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Research Paper

A bivalent recombinant immunotoxin with high potency against tumors with EGFR and EGFRvIII expression

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Pages 1764-1774 | Received 17 Apr 2015, Accepted 12 Sep 2015, Published online: 19 Jan 2016

References

  • Hatanpaa KJ, Burma S, Zhao D, Habib AA. Epidermal growth factor receptor in glioma: signal transduction, neuropathology, imaging, and radioresistance. Neoplasia 2010; 9:675-84; http://dx.doi.org/10.1593/neo.10688
  • Wikstrand CJ, Sampson JH, Bigner DD. EGFRvIII: an oncogene deletion mutant cell surface receptor target expressed by multiple tumour types. Expert Opin Ther Targets 2000; 4:497-514; http://dx.doi.org/10.1517/14728222.4.4.497
  • Kuan CT, Wikstrand CJ, Bigner DD. EGFRvIII as a promising target for antibody-based brain tumor therapy. Brain Tumor Pathol 2000; 17:71-8; PMID:11210174; http://dx.doi.org/10.1007/BF02482738
  • Lo HW. EGFR-targeted therapy in malignant glioma: novel aspects and mechanisms of drug resistance. Curr Mol Pharmacol 2010; 3:37-52; PMID:20030624; http://dx.doi.org/10.2174/1874467211003010037
  • Chung CH, Ely K, McGavran L, Varella-Garcia M, Parker J, Parker N, Jarrett C, Carter J, Murphy BA, Netterville J et al. Increased epidermal growth factor receptor gene copy number is associated with poor prognosis in head and neck squamous cell carcinomas. J Clin Oncol 2006; 24:4170-6; PMID:16943533; http://dx.doi.org/10.1200/JCO.2006.07.2587
  • Temam S, Kawaguchi H, El-Naggar AK, Jelinek J, Tang H, Liu DD, Lang W, Issa JP, Lee JJ, Mao L. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol 2007; 25:2164-70; PMID:17538160; http://dx.doi.org/10.1200/JCO.2006.06.6605
  • Sok JC, Coppelli FM, Thomas SM, Lango MN, Xi S, Hunt JL, Freilino ML, Graner MW, Wikstrand CJ, Bigner DD, et al. Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res 2006; 12:5064-73; PMID:16951222; http://dx.doi.org/10.1158/1078-0432.CCR-06-0913
  • Keller J, Shroyer KR, Batajoo SK, Zhao HL, Dong LM, Hayman MJ, Chan EL. Combination of phosphorylated and truncated EGFR correlates with higher tumor and nodal stage in head and neck cancer. Cancer Invest 2010; 28:1054-62; PMID:20873989; http://dx.doi.org/10.3109/07357907.2010.512602
  • Chen LF, Cohen EEW, Grandis JR. New Strategies in Head and Neck Cancer: epidermal growth factor receptor inhibition in head and neck cancer. Clin Cancer Res 2010; 16:2489-95; PMID:20406834; http://dx.doi.org/10.1158/1078-0432.CCR-09-2318
  • Cohen RB. Current challenges and clinical investigations of epidermal growth factor receptor (EGFR)- and ErbB family-targeted agents in the treatment of head and neck squamous cell carcinoma (HNSCC). Cancer Treat Rev 2014; 40:567-77; PMID:24216225; http://dx.doi.org/10.1016/j.ctrv.2013.10.002
  • Taylor TE, Furnari FB, Cavenee WK. Targeting EGFR for treatment of glioblastoma: molecular basis to overcome resistance. Curr Cancer Drug Targets 2012; 12:197-209; PMID:22268382; http://dx.doi.org/10.2174/156800912799277557
  • De Witt Hamer PC. Small molecule kinase inhibitors in glioblastoma: a systematic review of clinical studies. Neuro Oncol 2010; 12:304-16; PMID:20167819; http://dx.doi.org/10.1093/neuonc/nop068
  • Chong CR, Jänne PA. The quest to overcome resistance to EGFR-targeted therapies in cancer. Nat Med 2013; 19:1389-400; PMID:24202392; http://dx.doi.org/10.1038/nm.3388
  • Pastan I, Hassan R, FitzGerald DJ, Kreitman RJ. Immunotoxin treatment of cancer. Annu Rev Med 2007; 58:221-37; PMID:17059365; http://dx.doi.org/10.1146/annurev.med.58.070605.115320
  • Shan L, Wang PC. Recombinant immunotoxin therapy of solid tumors: challenges and strategies. J Basic Clin Med 2013; 2:1-6; PMID:25309827
  • Schmidt M Vakalopoulou E, Schneider DW, Wels W. Construction and functional characterization of scFv(14E1)-ETA - a novel, highly potent antibody-toxin specific for the EGF receptor. Br J Cancer 1997; 75:1575-84; PMID:9184171; http://dx.doi.org/10.1038/bjc.1997.270
