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Research Paper

NDRG1 overexpression promotes the progression of esophageal squamous cell carcinoma through modulating Wnt signaling pathway

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Pages 943-954 | Received 02 Mar 2016, Accepted 03 Jul 2016, Published online: 22 Aug 2016

References

  • Wei W, Bracher-Manecke JC, Zhao X, Davies NH, Zhou L, Ai R, Oliver L, Vallette F, Hendricks DT. Oncogenic but non-essential role of N-myc downstream regulated gene 1 in the progression of esophageal squamous cell carcinoma. Cancer Biol Ther 2013; 14:164-74; PMID:23192272; http://dx.doi.org/10.4161/cbt.22956
  • Botelho NK, Schneiders FI, Lord SJ, Freeman AK, Tyagi S, Nancarrow DJ, Hayward NK, Whiteman DC, Lord RV. Gene expression alterations in formalin-fixed, paraffin-embedded Barrett esophagus and esophageal adenocarcinoma tissues. Cancer Biol Ther 2010; 10:172-9; PMID:20543560; http://dx.doi.org/10.4161/cbt.10.2.12166
  • Li J, Ying J, Fan Y, Wu L, Ying Y, Chan AT, Srivastava G, Tao Q. WNT5A antagonizes WNT/β-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma. Cancer Biol Ther 2010; 10:617-24; PMID:20603606; http://dx.doi.org/10.4161/cbt.10.6.12609
  • Jain M, Kumar S, Upadhyay R, Lal P, Tiwari A, Ghoshal UC, Mittal B. Influence of apoptosis (BCL2, FAS), cell cycle (CCND1) and growth factor (EGF, EGFR) genetic polymorphisms on survival outcome: an exploratory study in squamous cell esophageal cancer. Cancer Biol Ther 2007; 6:1553-8; PMID:17912028; http://dx.doi.org/10.4161/cbt.6.10.4709
  • Sun J, Zhang D, Bae DH, Sahni S, Jansson P, Zheng Y, Zhao Q, Yue F, Zheng M, Kovacevic Z, et al. Metastasis suppressor, NDRG1, mediates its activity through signaling pathways and molecular motors. Carcinogenesis 2013; 34:1943-54; PMID:23671130; http://dx.doi.org/10.1093/carcin/bgt163
  • Lachat P, Shaw P, Gebhard S, van Belzen N, Chaubert P, Bosman FT. Expression of NDRG1, a differentiation-related gene, in human tissues. Histochem Cell Biol 2002; 118:399-408; PMID:12432451; http://dx.doi.org/10.1007/s00418-002-0460-9
  • Wang H, Qian H, Yu J, Zhang X, Zhang L, Fu M, Liang X, Zhan Q, Lin C. Administration of PUMA adenovirus increases the sensitivity of esophageal cancer cells to anticancer drugs. Cancer Biol Ther 2006; 5:380-5; PMID:16481741; http://dx.doi.org/10.4161/cbt.5.4.2477
  • Takaoka M, Kim SH, Okawa T, Michaylira CZ, Stairs DB, Johnstone CN, Andl CD, Rhoades B, Lee JJ, Klein-Szanto AJ, et al. IGFBP-3 regulates esophageal tumor growth through IGF-dependent and independent mechanisms. Cancer Biol Ther 2007; 6:534-40; PMID:17457048; http://dx.doi.org/10.4161/cbt.6.4.3832
  • Wang Y, Zhu H, Quan L, Zhou C, Bai J, Zhang G, Zhan Q, Xu N. Downregulation of survivin by RNAi inhibits the growth of esophageal carcinoma cells. Cancer Biol Ther 2005; 4:974-8; PMID:16082195; http://dx.doi.org/10.4161/cbt.4.9.1914
  • Yang Y, Goldstein BG, Chao HH, Katz JP. KLF4 and KLF5 regulate proliferation, apoptosis and invasion in esophageal cancer cells. Cancer Biol Ther 2005; 4:1216-21; PMID:16357509; http://dx.doi.org/10.4161/cbt.4.11.2090
  • Fang BA, Kovacevic Z, Park KC, Kalinowski DS, Jansson PJ, Lane DJ, Sahni S, Richardson DR. Molecular functions of the iron-regulated metastasis suppressor, NDRG1, and its potential as a molecular target for cancer therapy. Biochim Biophys Acta 2014; 1845:1-19; PMID:24269900; http://dx.doi.org/10.1016/j.bbagrm.2013.11.001
