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Research Paper

Role of glutaminyl-peptide cyclotransferase in breast cancer doxorubicin sensitivity

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Article: 2321767 | Received 02 Apr 2023, Accepted 18 Feb 2024, Published online: 28 Feb 2024

References

  • Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA-Cancer J Clin. 2021;71(3):209–13. doi:10.3322/caac.21660.
  • Miller KD, Nogueira L, Mariotto AB, Rowland JH, Yabroff KR, Alfano CM, Jemal A, Kramer JL, Siegel RL. Cancer treatment and survivorship statistics, 2019. CA-Cancer J Clin. 2019;69(5):363–385. doi:10.3322/caac.21565.
  • Sommer AK, Hermawan A, Ljepoja B, Fröhlich T, Arnold GJ, Wagner E, Roidl A. A proteomic analysis of chemoresistance development via sequential treatment with doxorubicin reveals novel players in MCF-7 breast cancer cells. Int J Mol Med. 2018;42(4):1987–1997. doi:10.3892/ijmm.2018.3781.
  • Mustafa YF, Mohammed NA. A promising oral 5-fluorouracil prodrug for lung tumor: synthesis, characterization and release. Biochem Cell Arch. 2021;21:1991–1999.
  • Su ZZ, Kang DC, Chen Y, Pekarskaya O, Chao W, Volsky DJ, Fisher PB. Identification and cloning of human astrocyte genes displaying elevated expression after infection with HIV-1 or exposure to HIV-1 envelope glycoprotein by rapid subtraction hybridization. Oncogene. 2002;21(22):3592–3602. doi:10.1038/sj.onc.1205445.
  • Yang L, Tian Y, Leong WS, Song H, Yang W, Wang M, Wang X, Kong J, Shan B, Song Z. Efficient and tumor-specific knockdown of MTDH gene attenuates paclitaxel resistance of breast cancer cells both in vivo and in vitro. Breast Cancer Res. 2018;20(1):113. doi:10.1186/s13058-018-1042-7.
  • Zhu K, Peng Y, Hu J, Zhan H, Yang L, Gao Q, Jia H, Luo R, Dai Z, Tang Z, et al. Metadherin–PRMT5 complex enhances the metastasis of hepatocellular carcinoma through the WNT–β-catenin signaling pathway. Carcinogenesis. 2020;41(2):130–138. doi:10.1093/carcin/bgz065.
  • Liu DC, Song LL, Li XZ, Liang Q, Zhang ZG, Han CH. Circular RNA circHIPK3 modulates prostate cancer progression via targeting miR-448/MTDH signaling. Clin Transl Oncol. 2021;23(12):2497–2506. doi:10.1007/s12094-021-02650-5.
  • Fu J, Peng J, Tu G. Knockdown MTDH inhibits glioma proliferation and migration and promotes apoptosis by downregulating MYBL2. Mediat Inflamm. 2022. 2022:1706787. doi:10.1155/2022/1706787.
  • Jiao Y, Yang H, Qian J, Gong Y, Liu H, Wu S, Cao L, Tang L. miR-3664‑5P suppresses the proliferation and metastasis of gastric cancer by attenuating the NF‑κB signaling pathway through targeting MTDH. Int J Oncol. 2019;54(3):845–858. doi:10.3892/ijo.2019.4680.
  • Manna D, Sarkar D. Multifunctional role of astrocyte elevated gene-1 (AEG-1) in cancer: focus on drug resistance. Cancers (Basel). 2021;13(8):1792. doi:10.3390/cancers13081792.
  • Song Z, Wang Y, Li C, Zhang D, Wang X. Molecular Modification of Metadherin/MTDH Impacts the Sensitivity of Breast Cancer to Doxorubicin. PloS One. 2015;10(5):e0127599. doi:10.1371/journal.pone.0127599.
  • Tang D, Ma J, Chu Z, Wang X, Zhao W, Zhang Q. Zhang Q apatinib-induced NF-κB inactivation sensitizes triple-negative breast cancer cells to doxorubicin. Am J Transl Res. 2020;12(7):3741–3753.
  • Kehlen A, Haegele M, Menge K, Gans K, Immel UD, Hoang-Vu C, Klonisch T, Demuth HU. Role of glutaminyl cyclases in thyroid carcinomas. Endocr Relat Cancer. 2013;20(1):79–90. doi:10.1530/ERC-12-0053.
  • Busby WH, Quackenbush GE, Humm J, Youngblood WW, Kizer JS. An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes. J Biol Chem. 1987;262(18):8532–8536. doi:10.1016/S0021-9258(18)47446-7.
  • Coimbra JR, Sobral PJ, Santos AE, Moreira PI, Salvador JA. An overview of glutaminyl cyclase inhibitors for Alzheimer’s disease. Future Med Chem. 2019;11(24):3179–3194. doi:10.4155/fmc-2019-0163.
  • Vijayan DK, Zhang KYJ. Human glutaminyl cyclase: structure, function, inhibitors and involvement in Alzheimer’s disease. Pharmacol Res. 2019. 147:104342. doi:10.1016/j.phrs.2019.104342.
  • Zhao T, Bao Y, Gan X, Wang J, Chen Q, Dai Z, Liu B, Wang A, Sun S, Yang F, et al. DNA methylation-regulated QPCT promotes sunitinib resistance by increasing HRAS stability in renal cell carcinoma. Theranostics. 2019;9(21):6175–6190. doi:10.7150/thno.35572.
  • Zhao T, Zhou Y, Wang Q, Wang J, Chen Q, Dai Z, Liu B, Wang A, Sun S, Yang F, et al. QPCT regulation by CTCF leads to sunitinib resistance in renal cell carcinoma by promoting angiogenesis. Int J Oncol. 2021;59(1):48. doi:10.3892/ijo.2021.5228.
