Hypoxia promotes non-small cell lung cancer cell stemness, migration, and invasion via promoting glycolysis by lactylation of SOX9

References

• Suster DI, Mino-Kenudson M. Molecular pathology of primary non-small cell lung cancer. Arch Med Res. 2020;51(8):784–10. doi:10.1016/j.arcmed.2020.08.004.
   PubMed Web of Science ®Google Scholar
• Zarogoulidis P, Matthaios D, Kosmidis C, Hohenforst-Schmidt W, Tsakiridis K, Mpaka S, Boukovinas I, Drougas D, Theofilatou V, Zaric B, et al. Effective early diagnosis for NSCLC: an algorithm. Expert Rev Respir Med. 2021;15(11):1437–1445. doi:10.1080/17476348.2021.1969916.
   PubMed Web of Science ®Google Scholar
• Sankar K, Gadgeel SM, Qin A. Molecular therapeutic targets in non-small cell lung cancer. Expert Rev Anticancer Ther. 2020;20(8):647–661. doi:10.1080/14737140.2020.1787156.
   PubMed Web of Science ®Google Scholar
• Broderick SR. Adjuvant and neoadjuvant immunotherapy in non-small cell lung cancer. Thorac Surg Clin. 2020;30(2):215–220. doi:10.1016/j.thorsurg.2020.01.001.
   PubMed Web of Science ®Google Scholar
• Duma N, Santana-Davila R, Molina JR. Non-small cell lung cancer: epidemiology, screening, diagnosis, and treatment. Mayo Clin Proc. 2019;94(8):1623–1640. doi:10.1016/j.mayocp.2019.01.013.
   PubMed Web of Science ®Google Scholar
• Wu T, Dai Y. Tumor microenvironment and therapeutic response. Cancer Lett. 2017;387:61–68. doi:10.1016/j.canlet.2016.01.043.
   PubMed Web of Science ®Google Scholar
• Shao C, Yang F, Miao S, Liu W, Wang C, Shu Y, Shen H. Role of hypoxia-induced exosomes in tumor biology. Mol Cancer. 2018;17(1):120. doi:10.1186/s12943-018-0869-y.
   PubMed Web of Science ®Google Scholar
• Jing X, Yang F, Shao C, Wei K, Xie M, Shen H, Shu Y. Role of hypoxia in cancer therapy by regulating the tumor microenvironment. Mol Cancer. 2019;18(1):157. doi:10.1186/s12943-019-1089-9.
   PubMed Web of Science ®Google Scholar
• Mennerich D, Kubaichuk K, Kietzmann T. Dubs, hypoxia, and cancer. Trends Cancer. 2019;5(10):632–653. doi:10.1016/j.trecan.2019.08.005.
   PubMed Web of Science ®Google Scholar
• Sun X, Lv X, Yan Y, Zhao Y, Ma R, He M, Wei M. Hypoxia-mediated cancer stem cell resistance and targeted therapy. Biomed Pharmacother. 2020;130:110623. doi:10.1016/j.biopha.2020.110623.
   PubMed Web of Science ®Google Scholar
• Salem A, Asselin MC, Reymen B, Jackson A, Lambin P, West CML, O’Connor JPB, Faivre-Finn C. Targeting hypoxia to improve non–small cell lung cancer outcome. J Natl Cancer Inst. 2018;110(1):14–30. doi:10.1093/jnci/djx160.
   Google Scholar
• Gruber HE, Norton HJ, Ingram JA, Hanley EN. The SOX9 transcription factor in the human disc: decreased immunolocalization with age and disc degeneration spine (phila Pa 1976). Spine. 2005;30(6):625–630. doi:10.1097/01.brs.0000155420.01444.c6.
   PubMed Web of Science ®Google Scholar
• Huang JQ, Wei FK, Xu XL, Ye SX, Song JW, Ding PK, Zhu J, Li HF, Luo XP, Gong H, et al. SOX9 drives the epithelial-mesenchymal transition in non-small-cell lung cancer through the Wnt/β-catenin pathway. J Transl Med. 2019;17(1):143. doi:10.1186/s12967-019-1895-2.
   PubMedGoogle Scholar
• Zhou Y, Shi H, Du Y, Zhao G, Wang X, Li Q, Liu J, Ye L, Shen Z, Guo Y, et al. lncRNA DLEU2 modulates cell proliferation and invasion of non-small cell lung cancer by regulating miR-30c-5p/SOX9 axis. Aging (Albany NY). 2019;11(18):7386–7401. doi:10.18632/aging.102226.
   PubMedGoogle Scholar
• Panda M, Tripathi SK, Biswal BK. SOX9: an emerging driving factor from cancer progression to drug resistance. Biochim Biophys Acta Rev Cancer. 2021;1875(2):188517. doi:10.1016/j.bbcan.2021.188517.
   PubMed Web of Science ®Google Scholar
• Sinthupibulyakit C, Ittarat W, Clair WH, Clair DK. p53 protects lung cancer cells against metabolic stress. Int J Oncol. 2010;37(6):1575–1581. doi:10.3892/ijo_00000811.
   PubMed Web of Science ®Google Scholar
• Zeng C, Wu Q, Wang J, Yao B, Ma L, Yang Z, Li J, Liu B. NOX4 supports glycolysis and promotes glutamine metabolism in non-small cell lung cancer cells. Free Radic Biol Med. 2016;101:236–248. doi:10.1016/j.freeradbiomed.2016.10.500.