  • Ochiai H, Archer GE, Herndon JE 2nd, Kuan CT, Mitchell DA, Bigner DD, Pastan IH, Sampson JH. EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells. Cancer Immunol Immunother 2008; 57:115-21; PMID:17634939; http://dx.doi.org/10.1007/s00262-007-0363-7
  • Chandramohan V, Bigner DD. A novel recombinant immunotoxin-based therapy targeting wild-type and mutant EGFR improves survival in murine models of glioblastoma. Oncoimmunol 2013; 2:e26852; http://dx.doi.org/10.4161/onci.26852
  • Chandramohan V, Bao X, Keir ST, Pegram CN, Szafranski SE, Piao H, Wikstrand CJ, McLendon RE, Kuan CT, Pastan IH, et al. Construction of an immunotoxin, D2C7-(scdsFv)-PE38KDEL, targeting EGFRwt and EGFRvIII for brain tumor therapy. Clin Cancer Res 2013; 19:4717-27; PMID:23857604; http://dx.doi.org/10.1158/1078-0432.CCR-12-3891
  • Azemar M, Schmidt M, Arlt F, Kennel P, Brandt B, Papadimitriou A, Groner B, Wels W. Recombinant antibody toxins specific for ErbB2 and EGF receptor inhibit the in vitro growth of human head and neck cancer cells and cause rapid tumor regression in vivo. Int J Cancer 2000; 86:269-75; PMID:10738256; http://dx.doi.org/10.1002/(SICI)1097-0215(20000415)86:2%3c269::AID-IJC18%3e3.0.CO;2-8
  • Sampson JH, Akabani G, Archer GE, Bigner DD, Berger MS, Friedman AH, Friedman HS, Herndon JE 2nd, Kunwar S, Marcus S, et al. Progress report of a Phase I study of the intracerebral microinfusion of a recombinant chimeric protein composed of transforming growth factor (TGF)-α and a mutated form of the Pseudomonas exotoxin termed PE-38 (TP-38) for the treatment of malignant brain tumors. J Neurooncol 2003; 65:27-35; PMID:14649883; http://dx.doi.org/10.1023/A:1026290315809
  • Panousis C, Rayzman VM, Johns TG, Renner C, Liu Z, Cartwright G, Lee FT, Wang D, Gan H, Cao D, et al. Engineering and characterisation of chimeric monoclonal antibody 806 (ch806) for targeted immunotherapy of tumours expressing de2-7 EGFR or amplified EGFR. Br J Cancer 2005; 92:1069-77; PMID:15770208; http://dx.doi.org/10.1038/sj.bjc.6602470
  • Luwor RB, Johns TG, Murone C, Huang HJ, Cavenee WK, Ritter G, Old LJ, Burgess AW, Scott AM. Monoclonal antibody 806 inhibits the growth of tumor xenografts expressing either the de2-7 or amplified epidermal growth factor receptor (EGFR) but not wild-type EGFR. Cancer Res 2001; 61:5355-61; PMID:11454674
  • Johns TG, Mellman I, Cartwright GA, Ritter G, Old LJ, Burgess AW, Scott AM. The antitumor monoclonal antibody 806 recognizes a high-mannose form of the EGF receptor that reaches the cell surface when cells over-express the receptor. FASEB J 2005; 19:780-2; PMID:15774576
  • Johns TG, Adams TE, Cochran JR, Hall NE, Hoyne PA, Olsen MJ, Kim YS, Rothacker J, Nice EC, Walker F, et al. Identification of the epitope for the epidermal growth factor receptor-specific monoclonal antibody 806 reveals that it preferentially recognizes an untethered form of the receptor. J Biol Chem 2004; 279:30375-84; PMID:15075331; http://dx.doi.org/10.1074/jbc.M401218200
  • Scott AM, Lee FT, Tebbutt N, Herbertson R, Gill SS, Liu Z, Skrinos E, Murone C, Saunder TH, Chappell B, et al. A phase I clinical trial with monoclonal antibody ch806 targeting transitional state and mutant epidermal growth factor receptors. Proc Natl Acad Sci USA 2007; 104:4071-6; PMID:17360479; http://dx.doi.org/10.1073/pnas.0611693104
  • Woo JH, Liu YY, Stavrou S, Neville DM. Increasing secretion of bivalent anti-T-cell immunotoxin by Pichia pastoris. Appl Environ Microbiol 2004; 70:3370-6; PMID:15184133; http://dx.doi.org/10.1128/AEM.70.6.3370-3376.2004
  • Kim GB, Wang Z, Liu YY, Stavrou S, Mathias A, Goodwin KJ, Thomas JM, Neville DM. A fold-back single-chain diabody format enhances the bioactivity of an anti-monkey CD3 recombinant diphtheria toxin-based immunotoxin. Protein Eng Des Sel 2007; 20:425-32; PMID:17693455; http://dx.doi.org/10.1093/protein/gzm040
