Direct conversion of mouse fibroblasts to GABAergic neurons with combined medium without the introduction of transcription factors or miRNAs

Reference

• Dreifuss JJ, Kelly JS, Krnjevic K. Cortical inhibition and gamma-aminobutyric acid. Exp Brain Res 1969; 9:137-54; PMID:5346460; http://dx.doi.org/10.1007/BF00238327
   PubMed Web of Science ®Google Scholar
• Marin O. Interneuron dysfunction in psychiatric disorders. Nat Rev Neurosci 2012; 13:107-20; PMID:22251963
   PubMed Web of Science ®Google Scholar
• Soldner F, Hockemeyer D, Beard C, Gao Q, Bell GW, Cook EG, Hargus G, Blak A, Cooper O, Mitalipova M, et al. Parkinson's disease patient-derived induced pluripotent stem cells free of viral reprogramming factors. Cell 2009; 136:964-77; PMID:19269371; http://dx.doi.org/10.1016/j.cell.2009.02.013
   PubMed Web of Science ®Google Scholar
• Yu J, Vodyanik MA, Smuga-Otto K, Antosiewicz-Bourget J, Frane JL, Tian S, Nie J, Jonsdottir GA, Ruotti V, Stewart R, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science 2007; 318:1917-20; PMID:18029452; http://dx.doi.org/10.1126/science.1151526
   PubMed Web of Science ®Google Scholar
• Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 126:663-76; PMID:16904174; http://dx.doi.org/10.1016/j.cell.2006.07.024
   PubMed Web of Science ®Google Scholar
• Rhee YH, Ko JY, Chang MY, Yi SH, Kim D, Kim CH, Shim JW, Jo AY, Kim BW, Lee H, et al. Protein-based human iPS cells efficiently generate functional dopamine neurons and can treat a rat model of Parkinson disease. J Clin Invest 2011; 121:2326-35; PMID:21576821; http://dx.doi.org/10.1172/JCI45794
   PubMed Web of Science ®Google Scholar
• Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Proc Natl Acad Sci U S A 2008; 105:5856-61; PMID:18391196; http://dx.doi.org/10.1073/pnas.0801677105
   PubMed Web of Science ®Google Scholar
• Jia F, Wilson KD, Sun N, Gupta DM, Huang M, Li Z, Panetta NJ, Chen ZY, Robbins RC, Kay MA, et al. A nonviral minicircle vector for deriving human iPS cells. Nat Methods 2010; 7:197-9; PMID:20139967; http://dx.doi.org/10.1038/nmeth.1426
   PubMed Web of Science ®Google Scholar
• Kim D, Kim CH, Moon JI, Chung YG, Chang MY, Han BS, Ko S, Yang E, Cha KY, Lanza R, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell 2009; 4:472-6; PMID:19481515; http://dx.doi.org/10.1016/j.stem.2009.05.005
   PubMed Web of Science ®Google Scholar
• Johnson MA, Weick JP, Pearce RA, Zhang SC. Functional neural development from human embryonic stem cells: accelerated synaptic activity via astrocyte coculture. J Neurosci 2007; 27:3069-77; PMID:17376968; http://dx.doi.org/10.1523/JNEUROSCI.4562-06.2007
   PubMed Web of Science ®Google Scholar
• Soldner F, Jaenisch R. Medicine. iPSC disease modeling. Science 2012; 338:1155-6; PMID:23197518; http://dx.doi.org/10.1126/science.1227682
   PubMed Web of Science ®Google Scholar
• Kim J, Efe JA, Zhu S, Talantova M, Yuan X, Wang S, Lipton SA, Zhang K, Ding S. Direct reprogramming of mouse fibroblasts to neural progenitors. Proc Natl Acad Sci U S A 2011; 108:7838-43; PMID:21521790; http://dx.doi.org/10.1073/pnas.1103113108
   PubMed Web of Science ®Google Scholar
• Han DW, Tapia N, Hermann A, Hemmer K, Hoing S, Arauzo-Bravo MJ, Zaehres H, Wu G, Frank S, Moritz S, et al. Direct reprogramming of fibroblasts into neural stem cells by defined factors. Cell Stem Cell 2012; 10:465-72; PMID:22445517; http://dx.doi.org/10.1016/j.stem.2012.02.021
