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Research Paper

BMSC-derived exosomal lncRNA PTENP1 suppresses the malignant phenotypes of bladder cancer by upregulating SCARA5 expression

, , , , & ORCID Icon
Pages 1-13 | Received 24 Oct 2021, Accepted 13 Jul 2022, Published online: 23 Aug 2022

References

  • Ruiz M, Cosenza S, Maumus M, Jorgensen C, Noel D. Therapeutic application of mesenchymal stem cells in osteoarthritis. Expert Opin Biol Ther. 2016;16:33–42. doi:10.1517/14712598.2016.1093108.
  • Fu D, Liu B, Jiang H, Li Z, Fan C, Zang L. Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting abl2. Genomics. 2021;113:1338–1348. doi:10.1016/j.ygeno.2021.03.011.
  • Liu W, Wang Y, Gong F, Rong Y, Luo Y, Tang P, Zhou Z, Zhou Z, Xu T, Jiang T, et al. Exosomes derived from bone mesenchymal stem cells repair traumatic spinal cord injury by suppressing the activation of a1 neurotoxic reactive astrocytes. J Neurotrauma. 2019;36(3):469–484. doi:10.1089/neu.2018.5835.
  • He C, Zheng S, Luo Y, Wang B. Exosome theranostics: biology and translational medicine. Theranostics. 2018;8(1):237–255. doi:10.7150/thno.21945.
  • Jiang S, Mo C, Guo S, Zhuang J, Huang B, Mao X. Human bone marrow mesenchymal stem cells-derived microRNA-205-containing exosomes impede the progression of prostate cancer through suppression of rhpn2. J Exp Clin Cancer Res. 2019;38(1):495. doi:10.1186/s13046-019-1488-1.
  • Cai H, Yang X, Gao Y, Xu Z, Yu B, Xu T, Li X, Xu W, Wang X,Hua L, et al. Exosomal microRNA-9-3p secreted from bmscs downregulates esm1 to suppress the development of bladder cancer. Mol Ther Nucleic Acids. 2019;18:787–800. doi:10.1016/j.omtn.2019.09.023.
  • Siegel RL, Miller KD, Jemal A. Cancer statistics, 2019. CA Cancer J Clin. 2019;69(1):7–34. doi:10.3322/caac.21551.
  • Jia Y, Ding X, Zhou L, Zhang L, Yang X. Mesenchymal stem cells-derived exosomal microRNA-139-5p restrains tumorigenesis in bladder cancer by targeting prc1. Oncogene. 2021;40(2):246–261. doi:10.1038/s41388-020-01486-7.
  • Baglio SR, Rooijers K, Koppers-Lalic D, Verweij FJ, Perez Lanzon M, Zini N, Naaijkens B, Perut F, Niessen HWM, Baldini N, et al. Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species. Stem Cell Res Ther. 2015;6(1):127. doi:10.1186/s13287-015-0116-z.
  • Zhao W, Qin P, Zhang D, Cui X, Gao J, Yu Z, Chia Y, Wang J, Li J. Long non-coding RNA pvt1 encapsulated in bone marrow mesenchymal stem cell-derived exosomes promotes osteosarcoma growth and metastasis by stabilizing erg and sponging mir-183-5p. Aging (Albany NY). 2019;11:9581–9596. doi:10.18632/aging.102406.
  • Leveille N, Baglio SR. Exosome-transferred lncrnas at the core of cancer bone lesions. Crit Rev Oncol Hematol. 2019;139:125–127. doi:10.1016/j.critrevonc.2019.03.002.
  • Fan Y, Sheng W, Meng Y, Cao Y, Li R. Lncrna ptenp1 inhibits cervical cancer progression by suppressing mir-106b. Artif Cells Nanomed Biotechnol. 2020;48:393–407. doi:10.1080/21691401.2019.1709852.
  • Hu S, Xu L, Li L, Luo D, Zhao H, Li D, Peng B. Overexpression of lncrna ptenp1 suppresses glioma cell proliferation and metastasis in vitro. Onco Targets Ther. 2019;12:147–156. doi:10.2147/OTT.S182537.
