NEDD4L inhibits glycolysis and proliferation of cancer cells in oral squamous cell carcinoma by inducing ENO1 ubiquitination and degradation

References

• Markopoulos AK. Current aspects on oral squamous cell carcinoma. The Open Dentistry Journal. 2012;6:126–130. doi:10.2174/1874210601206010126.
   PubMedGoogle Scholar
• Campbell CD, Mohajeri K, Malig M, Hormozdiari F, Nelson B, Du G, Patterson KM, Eng C, Torgerson DG, Hu D, et al. Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma. PloS one. 2014;9:e104396. doi:10.1371/journal.pone.0104396.
   PubMed Web of Science ®Google Scholar
• Lee DE, Yoo JE, Kim J, Kim S, Kim S, Lee H, Cheong H. NEDD4L downregulates autophagy and cell growth by modulating ULK1 and a glutamine transporter. Cell Death & Disease. 2020;11:38. doi:10.1038/s41419-020-2242-5.
   PubMed Web of Science ®Google Scholar
• Ye X, Wang L, Shang B, Wang Z, Wei W. NEDD4: a promising target for cancer therapy. Current Cancer Drug Targets. 2014;14:549–556. doi:10.2174/1568009614666140725092430.
   PubMed Web of Science ®Google Scholar
• Yang Q, Zhao J, Cui M, Gi S, Wang W, Han X. Nedd4L expression is decreased in ovarian epithelial cancer tissues compared to ovarian non-cancer tissue. The Journal of Obstetrics and Gynaecology Research. 2015;41:1959–1964. doi:10.1111/jog.12808.
   PubMed Web of Science ®Google Scholar
• He S, Deng J, Li G, Wang B, Cao Y, Tu Y. Down-regulation of Nedd4L is associated with the aggressive progression and worse prognosis of malignant glioma. Japanese Journal of Clinical Oncology. 2012;42:196–201. doi:10.1093/jjco/hyr195.
   PubMed Web of Science ®Google Scholar
• Jiang X, Zhang S, Yin Z, Sheng Y, Yan Q, Sun R, Lu M, Zhang Z, Li Y. The correlation between NEDD4L and HIF-1alpha levels as a gastric cancer prognostic marker. International Journal of Medical Sciences. 2019;16:1517–1524. doi:10.7150/ijms.34646.
   PubMed Web of Science ®Google Scholar
• Hu XY, Xu YM, Fu Q, Yu JJ, Huang J. Nedd4L expression is downregulated in prostate cancer compared to benign prostatic hyperplasia. European Journal of Surgical Oncology: The Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. 2009;35:527–531. doi:10.1016/j.ejso.2008.09.015.
   PubMed Web of Science ®Google Scholar
• Gao C, Pang L, Ren C, Ma T. Decreased expression of Nedd4L correlates with poor prognosis in gastric cancer patient. Medical Oncology. 2012;29:1733–1738. doi:10.1007/s12032-011-0061-3.
   PubMed Web of Science ®Google Scholar
• Yilmaz E, Gul M, Melekoglu R, Inci Coskun E, Sahin N, Gul S, Bastemur AG, Ciplak B. Neural precursor cell-expressed developmentally down-regulated 4-like: a new biomarker in the pathophysiology of endometrial cancer. The Journal of International Medical Research. 2018;46:3709–3716. doi:10.1177/0300060518777944.
   PubMed Web of Science ®Google Scholar
• Zhao F, Gong X, Liu A, Lv X, Hu B, Zhang H. Downregulation of Nedd4L predicts poor prognosis, promotes tumor growth and inhibits MAPK/ERK signal pathway in hepatocellular carcinoma. Biochemical and Biophysical Research Communications. 2018;495:1136–1143. doi:10.1016/j.bbrc.2017.11.139.
   PubMed Web of Science ®Google Scholar
• Yang H, Zhu J, Wang G, Liu H, Zhou Y, Qian J. STK35 Is ubiquitinated by NEDD4L and promotes glycolysis and inhibits apoptosis through regulating the AKT signaling pathway, influencing chemoresistance of colorectal cancer. Frontiers in Cell and Developmental Biology. 2020;8:582695. doi:10.3389/fcell.2020.582695.
