MYC-induced apoptosis in mammary epithelial cells is associated with repression of lineage-specific gene signatures

References

• Escot C, Theillet C, Lidereau R, Spyratos F, Champeme MH, Gest J, Callahan R. Genetic alteration of the c-myc protooncogene (MYC) in human primary breast carcinomas. Proc Natl Acad Sci U S A 1986; 83:4834-8; PMID:3014513; http://dx.doi.org/10.1073/pnas.83.13.4834
   PubMed Web of Science ®Google Scholar
• Dang C V. MYC on the path to cancer. Cell 2012; 149:22-35; PMID:22464321; http://dx.doi.org/10.1016/j.cell.2012.03.003
   PubMed Web of Science ®Google Scholar
• Lovén J, Orlando DA, Sigova AA, Lin CY, Rahl PB, Burge CB, Levens DL, Lee TI, Young RA. Revisiting global gene expression analysis. Cell 2012; 151:476-82; http://dx.doi.org/10.1016/j.cell.2012.10.012
   PubMed Web of Science ®Google Scholar
• Lin CY, Lovén J, Rahl PB, Paranal RM, Burge CB, Bradner JE, Lee TI, Young RA. Transcriptional amplification in tumor cells with elevated c-Myc. Cell 2012; 151:56-67; PMID:23021215; http://dx.doi.org/10.1016/j.cell.2012.08.026
   PubMed Web of Science ®Google Scholar
• Nie Z, Hu G, Wei G, Cui K, Yamane A, Resch W, Wang R, Green DR, Tessarollo L, Casellas R, et al. c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells. Cell 2012; 151:68-79; PMID:23021216; http://dx.doi.org/10.1016/j.cell.2012.08.033
   PubMed Web of Science ®Google Scholar
• Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, et al. Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles. Nature 2014; 511:483-7; PMID:25043018; http://dx.doi.org/10.1038/nature13473
   PubMed Web of Science ®Google Scholar
• Wiese KE, Haikala HM, von Eyss B, Wolf E, Esnault C, Rosenwald A, Treisman R, Klefström J, Eilers M. Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cells. EMBO J 2015; 34:1554-71; PMID:25896507; http://dx.doi.org/10.15252/embj.201490467
   PubMed Web of Science ®Google Scholar
• Sabò A, Kress TR, Pelizzola M, de Pretis S, Gorski MM, Tesi A, Morelli MJ, Bora P, Doni M, Verrecchia A, et al. Selective transcriptional regulation by Myc in cellular growth control and lymphomagenesis. Nature 2014; 511:488-92; PMID: 25043028 http://dx.doi.org/10.1038/nature13537
   PubMed Web of Science ®Google Scholar
• Askew DS, Ashmun RA, Simmons BC, Cleveland JL. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 1991; 6:1915-22; PMID:1923514
   PubMed Web of Science ®Google Scholar
• Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC. Induction of apoptosis in fibroblasts by c-myc protein. Cell 1992; 69:119-28; PMID:1555236; http://dx.doi.org/10.1016/0092-8674(92)90123-T
   PubMed Web of Science ®Google Scholar
• Hoffman B, Liebermann DA. Apoptotic signaling by c-MYC. Oncogene 2008; 27:6462-72; PMID:18955973; http://dx.doi.org/10.1038/onc.2008.312
   PubMed Web of Science ®Google Scholar
• Eischen CM, Weber JD, Roussel MF, Sherr CJ, Cleveland JL. Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis. Genes Dev 1999; 13:2658-69; PMID:10541552; http://dx.doi.org/10.1101/gad.13.20.2658
   PubMed Web of Science ®Google Scholar
• Pelengaris S, Khan M, Evan GI. Suppression of Myc-induced apoptosis in β cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 2002; 109:321-34; PMID:12015982; http://dx.doi.org/10.1016/S0092-8674(02)00738-9
   PubMed Web of Science ®Google Scholar
• Egle A, Harris AW, Bouillet P, Cory S. Bim is a suppressor of Myc-induced mouse B cell leukemia. Proc Natl Acad Sci U S A 2004; 101:6164-9; PMID:15079075; http://dx.doi.org/10.1073/pnas.0401471101
   PubMed Web of Science ®Google Scholar
• Stewart TA, Pattengale PK, Leder P. Spontaneous mammary adenocarcinomas in transgenic mice that carry and express MTV/myc fusion genes. Cell 1984; 38:627-37; PMID:6488314; http://dx.doi.org/10.1016/0092-8674(84)90257-5
   PubMed Web of Science ®Google Scholar
• Schoenenberger CA, Andres AC, Groner B, van der Valk M, LeMeur M, Gerlinger P. Targeted c-myc gene expression in mammary glands of transgenic mice induces mammary tumours with constitutive milk protein gene transcription. EMBO J 1988; 7:169-75; PMID:2834201
