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Research Paper

Role of transforming growth factor-β1 pathway in angiogenesis induced by chronic stress in colorectal cancer

, , , & ORCID Icon
Article: 2366451 | Received 16 Mar 2023, Accepted 06 Jun 2024, Published online: 10 Jun 2024

References

  • Carmeliet P, Jain RK. Molecular mechanisms and clinical applications of angiogenesis. Nature. 2011;473(7347):298–12. doi:10.1038/nature10144.
  • Lambrechts D, Lenz HJ, de Haas S, Carmeliet P, Scherer SJ. Markers of response for the antiangiogenic agent bevacizumab. J Clin Oncol. 2013;31(9):1219–30. doi:10.1200/JCO.2012.46.2762.
  • Recondo G Jr., Diaz-Canton E, de la Vega M, Greco M, Recondo G Sr., Valsecchi ME. Advances and new perspectives in the treatment of metastatic colon cancer. World J Gastrointest Oncol. 2014;6(7):211–24. doi:10.4251/wjgo.v6.i7.211.
  • Garcia J, Hurwitz HI, Sandler AB, Miles D, Coleman RL, Deurloo R, Chinot OL. Bevacizumab (Avastin(r)) in cancer treatment: A review of 15 years of clinical experience and future outlook. Cancer Treat Rev. 2020;86:102017. doi:10.1016/j.ctrv.2020.102017.
  • Chen N, Ren M, Li R, Deng X, Li Y, Yan K, Xiao L, Yang Y, Wang L, Luo M. et al. Bevacizumab promotes venous thromboembolism through the induction of PAI-1 in a mouse xenograft model of human lung carcinoma. Mol Cancer. 2015;14(1):140. doi:10.1186/s12943-015-0418-x.
  • Linden W, Vodermaier A, Mackenzie R, Greig D. Anxiety and depression after cancer diagnosis: prevalence rates by cancer type, gender, and age. J Affect Disord. 2012;141(2–3):343–51. doi:10.1016/j.jad.2012.03.025.
  • Deng YT, Zhong WN, Jiang Y. Measurement of distress and its alteration during treatment in patients with nasopharyngeal carcinoma. Head Neck. 2014;36(8):1077–86. doi:10.1002/hed.23412.
  • Pinquart M, Duberstein PR. Depression and cancer mortality: a meta-analysis. Psychol Med. 2010;40(11):1797–810. doi:10.1017/S0033291709992285.
  • Antoni MH. Psychosocial intervention effects on adaptation, disease course and biobehavioral processes in cancer. Brain Behav Immun. 2013;30:S88–98. doi:10.1016/j.bbi.2012.05.009.
  • Spiegel D. Mind matters in cancer survival. Psychooncology. 2012;21(6):588–93. doi:10.1002/pon.3067.
  • Thornton LM, Andersen BL, Blakely WP. The pain, depression, and fatigue symptom cluster in advanced breast cancer: Covariation with the hypothalamic–pituitary–adrenal axis and the sympathetic nervous system. Health Psychol. 2010;29(3):333–37. doi:10.1037/a0018836.
  • Yang EV, Kim SJ, Donovan EL, Chen M, Gross AC, Webster Marketon JI, Barsky SH, Glaser R. Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression. Brain Behav Immun. 2009;23(2):267–75. doi:10.1016/j.bbi.2008.10.005.
  • Sloan EK, Priceman SJ, Cox BF, Yu S, Pimentel MA, Tangkanangnukul V, Arevalo JM, Morizono K, Karanikolas BD, Wu L. et al. The sympathetic nervous system induces a metastatic switch in primary breast cancer. Cancer Res. 2010;70(18):7042–52. doi:10.1158/0008-5472.CAN-10-0522.
  • Thaker PH, Han LY, Kamat AA, Arevalo JM, Takahashi R, Lu C, Jennings NB, Armaiz-Pena G, Bankson JA, Ravoori M. et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med. 2006;12(8):939–44. doi:10.1038/nm1447.
  • Liu J, Deng GH, Zhang J, Wang Y, Xia XY, Luo XM, Deng YT, He SS, Mao YY, Peng XC. et al. The effect of chronic stress on anti-angiogenesis of sunitinib in colorectal cancer models. Psychoneuroendocrinology. 2015;52:130–42. doi:10.1016/j.psyneuen.2014.11.008.
  • Cheng Y, Gao XH, Li XJ, Cao QH, Zhao DD, Zhou JR, Wu HX, Wang Y, You LJ, Yang HB. et al. Depression promotes prostate cancer invasion and metastasis via a sympathetic-cAMP-FAK signaling pathway. Oncogene. 2018;37(22):2953–66. doi:10.1038/s41388-018-0177-4.
