1,665
Views
12
CrossRef citations to date
0
Altmetric
Reports

Loss of CDK5RAP2 affects neural but not non-neural mESC differentiation into cardiomyocytes

, , , , , , , & show all

References

  • Kaindl AM, Passemard S, Kumar P, Kraemer N, Issa L, Zwirner A, Gerard B, Verloes A, Mani S, Gressens P. Many roads lead to primary autosomal recessive microcephaly. Prog Neurobiol 2010; 90:363-83; PMID:19931588; http://dx.doi.org/10.1016/j.pneurobio.2009.11.002
  • Lizarraga SB, Margossian SP, Harris MH, Campagna DR, Han AP, Blevins S, Mudbhary R, Barker JE, Walsh CA, Fleming MD. Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors. Development 2010; 137:1907-17; PMID:20460369; http://dx.doi.org/10.1242/dev.040410
  • Buchman JJ, Tseng HC, Zhou Y, Frank CL, Xie Z, Tsai LH. Cdk5rap2 interacts with pericentrin to maintain the neural progenitor pool in the developing neocortex. Neuron 2010; 66:386-402; PMID:20471352; http://dx.doi.org/10.1016/j.neuron.2010.03.036
  • Fish JL, Kosodo Y, Enard W, Paabo S, Huttner WB. Aspm specifically maintains symmetric proliferative divisions of neuroepithelial cells. Proc Natl Acad Sci U S A 2006; 103:10438-43; PMID:16798874; http://dx.doi.org/10.1073/pnas.0604066103
  • Pulvers JN, Bryk J, Fish JL, Wilsch-Brauninger M, Arai Y, Schreier D, Naumann R, Helppi J, Habermann B, Vogt J, et al. Mutations in mouse Aspm (abnormal spindle-like microcephaly associated) cause not only microcephaly but also major defects in the germline. Proc Natl Acad Sci U S A 2010; 107:16595-600; PMID:20823249; http://dx.doi.org/10.1073/pnas.1010494107
  • Fietz SA, Huttner WB. Cortical progenitor expansion, self-renewal and neurogenesis-a polarized perspective. Curr Opin Neurobiol 2011; 21:23-35; PMID:21036598; http://dx.doi.org/10.1016/j.conb.2010.10.002
  • Bond J, Roberts E, Springell K, Lizarraga SB, Scott S, Higgins J, Hampshire DJ, Morrison EE, Leal GF, Silva EO, et al. A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. Nat Genet 2005; 37:353-5
  • Hassan MJ, Khurshid M, Azeem Z, John P, Ali G, Chishti MS, Ahmad W. Previously described sequence variant in CDK5RAP2 gene in a Pakistani family with autosomal recessive primary microcephaly. BMC Med Genet 2007; 8:58; PMID:17764569; http://dx.doi.org/10.1186/1471-2350-8-58
  • Pagnamenta AT, Murray JE, Yoon G, Sadighi Akha E, Harrison V, Bicknell LS, Ajilogba K, Stewart H, Kini U, Taylor JC, et al. A novel nonsense CDK5RAP2 mutation in a Somali child with primary microcephaly and sensorineural hearing loss. Am J Med Genet A 2012; 158A:2577-82; PMID:22887808; http://dx.doi.org/10.1002/ajmg.a.35558
  • Issa L, Mueller K, Seufert K, Kraemer N, Rosenkotter H, Ninnemann O, Buob M, Kaindl AM, Morris-Rosendahl DJ. Clinical and cellular features in patients with primary autosomal recessive microcephaly and a novel CDK5RAP2 mutation. Orphanet J Rare Dis 2013; 8:59; PMID:23587236; http://dx.doi.org/10.1186/1750-1172-8-59
  • Kraemer N, Issa L, Hauck SC, Mani S, Ninnemann O, Kaindl AM. What's the hype about CDK5RAP2? Cell Mol Life Sci 2011; 68:1719-36; PMID:21327915; http://dx.doi.org/10.1007/s00018-011-0635-4
  • Megraw TL, Sharkey JT, Nowakowski RS. Cdk5rap2 exposes the centrosomal root of microcephaly syndromes. Trends Cell Biol 2011; 21:470-80; PMID:21632253; http://dx.doi.org/10.1016/j.tcb.2011.04.007
  • Barker JE, Bernstein SE. Hertwig's anemia: characterization of the stem cell defect. Blood 1983; 61:765-9; PMID:6831040
