Expression of aromatase in tumor related stroma is associated with human bladder cancer progression

References

• Siegel RL, Miller KD, Jemal A. Cancer Statistics, 2017. CA Cancer J Clin. 2017;67:7–30. doi:10.3322/caac.21387.
   PubMed Web of Science ®Google Scholar
• Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. doi:10.3322/caac.21262.
   PubMed Web of Science ®Google Scholar
• Hemelt M, Yamamoto H, Cheng KK, Zeegers MP. The effect of smoking on the male excess of bladder cancer: a meta-analysis and geographical analyses. Int J Cancer. 2009;124:412–9. doi:10.1002/ijc.23856.
   PubMed Web of Science ®Google Scholar
• Castelao JE, Yuan JM, Skipper PL, Tannenbaum SR, Gago-Dominguez M, Crowder JS, et al. Gender- and smoking-related bladder cancer risk. J Natl Cancer Inst. 2001;93:538–45. doi:10.1093/jnci/93.7.538.
   PubMed Web of Science ®Google Scholar
• Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, et al. Cancer statistics, 2008. CA Cancer J Clin. 2008;58:71–96. doi:10.3322/CA.2007.0010.
   PubMed Web of Science ®Google Scholar
• Scosyrev E, Noyes K, Feng C, Messing E. Sex and racial differences in bladder cancer presentation and mortality in the US. Cancer. 2009;115:68–74. doi:10.1002/cncr.23986.
   PubMed Web of Science ®Google Scholar
• Lucca I, Klatte T, Fajkovic H, de Martino M, Shariat SF. Gender differences in incidence and outcomes of urothelial and kidney cancer. Nat Rev Urol. 2015;12:653. doi:10.1038/nrurol.2015.257.
   PubMed Web of Science ®Google Scholar
• Dobruch J, Daneshmand S, Fisch M, Lotan Y, Noon AP, Resnick MJ, et al. Gender and Bladder Cancer: A Collaborative Review of Etiology, Biology, and Outcomes. Eur Urol. 2016;69:300–10. doi:10.1016/j.eururo.2015.08.037.
   PubMed Web of Science ®Google Scholar
• Godoy G, Gakis G, Smith CL, Fahmy O. Effects of Androgen and Estrogen Receptor Signaling Pathways on Bladder Cancer Initiation and Progression. Bladder Cancer. 2016;2:127–37. doi:10.3233/BLC-160052.
   PubMed Web of Science ®Google Scholar
• Simpson ER, Davis SR. Minireview: aromatase and the regulation of estrogen biosynthesis–some new perspectives. Endocrinology. 2001;142:4589–94. doi:10.1210/endo.142.11.8547.
   PubMed Web of Science ®Google Scholar
• Santen RJ, Harvey HA. Use of aromatase inhibitors in breast carcinoma. Endocr Relat Cancer. 1999;6:75–92. doi:10.1677/erc.0.0060075.
   PubMed Web of Science ®Google Scholar
• Chavalmane AK, Comeglio P, Morelli A, Filippi S, Fibbi B, Vignozzi L, et al. Sex steroid receptors in male human bladder: expression and biological function. J Sex Med. 2010;7:2698–713. doi:10.1111/j.1743-6109.2010.01811.x.
   PubMed Web of Science ®Google Scholar
• Strauss L, Rantakari P, Sjogren K, Salminen A, Lauren E, Kallio J, et al. Seminal vesicles and urinary bladder as sites of aromatization of androgens in men, evidenced by a CYP19A1-driven luciferase reporter mouse and human tissue specimens. FASEB J. 2013;27:1342–50. doi:10.1096/fj.12-219048.
   PubMed Web of Science ®Google Scholar
• Suzuki T, Miki Y, Akahira J, Moriya T, Ohuchi N, Sasano H. Aromatase in human breast carcinoma as a key regulator of intratumoral sex steroid concentrations. Endocr J. 2008;55:455–63. doi:10.1507/endocrj.K07E-053.
   PubMed Web of Science ®Google Scholar
• Jarzabek K, Koda M, Walentowicz-Sadlecka M, Grabiec M, Laudanski P, Wolczynski S. Altered expression of ERs, aromatase, and COX2 connected to estrogen action in type 1 endometrial cancer biology. Tumour Biol. 2013;34:4007–16. doi:10.1007/s13277-013-0991-9.
   PubMed Web of Science ®Google Scholar
• Veerapaneni P, Kirma N, Nair HB, Hammes LS, Hall KL, Tekmal RR. Elevated aromatase expression correlates with cervical carcinoma progression. Gynecol Oncol. 2009;114:496–500. doi:10.1016/j.ygyno.2009.05.041.
   PubMed Web of Science ®Google Scholar
• Cunat S, Rabenoelina F, Daures JP, Katsaros D, Sasano H, Miller WR, et al. Aromatase expression in ovarian epithelial cancers. J Steroid Biochem Mol Biol. 2005;93:15–24. doi:10.1016/j.jsbmb.2004.10.021.