   PubMed Web of Science ®Google Scholar
• Sandgren EP, Schroeder JA, Ting Hu Qui, Palmiter RD, Brinster RL, Lee DC. Inhibition of mammary gland involution is associated with transforming growth factor α but not c-myc-induced tumorigenesis in transgenic mice. Cancer Res 1995; 55:3915-27; PMID:7641211
   PubMed Web of Science ®Google Scholar
• Hundley JE, Koester SK, Troyer DA, Hilsenbeck SG, Barrington RE, Windle JJ. Differential regulation of cell cycle characteristics and apoptosis in MMTV-myc and MMTV-ras mouse mammary tumors. Cancer Res 1997; 57(4):600-3; PMID:9044833
   PubMed Web of Science ®Google Scholar
• Jäger R, Herzer U, Schenkel J, Weiher H. Overexpression of Bcl−2 inhibits alveolar cell apoptosis during involution and accelerates c-myc-induced tumorigenesis of the mammary gland in transgenic mice. Oncogene 1997; 15:1787-95; http://dx.doi.org/10.1038/sj.onc.1201353
   PubMed Web of Science ®Google Scholar
• Conzen SD, Gottlob K, Kandel ES, Khanduri P, Wagner AJ, O'Leary M, Hay N. Induction of cell cycle progression and acceleration of apoptosis are two separable functions of c-Myc: transrepression correlates with acceleration of apoptosis. Mol Cell Biol 2000; 20:6008-18; PMID:10913183; http://dx.doi.org/10.1128/MCB.20.16.6008-6018.2000
   PubMed Web of Science ®Google Scholar
• Oster SK, Mao DYL, Kennedy J, Penn LZ. Functional analysis of the N-terminal domain of the Myc oncoprotein. Oncogene 2003; 22:1998-2010; PMID:12673205; http://dx.doi.org/10.1038/sj.onc.1206228
   PubMed Web of Science ®Google Scholar
• Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, Clark L, Bayani N, Coppe JP, Tong F, et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006; 10:515-27; PMID:17157791; http://dx.doi.org/10.1016/j.ccr.2006.10.008
   PubMed Web of Science ®Google Scholar
• Smid M, Wang Y, Zhang Y, Sieuwerts AM, Yu J, Klijn JGM, Foekens JA, Martens JWM. Subtypes of breast cancer show preferential site of relapse. Cancer Res 2008; 68:3108-14; PMID:18451135; http://dx.doi.org/10.1158/0008-5472.CAN-07-5644
   PubMed Web of Science ®Google Scholar
• Huper G, Marks JR. Isogenic normal basal and luminal mammary epithelial cells isolated by a novel method show a differential response to ionizing radiation. Cancer Res 2007; 67:2990-3001; PMID:17409405; http://dx.doi.org/10.1158/0008-5472.CAN-06-4065
   PubMed Web of Science ®Google Scholar
• Charafe-Jauffret E, Ginestier C, Monville F, Finetti P, Adélaïde J, Cervera N, Fekairi S, Xerri L, Jacquemier J, Birnbaum D, et al. Gene expression profiling of breast cell lines identifies potential new basal markers. Oncogene 2006; 25:2273-84; PMID:16288205; http://dx.doi.org/10.1038/sj.onc.1209254
   PubMed Web of Science ®Google Scholar
• Kamburov A, Pentchev K, Galicka H, Wierling C, Lehrach H, Herwig R. ConsensusPathDB: Toward a more complete picture of cell biology. Nucleic Acids Res 2011; 39:D712–D717.
   PubMed Web of Science ®Google Scholar
• Kamburov A, Stelzl U, Lehrach H, Herwig R. The ConsensusPathDB interaction database: 2013 update. Nucleic Acids Res 2013; 41:D793–D800
   PubMed Web of Science ®Google Scholar
• Kendrick H, Regan JL, Magnay F-A, Grigoriadis A, Mitsopoulos C, Zvelebil M, Smalley MJ. Transcriptome analysis of mammary epithelial subpopulations identifies novel determinants of lineage commitment and cell fate. BMC Genomics 2008; 9:591; PMID:19063729; http://dx.doi.org/10.1186/1471-2164-9-591
   PubMed Web of Science ®Google Scholar
• Lim E, Wu D, Pal B, Bouras T, Asselin-Labat M-L, Vaillant F, Yagita H, Lindeman GJ, Smyth GK, Visvader JE. Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways. Breast Cancer Res 2010; 12:R21; PMID:20346151; http://dx.doi.org/10.1186/bcr2560
   PubMed Web of Science ®Google Scholar
• Asselin-Labat M-L, Sutherland K D, Barker H, Thomas R, Shackleton M, Forrest NC, Hartley L, Robb L, Grosveld FG, van der Wees J, et al. Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation. Nat Cell Biol 2007; 9:201-9; PMID:17187062; http://dx.doi.org/10.1038/ncb1530
   PubMed Web of Science ®Google Scholar