  • Chang X, Xu X, Ma J, Xue X, Li Z, Deng P, Zhang S, Zhi Y, Chen J, Dai D. NDRG1 expression is related to the progression and prognosis of gastric cancer patients through modulating proliferation, invasion and cell cycle of gastric cancer cells. Mol Biol Rep 2014; 41:6215-23; PMID:24985974; http://dx.doi.org/10.1007/s11033-014-3501-2
  • Chen J, Li S, Yang Z, Lu G, Hu H. Correlation between NDRG1 and PTEN expression in endometrial carcinoma. Cancer Sci 2008; 99:706-10; PMID:18377423; http://dx.doi.org/10.1111/j.1349-7006.2008.00749.x
  • Mao Z, Sun J, Feng B, Ma J, Zang L, Dong F, Zhang D, Zheng M. The metastasis suppressor, N-myc downregulated gene 1 (NDRG1), is a prognostic biomarker for human colorectal cancer. PLoS One 2013; 8:e68206; PMID:23874544; http://dx.doi.org/10.1371/journal.pone.0068206
  • Matsuzaki E, Hiratsuka S, Hamachi T, Takahashi-Yanaga F, Hashimoto Y, Higashi K, Kobayashi M, Hirofuji T, Hirata M, Maeda K. Sphingosine-1-phosphate promotes the nuclear translocation of β-catenin and thereby induces osteoprotegerin gene expression in osteoblast-like cell lines. Bone 2013; 55:315-24; PMID:23612487; http://dx.doi.org/10.1016/j.bone.2013.04.008
  • Strzelczyk B, Szulc A, Rzepko R, Kitowska A, Skokowski J, Szutowicz A, Pawelczyk T. Identification of high-risk stage II colorectal tumors by combined analysis of the NDRG1 gene expression and the depth of tumor invasion. Ann Surg Oncol 2009; 16:1287-94; PMID:19259744; http://dx.doi.org/10.1245/s10434-009-0381-0
  • Lu WJ, Chua MS, So SK. Suppressing N-Myc downstream regulated gene 1 reactivates senescence signaling and inhibits tumor growth in hepatocellular carcinoma. Carcinogenesis 2014; 35:915-22; PMID:24302615; http://dx.doi.org/10.1093/carcin/bgt401
  • Lee JC, Chung LC, Chen YJ, Feng TH, Juang HH. N-myc downstream-regulated gene 1 downregulates cell proliferation, invasiveness, and tumorigenesis in human oral squamous cell carcinoma. Cancer Lett 2014; 355:242-52; PMID:25218595; http://dx.doi.org/10.1016/j.canlet.2014.08.035
  • Dos Santos M, da Cunha Mercante AM, Nunes FD, Leopoldino AM, de Carvalho MB, Gazito D, Lopez RV, Chiappini PB, de Carvalho Neto PB, Fukuyama EE, et al. Prognostic significance of NDRG1 expression in oral and oropharyngeal squamous cell carcinoma. Mol Biol Rep 2012; 39:10157-65; PMID:22972152; http://dx.doi.org/10.1007/s11033-012-1889-0
  • Nishio S, Ushijima K, Tsuda N, Takemoto S, Kawano K, Yamaguchi T, Nishida N, Kakuma T, Tsuda H, Kasamatsu T, et al. Cap43/NDRG1/Drg-1 is a molecular target for angiogenesis and a prognostic indicator in cervical adenocarcinoma. Cancer Lett 2008; 264:36-43; PMID:18281151; http://dx.doi.org/10.1016/j.canlet.2008.01.020
  • Sibold S, Roh V, Keogh A, Studer P, Tiffon C, Angst E, Vorburger SA, Weimann R, Candinas D, Stroka D. Hypoxia increases cytoplasmic expression of NDRG1, but is insufficient for its membrane localization in human hepatocellular carcinoma. FEBS Lett 2007; 581:989-94; PMID:17316623; http://dx.doi.org/10.1016/j.febslet.2007.01.080
  • Ando T, Ishiguro H, Kimura M, Mitsui A, Kurehara H, Sugito N, Tomoda K, Mori R, Takashima N, Ogawa R, et al. Decreased expression of NDRG1 is correlated with tumor progression and poor prognosis in patients with esophageal squamous cell carcinoma. Dis Esophagus 2006; 19:454-8; PMID:17069588; http://dx.doi.org/10.1111/j.1442-2050.2006.00618.x
