MDFI promotes the proliferation and tolerance to chemotherapy of colorectal cancer cells by binding ITGB4/LAMB3 to activate the AKT signaling pathway

References

• Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–15. doi:10.3322/caac.21660.
   PubMed Web of Science ®Google Scholar
• Potter SS. Single-cell RNA sequencing for the study of development, physiology and disease. Nat Rev Nephrol. 2018;14(8):479–92. doi:10.1038/s41581-018-0021-7.
   PubMed Web of Science ®Google Scholar
• Teng J, da Hora CC, Kantar RS, Nakano I, Wakimoto H, Batchelor TT, Chiocca EA, Badr CE, Tannous BA. Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models. Neuro Oncol. 2017;19:820–832. doi:10.1093/neuonc/now253.
   PubMed Web of Science ®Google Scholar
• Wang H, Gong P, Chen T, Gao S, Wu Z, Wang X, Li J, Marjani SL, Costa J, Weissman SM, et al. Colorectal cancer stem cell states uncovered by simultaneous single-cell analysis of transcriptome and telomeres. Adv Sci (Weinheim, Baden-Wurttemberg, Germany). 2021;8(8):2004320. doi:10.1002/advs.202004320.
   PubMedGoogle Scholar
• Hases L, Indukuri R, Birgersson M, Nguyen-Vu T, Lozano R, Saxena A, Hartman J, Frasor J, Gustafsson J-Å, Katajisto P, et al. Intestinal estrogen receptor beta suppresses colon inflammation and tumorigenesis in both sexes. Cancer Lett. 2020;492:54–62. doi:10.1016/j.canlet.2020.06.021.
   PubMed Web of Science ®Google Scholar
• Buechler SA, Stephens MT, Hummon AB, Ludwig K, Cannon E, Carter TC, Resnick J, Gökmen-Polar Y, Badve SS. ColoType: a forty gene signature for consensus molecular subtyping of colorectal cancer tumors using whole-genome assay or targeted RNA-sequencing. Sci Rep. 2020;10(1):12123. doi:10.1038/s41598-020-69083-y.
   PubMed Web of Science ®Google Scholar
• Park SR, Namkoong S, Friesen L, Cho CS, Zhang ZZ, Chen YC, Yoon E, Kim CH, Kwak H, Kang HM, et al. Single-cell transcriptome analysis of colon cancer cell response to 5-fluorouracil-induced DNA damage. Cell Rep. 2020;32(8):108077. doi:10.1016/j.celrep.2020.108077.
   PubMed Web of Science ®Google Scholar
• Lee HO, Hong Y, Etlioglu HE, Cho YB, Pomella V, Van den Bosch B, Vanhecke J, Verbandt S, Hong H, Min J-W, et al. Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer. Nat Genet. 2020;52(6):594–603. doi:10.1038/s41588-020-0636-z.
   PubMed Web of Science ®Google Scholar
• Chen CM, Kraut N, Groudine M, Weintraub H. I-mf, a novel myogenic repressor, interacts with members of the MyoD family. Cell. 1996;86(5):731–41. doi:10.1016/S0092-8674(00)80148-8.
   PubMed Web of Science ®Google Scholar
• Sui Y, Li X, Oh S, Zhang B, Freeman WM, Shin S, Janknecht R. Opposite roles of the JMJD1A interaction partners MDFI and MDFIC in colorectal cancer. Sci Rep. 2020;10(1):8710. doi:10.1038/s41598-020-65536-6.
   PubMed Web of Science ®Google Scholar
• Lin ZY, Chuang WL. Genes responsible for the characteristics of primary cultured invasive phenotype hepatocellular carcinoma cells. Biomed Pharmacother. 2012;66(6):454–458. doi:10.1016/j.biopha.2012.04.001.
   PubMed Web of Science ®Google Scholar
• Luo Y, Wong CJ, Kaz AM, Dzieciatkowski S, Carter KT, Morris SM, Wang J, Willis JE, Makar KW, Ulrich CM, et al. Differences in DNA methylation signatures reveal multiple pathways of progression from adenoma to colorectal cancer. Gastroenterology. 2014;147(2):418–29.e8. doi:10.1053/j.gastro.2014.04.039.
   PubMed Web of Science ®Google Scholar
• Wu T, Wang X, Li J, Song X, Wang Y, Wang Y, Zhang L, Li Z, Tian J. Identification of personalized chemoresistance genes in subtypes of basal-like breast cancer based on functional differences using pathway analysis. PloS ONE. 2015;10(6):e0131183. doi:10.1371/journal.pone.0131183.