  • Deng GH, Liu J, Zhang J, Wang Y, Peng XC, Wei YQ, Jiang Y. Exogenous norepinephrine attenuates the efficacy of sunitinib in a mouse cancer model. J Exp Clin Cancer Res. 2014;33(1):21. doi:10.1186/1756-9966-33-21.
  • Yang EV, Sood AK, Chen M, Li Y, Eubank TD, Marsh CB, Jewell S, Flavahan NA, Morrison C, Yeh PE. et al. Norepinephrine up-regulates the expression of vascular endothelial growth factor, matrix metalloproteinase (MMP)-2, and MMP-9 in nasopharyngeal carcinoma tumor cells. Cancer Res. 2006;66(21):10357–64. doi:10.1158/0008-5472.CAN-06-2496.
  • Krizanova O, Babula P, Pacak K. Stress, catecholaminergic system and cancer. Stress. 2016;19(4):419–28. doi:10.1080/10253890.2016.1203415.
  • Elenkov IJ, Chrousos GP. Stress hormones, proinflammatory and antiinflammatory cytokines, and autoimmunity. Ann N Y Acad Sci. 2002;966(1):290–303. doi:10.1111/j.1749-6632.2002.tb04229.x.
  • Sigala B, McKee C, Soeda J, Pazienza V, Morgan M, Lin CI, Selden C, Vander Borght S, Mazzoccoli G, Roskams T. et al. Sympathetic nervous system catecholamines and neuropeptide Y neurotransmitters are upregulated in human NAFLD and modulate the fibrogenic function of hepatic stellate cells. PLOS ONE. 2013;8(9):e72928. doi:10.1371/journal.pone.0072928.
  • Calon A, Espinet E, Palomo-Ponce S, Tauriello DV, Iglesias M, Cespedes MV, Sevillano M, Nadal C, Jung P, Zhang XH. et al. Dependency of colorectal cancer on a TGF-β-driven program in stromal cells for metastasis Initiation. Cancer Cell. 2012;22(5):571–84. doi:10.1016/j.ccr.2012.08.013.
  • Tsushima H, Ito N, Tamura S, Matsuda Y, Inada M, Yabuuchi I, Imai Y, Nagashima R, Misawa H, Takeda H. et al. Circulating transforming growth factor beta 1 as a predictor of liver metastasis after resection in colorectal cancer. Clin Cancer Res. 2001;7(5):1258–62.
  • Shi X, Guo LW, Seedial SM, Si Y, Wang B, Takayama T, Suwanabol PA, Ghosh S, DiRenzo D, Liu B. et al. TGF-β/Smad3 inhibit vascular smooth muscle cell apoptosis through an autocrine signaling mechanism involving VEGF-A. Cell Death Disease. 2014;5(7):e1317. doi:10.1038/cddis.2014.282.
  • Wu Y, Lucia K, Lange M, Kuhlen D, Stalla GK, Renner U. Hypoxia inducible factor-1 is involved in growth factor, glucocorticoid and hypoxia mediated regulation of vascular endothelial growth factor-A in human meningiomas. J Neurooncol. 2014;119(2):263–73. doi:10.1007/s11060-014-1503-5.
  • Mazzocca A, Fransvea E, Lavezzari G, Antonaci S, Giannelli G. Inhibition of transforming growth factor β receptor I kinase blocks hepatocellular carcinoma growth through neo-angiogenesis regulation. Hepatology. 2009;50(4):1140–51. doi:10.1002/hep.23118.
  • Fransvea E, Angelotti U, Antonaci S, Giannelli G. Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology. 2008;47(5):1557–66. doi:10.1002/hep.22201.
  • Varadan V, Kamalakaran S, Gilmore H, Banerjee N, Janevski A, Miskimen KL, Williams N, Basavanhalli A, Madabhushi A, Lezon-Geyda K. et al. Brief-exposure to preoperative bevacizumab reveals a TGF-β signature predictive of response in HER2-negative breast cancers. Int J Cancer. 2016;138(3):747–57. doi:10.1002/ijc.29808.
  • Wang Z, Zhou J, Fan J, Tan CJ, Qiu SJ, Yu Y, Huang XW, Tang ZY. Sirolimus inhibits the growth and metastatic progression of hepatocellular carcinoma. J Cancer Res Clin Oncol. 2009;135(5):715–22. doi:10.1007/s00432-008-0506-z.