  • Symes AJ, Eilertsen M, Millar M, Nariculam J, Freeman A, Notara M, Feneley MR, Patel HR, Masters JR, Ahmed A. Quantitative analysis of BTF3, HINT1, NDRG1 and ODC1 protein over-expression in human prostate cancer tissue. PLoS One 2013; 8:e84295; PMID:24386364; http://dx.doi.org/10.1371/journal.pone.0084295
  • Wang D, Tian X, Jiang Y. NDRG1/Cap43 overexpression in tumor tissues and serum from lung cancer patients. J Cancer Res Clin Oncol 2012; 138:1813-20; PMID:22722710; http://dx.doi.org/10.1007/s00432-012-1236-9
  • Sohda M, Mochida Y, Kato H, Miyazaki T, Nakajima M, Fukuchi M, Manda R, Fukai Y, Masuda N, Ono M, et al. Overexpression of Cap43 is associated with malignant status of esophageal cancer. Anticancer Res 2009; 29:965-70; PMID:19414333
  • Ureshino H, Murakami Y, Watari K, Izumi H, Kawahara A, Kage M, Arao T, Nishio K, Yanagihara K, Kinoshita H, et al. N-myc downstream regulated gene 1 (NDRG1) promotes metastasis of human scirrhous gastric cancer cells through epithelial mesenchymal transition. PLoS One 2012; 7:e41312; PMID:22844455; http://dx.doi.org/10.1371/journal.pone.0041312
  • Shimada Y, Imamura M, Wagata T, Yamaguchi N, Tobe T. Characterization of 21 newly established esophageal cancer cell lines. Cancer 1992; 69:277-84; PMID:1728357; http://dx.doi.org/10.1002/1097-0142(19920115)69:2%3c277::AID-CNCR2820690202%3e3.0.CO;2-C
  • Xu Y, Zhou L, Huang J, Liu F, Yu J, Zhan Q, Zhang L, Zhao X. Role of Smac in determining the chemotherapeutic response of esophageal squamous cell carcinoma. Clin Cancer Res 2011; 17:5412-22; PMID:21676925; http://dx.doi.org/10.1158/1078-0432.CCR-11-0426
  • He S, Wang L, Miao L, Wang T, Du F, Zhao L, Wang X. Receptor interacting protein kinase-3 determines cellular necrotic response to TNF-α. Cell 2009; 137:1100-11; PMID:19524512; http://dx.doi.org/10.1016/j.cell.2009.05.021
  • Hao XP, Pretlow TG, Rao JS, Pretlow TP. Beta-catenin expression is altered in human colonic aberrant crypt foci. Cancer Res 2001; 61:8085-8; PMID:11719432
  • Roy S, Chakravarty D, Cortez V, De Mukhopadhyay K, Bandyopadhyay A, Ahn JM, Raj GV, Tekmal RR, Sun L, Vadlamudi RK. Significance of PELP1 in ER-negative breast cancer metastasis. Mol Cancer Res 2012; 10:25-33; PMID:22086908; http://dx.doi.org/10.1158/1541-7786.MCR-11-0456
  • Xu Y, Lin Z, Zhao N, Zhou L, Liu F, Cichacz Z, Zhang L, Zhan Q, Zhao X. Receptor interactive protein kinase 3 promotes Cisplatin-triggered necrosis in apoptosis-resistant esophageal squamous cell carcinoma cells. PLoS One 2014 Jun 24; 9(6):e100127; PMID:24959694; http://dx.doi.org/10.1371/journal.pone.0100127
  • Han B, Li W, Sun Y, Zhou L, Xu Y, Zhao X. A prolyl-hydroxylase inhibitor, ethyl-3,4-dihydroxybenzoate, induces cell autophagy and apoptosis in esophageal squamous cell carcinoma cells via up-regulation of BNIP3 and N-myc downstream-regulated gene-1. PLoS One 2014; 9:e107204; PMID:25232961; http://dx.doi.org/10.1371/journal.pone.0107204
  • Wissing MD, Mendonca J, Kim E, Shim JS, Kaelber NS, Kant H, Hammers H, Commes T, Van Diest PJ, Liu JO, et al. Identification of cetrimonium bromide and irinotecan as compounds with synthetic lethality against NDRG1 deficient prostate cancer cells. Cancer Biol Ther 2013; 14:401-10; PMID:23377825; http://dx.doi.org/10.4161/cbt.23759
