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Research Paper

Down-regulating HIF-1α by lentivirus-mediated shRNA for therapy of triple negative breast cancer

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Pages 866-875 | Received 09 Jan 2015, Accepted 09 Apr 2015, Published online: 11 Jun 2015

References

  • Ban KA, Godellas CV. Epidemiology of Breast Cancer. Surg Oncol Clin N Am 2014; 23:409–22; PMID:24882341; http://dx.doi.org/10.1016/j.soc.2014.03.011
  • Siegel R, Ma J, Zou Z, Jemal A. Cancer statistics, 2014. CA Cancer J Clin 2014; 64:9–29; PMID:24399786; http://dx.doi.org/10.3322/caac.21208
  • DeSantis C, Ma J, Bryan L, Jemal A. Breast cancer statistics, 2013. CA Cancer J Clin 2014; 64:52–62; PMID:24114568; http://dx.doi.org/10.3322/caac.21203
  • de Boer M, van Dijck JA, Bult P, Borm GF, Tjan-Heijnen VC. Breast cancer prognosis and occult lymph node metastases, isolated tumor cells, and micrometastases. J Natl Cancer Inst 2010; 102:410–25; PMID:20190185; http://dx.doi.org/10.1093/jnci/djq008
  • Bernard-Marty C, Cardoso F, Piccart MJ. Facts and controversies in systemic treatment of metastatic breast cancer. Oncologist 2004; 9:617–32; PMID:15561806; http://dx.doi.org/10.1634/theoncologist.9-6-617
  • de Ruijter TC, Veeck J, de Hoon JP, van Engeland M, Tjan-Heijnen VC. Characteristics of triple-negative breast cancer. J Cancer Res Clin Oncol 2011; 137:183–92; PMID:21069385; http://dx.doi.org/10.1007/s00432-010-0957-x
  • Yadav BS, Sharma SC, Chanana P, Jhamb S. Systemic treatment strategies for triple-negative breast cancer. World J Clin Oncol 2014; 5:125–33; PMID:24829859; http://dx.doi.org/10.5306/wjco.v5.i2.125
  • Barsoum IB, Koti M, Siemens DR, Graham CH. Mechanisms of hypoxia-mediated immune escape in cancer. Cancer Res 2014; (24):7185-90.
  • Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, et al. Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium. J Enzyme Inhib Med Chem 2014; 27:1–33; http://dx.doi.org/10.3109/14756366.2014.966704
  • Wang GL, Semenza GL. Purification and characterization of hypoxiainducible factor-1. J Biol Chem 1995;270:1230–7; PMID:7836384; http://dx.doi.org/10.1074/jbc.270.3.1230
  • Salceda S, Beck I, Caro J. Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia. Arch Biochem Biophys 1996; 334:389–94; PMID:8900415; http://dx.doi.org/10.1006/abbi.1996.0469
  • Liu L, Marti GP, Wei X, Zhang X, Zhang H, Liu YV, Nastai M, Semenza GL, Harmon JW. Age-dependent impairment of HIF-1alpha expression in diabetic mice: Correction with electroporation-facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells. J Cell Physiol 2008; 217:319–27; PMID:18506785; http://dx.doi.org/10.1002/jcp.21503
  • Shibuya M. VEGF-VEGFR Signals in Health and Disease. Biomol Ther (Seoul). 2014; 22:1–9; PMID:24596615; http://dx.doi.org/10.4062/biomolther.2013.113
  • Semenza GL. Signal transduction to hypoxia-inducible factor 1. Biochem Pharmacol 2002; 64:993–8; PMID:12213597; http://dx.doi.org/10.1016/S0006-2952(02)01168-1
  • Agani F, Jiang BH. Oxygen-independent regulation of HIF-1: novel involvement of PI3K/AKT/mTOR pathway in cancer. Curr Cancer Drug Targets. 2013;13:245–251; PMID:23297826; http://dx.doi.org/10.2174/1568009611313030003
  • Subtil FS, Wilhelm J, Bill V, Westholt N, Rudolph S, Fischer J, Scheel S, Seay U, Fournier C, Taucher-Scholz G, et al. Carbon ion radiotherapy of human lung cancer attenuates HIF-1 signaling and acts with considerably enhanced therapeutic efficiency. FASEB J. 2014;28:1412–21; PMID:24347608; http://dx.doi.org/10.1096/fj.13-242230
