx.doi.org/10.1007/s00432-010-0943-3
   PubMed Web of Science ®Google Scholar
• Jennings MT, Maciunas RJ, Carver R, Bascom CC, Juneau P, Misulis K, Moses HL. TGF beta 1 and TGF beta 2 are potential growth regulators for low-grade and malignant gliomas in vitro: evidence in support of an autocrine hypothesis. Int J Cancer 1991; 49:129–39; PMID:1874566; http://dx.doi.org/10.1002/ijc.2910490124
   PubMed Web of Science ®Google Scholar
• Wittekind C, Neid M. Cancer invasion and metastasis. Oncology 2005; 69 (Suppl 1):14–6; PMID:16210871; http://dx.doi.org/10.1159/000086626
   PubMed Web of Science ®Google Scholar
• Brat DJ, Bellail AC, Van Meir EG. The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis. Neuro Oncol 2005; 7:122–33; PMID:15831231; http://dx.doi.org/10.1215/S1152851704001061
   PubMed Web of Science ®Google Scholar
• Raychaudhuri B, Vogelbaum MA. IL-8 is a mediator of NF-kappaB induced invasion by gliomas. J Neurooncol 2011; 101:227–35; PMID:20577780; http://dx.doi.org/10.1007/s11060-010-0261-2
   PubMed Web of Science ®Google Scholar
• Sun CX, Magalhaes MA, Glogauer M. Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor. J Cell Biol 2007; 179:239–45; PMID:17954607; http://dx.doi.org/10.1083/jcb.200705122
   PubMed Web of Science ®Google Scholar
• Desbaillets I, Diserens AC, de Tribolet N, Hamou MF, Van Meir EG. Regulation of interleukin-8 expression by reduced oxygen pressure in human glioblastoma. Oncogene 1999; 18:1447–56; PMID:10050881; http://dx.doi.org/10.1038/sj.onc.1202424
   PubMed Web of Science ®Google Scholar
• Salmaggi A, Eoli M, Frigerio S, Silvani A, Gelati M, Corsini E, Broggi G, Boiardi A. Intracavitary VEGF, bFGF, IL-8, IL-12 levels in primary and recurrent malignant glioma. J Neurooncol 2003; 62:297–303; PMID:12777082; http://dx.doi.org/10.1023/A:1023367223575
   PubMed Web of Science ®Google Scholar
• Hoffmann E, Dittrich-Breiholz O, Holtmann H, Kracht M. Multiple control of interleukin-8 gene expression. J Leukoc Biol 2002; 72:847–55; PMID:12429706
   PubMed Web of Science ®Google Scholar
• Smyth MJ, Zachariae CO, Norihisa Y, Ortaldo JR, Hishinuma A, Matsushima K. IL-8 gene expression and production in human peripheral blood lymphocyte subsets. J Immunol 1991; 146:3815–23; PMID:1827816
   PubMed Web of Science ®Google Scholar
• Xie K. Interleukin-8 and human cancer biology. Cytokine Growth Factor Rev 2001; 12:375–91; PMID:11544106; http://dx.doi.org/10.1016/S1359-6101(01)00016-8
   PubMed Web of Science ®Google Scholar
• Bates RC, DeLeo MJ, 3rd, Mercurio AM. The epithelial-mesenchymal transition of colon carcinoma involves expression of IL-8 and CXCR-1-mediated chemotaxis. Exp Cell Res 2004; 299:315–24; PMID:15350531; http://dx.doi.org/10.1016/j.yexcr.2004.05.033
   PubMed Web of Science ®Google Scholar
• Slettenaar VI, Wilson JL. The chemokine network: a target in cancer biology? Adv Drug Deliv Rev 2006; 58:962–74; PMID:16996642; http://dx.doi.org/10.1016/j.addr.2006.03.012
   PubMed Web of Science ®Google Scholar
• Jarzynka MJ, Hu B, Hui KM, Bar-Joseph I, Gu W, Hirose T, Haney LB, Ravichandran KS, Nishikawa R, Cheng SY. ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion. Cancer Res 2007; 67:7203–11; PMID:17671188; http://dx.doi.org/10.1158/0008-5472.CAN-07-0473
   PubMed Web of Science ®Google Scholar