  • Clevers H, Nusse R. Wnt/β-catenin signaling and disease. Cell 2012; 149:1192-205; PMID:22682243; http://dx.doi.org/10.1016/j.cell.2012.05.012
  • Chen B, Zaveri PG, Longtine MS, Nelson DM. N-myc downstream-regulated gene 1 (NDRG1) mediates pomegranate juice protection from apoptosis in hypoxic BeWo cells but not in primary human trophoblasts. Placenta 2015; 36:847-53; PMID:26028238; http://dx.doi.org/10.1016/j.placenta.2015.05.009
  • Chen Z, Zhang D, Yue F, Zheng M, Kovacevic Z, Richardson DR. The iron chelators Dp44mT and DFO inhibit TGF-β-induced epithelial-mesenchymal transition via up-regulation of N-Myc downstream-regulated gene 1 (NDRG1). J Biol Chem 2012; 287:17016-28; PMID:22453918; http://dx.doi.org/10.1074/jbc.M112.350470
  • Liu W, Iiizumi-Gairani M, Okuda H, Kobayashi A, Watabe M, Pai SK, Pandey PR, Xing F, Fukuda K, Modur V, et al. KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer. J Biol Chem 2011; 286:18949-59; PMID:21454613; http://dx.doi.org/10.1074/jbc.M111.232637
  • Pearce LR, Sommer EM, Sakamoto K, Wullschleger S, Alessi DR. Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem J 2011; 436:169-79; PMID:21413931; http://dx.doi.org/10.1042/BJ20102103
  • MacDonald BT, Tamai K, He X. Wnt/β-catenin signaling: components, mechanisms, and diseases. Dev Cell 2009; 17:9-26; PMID:19619488; http://dx.doi.org/10.1016/j.devcel.2009.06.016
  • Liu W, Xing F, Iiizumi-Gairani M, Okuda H, Watabe M, Pai SK, Pandey PR, Hirota S, Kobayashi A, Mo YY, et al. N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis. EMBO Mol Med 2012; 4:93-108; PMID:22246988; http://dx.doi.org/10.1002/emmm.201100190
  • Jin R, Liu W, Menezes S, Yue F, Zheng M, Kovacevic Z, Richardson DR. The metastasis suppressor NDRG1 modulates the phosphorylation and nuclear translocation of β-catenin through mechanisms involving FRAT1 and PAK4. J Cell Sci 2014; 127:3116-30; PMID:24829151; http://dx.doi.org/10.1242/jcs.147835
  • Melotte V, Qu X, Ongenaert M, van Criekinge W, de Bruine AP, Baldwin HS, van Engeland M. The N-myc downstream regulated gene (NDRG) family: diverse functions, multiple applications. FASEB J 2010; 24:4153-66; PMID:20667976; http://dx.doi.org/10.1096/fj.09-151464
  • Hanson AJ, Wallace HA, Freeman TJ, Beauchamp RD, Lee LA, Lee E. XIAP monoubiquitylates Groucho/TLE to promote canonical Wnt signaling. Mol Cell 2012; 45:619-28; PMID:22304967; http://dx.doi.org/10.1016/j.molcel.2011.12.032
  • Buscarlet M, Perin A, Laing A, Brickman JM, Stifani S. Inhibition of cortical neuron differentiation by Groucho/TLE1 requires interaction with WRPW, but not Eh1, repressor peptides. J Biol Chem 2008; 283:24881-8; PMID:18611861; http://dx.doi.org/10.1074/jbc.M800722200
  • Roth M, Bonev B, Lindsay J, Lea R, Panagiotaki N, Houart C, Papalopulu N. FoxG1 and TLE2 act cooperatively to regulate ventral telencephalon formation. Development 2010; 137:1553-62; PMID:20356955; http://dx.doi.org/10.1242/dev.044909
  • He Z, Liu Y, Liang D, Wang Z, Robertson ES, Lan K. Cellular corepressor TLE2 inhibits replication-and-transcription- activator-mediated transactivation and lytic reactivation of Kaposi's sarcoma-associated herpesvirus. J Virol 2010; 84:2047-62; PMID:19939918; http://dx.doi.org/10.1128/JVI.01984-09