   PubMed Web of Science ®Google Scholar
• Coant N, García-Barros M, Zhang Q, Obeid LM, Hannun YA. AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells. Oncogene. 2018;37(28):3852–63. doi:10.1038/s41388-018-0236-x.
   PubMed Web of Science ®Google Scholar
• Yu J, Wang X, Lu Q, Wang J, Li L, Liao X, Zhu W, Lv L, Zhi X, Yu J, et al. Extracellular 5′-nucleotidase (CD73) promotes human breast cancer cells growth through AKT/GSK-3β/β-catenin/cyclinD1 signaling pathway. Int J Cancer. 2018;142(5):959–967. doi:10.1002/ijc.31112.
   PubMed Web of Science ®Google Scholar
• Zhu Z, Song J, Guo Y, Huang Z, Chen X, Dang X, Huang Y, Wang Y, Ou W, Yang Y, et al. LAMB3 promotes tumour progression through the AKT–FOXO3/4 axis and is transcriptionally regulated by the BRD2/acetylated ELK4 complex in colorectal cancer. Oncogene. 2020;39(24):4666–4680. doi:10.1038/s41388-020-1321-5.
   PubMed Web of Science ®Google Scholar
• Papadatos-Pastos D, Rabbie R, Ross P, Sarker D. The role of the PI3K pathway in colorectal cancer. Crit Rev Oncol Hematol. 2015;94(1):18–30. doi:10.1016/j.critrevonc.2014.12.006.
   PubMed Web of Science ®Google Scholar
• Leng C, Zhang ZG, Chen WX, Luo HP, Song J, Dong W, Zhu X-R, Chen X-P, Liang H-F, Zhang B-X, et al. An integrin beta4-EGFR unit promotes hepatocellular carcinoma lung metastases by enhancing anchorage independence through activation of FAK–AKT pathway. Cancer Lett. 2016;376(1):188–196. doi:10.1016/j.canlet.2016.03.023.
   PubMed Web of Science ®Google Scholar
• Zhang J, Li Y, Liu H, Zhang J, Wang J, Xia J, Zhang Y, Yu X, Ma J, Huang M, et al. Genome-wide CRISPR/Cas9 library screen identifies PCMT1 as a critical driver of ovarian cancer metastasis. J Exp Clin Cancer Res. 2022;41(1):24. doi:10.1186/s13046-022-02242-3.
   PubMed Web of Science ®Google Scholar
• de Fougerolles AR, Chi-Rosso G, Bajardi A, Gotwals P, Green CD, Koteliansky VE. Global Expression Analysis of Extracellular Matrix–Integrin Interactions in Monocytes. Immunity. 2000;13(6):749–758. doi:10.1016/S1074-7613(00)00073-X.
   PubMed Web of Science ®Google Scholar
• Zhang H, Pan YZ, Cheung M, Cao M, Yu C, Chen L, Zhan L, He Z-W, Sun C-Y. LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway. Cell Death Disease. 2019;10(3):230. doi:10.1038/s41419-019-1320-z.
   PubMedGoogle Scholar
• Ma P, Zhang P, Chen S, Shi W, Ye J, Chen S, Ju R, Liu B, Zheng Y, Liu Y, et al. Immune cell landscape of patients with diabetic macular edema by single-cell RNA analysis. Front Pharmacol. 2021;12:754933. doi:10.3389/fphar.2021.754933.
   PubMed Web of Science ®Google Scholar
• Mohamed TMA, Ang YS, Radzinsky E, Zhou P, Huang Y, Elfenbein A, Foley A, Magnitsky S, Srivastava D. Regulation of Cell Cycle to stimulate adult cardiomyocyte proliferation and cardiac regeneration. Cell. 2018;173(1):104–16.e12. doi:10.1016/j.cell.2018.02.014.
   PubMed Web of Science ®Google Scholar
• Mauri G, Gori V, Bonazzina E, Amatu A, Tosi F, Bencardino K, Ruggieri L, Patelli G, Arena S, Bardelli A, et al. Oxaliplatin retreatment in metastatic colorectal cancer: Systematic review and future research opportunities. Cancer Treat Rev. 2020;91:102112. doi:10.1016/j.ctrv.2020.102112.