  • Warfel NA, El-Deiry WS. HIF-1 signaling in drug resistance to chemotherapy. Curr Med Chem. 2014;21:3021–8; PMID:24735366; http://dx.doi.org/10.2174/0929867321666140414101056
  • Miura Y, Ohnami S, Yoshida K, Ohashi M, Nakano M, Fukuhara M, Yanagi K, Matsushita A, Uchida E, Asaka M, et al. Intraperitoneal injection of adenovirus expressing antisense K-ras RNA suppresses peritoneal dissemination of hamster syngeneic pancreatic cancer without systemic toxicity. Cancer Lett 2005; 218:53–62; PMID:15639340; http://dx.doi.org/10.1016/j.canlet.2004.08.015
  • Trujillo MA, Oneal MJ, Davydova J, Bergert E, Yamamoto M, Morris JC 3rd. Construction of an MUC-1 promoter driven, conditionally replicating adenovirus that expresses the sodium iodide symporter for gene therapy of breast cancer. Breast Cancer Res 2009; 11:R53; PMID:19635153; http://dx.doi.org/10.1186/bcr2342
  • Young LS, Searle PF, Onion D, Mautner V. Viral gene therapy strategies: from basic science to clinical application. J Pathol 2006; 208:299–318; PMID:16362990; http://dx.doi.org/10.1002/path.1896
  • Monti E, Gariboldi MB. HIF-1 as a target for cancer chemotherapy, chemosensitization and chemoprevention. Curr Mol Pharmacol. 2011; 4:62–77; PMID:20958262; http://dx.doi.org/10.2174/1874467211104010062
  • Meijer TW, Kaanders JH, Span PN, Bussink J. Targeting hypoxia, HIF-1, and tumor glucose metabolism to improve radiotherapy efficacy. Clin Cancer Res. 2012;18:5585–94; PMID:23071360; http://dx.doi.org/10.1158/1078-0432.CCR-12-0858
  • Wilczynski J, Duechler M, Czyz M. Targeting NF-κB and HIF-1 pathways for the treatment of cancer: part II. Arch Immunol Ther Exp (Warsz). 2011;59:301–7; PMID:21625847
  • Zhu X, LI Q, Li S, Chen B, Zou H. HIF-1α decoy oligodeoxynucleotides inhibit HIF-1α signaling and breast cancer proliferation. Int J Oncol 2015; 46: 215–22; PMID:25334080
  • Newman LA, Reis-Filho JS, Morrow M, Carey LA, King TA. The 2014 Society of Surgical Oncology Susan G. Komen for the Cure Symposium: Triple-Negative Breast Cancer. Ann Surg Oncol. 2015; 22(3):874-82.
  • Foulkes WD, Smith IE, Reis JS. Triple-Negative Breast Cancer. N Engl J Med 2010; 363: 1938–48; PMID:21067385; http://dx.doi.org/10.1056/NEJMra1001389
  • Cleator S, Heller W, Coombes RC. Triple-negative breast cancer: therapeutic options. Lancet Oncol 2007; 8: 235–44; PMID:17329194; http://dx.doi.org/10.1016/S1470-2045(07)70074-8
  • Sohn J, Liu S, Parinyanitikul N, Lee J, Hortobagyi GN, Mills GB, Ueno NT, Gonzalez-Angulo AM. cMET Activation and EGFR-Directed Therapy Resistance in Triple-Negative Breast Cancer. J cancer 2014; 5: 745–53; PMID:25368674; http://dx.doi.org/10.7150/jca.9696
  • Al-Hajj M, Wicha MS, Benito-Hernandez A, Morrison SJ, Clarke MF: Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci USA 2003; 100:3983–8; PMID:12629218; http://dx.doi.org/10.1073/pnas.0530291100
  • Li S, Li Q. Cancer stem cells and tumor metastasis. Int J Oncol 2014; 44:1806–12; PMID:24691919
  • Li S, Li Q. Cancer stem cells, lymphangiogenesis, and lymphatic metastasis. Cancer Lett 2015; 357(2):438-47 pii: S0304-3835(14)00756-3. doi: 10.1016/j.canlet.2014.12.013. [Epub ahead of print].
  • Semenza GL. HIF-1 and human disease: one highly involved factor. Genes Dev 2000; 14:1983–91; PMID:10950862