   PubMed Web of Science ®Google Scholar
• Kim SM, Flasskamp H, Hermann A, Arauzo-Bravo MJ, Lee SC, Lee SH, Seo EH, Storch A, Lee HT, Scholer HR, et al. Direct conversion of mouse fibroblasts into induced neural stem cells. Nat Protoc 2014; 9:871-81; PMID:24651499; http://dx.doi.org/10.1038/nprot.2014.056
   PubMed Web of Science ®Google Scholar
• Ring KL, Tong LM, Balestra ME, Javier R, Andrews-Zwilling Y, Li G, Walker D, Zhang WR, Kreitzer AC, Huang Y. Direct reprogramming of mouse and human fibroblasts into multipotent neural stem cells with a single factor. Cell Stem Cell 2012; 11:100-9; PMID:22683203; http://dx.doi.org/10.1016/j.stem.2012.05.018
   PubMed Web of Science ®Google Scholar
• Ambasudhan R, Talantova M, Coleman R, Yuan X, Zhu S, Lipton SA, Ding S. Direct reprogramming of adult human fibroblasts to functional neurons under defined conditions. Cell Stem Cell 2011; 9:113-8; PMID:21802386; http://dx.doi.org/10.1016/j.stem.2011.07.002
   PubMed Web of Science ®Google Scholar
• Ang CE, Wernig M. Induced neuronal reprogramming. J Comp Neurol 2014; 522:2877-86; PMID:24771471; http://dx.doi.org/10.1002/cne.23620
   PubMed Web of Science ®Google Scholar
• Buffo A, Vosko MR, Erturk D, Hamann GF, Jucker M, Rowitch D, Gotz M. Expression pattern of the transcription factor Olig2 in response to brain injuries: implications for neuronal repair. Proc Natl Acad Sci U S A 2005; 102:18183-8; PMID:16330768; http://dx.doi.org/10.1073/pnas.0506535102
   PubMed Web of Science ®Google Scholar
• Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Sudhof TC, Wernig M. Direct conversion of fibroblasts to functional neurons by defined factors. Nature 2010; 463:1035-41; PMID:20107439; http://dx.doi.org/10.1038/nature08797
   PubMed Web of Science ®Google Scholar
• Son EY, Ichida JK, Wainger BJ, Toma JS, Rafuse VF, Woolf CJ, Eggan K. Conversion of mouse and human fibroblasts into functional spinal motor neurons. Cell Stem Cell 2011; 9:205-18; PMID:21852222; http://dx.doi.org/10.1016/j.stem.2011.07.014
   PubMed Web of Science ®Google Scholar
• Oh SI, Park HS, Hwang I, Park HK, Choi KA, Jeong H, Kim SW, Hong S. Efficient reprogramming of mouse fibroblasts to neuronal cells including dopaminergic neurons. ScientificWorldJournal 2014; 2014:957548; PMID:24991651
   PubMed Web of Science ®Google Scholar
• Caiazzo M, Dell'Anno MT, Dvoretskova E, Lazarevic D, Taverna S, Leo D, Sotnikova TD, Menegon A, Roncaglia P, Colciago G, et al. Direct generation of functional dopaminergic neurons from mouse and human fibroblasts. Nature 2011; 476:224-7; PMID:21725324; http://dx.doi.org/10.1038/nature10284
   PubMed Web of Science ®Google Scholar
• Pfisterer U, Kirkeby A, Torper O, Wood J, Nelander J, Dufour A, Bjorklund A, Lindvall O, Jakobsson J, Parmar M. Direct conversion of human fibroblasts to dopaminergic neurons. Proc Natl Acad Sci U S A 2011; 108:10343-8; PMID:21646515; http://dx.doi.org/10.1073/pnas.1105135108
   PubMed Web of Science ®Google Scholar
• Xue Y, Ouyang K, Huang J, Zhou Y, Ouyang H, Li H, Wang G, Wu Q, Wei C, Bi Y, et al. Direct conversion of fibroblasts to neurons by reprogramming PTB-regulated microRNA circuits. Cell 2013; 152:82-96; PMID:23313552; http://dx.doi.org/10.1016/j.cell.2012.11.045
   PubMed Web of Science ®Google Scholar