  • Zhang J, Deng YT, Liu J, Wang YQ, Yi TW, Huang BY, He SS, Zheng B, Jiang Y. Norepinephrine induced epithelial–mesenchymal transition in HT-29 and A549 cells in vitro. J Cancer Res Clin Oncol. 2016;142(2):423–35. doi:10.1007/s00432-015-2044-9.
  • Barrett CS, Millena AC, Khan SA. TGF-β effects on prostate cancer cell migration and invasion require FosB. Prostate. 2017;77(1):72–81. doi:10.1002/pros.23250.
  • Gu HF, Tang CK, Yang YZ. Psychological stress, immune response, and atherosclerosis. Atherosclerosis. 2012;223(1):69–77. doi:10.1016/j.atherosclerosis.2012.01.021.
  • Jeon SW, Kim YK. Neuroinflammation and cytokine abnormality in major depression: Cause or consequence in that illness? World J Psychiatry. 2016;6(3):283–93. doi:10.5498/wjp.v6.i3.283.
  • Dhabhar FS, Saul AN, Holmes TH, Daugherty C, Neri E, Tillie JM, Kusewitt D, Oberyszyn TM, Rameshwar P. High-anxious individuals show increased chronic stress burden, decreased protective immunity, and increased cancer progression in a mouse model of squamous cell carcinoma. PLOS ONE. 2012;7(4):e33069. doi:10.1371/journal.pone.0033069.
  • Feng Z, Liu L, Zhang C, Zheng T, Wang J, Lin M, Zhao Y, Wang X, Levine AJ, Hu W. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci USA. 2012;109(18):7013–18. doi:10.1073/pnas.1203930109.
  • Kim HR, Moon S, Lee HK, Kang JL, Oh S, Seoh JY. Immune dysregulation in chronic stress: a quantitative and functional assessment of regulatory T cells. Neuroimmunomodulation. 2012;19(3):187–94. doi:10.1159/000331586.
  • Wu X, Liu BJ, Ji S, Wu JF, Xu CQ, Du YJ, You XF, Li B, Le JJ, Xu HL. et al. Social defeat stress promotes tumor growth and angiogenesis by upregulating vascular endothelial growth factor/extracellular signal-regulated kinase/matrix metalloproteinase signaling in a mouse model of lung carcinoma. Mol Med Rep. 2015;12(1):1405–12. doi:10.3892/mmr.2015.3559.
  • Barron TI, Connolly RM, Sharp L, Bennett K, Visvanathan K. Beta blockers and breast cancer mortality: a population- based study. J Clin Oncol. 2011;29(19):2635–44. doi:10.1200/JCO.2010.33.5422.
  • Powe DG, Voss MJ, Zanker KS, Habashy HO, Green AR, Ellis IO, Entschladen F. Beta-blocker drug therapy reduces secondary cancer formation in breast cancer and improves cancer specific survival. Oncotarget. 2010;1(7):628–38. doi:10.18632/oncotarget.197.
  • Watkins JL, Thaker PH, Nick AM, Ramondetta LM, Kumar S, Urbauer DL, Matsuo K, Squires KC, Coleman RL, Lutgendorf SK. et al. Clinical impact of selective and nonselective beta-blockers on survival in patients with ovarian cancer. Cancer. 2015;121(19):3444–51. doi:10.1002/cncr.29392.
  • Lu H, Liu X, Guo F, Tan S, Wang G, Liu H, Wang J, He X, Mo Y, Shi B. Impact of beta-blockers on prostate cancer mortality: a meta-analysis of 16,825 patients. Onco Targets Ther. 2015;8:985–90. doi:10.2147/OTT.S78836.
  • Lin Q, Wang F, Yang R, Zheng X, Gao H, Zhang P, Zhou Y. Effect of chronic restraint stress on human colorectal carcinoma growth in mice. PLOS ONE. 2013;8(4):e61435. doi:10.1371/journal.pone.0061435.
  • Crema L, Schlabitz M, Tagliari B, Cunha A, Simao F, Krolow R, Pettenuzzo L, Salbego C, Vendite D, Wyse AT. et al. Na+, K+ ATPase activity is reduced in amygdala of rats with chronic stress-induced anxiety-like behavior. Neurochem Res. 2010;35(11):1787–95. doi:10.1007/s11064-010-0245-9.
  • Christiansen SH, Olesen MV, Wortwein G, Woldbye DP. Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice. Behav Brain Res. 2011;216(2):585–91. doi:10.1016/j.bbr.2010.08.044.
  • Yang R, Lin Q, Gao HB, Zhang P. Stress-related hormone norepinephrine induces interleukin-6 expression in GES-1 cells. Braz J Med Biol Res. 2014;47(2):101–09. doi:10.1590/1414-431X20133346.