• Cote JF, Vuori K. GEF what? Dock180 and related proteins help Rac to polarize cells in new ways. Trends Cell Biol 2007; 17:383–93; PMID:17765544; http://dx.doi.org/10.1016/j.tcb.2007.05.001
   PubMed Web of Science ®Google Scholar
• Brugnera E, Haney L, Grimsley C, Lu M, Walk SF, Tosello-Trampont AC, Macara IG, Madhani H, Fink GR, Ravichandran KS. Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complex. Nat Cell Biol 2002; 4:574–82; PMID:12134158
   PubMed Web of Science ®Google Scholar
• Velpula KK, Dasari VR, Tsung AJ, Dinh DH, Rao JS. Cord blood stem cells revert glioma stem cell EMT by down regulating transcriptional activation of Sox2 and Twist1. Oncotarget 2011; 2:1028–42; PMID:22184289
   PubMed Web of Science ®Google Scholar
• Yu J, Ren X, Chen Y, Liu P, Wei X, Li H, Ying G, Chen K, Winkler H, Hao X. Dysfunctional activation of neurotensin/IL-8 pathway in hepatocellular carcinoma is associated with increased inflammatory response in microenvironment, more epithelial mesenchymal transition in cancer and worse prognosis in patients. PLoS One 2013; 8:e56069; PMID:23418512; http://dx.doi.org/10.1371/journal.pone.0056069
   PubMed Web of Science ®Google Scholar
• Palena C, Hamilton DH, Fernando RI. Influence of IL-8 on the epithelial-mesenchymal transition and the tumor microenvironment. Future Oncol 2012; 8:713–22; PMID:22764769; http://dx.doi.org/10.2217/fon.12.59
   PubMed Web of Science ®Google Scholar
• Li XJ, Peng LX, Shao JY, Lu WH, Zhang JX, Chen S, Chen ZY, Xiang YQ, Bao YN, Zheng FJ, et al. As an independent unfavorable prognostic factor, IL-8 promotes metastasis of nasopharyngeal carcinoma through induction of epithelial-mesenchymal transition and activation of AKT signaling. Carcinogenesis 2012; 33:1302–9; PMID:22610073; http://dx.doi.org/10.1093/carcin/bgs181
   PubMed Web of Science ®Google Scholar
• Zhang B, Yin C, Li H, Shi L, Liu N, Sun Y, Lu S, Liu Y, Sun L, Li X, et al. Nir1 promotes invasion of breast cancer cells by binding to chemokine (C-C motif) ligand 18 through the PI3K/Akt/GSK3beta/Snail signalling pathway. Eur J Cancer 2013; 49 (18):3900–13; PMID:24001613; http://dx.doi.org/10.1016/j.ejca.2013.07.146
   PubMed Web of Science ®Google Scholar
• Das G, Shiras A, Shanmuganandam K, Shastry P. Rictor regulates MMP-9 activity and invasion through Raf-1-MEK-ERK signaling pathway in glioma cells. Mol Carcinog 2011; 50:412–23; PMID:21557327; http://dx.doi.org/10.1002/mc.20723
   PubMed Web of Science ®Google Scholar
• Takino T, Nakada M, Miyamori H, Yamashita J, Yamada KM, Sato H. CrkI adapter protein modulates cell migration and invasion in glioblastoma. Cancer Res 2003; 63:2335–7; PMID:12727859
   PubMed Web of Science ®Google Scholar
• Shamaladevi N, Lyn DA, Escudero DO, Lokeshwar BL. CXC receptor-1 silencing inhibits androgen-independent prostate cancer. Cancer Res 2009; 69:8265–74; PMID:19861539; http://dx.doi.org/10.1158/0008-5472.CAN-09-0374
   PubMed Web of Science ®Google Scholar
• Bar-Eli M. Role of interleukin-8 in tumor growth and metastasis of human melanoma. Pathobiology 1999; 67:12–8; PMID:9873223; http://dx.doi.org/10.1159/000028045
   PubMed Web of Science ®Google Scholar
• Van Haastert PJ, Devreotes PN. Chemotaxis: signalling the way forward. Nat Rev Mol Cell Biol 2004; 5:626–34; PMID:15366706; http://dx.doi.org/10.1038/nrm1435
   PubMed Web of Science ®Google Scholar
• Pollard TD, Borisy GG. Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003; 112:453–65; PMID:12600310; http://dx.doi.org/10.1016/S0092-8674(03)00120-X