   PubMed Web of Science ®Google Scholar
• Vodenkova S, Buchler T, Cervena K, Veskrnova V, Vodicka P, Vymetalkova V. 5-fluorouracil and other fluoropyrimidines in colorectal cancer: Past, present and future. Pharmacol Ther. 2020;206:107447. doi:10.1016/j.pharmthera.2019.107447.
   PubMed Web of Science ®Google Scholar
• Ren X, Kang B, Zhang Z. Understanding tumor ecosystems by single-cell sequencing: promises and limitations. Genome Biol. 2018;19(1):211. doi:10.1186/s13059-018-1593-z.
   PubMedGoogle Scholar
• Kulkarni RA, Bak DW, Wei D, Bergholtz SE, Briney CA, Shrimp JH, Alpsoy A, Thorpe AL, Bavari AE, Crooks DR, et al. A chemoproteomic portrait of the oncometabolite fumarate. Nat Chem Biol. 2019;15(4):391–400. doi:10.1038/s41589-018-0217-y.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Bian S, Zhou X, Cui Y, Wang W, Wen L, Guo L, Fu W, Tang F. Single-cell multiomics sequencing reveals prevalent genomic alterations in tumor stromal cells of human colorectal cancer. Cancer Cell. 2020;38(6):818–28.e5. doi:10.1016/j.ccell.2020.09.015.
   PubMed Web of Science ®Google Scholar
• Kennedy SA, Jarboui MA, Srihari S, Raso C, Bryan K, Dernayka L, Charitou T, Bernal-Llinares M, Herrera-Montavez C, Krstic A, et al. Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D). Nat Commun. 2020;11(1):499. doi:10.1038/s41467-019-14224-9.
   PubMed Web of Science ®Google Scholar
• Tan YQ, Li YT, Yan TF, Xu Y, Liu BH, Yang JA, Yang X, Chen QX, Zhang HB. Six Immune Associated Genes Construct Prognostic Model Evaluate Low-Grade Glioma. Front Immunol. 2020;11:606164. doi:10.3389/fimmu.2020.606164.
   PubMed Web of Science ®Google Scholar
• Zhang Q, Guo Y, Zhang B, Liu H, Peng Y, Wang D, Zhang D. Identification of hub biomarkers of myocardial infarction by single-cell sequencing, bioinformatics, and machine learning. Front Cardiovasc Med. 2022;9:939972. doi:10.3389/fcvm.2022.939972.
   PubMed Web of Science ®Google Scholar
• Sultana A, Alam MS, Liu X, Sharma R, Singla RK, Gundamaraju R, Shen B. Single-cell RNA-seq analysis to identify potential biomarkers for diagnosis, and prognosis of non-small cell lung cancer by using comprehensive bioinformatics approaches. Transl Oncol. 2022;27:101571. doi:10.1016/j.tranon.2022.101571.
   PubMed Web of Science ®Google Scholar
• Liang JY, Wang DS, Lin HC, Chen XX, Yang H, Zheng Y, Li Y-H. A novel ferroptosis-related gene signature for overall survival prediction in patients with hepatocellular carcinoma. Int J Biol Sci. 2020;16(13):2430–2441. doi:10.7150/ijbs.45050.
   PubMed Web of Science ®Google Scholar
• MacLellan A, Moore-Connors J, Grant S, Cahill L, Langille MGI, Van Limbergen J. The impact of exclusive enteral nutrition (EEN) on the gut microbiome in Crohn’s disease: a review. Nutrients. 2017;9(5):0447. doi:10.3390/nu9050447.
   PubMed Web of Science ®Google Scholar
• Li R, Yin YH, Ji XL, Liu X, Li JP, Pan-Cancer Prognostic Y-Q. Pan-Cancer Prognostic, Immunity, Stemness, and Anticancer Drug Sensitivity Characterization of N6-Methyladenosine RNA Modification Regulators in Human Cancers. Front Mol Biosci. 2021;8:644620. doi:10.3389/fmolb.2021.644620.
   PubMed Web of Science ®Google Scholar
• Fu XW, Song CQ. Identification and validation of pyroptosis-related gene signature to predict prognosis and reveal immune infiltration in hepatocellular carcinoma. Front Cell Dev Biol. 2021;9:748039. doi:10.3389/fcell.2021.748039.
   PubMed Web of Science ®Google Scholar
• Carter JL, Hege K, Yang J, Kalpage HA, Su Y, Edwards H, Hüttemann M, Taub JW, Ge Y. Targeting multiple signaling pathways: the new approach to acute myeloid leukemia therapy. Sig Transduct Target Ther. 2020;5(1):288. doi:10.1038/s41392-020-00361-x.