   PubMed Web of Science ®Google Scholar
• Tanksley JP, Chen X, Coffey RJ, Liu C. NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling. PloS one. 2013;8:e81514. doi:10.1371/journal.pone.0081514.
   PubMed Web of Science ®Google Scholar
• Novellasdemunt L, Kucharska A, Jamieson C, Prange-Barczynska M, Baulies A, Antas P, van der Vaart J, Gehart H, Maurice MM, Li VS, et al. NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor. The EMBO Journal. 2020;39:e102771. doi:10.15252/embj.2019102771.
   PubMed Web of Science ®Google Scholar
• Chen JM, Chiu SC, Chen KC, Huang YJ, Liao YA, Yu CR. Enolase 1 differentially contributes to cell transformation in lung cancer but not in esophageal cancer. Oncology Letters. 2020;19:3189–3196. doi:10.3892/ol.2020.11427.
   PubMed Web of Science ®Google Scholar
• Zuo J, Wang B, Long M, Gao Z, Zhang Z, Wang H, Wang X, Li R, Dong K, Zhang H, et al. The type 1 transmembrane glycoprotein B7-H3 interacts with the glycolytic enzyme ENO 1 to promote malignancy and glycolysis in HeLa cells. FEBS Letters. 2018;592:2476–2488. doi:10.1002/1873-3468.13164.
   PubMed Web of Science ®Google Scholar
• Yang T, Shu X, Zhang HW, Sun LX, Yu L, Liu J, Sun L-C, Yang Z-H, Ran Y-L. Enolase 1 regulates stem cell-like properties in gastric cancer cells by stimulating glycolysis. Cell Death & Disease. 2020;11:870. doi:10.1038/s41419-020-03087-4.
   PubMed Web of Science ®Google Scholar
• Ganapathy-Kanniappan S, Geschwind JF. Tumor glycolysis as a target for cancer therapy: progress and prospects. Molecular Cancer. 2013;12:152. doi:10.1186/1476-4598-12-152.
   PubMed Web of Science ®Google Scholar
• Nowak N, Kulma A, Gutowicz J. Up-regulation of key glycolysis proteins in cancer development. Open Life Sciences. 2018;13:569–581. doi:10.1515/biol-2018-0068.
   PubMed Web of Science ®Google Scholar
• Yin H, Wang L, Liu HL. ENO1 overexpression in pancreatic cancer patients and its clinical and diagnostic significance. Gastroenterology Research and Practice. 2018;2018:3842198. doi:10.1155/2018/3842198.
   PubMed Web of Science ®Google Scholar
• Song Y, Luo Q, Long H, Hu Z, Que T, Zhang X, Li Z, Wang G, Yi L, Liu Z, et al. Alpha-enolase as a potential cancer prognostic marker promotes cell growth, migration, and invasion in glioma. Molecular Cancer. 2014;13:65. doi:10.1186/1476-4598-13-65.
   PubMed Web of Science ®Google Scholar
• Li HJ, Ke FY, Lin CC, Lu MY, Kuo YH, Wang YP, Liang K-H, Lin S-C, Chang Y-H, Chen H-Y, et al. ENO1 promotes lung cancer metastasis via HGFR and WNT signaling-driven epithelial-mesenchymal transition. Cancer Research. 2021;81:4094–4109. doi:10.1158/0008-5472.CAN-20-3543.
   PubMed Web of Science ®Google Scholar
• Hsiao KC, Shih NY, Fang HL, Huang TS, Kuo CC, Chu PY, Hung Y-M, Chou S-W, Yang -Y-Y, Chang G-C, et al. Surface alpha-enolase promotes extracellular matrix degradation and tumor metastasis and represents a new therapeutic target. PloS one. 2013;8:e69354. doi:10.1371/journal.pone.0069354.
   PubMed Web of Science ®Google Scholar
• Principe M, Borgoni S, Cascione M, Chattaragada MS, Ferri-Borgogno S, Capello M, Bulfamante S, Chapelle J, Di Modugno F, Defilippi P, et al. Alpha-enolase (ENO1) controls alpha v/beta 3 integrin expression and regulates pancreatic cancer adhesion, invasion, and metastasis. Journal of Hematology & Oncology. 2017;10:16. doi:10.1186/s13045-016-0385-8.