   PubMed Web of Science ®Google Scholar
• Insall RH, Machesky LM. Actin dynamics at the leading edge: from simple machinery to complex networks. Dev Cell 2009; 17:310–22; PMID:19758556; http://dx.doi.org/10.1016/j.devcel.2009.08.012
   PubMed Web of Science ®Google Scholar
• Raftopoulou M, Hall A. Cell migration: Rho GTPases lead the way. Dev Biol 2004; 265:23–32; PMID:14697350; http://dx.doi.org/10.1016/j.ydbio.2003.06.003
   PubMed Web of Science ®Google Scholar
• Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139:871–90; PMID:19945376; http://dx.doi.org/10.1016/j.cell.2009.11.007
   PubMed Web of Science ®Google Scholar
• Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119:1420–8; PMID:19487818; http://dx.doi.org/10.1172/JCI39104
   PubMed Web of Science ®Google Scholar
• Huang ZY, Wu Y, Hedrick N, Gutmann DH. T-cadherin-mediated cell growth regulation involves G2 phase arrest and requires p21(CIP1/WAF1) expression. Mol Cell Biol 2003; 23:566–78; PMID:12509455; http://dx.doi.org/10.1128/MCB.23.2.566-578.2003
   PubMed Web of Science ®Google Scholar
• Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005; 17:548–58; PMID:16098727; http://dx.doi.org/10.1016/j.ceb.2005.08.001
   PubMed Web of Science ®Google Scholar
• Wu Y, Deng J, Rychahou PG, Qiu S, Evers BM, Zhou BP. Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell 2009; 15:416–28; PMID:19411070; http://dx.doi.org/10.1016/j.ccr.2009.03.016
   PubMed Web of Science ®Google Scholar
• Yook JI, Li XY, Ota I, Fearon ER, Weiss SJ. Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem 2005; 280:11740–8; PMID:15647282; http://dx.doi.org/10.1074/jbc.M413878200
   PubMed Web of Science ®Google Scholar
• Pilot-Storck F, Chopin E, Rual JF, Baudot A, Dobrokhotov P, Robinson-Rechavi M, Brun C, Cusick ME, Hill DE, Schaeffer L, et al. Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor. Mol Cell Proteomics 2010; 9:1578–93; PMID:20368287; http://dx.doi.org/10.1074/mcp.M900568-MCP200
   PubMed Web of Science ®Google Scholar
• Pardo R, Andreolotti AG, Ramos B, Picatoste F, Claro E. Opposed effects of lithium on the MEK-ERK pathway in neural cells: inhibition in astrocytes and stimulation in neurons by GSK3 independent mechanisms. J Neurochem 2003; 87:417–26; PMID:14511119; http://dx.doi.org/10.1046/j.1471-4159.2003.02015.x
   PubMed Web of Science ®Google Scholar
• Bonavia R, Inda MM, Vandenberg S, Cheng SY, Nagane M, Hadwiger P, Tan P, Sah DW, Cavenee WK, Furnari FB. EGFRvIII promotes glioma angiogenesis and growth through the NF-kappaB, interleukin-8 pathway. Oncogene 2012; 31:4054–66; PMID:22139077; http://dx.doi.org/10.1038/onc.2011.563
   PubMed Web of Science ®Google Scholar
• Kim DS, Kim JH, Lee JK, Choi SJ, Kim JS, Jeun SS, Oh W, Yang YS, Chang JW. Overexpression of CXC chemokine receptors is required for the superior glioma-tracking property of umbilical cord blood-derived mesenchymal stem cells. Stem Cells Dev 2009; 18:511–9; PMID:18624673; http://dx.doi.org/10.1089/scd.2008.0050
   PubMed Web of Science ®Google Scholar
• Yan J, Mihaylov V, Xu X, Brzostowski JA, Li H, Liu L, Veenstra TD, Parent CA, Jin T. A Gbetagamma effector, ElmoE, transduces GPCR signaling to the actin network during chemotaxis. Dev Cell 2012; 22:92–103; PMID:22264729; http://dx.doi.org/10.1016/j.devcel.2011.11.007
   PubMed Web of Science ®Google Scholar