Overexpression of pyruvate kinase M2 associates with aggressive clinicopathological features and unfavorable prognosis in oral squamous cell carcinoma

References

• Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127:2893-917; PMID:21351269; http://dx.doi.org/10.1002/ijc.25516
   PubMed Web of Science ®Google Scholar
• Rapidis AD, Gullane P, Langdon JD, Lefebvre JL, Scully C, Shah JP. Major advances in the knowledge and understanding of the epidemiology, aetiopathogenesis, diagnosis, management and prognosis of oral cancer. Oral Oncol 2009; 45:299-300; PMID:19411038; http://dx.doi.org/10.1016/j.oraloncology.2009.04.001
   PubMed Web of Science ®Google Scholar
• Bello IO, Soini Y, Salo T. Prognostic evaluation of oral tongue cancer: means, markers and perspectives (II). Oral Oncol 2010; 46:636-43; PMID:20637679; http://dx.doi.org/10.1016/j.oraloncology.2010.06.008
   PubMed Web of Science ®Google Scholar
• Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell 2011; 144:646-74; PMID:21376230; http://dx.doi.org/10.1016/j.cell.2011.02.013
   PubMed Web of Science ®Google Scholar
• Ward PS, Thompson CB. Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell 2012; 21:297-308; PMID:22439925; http://dx.doi.org/10.1016/j.ccr.2012.02.014
   PubMed Web of Science ®Google Scholar
• Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer 2011; 11:85-95; PMID:21258394; http://dx.doi.org/10.1038/nrc2981
   PubMed Web of Science ®Google Scholar
• Tamada M, Suematsu M, Saya H. Pyruvate kinase M2: multiple faces for conferring benefits on cancer cells. Clin Cancer Res 2012; 18:5554-61; PMID:23071357; http://dx.doi.org/10.1158/1078-0432.CCR-12-0859
   PubMed Web of Science ®Google Scholar
• Peng XC, Gong FM, Zhao YW, Zhou LX, Xie YW, Liao HL, Lin HJ, Li ZY, Tang MH, Tong AP. Comparative proteomic approach identifies PKM2 and cofilin-1 as potential diagnostic, prognostic and therapeutic targets for pulmonary adenocarcinoma. PLoS One 2011; 6:e27309; PMID:22087286
   PubMedGoogle Scholar
• Altenberg B, Greulich KO. Genes of glycolysis are ubiquitously overexpressed in 24 cancer classes. Genomics 2004; 84:1014-20; PMID:15533718; http://dx.doi.org/10.1016/j.ygeno.2004.08.010
   PubMed Web of Science ®Google Scholar
• Yin L, Wang X, Luo C, Liu H, Zhang L, Zhang H, Zhang Y. The value of expression of M2-PK and VEGF in patients with advanced gastric cancer. Cell Biochem Biophys 2013; 67:1033-9; PMID:23625175; http://dx.doi.org/10.1007/s12013-013-9601-0
   PubMed Web of Science ®Google Scholar
• Pelicano H, Martin DS, Xu RH, Huang P. Glycolysis inhibition for anticancer treatment. Oncogene 2006; 25:4633-46; PMID:16892078; http://dx.doi.org/10.1038/sj.onc.1209597
   PubMed Web of Science ®Google Scholar
• Parnell KM, Foulks JM, Nix RN, Clifford A, Bullough J, Luo B, Senina A, Vollmer D, Liu J, McCarthy V, et al. Pharmacologic activation of PKM2 slows lung tumor xenograft growth. Mol Cancer Ther 2013; 12:1453-60; PMID:23720766; http://dx.doi.org/10.1158/1535-7163.MCT-13-0026
   PubMed Web of Science ®Google Scholar
• Goldberg MS, Sharp PA. Pyruvate kinase M2-specific siRNA induces apoptosis and tumor regression. J Exp Med 2012; 209:217-24; PMID:22271574; http://dx.doi.org/10.1084/jem.20111487
   PubMed Web of Science ®Google Scholar
• Wong TS, Liu XB, Chung-Wai Ho A, Po-Wing Yuen A, Wai-Man Ng R, Ignace Wei W. Identification of pyruvate kinase type M2 as potential oncoprotein in squamous cell carcinoma of tongue through microRNA profiling. Int J Cancer 2008; 123:251-7.