   PubMed Web of Science ®Google Scholar
• Li Y, Zhao L, Li XF. Hypoxia and the tumor microenvironment. Technol Cancer Res Treat. 2021;20:15330338211036304. doi:10.1177/15330338211036304.
   Web of Science ®Google Scholar
• Chang J, Erler J. Hypoxia-mediated metastasis. Adv Exp Med Biol. 2014;772:55–81. doi:10.1007/978-1-4614-5915-6_3.
   PubMed Web of Science ®Google Scholar
• Otero-Albiol D, Carnero A. Cellular senescence or stemness: hypoxia flips the coin. J Exp Clin Cancer Res. 2021;40(1):243. doi:10.1186/s13046-021-02035-0.
   PubMed Web of Science ®Google Scholar
• Bose S, Le A. Glucose metabolism in cancer. Adv Exp Med Biol. 2018;1063:3–12. doi:10.1007/978-3-319-77736-8_1.
   PubMed Web of Science ®Google Scholar
• Lu J, Tan M, Cai Q. The Warburg effect in tumor progression: mitochondrial oxidative metabolism as an anti-metastasis mechanism. Cancer Lett. 2015;356(2 Pt A):156–164. doi:10.1016/j.canlet.2014.04.001.
   PubMed Web of Science ®Google Scholar
• Kierans SJ, Taylor CT. Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology. J Physiol. 2021;599(1):23–37. doi:10.1113/JP280572.
   PubMed Web of Science ®Google Scholar
• Hua Q, Mi B, Xu F, Wen J, Zhao L, Liu J, Huang G. Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis. Theranostics. 2020;10(11):4762–4778. doi:10.7150/thno.43839.
   PubMed Web of Science ®Google Scholar
• Zhang L, Ke J, Min S, Wu N, Liu F, Qu Z, Li W, Wang H, Qian Z, Wang X. Hyperbaric oxygen therapy represses the Warburg effect and epithelial-mesenchymal transition in hypoxic NSCLC cells via the HIF-1α/PFKP axis. Front Oncol. 2021;11:691762. doi:10.3389/fonc.2021.691762.
   PubMedGoogle Scholar
• Zhang Y, Zhai Z, Duan J, Wang X, Zhong J, Wu L, Li A, Cao M, Wu Y, Shi H, et al. Lactate: the mediator of metabolism and immunosuppression. Front Endocrinol (Lausanne). 2022;13:901495. doi:10.3389/fendo.2022.901495.
   PubMed Web of Science ®Google Scholar
• Chen AN, Luo Y, Yang YH, Fu JT, Geng XM, Shi JP, Yang J. Lactylation, a novel metabolic reprogramming code: current status and prospects. Front Immunol. 2021;12:688910. doi:10.3389/fimmu.2021.688910.
   PubMed Web of Science ®Google Scholar
• Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, Liu W, Kim S, Lee S, Perez-Neut M, et al. Metabolic regulation of gene expression by histone lactylation. Nature. 2019;574(7779):575–580. doi:10.1038/s41586-019-1678-1.
   PubMed Web of Science ®Google Scholar
• Gao M, Zhang N, Liang W. Systematic analysis of lysine lactylation in the plant fungal pathogen botrytis cinerea. Front Microbiol. 2020;11:594743. doi:10.3389/fmicb.2020.594743.
   PubMed Web of Science ®Google Scholar
• Qiao Z, Li Y, Li S, Liu S, Cheng Y. 2024. Hypoxia-induced SHMT2 protein lactylation facilitates glycolysis and stemness of esophageal cancer cells. Mol Cell Biochem. doi:10.1007/s11010-023-04913-x.
   PubMed Web of Science ®Google Scholar
• Miao Z, Zhao X, Liu X. Hypoxia induced β-catenin lactylation promotes the cell proliferation and stemness of colorectal cancer through the wnt signaling pathway. Exp Cell Res. 2023;422(1):113439. doi:10.1016/j.yexcr.2022.113439.
   PubMed Web of Science ®Google Scholar
• Xu YR, Yang WX. SOX-mediated molecular crosstalk during the progression of tumorigenesis. Semin Cell Dev Biol. 2017;63:23–34. doi:10.1016/j.semcdb.2016.07.028.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wu Y, Su X. PLOD1 promotes cell growth and aerobic glycolysis by regulating the SOX9/PI3K/Akt/mTOR signaling pathway in gastric cancer. Front Biosci (Landmark Ed). 2021;26(8):322–334. doi:10.52586/4946.
   PubMed Web of Science ®Google Scholar
• Siu MKY, Jiang YX, Wang JJ, Leung THY, Han CY, Tsang BK, Cheung ANY, Ngan HYS, Chan KKL. Hexokinase 2 regulates ovarian cancer cell migration, invasion and stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 signaling cascades. Cancers Basel. 2019;11(6):813. doi:10.3390/cancers11060813.
   PubMed Web of Science ®Google Scholar
• Ji J, Xie M, Qian Q, Xu Y, Shi W, Chen Z, Ren D, Liu W, He X, Lv M, et al. SOX9-mediated UGT8 expression promotes glycolysis and maintains the malignancy of non-small cell lung cancer. Biochem Biophys Res Commun. 2022;587:139–145. doi:10.1016/j.bbrc.2021.11.099.
   PubMed Web of Science ®Google Scholar