   PubMed Web of Science ®Google Scholar
• Liu J, Yang Q, Sun H, Wang X, Saiyin H, Zhang H. The circ-AMOTL1/ENO1 axis implicated in the tumorigenesis of OLP-associated oral squamous cell carcinoma. Cancer Management and Research. 2020;12:7219–7230. doi:10.2147/CMAR.S251348.
   PubMed Web of Science ®Google Scholar
• Wu F, Shi X, Zhang R, Tian Y, Wang X, Wei C, Li D, Li X, Kong X, Liu Y, et al. Regulation of proliferation and cell cycle by protein regulator of cytokinesis 1 in oral squamous cell carcinoma. Cell Death & Disease. 2018;9:564. doi:10.1038/s41419-018-0618-6.
   PubMed Web of Science ®Google Scholar
• Abukhdeir AM, Park BH. P21 and p27: roles in carcinogenesis and drug resistance. Expert Reviews in Molecular Medicine. 2008;10:e19. doi:10.1017/S1462399408000744.
   PubMedGoogle Scholar
• Shamloo B, Usluer S. p21 in cancer research. Cancers. 2019;11:1178.
   PubMed Web of Science ®Google Scholar
• Yang Q, Al-Hendy A. The emerging role of p27 in development of diseases. Cancer Studies and Molecular Medicine: Open Journal. 2018;4:e1–e3. doi:10.17140/CSMMOJ-4-e006.
   PubMedGoogle Scholar
• Yu L, Chen X, Sun X, Wang L, Chen S. The glycolytic switch in tumors: how many players are involved? Journal of Cancer. 2017;8:3430–3440. doi:10.7150/jca.21125.
   PubMed Web of Science ®Google Scholar
• Wang Z, Dang T, Liu T, Chen S, Li L, Huang S, Fang M. NEDD4L protein catalyzes ubiquitination of PIK3CA protein and regulates PI3K-AKT signaling. The Journal of Biological Chemistry. 2016;291:17467–17477. doi:10.1074/jbc.M116.726083.
   PubMed Web of Science ®Google Scholar
• Mookerjee SA, Brand MD. Measurement and analysis of extracellular acid production to determine glycolytic rate. Journal of Visualized Experiments: JoVE. 2015:e53464. 10.3791/53464.
   PubMed Web of Science ®Google Scholar
• Pelletier M, Billingham LK, Ramaswamy M, Siegel RM. Extracellular flux analysis to monitor glycolytic rates and mitochondrial oxygen consumption. Methods in Enzymology. 2014;542:125–149.
   PubMed Web of Science ®Google Scholar
• Sun X, Kaufman PD. Ki-67: more than a proliferation marker. Chromosoma. 2018;127:175–186. doi:10.1007/s00412-018-0659-8.
   PubMed Web of Science ®Google Scholar
• Didiasova M, Schaefer L, Wygrecka M. When place matters: shuttling of enolase-1 across cellular compartments. Frontiers in Cell and Developmental Biology. 2019;7:61. doi:10.3389/fcell.2019.00061.
   PubMed Web of Science ®Google Scholar
• Nandi D, Tahiliani P, Kumar A, Chandu D. The ubiquitin-proteasome system. Journal of Biosciences. 2006;31:137–155. doi:10.1007/BF02705243.
   PubMed Web of Science ®Google Scholar
• Goel P, Manning JA, Kumar S. NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins. Gene. 2015;557:1–10. doi:10.1016/j.gene.2014.11.051.
   PubMed Web of Science ®Google Scholar
• Liu L, Chen J, Cai X, Yao Z, Huang J. Progress in targeted therapeutic drugs for oral squamous cell carcinoma. Surgical Oncology. 2019;31:90–97. doi:10.1016/j.suronc.2019.09.001.