   PubMed Web of Science ®Google Scholar
• Feng C, Gao Y, Wang C, Yu X, Zhang W, Guan H, Shan Z, Teng W. Aberrant overexpression of pyruvate kinase M2 is associated with aggressive tumor features and the BRAF mutation in papillary thyroid cancer. J Clin Endocrinol Metab 2013; 98:E1524-33; PMID:23846818; http://dx.doi.org/10.1210/jc.2012-4258
   PubMedGoogle Scholar
• Yuan C, Li Z, Wang Y, Qi B, Zhang W, Ye J, Wu H, Jiang H, Song LN, Yang J, et al. Overexpression of metabolic markers PKM2 and LDH5 correlates with aggressive clinicopathological features and adverse patient prognosis in tongue cancer. Histopathology 2014; 65:595-605; PMID:24762230; http://dx.doi.org/10.1111/his.12441
   PubMed Web of Science ®Google Scholar
• Chen YK, Yang SH, Huang AH, Hsue SS, Lin LM. Aberrant expression in multiple components of the transforming growth factor-beta1-induced Smad signaling pathway during 7,12-dimethylbenz[a]anthracene-induced hamster buccal-pouch squamous-cell carcinogenesis. Oral Oncol 2011; 47:262-7
   PubMed Web of Science ®Google Scholar
• Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029-33; PMID:19460998; http://dx.doi.org/10.1126/science.1160809
   PubMed Web of Science ®Google Scholar
• Rhodus NL, Kerr AR, Patel K. Oral cancer: leukoplakia, premalignancy, and squamous cell carcinoma. Dent Clin North Am 2014; 58:315-40; PMID:24655525; http://dx.doi.org/10.1016/j.cden.2013.12.004
   PubMedGoogle Scholar
• Vidya Priyadarsini R, Kumar N, Khan I, Thiyagarajan P, Kondaiah P, Nagini S. Gene expression signature of DMBA-induced hamster buccal pouch carcinomas: modulation by chlorophyllin and ellagic acid. PLoS One 2012; 7:e34628; PMID:22485181; http://dx.doi.org/10.1371/journal.pone.0034628
   PubMedGoogle Scholar
• Li J, Liang F, Yu D, Qing H, Yang Y. Development of a 4-nitroquinoline-1-oxide model of lymph node metastasis in oral squamous cell carcinoma. Oral Oncol 2013; 49:299-305; PMID:23187306; http://dx.doi.org/10.1016/j.oraloncology.2012.10.013
   PubMed Web of Science ®Google Scholar
• Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol 2012; 14:1295-304; PMID:23178880; http://dx.doi.org/10.1038/ncb2629
   PubMed Web of Science ®Google Scholar
• Wang HJ, Hsieh YJ, Cheng WC, Lin CP, Lin YS, Yang SF, Chen CC, Izumiya Y, Yu JS, Kung HJ, et al. JMJD5 regulates PKM2 nuclear translocation and reprograms HIF-1alpha-mediated glucose metabolism. Proc Natl Acad Sci U S A 2014; 111:279-84; PMID:24344305; http://dx.doi.org/10.1073/pnas.1311249111
   PubMed Web of Science ®Google Scholar
• Hamabe A, Konno M, Tanuma N, Shima H, Tsunekuni K, Kawamoto K, Nishida N, Koseki J, Mimori K, Gotoh N, et al. Role of pyruvate kinase M2 in transcriptional regulation leading to epithelial-mesenchymal transition. Proc Natl Acad Sci U S A 2014; 111:15526-31; PMID:25313085; http://dx.doi.org/10.1073/pnas.1407717111
   PubMed Web of Science ®Google Scholar
• Li Z, Wang Y, Qiu J, Li Q, Yuan C, Zhang W, Wang D, Ye J, Jiang H, Yang J, et al. The polycomb group protein EZH2 is a novel therapeutic target in tongue cancer. Oncotarget 2013; 4:2532-49; PMID:24345883
   PubMedGoogle Scholar
• Li Z, Wang Y, Yuan C, Zhu Y, Qiu J, Zhang W, Qi B, Wu H, Ye J, Jiang H, et al. Oncogenic roles of Bmi1 and its therapeutic inhibition by histone deacetylase inhibitor in tongue cancer. Lab Invest 2014; 94:1431-45; PMID:25286028; http://dx.doi.org/10.1038/labinvest.2014.123
   PubMed Web of Science ®Google Scholar