• Xie ST, Lu F, Zhang XJ, Shen Q, He Z, Gao WQ, Hu DH, Yang H. Retinoic acid and human olfactory ensheathing cells cooperate to promote neural induction from human bone marrow stromal stem cells. Neuromolecular Med 2013; 15:252-64; PMID:23288654; http://dx.doi.org/10.1007/s12017-012-8215-9
   PubMed Web of Science ®Google Scholar
• Lu J, Ashwell K. Olfactory ensheathing cells: their potential use for repairing the injured spinal cord. Spine (Phila Pa 1976) 2002; 27:887-92; PMID:11935115; http://dx.doi.org/10.1097/00007632-200204150-00021
   PubMed Web of Science ®Google Scholar
• Roloff F, Ziege S, Baumgartner W, Wewetzer K, Bicker G. Schwann cell-free adult canine olfactory ensheathing cell preparations from olfactory bulb and mucosa display differential migratory and neurite growth-promoting properties in vitro. BMC Neurosci 2013; 14:141; PMID:24219805; http://dx.doi.org/10.1186/1471-2202-14-141
   PubMed Web of Science ®Google Scholar
• Ramon-Cueto A, Avila J. Olfactory ensheathing glia: properties and function. Brain Res Bull 1998; 46:175-87; PMID:9667810; http://dx.doi.org/10.1016/S0361-9230(97)00463-2
   PubMed Web of Science ®Google Scholar
• Wewetzer K, Grothe C, Claus P. In vitro expression and regulation of ciliary neurotrophic factor and its alpha receptor subunit in neonatal rat olfactory ensheathing cells. Neurosci Lett 2001; 306:165-8; PMID:11406321; http://dx.doi.org/10.1016/S0304-3940(01)01891-2
   PubMed Web of Science ®Google Scholar
• Parmantier E, Lynn B, Lawson D, Turmaine M, Namini SS, Chakrabarti L, McMahon AP, Jessen KR, Mirsky R. Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron 1999; 23:713-24; PMID:10482238; http://dx.doi.org/10.1016/S0896-6273(01)80030-1
   PubMed Web of Science ®Google Scholar
• Liem KF, Jr., Jessell TM, Briscoe J. Regulation of the neural patterning activity of sonic hedgehog by secreted BMP inhibitors expressed by notochord and somites. Development 2000; 127:4855-66; PMID:11044400
   PubMed Web of Science ®Google Scholar
• Chambers SM, Fasano CA, Papapetrou EP, Tomishima M, Sadelain M, Studer L. Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol 2009; 27:275-80; PMID:19252484; http://dx.doi.org/10.1038/nbt.1529
   PubMed Web of Science ®Google Scholar
• Ladewig J, Mertens J, Kesavan J, Doerr J, Poppe D, Glaue F, Herms S, Wernet P, Kogler G, Muller FJ, et al. Small molecules enable highly efficient neuronal conversion of human fibroblasts. Nat Methods 2012; 9:575-8; PMID:22484851; http://dx.doi.org/10.1038/nmeth.1972
   PubMed Web of Science ®Google Scholar
• Yuste R, MacLean J, Vogelstein J, Paninski L. Imaging action potentials with calcium indicators. Cold Spring Harbor Protocols 2011; 2011:985-9; PMID:21807854; http://dx.doi.org/10.1101/pdb.prot5650
   PubMedGoogle Scholar
• Grienberger C, Konnerth A. Imaging calcium in neurons. Neuron 2012; 73:862-85; PMID:22405199; http://dx.doi.org/10.1016/j.neuron.2012.02.011
   PubMed Web of Science ®Google Scholar
• Zheng M, Cao P, Yang J, Xu XZ, Feng Z. Calcium imaging of multiple neurons in freely behaving C. elegans. J Neurosci Methods 2012; 206:78-82; PMID:22260981; http://dx.doi.org/10.1016/j.jneumeth.2012.01.002
   PubMed Web of Science ®Google Scholar
• Tatard VM, D'Ippolito G, Diabira S, Valeyev A, Hackman J, McCarthy M, Bouckenooghe T, Menei P, Montero-Menei CN, Schiller PC. Neurotrophin-directed differentiation of human adult marrow stromal cells to dopaminergic-like neurons. Bone 2007; 40:360-73; PMID:17085092; http://dx.doi.org/10.1016/j.bone.2006.09.013