   PubMed Web of Science ®Google Scholar
• Li M, Gao F, Zhao Q, Zuo H, Liu W, Li W. Tanshinone IIA inhibits oral squamous cell carcinoma via reducing Akt-c-Myc signaling-mediated aerobic glycolysis. Cell Death & Disease. 2020;11:381. doi:10.1038/s41419-020-2579-9.
   PubMed Web of Science ®Google Scholar
• Wei J, Wu J, Xu W, Nie H, Zhou R, Wang R, Liu Y, Tang G, Wu J. Salvianolic acid B inhibits glycolysis in oral squamous cell carcinoma via targeting PI3K/AKT/HIF-1alpha signaling pathway. Cell Death & Disease. 2018;9:599. doi:10.1038/s41419-018-0623-9.
   PubMed Web of Science ®Google Scholar
• Han L, Cheng J, Li A. hsa_circ_0072387 suppresses proliferation, metastasis, and glycolysis of oral squamous cell carcinoma cells by downregulating miR-503-5p. Cancer Biotherapy & Radiopharmaceuticals. 2021;36:84–94. doi:10.1089/cbr.2019.3371.
   PubMed Web of Science ®Google Scholar
• Zheng M, Cao MX, Yu XH, Li L, Wang K, Wang SS, Wang H-F, Tang Y-J, Tang Y-L, Liang X-H, et al. STAT3 promotes invasion and aerobic glycolysis of human oral squamous cell carcinoma via inhibiting FoxO1. Frontiers in Oncology. 2019;9:1175. doi:10.3389/fonc.2019.01175.
   PubMed Web of Science ®Google Scholar
• Salah Z, Cohen S, Itzhaki E, Aqeilan RI. NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation. Cell Cycle. 2013;12:3817–3823. doi:10.4161/cc.26672.
   PubMed Web of Science ®Google Scholar
• Sakata T, Sakaguchi H, Tsuda L, Higashitani A, Aigaki T, Matsuno K, Hayashi S. Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation. Current Biology: CB. 2004;14:2228–2236. doi:10.1016/j.cub.2004.12.028.
   PubMed Web of Science ®Google Scholar
• Guo X-Y, Liu -T-T, Zhu W-J, Liu H-T, Zhang G-H, Song L. CircKDM4B suppresses breast cancer progression via the miR-675/NEDD4L axis. Oncogene 2022:1–12.
   Google Scholar
• Guarnieri A, Towers C, Drasin D, Oliphant M, Andrysik Z, Hotz T, Vartuli RL, Linklater ES, Pandey A, Khanal S, et al. The miR-106b-25 cluster mediates breast tumor initiation through activation of NOTCH1 via direct repression of NEDD4L. Oncogene. 2018;37:3879–3893. doi:10.1038/s41388-018-0239-7.
   PubMed Web of Science ®Google Scholar
• Klement RJ, Kammerer U. Is there a role for carbohydrate restriction in the treatment and prevention of cancer? Nutrition & Metabolism. 2011;8:75. doi:10.1186/1743-7075-8-75.
   PubMed Web of Science ®Google Scholar
• Liu Y, Cao Y, Zhang W, Bergmeier S, Qian Y, Akbar H, Colvin R, Ding J, Tong L, Wu S, et al. A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Molecular Cancer Therapeutics. 2012;11:1672–1682. doi:10.1158/1535-7163.MCT-12-0131.
   PubMed Web of Science ®Google Scholar
• Vander Heiden MG, Christofk HR, Schuman E, Subtelny AO, Sharfi H, Harlow EE, Xian J, Cantley LC. Identification of small molecule inhibitors of pyruvate kinase M2. Biochemical Pharmacology. 2010;79:1118–1124. doi:10.1016/j.bcp.2009.12.003.
   PubMed Web of Science ®Google Scholar
• Price GS, Page RL, Riviere JE, Cline JM, Thrall DE. Pharmacokinetics and toxicity of oral and intravenous lonidamine in dogs. Cancer Chemotherapy and Pharmacology. 1996;38:129–135. doi:10.1007/s002800050460.
   PubMed Web of Science ®Google Scholar
• Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung M-C, et al. Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013;15:1486–1494. doi:10.1038/ncb2874.
   PubMed Web of Science ®Google Scholar