Cordycepin induces cell cycle arrest and apoptosis by inducing DNA damage and up-regulation of p53 in Leukemia cells

References

• Hwang IK, Lim SS, Yoo KY, Lee YS, Kim HG, Kang IJ, Kwon HJ, Park J, Choi SY, Won MH. A Phytochemically characterized extract of cordyceps militaris and cordycepin protect hippocampal neurons from ischemic injury in gerbils. Planta Med 2008; 74:114-9; PMID:18214814; http://dx.doi.org/10.1055/s-2008-1034277
   PubMed Web of Science ®Google Scholar
• Choi SB, Park CH, Choi MK, Jun DW, Park S. Improvement of insulin resistance and insulin secretion by water extracts of cordyceps militaris, phellinus linteus, and paecilomyces tenuipes in 90% pancreatectomized rats. Biosci Biotechnol Biochem 2004; 68:2257-64; PMID:15564662; http://dx.doi.org/10.1271/bbb.68.2257
   PubMed Web of Science ®Google Scholar
• Jung K, Kim IH, Han D. Effect of medicinal plant extracts on forced swimming capacity in mice. J Ethnopharmacol 2004; 93:75-81; PMID:15182908; http://dx.doi.org/10.1016/j.jep.2004.03.022
   PubMed Web of Science ®Google Scholar
• Won SY, Park EH. Anti-inflammatory and related pharmacological activities of cultured mycelia and fruiting bodies of Cordyceps militaris. J Ethnopharmacol 2005; 96:555-61; PMID:15619578; http://dx.doi.org/10.1016/j.jep.2004.10.009
   PubMed Web of Science ®Google Scholar
• Ahn YJ, Park SJ, Lee SG, Shin SC, Choi DH. Cordycepin: selective growth inhibitor derived from liquid culture of cordyceps militaris against clostridium spp. J Agri Food Chem 2000; 48:2744-8; PMID:10898616; http://dx.doi.org/10.1021/jf990862n
   PubMed Web of Science ®Google Scholar
• Muller WE, Weiler BE, Charubala R, Pfleiderer W, Leserman L, Sobol RW, Suhadolnik RJ, Schroder HC. Cordycepin analogues of 2',5'-oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Biochemistry 1991; 30:2027-33; PMID:1705437; http://dx.doi.org/10.1021/bi00222a004
   PubMed Web of Science ®Google Scholar
• Wu JY, Zhang QX, Leung PH. Inhibitory effects of ethyl acetate extract of cordyceps sinensis mycelium on various cancer cells in culture and B16 melanoma in C57BL/6 mice. Phytomedicine 2007; 14:43-9; PMID:16423520; http://dx.doi.org/10.1016/j.phymed.2005.11.005
   PubMed Web of Science ®Google Scholar
• Chang Y, Jeng KC, Huang KF, Lee YC, Hou CW, Chen KH, Cheng FY, Liao JW, Chen YS. Effect of cordyceps militaris supplementation on sperm production, sperm motility and hormones in sprague-dawley rats. Am J Chin Med 2008; 36:849-59; PMID:19051352; http://dx.doi.org/10.1142/S0192415X08006296
   PubMed Web of Science ®Google Scholar
• Cunningham KG, Manson W, Spring FS, Hutchinson SA. Cordycepin, a metabolic product isolated from cultures of cordyceps militaris (Linn.) Link. Nature 1950; 166:949; PMID:14796634.
   PubMed Web of Science ®Google Scholar
• Muller WE, Seibert G, Beyer R, Breter HJ, Maidhof A, Zahn RK. Effect of cordycepin on nucleic acid metabolism in L5178Y cells and on nucleic acid-synthesizing enzyme systems. Cancer Res 1977; 37:3824-33; PMID:332340.
   PubMed Web of Science ®Google Scholar
• Chang W, Lim S, Song H, Song BW, Kim HJ, Cha MJ, Sung JM, Kim TW, Hwang KC. Cordycepin inhibits vascular smooth muscle cell proliferation. Europ J Pharmacol 2008; 597:64-9; PMID:18782572; http://dx.doi.org/10.1016/j.ejphar.2008.08.030
   PubMed Web of Science ®Google Scholar
• Lee SJ, Kim SK, Choi WS, Kim WJ, Moon SK. Cordycepin causes p21WAF1-mediated G2/M cell-cycle arrest by regulating c-jun N-terminal kinase activation in human bladder cancer cells. Arch Biochem Biophys 2009; 490:103-9; PMID:19733546; http://dx.doi.org/10.1016/j.abb.2009.09.001
   PubMed Web of Science ®Google Scholar
• Lee EJ, Kim WJ, Moon SK. Cordycepin suppresses TNF-α-induced invasion, migration and matrix metalloproteinase-9 expression in human bladder cancer cells. Phytother Res 2010; 24:1755-61; PMID:20564512; http://dx.doi.org/10.1002/ptr.3132
   PubMed Web of Science ®Google Scholar
• Jeong JW, Jin CY, Park C, Han MH, Kim GY, Moon SK, Kim CG, Jeong YK, Kim WJ, Lee JD, et al. Inhibition of migration and invasion of LNCaP human prostate carcinoma. Int J Oncol 2012; PMID:22246470; 10.3892/ijo.2012.1332
   PubMed Web of Science ®Google Scholar
• Koc Y, Urbano AG, Sweeney EB, McCaffrey R. Induction of apoptosis by cordycepin in ADA-inhibited TdT-positive leukemia cells. Leukemia 1996; 10:1019-24; PMID:8667637
   PubMed Web of Science ®Google Scholar
• Chen Y, Chen YC, Lin YT, Huang SH, Wang SM. Cordycepin induces apoptosis of CGTH W-2 thyroid carcinoma cells through the calcium-calpain-caspase 7-PARP pathway. J Agri Food Chem 2010; 58:11645-52; PMID:20961042; http://dx.doi.org/10.1021/jf1028976