  • Zhang F, Shan L, Liu Y, Neville D, Woo JH, Chen Y, Korotcov A, Lin S, Huang S, Sridhar R, et al. An anti-PSMA bivalent immunotoxin exhibits specificity and efficacy for prostate cancer imaging and therapy. Adv Healthc Mater 2013; 2:736-44; PMID:23184611; http://dx.doi.org/10.1002/adhm.201200254
  • Liu YY, Woo JH, Neville DM. Overexpression of an anti-CD3 immunotoxin increases expression and secretion of molecular chaperone BiP/Kar2p by Pichia pastoris. Appl Environ Microbiol 2005; 71:5332-40; PMID:16151122; http://dx.doi.org/10.1128/AEM.71.9.5332-5340.2005
  • Hauser BR, Zhu X, Califano J, Gu X. Detection of gene copy number of epidermal growth factor receptor in head and neck squamous cell carcinomas cell lines. Cancer Res 2008; 68: 3413; PMID:18451169; http://dx.doi.org/10.1158/0008-5472.CAN-07-1919
  • Hauser BR. Epidermal growth factor receptor (EGFR) gene expression and its related biomarkers in head and neck squamous cell carcinoma [master's thesis]. [Washington DC]: Howard University; 2008. 58 p.
  • Liu YY, Woo JH, Neville DM. Targeted introduction of a diphtheria toxin resistant mutation into the chromosomal EF-2 locus of Pichia pastoris and expression of immunotoxin in the EF-2 mutants. Protein Expr Purif 2003; 30:262-74; PMID:12880776; http://dx.doi.org/10.1016/S1046-5928(03)00129-3
  • Li YM, Vallera DA, Hall WA. Diphtheria toxin-based targeted toxin therapy for brain tumors. J Neurooncol 2013; 114:155-64; PMID:23695514; http://dx.doi.org/10.1007/s11060-013-1157-8
  • Adkins I, Holubova J, Kosova M, Sadilkova L. Bacteria and their toxins tamed for immunotherapy. Curr Pharm Biotechnol 2012; 13:1446-73; PMID:22339216; http://dx.doi.org/10.2174/138920112800784835
  • Matar AJ, Pathiraja V, Wang Z, Duran-Struuck R, Gusha A, Crepeau R, Tasaki M, Sachs DH, Huang CA. Effect of pre-existing anti-diphtheria toxin antibodies on T cell depletion levels following diphtheria toxin-based recombinant anti-monkey CD3 immunotoxin treatment. Transpl Immunol 2012; 27:52-4; PMID:22676970; http://dx.doi.org/10.1016/j.trim.2012.05.003
  • Manoukian G, Hagemeister F. Denileukin diftitox: a novel immunotoxin. Expert Opin Biol Ther 2009; 9:1445-51; PMID:19817678; http://dx.doi.org/10.1517/14712590903348135
  • Woo JH, Liu JS, Kang SH, Singh R, Park SK, Su Y, Ortiz J, Neville DM, Willingham MC, Frankel AE. GMP production and characterization of the bivalent anti-human T cell immunotoxin, A-dmDT390-bisFv(UCHT1), for phase I/II clinical trials. Protein Expr Purif 2008; 58:1-11; PMID:18160309; http://dx.doi.org/10.1016/j.pep.2007.11.006
  • Bühler P, Wetterauer D, Gierschner D, Wetterauer U, Beile UE, Wolf P. Influence of structural variations on biological activity of anti-PSMA scFv and immunotoxins targeting prostate cancer. Anticancer Res 2010; 30:3373-9; PMID:20944111
  • Thompson J, Stavrou S, Weetall M, Hexham JM, Digan ME, Wang Z, Woo JH, Yu Y, Mathias A, Liu YY, et al. Improved binding of a bivalent single-chain immunotoxin results in increased efficacy for in vivo T-cell depletion. Protein Eng 2001; 14:1035-41; PMID:11809934; http://dx.doi.org/10.1093/protein/14.12.1035
  • Nagane M, Coufal F, Lin H, Bögler O, Cavenee WK, Huang HJ. A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis. Cancer Res 1996; 56:5079-86; PMID:8895767
  • Nishikawa R, Ji XD, Harmon RC, Lazar CS, Gill GN, Cavenee WK, Huang HJ. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci USA 1994; 91:7727-31; PMID:8052651; http://dx.doi.org/10.1073/pnas.91.16.7727
  • Inda MM, Bonavia R, Mukasa A, Narita Y, Sah DW, Vandenberg S, Brennan C, Johns TG, Bachoo R, Hadwiger P, et al. Tumor heterogeneity is an active process maintained by a mutant EGFR-induced cytokine circuit in glioblastoma. Genes Dev 2010; 24:1731-45; PMID:20713517; http://dx.doi.org/10.1101/gad.1890510

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