  • Russell ES, McFarland EC, Peters H. Gametic and pleiotropic defects in mouse fetuses with Hertwig's macrocytic anemia. Dev Biol 1985; 110:331-7; PMID:4018402; http://dx.doi.org/10.1016/0012-1606(85)90092-2
  • Visan A, Hayess K, Sittner D, Pohl EE, Riebeling C, Slawik B, Gulich K, Oelgeschläger M, Luch A, Seiler AE. Neural differentiation of mouse embryonic stem cells as a tool to assess developmental neurotoxicity in vitro. Neurotoxicology 2012; 33:1135-46; PMID:22732190; http://dx.doi.org/10.1016/j.neuro.2012.06.006
  • Abranches E, Silva M, Pradier L, Schulz H, Hummel O, Henrique D, Bekman E. Neural differentiation of embryonic stem cells in vitro: a road map to neurogenesis in the embryo. PLoS One 2009; 4:e6286; PMID:19621087; http://dx.doi.org/10.1371/journal.pone.0006286
  • Ying QL, Stavridis M, Griffiths D, Li M, Smith A. Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture. Nat Biotechnol 2003; 21:183-6; PMID:12524553; http://dx.doi.org/10.1038/nbt780
  • Wang Z, Wu T, Shi L, Zhang L, Zheng W, Qu JY, Niu R, Qi RZ. A conserved motif of CDK5RAP2 mediates its localization to centrosomes and the Golgi complex. J Biol Chem 2010; 285(29):22658-65
  • Issa L, Kraemer N, Rickert CH, Sifringer M, Ninnemann O, Stoltenburg-Didinger G, Kaindl AM. CDK5RAP2 Expression During Murine and Human Brain Development Correlates with Pathology in Primary Autosomal Recessive Microcephaly. Cereb Cortex 2013; 23:2245-60; PMID:22806269; http://dx.doi.org/10.1093/cercor/bhs212
  • Lucocq JM, Warren G. Fragmentation and partitioning of the Golgi apparatus during mitosis in HeLa cells. EMBO J 1987; 6:3239-46; PMID:3428259
  • Robbins E, Gonatas NK. The Ultrastructure of a Mammalian Cell during the Mitotic Cycle. J Cell Biol 1964; 21:429-63; PMID:14189913; http://dx.doi.org/10.1083/jcb.21.3.429
  • Chae HJ, Kang JS, Byun JO, Han KS, Kim DU, Oh SM, Kim HM, Chae SW, Kim HR. Molecular mechanism of staurosporine-induced apoptosis in osteoblasts. Pharmacol Res 2000; 42:373-81; PMID:10987998; http://dx.doi.org/10.1006/phrs.2000.0700
  • Feng G, Kaplowitz N. Mechanism of staurosporine-induced apoptosis in murine hepatocytes. Am J Physiol Gastrointest Liver Physiol 2002; 282:G825-34; PMID:11960779; http://dx.doi.org/10.1152/ajpgi.00467.2001
  • Seiler AE, Spielmann H. The validated embryonic stem cell test to predict embryotoxicity in vitro. Nat Protoc 2011; 6:961-78; PMID:21720311; http://dx.doi.org/10.1038/nprot.2011.348
  • Maltsev VA, Rohwedel J, Hescheler J, Wobus AM. Embryonic stem cells differentiate in vitro into cardiomyocytes representing sinusnodal, atrial and ventricular cell types. Mech Dev 1993; 44:41-50; PMID:8155574; http://dx.doi.org/10.1016/0925-4773(93)90015-P
  • Sachinidis A, Fleischmann BK, Kolossov E, Wartenberg M, Sauer H, Hescheler J. Cardiac specific differentiation of mouse embryonic stem cells. Cardiovasc Res 2003; 58:278-91; PMID:12757863; http://dx.doi.org/10.1016/S0008-6363(03)00248-7
  • Wobus AM, Wallukat G, Hescheler J. Pluripotent mouse embryonic stem cells are able to differentiate into cardiomyocytes expressing chronotropic responses to adrenergic and cholinergic agents and Ca2+ channel blockers. Differentiation 1991; 48:173-82; PMID:1725163; http://dx.doi.org/10.1111/j.1432-0436.1991.tb00255.x