  • Shen M, Wei Y, Kim H, Wan L, Jiang YZ, Hang X, Raba M, Remiszewski S, Rowicki M, Wu CG, et al. Small-molecule inhibitors that disrupt the MTDH–SND1 complex suppress breast cancer progression and metastasis. Nat Cancer. 2022;3(1):43–59. doi:10.1038/s43018-021-00279-5.
  • Tokunaga E, Nakashima Y, Yamashita N, Hisamatsu Y, Okada S, Akiyoshi S, Aishima S, Kitao H, Morita M, Maehara Y. Overexpression of metadherin/MTDH is associated with an aggressive phenotype and a poor prognosis in invasive breast cancer. Breast Cancer-Tokyo. 2014;21(3):341–349. doi:10.1007/s12282-012-0398-2.
  • Fang J, Zhu H, Xu P, Jiang R. Zingerone suppresses proliferation, invasion, and migration of hepatocellular carcinoma cells by the inhibition of MTDH-mediated PI3K/Akt pathway. J Recept Signal Transduct Res. 2022;42(4):409–417. doi:10.1080/10799893.2021.1988970.
  • Pei G, Luo M, Ni X, Wu J, Wang S, Ma Y, Yu J. Autophagy facilitates metadherin-induced chemotherapy resistance through the AMPK/ATG5 pathway in gastric cancer. Cell Physiol Biochem. 2018;46(2):847–859. doi:10.1159/000488742.
  • Zhu K, Peng Y, Hu J, Zhan H, Yang L, Gao Q, Jia H, Luo R, Dai Z, Tang Z, et al. Metadherin-PRMT5 complex enhances the metastasis of hepatocellular carcinoma through the WNT-β-catenin signaling pathway. Carcinogenesis. 2020;41(2):130–138. doi:10.1093/carcin/bgz065.
  • Han C, Fu Y, Zeng N, Yin J, Li Q. LncRNA FAM83H-AS1 promotes triple-negative breast cancer progression by regulating the miR-136-5p/metadherin axis. Aging (Albany NY). 2020;12(4):3594–3616. doi:10.18632/aging.102832.
  • Cai Y, Zhao X, Chen D, Zhang F, Chen Q, Shao CC, Ouyang YX, Feng J, Cui L, Chen M, et al. Circ-NOL10 regulated by MTDH/CASC3 inhibits breast cancer progression and metastasis via multiple miRnas and PDCD4. Mol Ther Nucleic Acids. 2021;26:773–786. doi:10.1016/j.omtn.2021.09.013.
  • Wang Y, Dong L, Wan F, Chen F, Liu D, Chen D, Long J. MiR-9-3p regulates the biological functions and drug resistance of gemcitabine-treated breast cancer cells and affects tumor growth through targeting MTDH. Cell Death Disease. 2021;12(10):861. doi:10.1038/s41419-021-04145-1.
  • Liang Y, Hu J, Li J, Liu Y, Yu J, Zhuang X, Mu L, Kong X, Hong D, Yang Q, et al. Epigenetic activation of TWIST1 by MTDH promotes cancer stem–like cell traits in breast cancer. Cancer Research. 2015;75(17):3672–3680. doi:10.1158/0008-5472.CAN-15-0930.
  • Yuan L, Shi RR, Rao SM, Song JL, Cui MC. Reversal of resistance to adriamycin in human breast cancer cell line MCF-7/ADM by silencing AEG-1 gene and its mechanism. Sheng Li Xue Bao. 2014;66(5):625–630.
  • Nicoletto RE, Ofner CM. Cytotoxic mechanisms of doxorubicin at clinically relevant concentrations in breast cancer cells. Cancer Chemother Pharmacol. 2022;89(3):285–311. doi:10.1007/s00280-022-04400-y.
  • Housman G, Byler S, Heerboth S, Lapinska K, Longacre M, Snyder N, Sarkar S. Drug resistance in cancer: an overview. Cancers (Basel). 2014;6(3):1769–1792. doi:10.3390/cancers6031769.
  • Gillis JS. Microarray evidence of glutaminyl cyclase gene expression in melanoma: implications for tumor antigen specific immunotherapy. J Transl Med. 2006;4(1):27. doi:10.1186/1479-5876-4-27.
  • Jarzab B, Wiench M, Fujarewicz K, Simek K, Jarzab M, Oczko-Wojciechowska M, Wloch J, Czarniecka A, Chmielik E, Lange D, et al. Gene expression profile of papillary thyroid cancer: sources of variability and diagnostic implications. Cancer Res. 2005;65(4):1587–1597. doi:10.1158/0008-5472.CAN-04-3078.
  • Fluge Ø, Bruland O, Akslen LA, Lillehaug JR, Varhaug JE. Gene expression in poorly differentiated papillary thyroid carcinomas. Thyroid. 2006;16(2):161–175. doi:10.1089/thy.2006.16.161.
  • Griffith OL, Melck A, Jones SJ, Wiseman SM. Meta-analysis and meta-review of thyroid cancer gene expression profiling studies identifies important diagnostic biomarkers. J Clin Oncol. 2006;24(31):5043–5051. doi:10.1200/JCO.2006.06.7330.
  • Abdin SM, Tolba MF, Zaher DM, Omar HA. Nuclear factor-κB signaling inhibitors revert multidrug-resistance in breast cancer cells. Chem Biol Interact. 2021. 340:109450. doi:10.1016/j.cbi.2021.109450.
  • Mustafa YF. Synthesis, characterization, and biomedical assessment of novel bisimidazole–coumarin conjugates. Appl Nanosci. 2021;13(3):1907–1918. doi:10.1007/s13204-021-01872-x.