   PubMed Web of Science ®Google Scholar
• Zanotelli MR, Zhang J, Reinhart-King CA. Mechanoresponsive metabolism in cancer cell migration and metastasis. Cell Metab. 2021;33(7):1307–21. doi:10.1016/j.cmet.2021.04.002.
   PubMed Web of Science ®Google Scholar
• Vafaeie F, Nomiri S, Ranjbaran J, Safarpour H. ACAN, MDFI, and CHST1 as Candidate genes in gastric cancer: a comprehensive Insilco analysis. Asian Pac J Cancer Prev. 2022;23(2):683–694. doi:10.31557/APJCP.2022.23.2.683.
   PubMedGoogle Scholar
• Kisiel JB, Yab TC, Taylor WR, Chari ST, Petersen GM, Mahoney DW, Ahlquist DA. Stool DNA testing for the detection of pancreatic cancer: assessment of methylation marker candidates. Cancer. 2012;118(10):2623–2631. doi:10.1002/cncr.26558.
   PubMed Web of Science ®Google Scholar
• Chen P, Quan Z, Song X, Gao Z, Yuan K. MDFI is a novel biomarker for poor prognosis in LUAD. Front Oncol. 2022;12:1005962. doi:10.3389/fonc.2022.1005962.
   PubMedGoogle Scholar
• Mi C, Zhao Y, Ren L, Zhang D. Inhibition of MDFI attenuates proliferation and glycolysis of Helicobacter pylori-infected gastric cancer cells by inhibiting Wnt/β-catenin pathway. Cell Biol Int. 2022;46(12):2198–206. doi:10.1002/cbin.11907.
   PubMed Web of Science ®Google Scholar
• Huang W, Gu J, Tao T, Zhang J, Wang H, Fan Y. MiR-24-3p inhibits the progression of pancreatic ductal adenocarcinoma through LAMB3 downregulation. Front Oncol. 2019;9:1499. doi:10.3389/fonc.2019.01499.
   PubMed Web of Science ®Google Scholar
• Ferraro A, Kontos CK, Boni T, Bantounas I, Siakouli D, Kosmidou V, Vlassi M, Spyridakis Y, Tsipras I, Zografos G, et al. Epigenetic regulation of miR-21 in colorectal cancer: ITGB4 as a novel miR-21 target and a three-gene network (miR-21-ITGΒ4-PDCD4) as predictor of metastatic tumor potential. Epigenetics. 2014;9(1):129–41. doi:10.4161/epi.26842.
   PubMed Web of Science ®Google Scholar
• Chen D, Chen J, Gao J, Zhang Y, Ma Y, Wei W, Wei Y. LncRNA DDX11-AS1 promotes bladder cancer occurrence via protecting LAMB3 from downregulation by sponging miR-2355-5p. Cancer Biother Radiopharm. 2020;35(5):319–328. doi:10.1089/cbr.2019.3021.
   PubMed Web of Science ®Google Scholar
• Chen CY, Wu PY, Van Scoyk M, Simko SA, Chou CF, Winn RA. KCNF1 promotes lung cancer by modulating ITGB4 expression. Cancer Gene Ther. 2023;30:414–423. doi:10.1038/s41417-022-00560-4.
   PubMed Web of Science ®Google Scholar
• Huang H, Park S, Zhang H, Park S, Kwon W, Kim E, Zhang X, Jang S, Yoon D, Choi S-K, et al. Targeting AKT with costunolide suppresses the growth of colorectal cancer cells and induces apoptosis in vitro and in vivo. J Exp Clin Cancer Res. 2021;40(1):114. doi:10.1186/s13046-021-01895-w.
   PubMed Web of Science ®Google Scholar
• Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, et al. ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer. J Exp Clin Cancer Res. 2022;41(1):15. doi:10.1186/s13046-021-02229-6.
   PubMed Web of Science ®Google Scholar
• Mabbott NA, Baillie JK, Brown H, Freeman TC, Hume DA. An expression atlas of human primary cells: inference of gene function from coexpression networks. Bmc Genom. 2013;14(1):632. doi:10.1186/1471-2164-14-632.
   PubMedGoogle Scholar
• Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA. 2005;102(43):15545–15550. doi:10.1073/pnas.0506580102.
   PubMed Web of Science ®Google Scholar