  • Zhong XL, Wang L, Yan X, Yang XK, Xiu H, Zhao M, Wang X, Liu J. Mir-20a acted as a cerna of lncrna PTEN and promoted bladder cancer cell proliferation and migration by regulating pdcd4. Eur Rev Med Pharmacol Sci. 2020;24:2955–2964. doi:10.26355/eurrev_202003_20660.
  • Chi Y, Wang D, Wang J, Yu W, Yang J. 2019. Long non-coding RNA in the pathogenesis of cancers. Cells. 8. DOI:10.3390/cells8091015
  • Iqbal MA, Arora S, Prakasam G, Calin GA, Syed MA. microRNA in lung cancer: role, mechanisms, pathways and therapeutic relevance. Mol Aspects Med. 2019;70:3–20. doi:10.1016/j.mam.2018.07.003.
  • Ganju A, Khan S, Hafeez BB, Behrman SW, Yallapu MM, Chauhan SC, Jaggi M. miRNA nanotherapeutics for cancer. Drug Discov Today. 2017;22:424–432. doi:10.1016/j.drudis.2016.10.014.
  • Yang C, Yuan W, Yang X, Li P, Wang J, Han J, Tao J, Li P, Yang H, Lv Q, et al. Circular RNA circ-itch inhibits bladder cancer progression by sponging mir-17/mir-224 and regulating p21, PTEN expression. Mol Cancer. 2018;17:19. doi:10.1186/s12943-018-0771-7.
  • Chen CL, Tseng YW, Wu JC, Chen GY, Lin KC, Hwang SM, Hu YC. Suppression of hepatocellular carcinoma by baculovirus-mediated expression of long non-coding RNA ptenp1 and microRNA regulation. Biomaterials. 2015;44:71–81. doi:10.1016/j.biomaterials.2014.12.023.
  • You K, Su F, Liu L, Lv X, Zhang J, Zhang Y, Liu B. Scara5 plays a critical role in the progression and metastasis of breast cancer by inactivating the erk1/2, stat3, and akt signaling pathways. Mol Cell Biochem. 2017;435:47–58. doi:10.1007/s11010-017-3055-4.
  • Wen X, Wang N, Zhang F, Dong C. Overexpression of scara5 inhibits tumor proliferation and invasion in osteosarcoma via suppression of the fak signaling pathway. Mol Med Rep. 2016;13:2885–2891. doi:10.3892/mmr.2016.4857.
  • Liu J, Zeng ML, Shi PC, Cao YP, Zhang JL, Xie YP. Scara5 is a novel biomarker in colorectal cancer by comprehensive analysis. Clin Lab. 2020;66. doi:10.7754/Clin.Lab.2019.191015.
  • Liu Y, Tan Y-R, Sun -W-W, Ju W-T, Fu Y, Wang L-Z, Li J, Zhang C-P, Zhang Z-Y, Zhong L-P, et al. Identification of scara5 as a potential biomarker for oral squamous cell carcinoma using maldi-tof-ms analysis. Proteomics Clin Appl. 2018;12(5):e1700180. doi:10.1002/prca.201700180.
  • Wang F, Cao X, Yin L, Wang Q, and He Z. Identification of scara5 gene as a potential immune-related biomarker for triple-negative breast cancer by integrated analysis. DNA Cell Biol. 2020;39(10):1813–1824. doi:10.1089/dna.2020.5449.
  • Baker N, Boyette LB, Tuan RS. Characterization of bone marrow-derived mesenchymal stem cells in aging. Bone. 2015;70:37–47. doi:10.1016/j.bone.2014.10.014.
  • Sun Z, Yang S, Zhou Q, Wang G, Song J, Li Z, Zhang Z, Xu J, Xia K, Chang Y, et al. Emerging role of exosome-derived long non-coding RNAs in tumor microenvironment. Mol Cancer. 2018;17(1):82. doi:10.1186/s12943-018-0831-z.