   PubMed Web of Science ®Google Scholar
• Yang H, He BR, Hao DJ. Biological roles of olfactory ensheathing cells in facilitating neural regeneration: a systematic review. Mol Neurobiol 2015; 51(1):168-79; PMID:24615159
   PubMed Web of Science ®Google Scholar
• Zhou XF, Rush RA. Functional roles of neurotrophin 3 in the developing and mature sympathetic nervous system. Mol Neurobiol 1996; 13:185-97; PMID:8989769; http://dx.doi.org/10.1007/BF02740622
   PubMed Web of Science ®Google Scholar
• Ohtsuka M, Soumiya H, Hanai M, Furukawa S, Fukumitsu H. Neurotrophin-3 influences the number and the laminar fate of cortical progenitors in the developing cerebral cortex of mice through the MEK/ERK1/2 signaling pathway. Biomed Res 2013; 34:231-9; PMID:24190235; http://dx.doi.org/10.2220/biomedres.34.231
   PubMed Web of Science ®Google Scholar
• Gash DM, Zhang Z, Ovadia A, Cass WA, Yi A, Simmerman L, Russell D, Martin D, Lapchak PA, Collins F, et al. Functional recovery in parkinsonian monkeys treated with GDNF. Nature 1996; 380:252-5; PMID:8637574; http://dx.doi.org/10.1038/380252a0
   PubMed Web of Science ®Google Scholar
• Johansson M, Friedemann M, Hoffer B, Stromberg I. Effects of glial cell line-derived neurotrophic factor on developing and mature ventral mesencephalic grafts in oculo. Exp Neurol 1995; 134:25-34; PMID:7672036; http://dx.doi.org/10.1006/exnr.1995.1033
   PubMed Web of Science ®Google Scholar
• Zhou JM, Chu JX, Chen XJ. An improved protocol that induces human embryonic stem cells to differentiate into neural cells in vitro. Cell Biol Int 2008; 32:80-5; PMID:17945517; http://dx.doi.org/10.1016/j.cellbi.2007.08.015
   PubMed Web of Science ®Google Scholar
• Urban N, Martin-Ibanez R, Herranz C, Esgleas M, Crespo E, Pardo M, Crespo-Enriquez I, Mendez-Gomez HR, Waclaw R, Chatzi C, et al. Nolz1 promotes striatal neurogenesis through the regulation of retinoic acid signaling. Neural Dev 2010; 5:21; PMID:20735826; http://dx.doi.org/10.1186/1749-8104-5-21
   PubMed Web of Science ®Google Scholar
• Ramon-Cueto A, Cordero MI, Santos-Benito FF, Avila J. Functional recovery of paraplegic rats and motor axon regeneration in their spinal cords by olfactory ensheathing glia. Neuron 2000; 25:425-35; PMID:10719896; http://dx.doi.org/10.1016/S0896-6273(00)80905-8
   PubMed Web of Science ®Google Scholar
• Xu HM, Liao B, Zhang QJ, Wang BB, Li H, Zhong XM, Sheng HZ, Zhao YX, Zhao YM, Jin Y. Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J Biol Chem 2004; 279:23495-503; PMID:15047715; http://dx.doi.org/10.1074/jbc.M400516200
   PubMed Web of Science ®Google Scholar
• Resende RR, da Costa JL, Kihara AH, Adhikari A, Lorencon E. Intracellular Ca2+ regulation during neuronal differentiation of murine embryonal carcinoma and mesenchymal stem cells. Stem Cell Dev 2010; 19:379-94; PMID:19032055; http://dx.doi.org/10.1089/scd.2008.0289
   PubMed Web of Science ®Google Scholar
• Resende RR, Majumder P, Gomes KN, Britto LR, Ulrich H. P19 embryonal carcinoma cells as in vitro model for studying purinergic receptor expression and modulation of N-methyl-D-aspartate-glutamate and acetylcholine receptors during neuronal differentiation. Neuroscience 2007; 146:1169-81; PMID:17418494; http://dx.doi.org/10.1016/j.neuroscience.2007.02.041
   PubMed Web of Science ®Google Scholar