   PubMed Web of Science ®Google Scholar
• Pan BS, Lin CY, Huang BM. The effect of cordycepin on steroidogenesis and apoptosis in MA-10 mouse leydig tumor cells. EvidBased Complement Alternat Med 2011; 2011:750468; PMID:21716681; 10.1155/2011/750468
   PubMed Web of Science ®Google Scholar
• Foss FM. Combination therapy with purine nucleoside analogs. Oncology (Williston Park) 2000; 14:31-5; PMID:10887642
   PubMedGoogle Scholar
• Milella M, Kornblau SM, Estrov Z, Carter BZ, Lapillonne H, Harris D, Konopleva M, Zhao S, Estey E, Andreeff M. Therapeutic targeting of the MEK/MAPK signal transduction module in acute myeloid leukemia. J Clin Invest 2001; 108:851-9; PMID:11560954; http://dx.doi.org/10.1172/JCI12807
   PubMed Web of Science ®Google Scholar
• Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem 1998; 273:5858-68; PMID:9488723; http://dx.doi.org/10.1074/jbc.273.10.5858
   PubMed Web of Science ®Google Scholar
• Falck J, Mailand N, Syljuasen RG, Bartek J, Lukas J. The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis. Nature 2001; 410:842-7; PMID:11298456; http://dx.doi.org/10.1038/35071124
   PubMed Web of Science ®Google Scholar
• Kroemer G, Dallaporta B, Resche-Rigon M. The mitochondrial death/life regulator in apoptosis and necrosis. Annu Rev Physiol 1998; 60:619-42; PMID:9558479; http://dx.doi.org/10.1146/annurev.physiol.60.1.619
   PubMed Web of Science ®Google Scholar
• Takahashi R, Deveraux Q, Tamm I, Welsh K, Assa-Munt N, Salvesen GS, Reed JC. A single BIR domain of XIAP sufficient for inhibiting caspases. J Biol Chem 1998; 273:7787-90; PMID:9525868; http://dx.doi.org/10.1074/jbc.273.14.7787
   PubMed Web of Science ®Google Scholar
• Towatari M, Iida H, Tanimoto M, Iwata H, Hamaguchi M, Saito H. Constitutive activation of mitogen-activated protein kinase pathway in acute leukemia cells. Leukemia 1997; 11(4):479-84; PMID:9096686; http://dx.doi.org/10.1038/sj.leu.2400617
   PubMed Web of Science ®Google Scholar
• Wong VC, Cash HL, Morse JL, Lu S, Zhitkovich A. S-phase sensing of DNA-protein crosslinks triggers topBP1-independent ATR activation and p53-mediated cell death by formaldehyde. Cell Cycle 2012; 11:2526-37; PMID:22722496; http://dx.doi.org/10.4161/cc.20905
   PubMed Web of Science ®Google Scholar
• Hopker K, Hagmann H, Khurshid S, Chen S, Schermer B, Benzing T, Reinhardt HC. Putting the brakes on p53-driven apoptosis. Cell Cycle 2012; 11:4122-8; PMID:22983126; http://dx.doi.org/10.4161/cc.21997
   PubMed Web of Science ®Google Scholar
• Wang B, Xiao Z, Ko HL, Ren EC. The p53 response element and transcriptional repression. Cell Cycle 2010; 9:870-9; PMID:20160511; http://dx.doi.org/10.4161/cc.9.5.10825
   PubMed Web of Science ®Google Scholar
• van den Heuvel S, Harlow E. Distinct roles for cyclin-dependent kinases in cell cycle control. Science 1993; 262:2050-4; PMID:8266103; http://dx.doi.org/10.1126/science.8266103
   PubMed Web of Science ®Google Scholar
• Hu B, Mitra J, van den Heuvel S, Enders GH. S and G2 phase roles for cdk2 revealed by inducible expression of a dominant-negative mutant in human cells. Mol Cell Biol 2001; 21:2755-66; PMID:11283255; http://dx.doi.org/10.1128/MCB.21.8.2755-2766.2001
   PubMed Web of Science ®Google Scholar
• Dewson G, Snowden RT, Almond JB, Dyer MJ, Cohen GM. Conformational change and mitochondrial translocation of bax accompany proteasome inhibitor-induced apoptosis of chronic lymphocytic leukemic cells. Oncogene 2003; 22:2643-54; PMID:12730678; http://dx.doi.org/10.1038/sj.onc.1206326
   PubMed Web of Science ®Google Scholar
• Lanaro C, Franco-Penteado CF, Albuqueque DM, Saad ST, Conran N, Costa FF. Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy. J Leukoc Biol 2009; 85:235-42; PMID:19004988; http://dx.doi.org/10.1189/jlb.0708445
   PubMed Web of Science ®Google Scholar
• Chen K, Perez-Stable C, D'Ippolito G, Schiller PC, Roos BA, Howard GA. Human bone marrow-derived stem cell proliferation is inhibited by hepatocyte growth factor via increasing the cell cycle inhibitors p53, p21 and p27. Bone 2011; 49:1194-204; PMID:21907315; http://dx.doi.org/10.1016/j.bone.2011.08.023
   PubMed Web of Science ®Google Scholar
• Olivero OA, Tejera AM, Fernandez JJ, Taylor BJ, Das S, Divi RL, Poirier MC. Zidovudine induces S-phase arrest and cell cycle gene expression changes in human cells. Mutagenesis 2005; 20:139-46; PMID:15784690; http://dx.doi.org/10.1093/mutage/gei019
   PubMed Web of Science ®Google Scholar