  • Wu M, Chen X, Lou J, Zhang S, Zhang X, Huang L, Sun R, Huang P, Wang F, Pan S. TGF-β1 contributes to CD8+ Treg induction through p38 MAPK signaling in ovarian cancer microenvironment. Oncotarget. 2016;7(28):44534–44. doi:10.18632/oncotarget.10003.
  • Rouce RH, Shaim H, Sekine T, Weber G, Ballard B, Ku S, Barese C, Murali V, Wu MF, Liu H. et al. The TGF-β/SMAD pathway is an important mechanism for NK cell immune evasion in childhood B-acute lymphoblastic leukemia. Leukemia. 2016;30(4):800–11. doi:10.1038/leu.2015.327.
  • Choi MJ, Cho KH, Lee S, Bae YJ, Jeong KJ, Rha SY, Choi EJ, Park JH, Kim JM, Lee JS. et al. hTERT mediates norepinephrine-induced Slug expression and ovarian cancer aggressiveness. Oncogene. 2015;34(26):3402–12. doi:10.1038/onc.2014.270.
  • Shan T, Cui X, Li W, Lin W, Li Y, Chen X, Wu T. Novel regulatory program for norepinephrine-induced epithelial–mesenchymal transition in gastric adenocarcinoma cell lines. Cancer Sci. 2014;105(7):847–56. doi:10.1111/cas.12438.
  • Gupta DK, Singh N, Sahu DK. TGF-beta Mediated Crosstalk Between Malignant Hepatocyte and Tumor Microenvironment in Hepatocellular Carcinoma. Cancer Growth Metastasis. 2014;7:1–8. doi:10.4137/CGM.S14205.
  • Xie Q, Xie J, Zhong J, Cun X, Lin S, Lin Y, Cai X. Hypoxia enhances angiogenesis in an adipose-derived stromal cell/endothelial cell co-culture 3D gel model. Cell Prolif. 2016;49(2):236–45. doi:10.1111/cpr.12244.
  • Li GC, Zhang HW, Zhao QC, Sun LI, Yang JJ, Hong L, Feng F, Cai L. Mesenchymal stem cells promote tumor angiogenesis via the action of transforming growth factor β1. Oncol Lett. 2016;11(2):1089–94. doi:10.3892/ol.2015.3997.
  • Liu SG, Yuan SH, Wu HY, Liu J, Huang CS. The clinical research of serum VEGF, TGF-β1, and endostatin in non-small cell lung cancer. Cell Biochem Biophys. 2015;72(1):165–69. doi:10.1007/s12013-014-0431-5.
  • Tang L, Pei H, Yang Y, Wang X, Wang T, Gao E, Li D, Yang Y, Yang D. The inhibition of calpains ameliorates vascular restenosis through MMP2/TGF-β1 pathway. Sci Rep. 2016;6(1):29975. doi:10.1038/srep29975.
  • Shan T, Ma J, Ma Q, Guo K, Guo J, Li X, Li W, Liu J, Huang C, Wang F. et al. β2-AR-HIF-1α: A novel regulatory axis for stress-induced pancreatic tumor growth and angiogenesis. Curr Mol Med. 2013;13(6):1023–34. doi:10.2174/15665240113139990055.
  • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell. 2009;139(5):871–90. doi:10.1016/j.cell.2009.11.007.
  • Shenoy AK, Jin Y, Luo H, Tang M, Pampo C, Shao R, Siemann DW, Wu L, Heldermon CD, Law BK. et al. Epithelial-to-mesenchymal transition confers pericyte properties on cancer cells. J Clin Invest. 2016;126(11):4174–86. doi:10.1172/JCI86623.
  • Fantozzi A, Gruber DC, Pisarsky L, Heck C, Kunita A, Yilmaz M, Meyer-Schaller N, Cornille K, Hopfer U, Bentires-Alj M. et al. VEGF-mediated angiogenesis links EMT-induced cancer stemness to tumor initiation. Cancer Res. 2014;74(5):1566–75. doi:10.1158/0008-5472.CAN-13-1641.
  • Kong D, Zhou H, Neelakantan D, Hughes CJ, Hsu JY, Srinivasan RR, Lewis MT, Ford HL. VEGF-C mediates tumor growth and metastasis through promoting EMT-epithelial breast cancer cell crosstalk. Oncogene. 2021;40(5):964–79. doi:10.1038/s41388-020-01539-x.
  • Shilpa P, Kaveri K, Salimath BP. Anti-metastatic action of anacardic acid targets VEGF-induced signalling pathways in epithelial to mesenchymal transition. Drug Discov Ther. 2015;9(1):53–65. doi:10.5582/ddt.2014.01042.