  • Bos R, van der Groep P, Greijer AE, Shvarts A, Meijer S, Pinedo HM, Semenza GL, van Diest PJ, van der Wall E. Levels of hypoxia-inducible factor-1alpha independently predict prognosis in patients with lymph node negative breast carcinoma. Cancer 2003; 97:1573–81; PMID:12627523; http://dx.doi.org/10.1002/cncr.11246
  • Martin SK, Diamond P, Gronthos S, Peet DJ, Zannettino AC. The emerging role of hypoxia, HIF-1 and HIF-2 in multiple myeloma. Leukemia 2011; 25:1533–42; PMID:21637285; http://dx.doi.org/10.1038/leu.2011.122
  • Kamlah F, Eul BG, Li S, Lang N, Marsh LM, Seeger W, Grimminger F, Rose F, Hänze J. Intravenous injection of siRNA directed against hypoxia-inducible factors prolongs survival in a Lewis lung carcinoma cancer model. Cancer Gene Ther 2009; 16:195–205; PMID:18818708
  • Greijer AE, van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. J Clin Pathol 2004; 57:1009–14; PMID:15452150; http://dx.doi.org/10.1136/jcp.2003.015032
  • Akakura N, Kobayashi M, Horiuchi I, Suzuki A, Wang J, Chen J, Niizeki H, Kawamura Ki, Hosokawa M, Asaka M. Constitutive expression of hypoxia-inducible factor-1 α renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation. Cancer Res 2001; 61:6548–54; PMID:11522653
  • Chen C, Yu Z. siRNA Targeting HIF-1α Induces Apoptosis of Pancreatic Cancer Cells through NF-κB-independent and –dependent Pathways under Hypoxic Conditions. Anticancer Res 2009; 29: 1367–72; PMID:19414389
  • Shimizu S, Eguchi Y, Kosaka H, Kamiike W, Matsuda H, Tsujimoto Y. Prevention of hypoxia-induced cell death by Bcl−2 and Bcl−xL. Nature 1995; 374:811–3; PMID:7723826; http://dx.doi.org/10.1038/374811a0
  • Goda N, Ryan HE, Khadivi B, McNulty W, Rickert RC, Johnson RS. Hypoxia-inducible factor 1 α is essential for cell cycle arrest during hypoxia. Mol Cell Biol 2003; 23:359–69; PMID:12482987; http://dx.doi.org/10.1128/MCB.23.1.359-369.2003
  • Wu WD, Hu ZM, Shang MJ, Zhao DJ, Zhang CW, Hong DF, Huang DS. Cordycepin down-regulates multiple drug resistant (MDR)/HIF-1α through regulating AMPK/mTORC1 signaling in GBC-SD gallbladder cancer cells. Int J Mol Sci 2014;15:12778–90; PMID:25046749; http://dx.doi.org/10.3390/ijms150712778
  • Stavrovskaya AA, Stromskaya TP. Transport proteins of the ABC family and multidrug resistance of tumor cells. Biochemistry (Mosc) 2008; 73:592–604; PMID:18605983; http://dx.doi.org/10.1134/S0006297908050118
  • Chen L, Feng P, Li S, Long D, Cheng J, Lu Y, Zhou D. Effect of hypoxiainducible factor-1alpha silencing on the sensitivity of human brain glioma cells to doxorubicin and etoposide. Neurochem Res 2009; 34:984–90; PMID:18937067; http://dx.doi.org/10.1007/s11064-008-9864-9
  • Comerford KM, Wallace TJ, Karhausen J, Louis NA, Montalto MC, Colgan SP. Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. Cancer Res 2002; 62:3387–94; PMID:12067980
  • Liao H, Wang G, Gu L, Huang S, Chen X, Li Y, Cai S. HIF-1α siRNA and Cisplatin in Combination Suppress Tumor Growth in a Nude Mice Model of Esophageal Squamous Cell Carcinoma. Asian Pacific J Cancer Prev 2012; 13:473–7; http://dx.doi.org/10.7314/APJCP.2012.13.2.473
  • Rajagopalan S, Olin J, Deitcher S, Pieczek A, Laird J, Grossman PM, Goldman CK, McEllin K, Kelly R, Chronos N. Use of a constitutively active hypoxia-inducible factor-1alpha transgene as a therapeutic strategy in no-option critical limb ischemia patients: phase I dose-escalation experience. Circulation 2007;115:1234–43; PMID:17309918

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