   PubMed Web of Science ®Google Scholar
• Grindstad T, Skjefstad K, Andersen S, Ness N, Nordby Y, Al-Saad S, et al. Estrogen receptors alpha and beta and aromatase as independent predictors for prostate cancer outcome. Sci Rep. 2016;6:33114. doi:10.1038/srep33114.
   PubMed Web of Science ®Google Scholar
• Verma MK, Miki Y, Sasano H. Aromatase in human lung carcinoma. Steroids. 2011;76:759–64. doi:10.1016/j.steroids.2011.02.020.
   PubMed Web of Science ®Google Scholar
• Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Miki Y, et al. Aromatase in colon carcinoma. Anticancer Res. 2012;32:3069–75.
   PubMed Web of Science ®Google Scholar
• Nguyen DP, O'Malley P, Al Hussein Al Awamlh B, Furrer MA, Mongan NP, Robinson BD, et al. Association of Aromatase With Bladder Cancer Stage and Long-Term Survival: New Insights Into the Hormonal Paradigm in Bladder Cancer. Clin Genitourin Cancer. 2017;15(2):256–262.e1. doi:10.1016/j.clgc.2016.05.017. PubMed PMID: 27324053.
   PubMed Web of Science ®Google Scholar
• Segawa T, Shozu M, Murakami K, Kasai T, Shinohara K, Nomura K, et al. Aromatase expression in stromal cells of endometrioid endometrial cancer correlates with poor survival. Clin Cancer Res. 2005;11:2188–94. doi:10.1158/1078-0432.CCR-04-1859.
   PubMed Web of Science ®Google Scholar
• Mah V, Marquez D, Alavi M, Maresh EL, Zhang L, Yoon N, et al. Expression levels of estrogen receptor beta in conjunction with aromatase predict survival in non-small cell lung cancer. Lung Cancer. 2011;74:318–25. doi:10.1016/j.lungcan.2011.03.009.
   PubMed Web of Science ®Google Scholar
• Bollet MA, Savignoni A, De Koning L, Tran-Perennou C, Barbaroux C, Degeorges A, et al. Tumor aromatase expression as a prognostic factor for local control in young breast cancer patients after breast-conserving treatment. Breast Cancer Res. 2009;11:R54. doi:10.1186/bcr2343.
   PubMed Web of Science ®Google Scholar
• Singer CF, Fink-Retter A, Gschwantler-Kaulich D, Thalhammer T, Hudelist G, Mueller R, et al. Selective spatial upregulation of intratumoral stromal aromatase in breast cancer patients: evidence for imbalance of local estrogen metabolism. Endocr Relat Cancer. 2006;13:1101–7. doi:10.1677/erc.1.01230.
   PubMed Web of Science ®Google Scholar
• Riemsma R, Forbes CA, Kessels A, Lykopoulos K, Amonkar MM, Rea DW, et al. Systematic review of aromatase inhibitors in the first-line treatment for hormone sensitive advanced or metastatic breast cancer. Breast Cancer Res Treat. 2010;123:9–24. doi:10.1007/s10549-010-0974-0.
   PubMed Web of Science ®Google Scholar
• Edge SB, American Joint Committee on Cancer. AJCC cancer staging manual. New York; London: Springer, 2010.
   Google Scholar
• Humphrey PA, Moch H, Cubilla AL, Ulbright TM, Reuter VE. The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part B: Prostate and Bladder Tumours. Eur Urol. 2016;70:106–19. doi:10.1016/j.eururo.2016.02.028.
   PubMed Web of Science ®Google Scholar
• Ide H, Miyamoto H. Steroid Hormone Receptor Signals as Prognosticators for Urothelial Tumor. Dis Markers. 2015;2015:840640. doi:10.1155/2015/840640.
   PubMed Web of Science ®Google Scholar
• Li Y, Izumi K, Miyamoto H. The role of the androgen receptor in the development and progression of bladder cancer. Jpn J Clin Oncol. 2012;42:569–77. doi:10.1093/jjco/hys072.
   PubMed Web of Science ®Google Scholar
• Chang C, Lee SO, Yeh S, Chang TM. Androgen receptor (AR) differential roles in hormone-related tumors including prostate, bladder, kidney, lung, breast and liver. Oncogene. 2014;33:3225–34. doi:10.1038/onc.2013.274.
   PubMed Web of Science ®Google Scholar
• Miki Y, Suzuki T, Tazawa C, Yamaguchi Y, Kitada K, Honma S, et al. Aromatase localization in human breast cancer tissues: possible interactions between intratumoral stromal and parenchymal cells. Cancer Res. 2007;67:3945–54. doi:10.1158/0008-5472.CAN-06-3105.
   PubMed Web of Science ®Google Scholar
• Liao D, Luo Y, Markowitz D, Xiang R, Reisfeld RA. Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model. PLoS One. 2009;4:e7965. doi:10.1371/journal.pone.0007965.
   PubMed Web of Science ®Google Scholar
• Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 1999;59:5002–11.
   PubMed Web of Science ®Google Scholar
• US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT00589017?term=NCT00589017&rank=1.
   Google Scholar
• US National Library of Medicine. ClinicalTrials.gov [online], https://clinicaltrials.gov/ct2/show/NCT02197897?term=NCT02197897&rank=1.
   Google Scholar