  • Sanchez Calle A, Kawamura Y, Yamamoto Y, Takeshita F, Ochiya T. Emerging roles of long non-coding RNA in cancer. Cancer Science. 2018;109(7):2093–2100. doi:10.1111/cas.13642.
  • Zheng R, Du M, Wang X, Xu W, Liang J, Wang W, Lv Q, Qin C, Chu H, Wang M, et al. Exosome–transmitted long non-coding RNA PTENP1 suppresses bladder cancer progression. Mol Cancer. 2018;17(1):143. doi:10.1186/s12943-018-0880-3.
  • Wang J, Yang K, Yuan W, Gao Z. Determination of serum exosomal h19 as a noninvasive biomarker for bladder cancer diagnosis and prognosis. Med Sci Monit. 2018;24:9307–9316. doi:10.12659/MSM.912018.
  • Ridge SM, Sullivan FJ, Glynn SA. Mesenchymal stem cells: key players in cancer progression. Mol Cancer. 2017;16(1):31. doi:10.1186/s12943-017-0597-8.
  • Klopp AH, Gupta A, Spaeth E, Andreeff M, Marini F. Concise review: dissecting a discrepancy in the literature: do mesenchymal stem cells support or suppress tumor growth? Stem Cells. 2011;29(1):11–19. doi:10.1002/stem.559. 3rd.
  • Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, et al. Vegfr1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature. 2005;438(7069):820–827. doi:10.1038/nature04186.
  • Biancone L, Bruno S, Deregibus MC, Tetta C, Camussi G. Therapeutic potential of mesenchymal stem cell-derived microvesicles. Nephrol Dial Transplant. 2012;27(8):3037–3042. doi:10.1093/ndt/gfs168.
  • Li B, Xu H, Han H, Song S, Zhang X, Ouyang L, Qian C, Hong Y, Qiu Y, Zhou W, et al. Exosome-mediated transfer of lncrunx2-as1 from multiple myeloma cells to MSCs contributes to osteogenesis. Oncogene. 2018;37(41):5508–5519. doi:10.1038/s41388-018-0359-0.
  • Li Z, Jiang P, Li J, Peng M, Zhao X, Zhang X, Chen K, Zhang Y, Liu H, Gan L, et al. Tumor-derived exosomal lnc-sox2ot promotes emt and stemness by acting as a cerna in pancreatic ductal adenocarcinoma. Oncogene. 2018;37(28):3822–3838. doi:10.1038/s41388-018-0237-9.
  • Chen C, Luo Y, He W, Zhao Y, Kong Y, Liu H, Zhong G, Li Y, Li J, Huang J, et al. Exosomal long noncoding RNA lnmat2 promotes lymphatic metastasis in bladder cancer. J Clin Invest. 2020;130(1):404–421. doi:10.1172/JCI130892.
  • Yu G, Yao W, Gumireddy K, Li A, Wang J, Xiao W, Chen K, Xiao H, Li H, Tang K, et al. Pseudogene ptenp1 functions as a competing endogenous RNA to suppress clear-cell renal cell carcinoma progression. Mol Cancer Ther. 2014;13(12):3086–3097. doi:10.1158/1535-7163.MCT-14-0245.
  • Zhang R, Guo Y, Ma Z, Ma G, Xue Q, Li F, Liu L. Long non-coding RNA ptenp1 functions as a cerna to modulate PTEN level by decoying mir-106b and mir-93 in gastric cancer. Oncotarget. 2017;8(16):26079–26089. doi:10.18632/oncotarget.15317.
  • Qian -Y-Y, Li K, Liu Q-Y, Liu Z-S. Long non-coding RNA ptenp1 interacts with mir-193a-3p to suppress cell migration and invasion through the PTEN pathway in hepatocellular carcinoma. Oncotarget. 2017;8(64):107859–107869. doi:10.18632/oncotarget.22305.
  • Lu X-S, Huang M-L, Chen L-B, Liu S-C, Huang Z-X, Liu S-M. WITHDRAWN: SCARA5 regulated by MEG3/miR-141 axis attenuates proliferation, migration and invasion of bladder cancer. Life Sci. 2021:119619. doi:10.1016/j.lfs.2021.119619