  • Banach K, Halbach MD, Hu P, Hescheler J, Egert U. Development of electrical activity in cardiac myocyte aggregates derived from mouse embryonic stem cells. Am J Physiol Heart Circ Physiol 2003; 284:H2114-23; PMID:12573993; http://dx.doi.org/10.1152/ajpheart.01106.2001
  • Fong KW, Choi YK, Rattner JB, Qi RZ. CDK5RAP2 is a pericentriolar protein that functions in centrosomal attachment of the gamma-tubulin ring complex. Mol Biol Cell 2008; 19:115-25; PMID:17959831; http://dx.doi.org/10.1091/mbc.E07-04-0371
  • Lee S, Rhee K. CEP215 is involved in the dynein-dependent accumulation of pericentriolar matrix proteins for spindle pole formation. Cell Cycle 2010; 9:774-83; PMID:20139723
  • Haren L, Stearns T, Luders J. Plk1-dependent recruitment of gamma-tubulin complexes to mitotic centrosomes involves multiple PCM components. PLoS One 2009; 4:e5976; PMID:19543530; http://dx.doi.org/10.1371/journal.pone.0005976
  • Zhang X, Liu D, Lv S, Wang H, Zhong X, Liu B, Wang B, Liao J, Li J, Pfeifer GP, et al. CDK5RAP2 is required for spindle checkpoint function. Cell Cycle 2009; 8:1206-16; PMID:19282672; http://dx.doi.org/10.4161/cc.8.8.8205
  • Kim S, Rhee K. Importance of the CEP215-pericentrin interaction for centrosome maturation during mitosis. PLoS One 2014; 9:e87016; PMID:24466316; http://dx.doi.org/10.1371/journal.pone.0087016
  • Manning JA, Colussi PA, Koblar SA, Kumar S. Nedd1 expression as a marker of dynamic centrosomal localization during mouse embryonic development. Histochem Cell Biol 2008; 129:751-64; PMID:18239929; http://dx.doi.org/10.1007/s00418-008-0392-0
  • Shitamukai A, Matsuzaki F. Control of asymmetric cell division of mammalian neural progenitors. Dev Growth Differ 2012; 54:277-86; PMID:22524601; http://dx.doi.org/10.1111/j.1440-169X.2012.01345.x
  • Xie Z, Moy LY, Sanada K, Zhou Y, Buchman JJ, Tsai LH. Cep120 and TACCs control interkinetic nuclear migration and the neural progenitor pool. Neuron 2007; 56:79-93; PMID:17920017
  • Taverna E, Huttner WB. Neural progenitor nuclei IN motion. Neuron 2010; 67:906-14; PMID:20869589; http://dx.doi.org/10.1016/j.neuron.2010.08.027
  • Reiner O, Sapir T. Polarity regulation in migrating neurons in the cortex. Mol Neurobiol 2009; 40:1-14; PMID:19330467; http://dx.doi.org/10.1007/s12035-009-8065-0
  • de Anda FC, Pollarolo G, Da Silva JS, Camoletto PG, Feiguin F, Dotti CG. Centrosome localization determines neuronal polarity. Nature 2005; 436:704-8; PMID:16079847; http://dx.doi.org/10.1038/nature03811
  • Ching YP, Qi Z, Wang JH. Cloning of three novel neuronal Cdk5 activator binding proteins. Gene 2000; 242:285-94; PMID:10721722; http://dx.doi.org/10.1016/S0378-1119(99)00499-0
  • Smith AG, Heath JK, Donaldson DD, Wong GG, Moreau J, Stahl M, Rogers D. Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides. Nature 1988; 336:688-90; PMID:3143917; http://dx.doi.org/10.1038/336688a0
  • Williams RL, Hilton DJ, Pease S, Willson TA, Stewart CL, Gearing DP, Wagner EF, Metcalf D, Nicola NA, Gough NM. Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 1988; 336:684-7; PMID:3143916; http://dx.doi.org/10.1038/336684a0
  • Kraemer N, Neubert G, Issa L, Ninnemann O, Seiler AE, Kaindl AM. Reference genes in the developing murine brain and in differentiating embryonic stem cells. Neurol Res 2012; 34:664-8; PMID:22735032; http://dx.doi.org/10.1179/1743132812Y.0000000060

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.