• Shackleton M, Vaillant F, Simpson KJ, Stingl J, Smyth GK, Asselin-Labat ML, Wu L, Lindeman GJ, Visvader JE. Generation of a functional mammary gland from a single stem cell. Nature 2006; 439:84-8; PMID:16397499; http://dx.doi.org/10.1038/nature04372
   PubMed Web of Science ®Google Scholar
• Debnath J, Brugge JS. Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 2005; 5:675-88; PMID:16148884; http://dx.doi.org/10.1038/nrc1695
   PubMed Web of Science ®Google Scholar
• Partanen JI, Nieminen AI, Mäkelä TP, Klefstrom J. Suppression of oncogenic properties of c-Myc by LKB1-controlled epithelial organization. Proc Natl Acad Sci U S A 2007; 104:14694-9; PMID:17766436; http://dx.doi.org/10.1073/pnas.0704677104
   PubMed Web of Science ®Google Scholar
• Buchwalter G, Hickey M, Cromer A, Selfors L, Gunawardane R, Frishman J, Jeselsohn R, Lim E, Chi D, Fu X, et al. PDEF Promotes Luminal Differentiation and Acts as a Survival Factor for ER-Positive Breast Cancer Cells. Cancer Cell 2013; 23:753-67; PMID:23764000; http://dx.doi.org/10.1016/j.ccr.2013.04.026
   PubMed Web of Science ®Google Scholar
• Chen D, Kon N, Zhong J, Zhang P, Yu L, Gu W. Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression. Mol Cell 2013; 51:46-56; PMID:23747016; http://dx.doi.org/10.1016/j.molcel.2013.05.006
   PubMed Web of Science ®Google Scholar
• Murphy DJ, Junttila MR, Pouyet L, Karnezis A, Shchors K, Bui DA, Brown-Swigart L, Johnson L, Evan GI. Distinct Thresholds Govern Myc's Biological Output In Vivo. Cancer Cell 2008; 14:447-57; PMID:19061836; http://dx.doi.org/10.1016/j.ccr.2008.10.018
   PubMed Web of Science ®Google Scholar
• Stoelzle T, Schwarb P, Trumpp A, Hynes NE. c-Myc affects mRNA translation, cell proliferation and progenitor cell function in the mammary gland. BMC Biol 2009; 7:63; PMID:19785743; http://dx.doi.org/10.1186/1741-7007-7-63
   PubMed Web of Science ®Google Scholar
• Von Eyss B, Jaenicke LA, Kortlever RM, Royla N, Wiese KE, Letschert S, Sauer M, Rosenwald A, Evan GI, Kempa S, et al. A MYC-driven change in mitochondrial dynamics limits YAP/TAZ function in mammary epithelial cells and breast cancer. Cancer Cell 28(6): 743–757.
   Google Scholar
• Arnold I, Watt FM. c-Myc activation in transgenic mouse epidermis results in mobilization of stem cells and differentiation of their progeny. Curr Biol 2001; 11:558-68; PMID:11369200; http://dx.doi.org/10.1016/S0960-9822(01)00154-3
   PubMed Web of Science ®Google Scholar
• Waikel RL, Kawachi Y, Waikel PA, Wang XJ, Roop DR. Deregulated expression of c-Myc depletes epidermal stem cells. Nat Genet 2001; 28:165-8; PMID:11381265; http://dx.doi.org/10.1038/88889
   PubMed Web of Science ®Google Scholar
• Frye M, Gardner C, Li ER, Arnold I, Watt FM. Evidence that Myc activation depletes the epidermal stem cell compartment by modulating adhesive interactions with the local microenvironment. Development 2003; 130:2793-808; PMID:12736221; http://dx.doi.org/10.1242/dev.00462
   PubMed Web of Science ®Google Scholar
• Watt FM, Frye M, Benitah SA. MYC in mammalian epidermis: how can an oncogene stimulate differentiation? Nat Rev Cancer 2008; 8:234-42; PMID:18292777; http://dx.doi.org/10.1038/nrc2328
   PubMed Web of Science ®Google Scholar
• Gebhardt A, Frye M, Herold S, Benitah SA, Braun K, Samans B, Watt FM, Elsässer HP, Eilers M. Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1. J Cell Biol 2006; 172:139-49; PMID:16391002; http://dx.doi.org/10.1083/jcb.200506057
   PubMed Web of Science ®Google Scholar
• Hynes NE, Stoelzle T. Key signalling nodes in mammary gland development and cancer: Myc. Breast Cancer Res 2009; 11:210; PMID:19849814; http://dx.doi.org/10.1186/bcr2406
   PubMed Web of Science ®Google Scholar
• Horiuchi D, Kusdra L, Huskey NE, Chandriani S, Lenburg ME, Gonzalez-Angulo AM, Creasman KJ, Bazarov AV., Smyth JW, Davis SE, et al. MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition. J. Exp. Med.2012; 209:679-96
   Web of Science ®Google Scholar
• Molyneux G, Geyer FC, Magnay FA, McCarthy A, Kendrick H, Natrajan R, MacKay A, Grigoriadis A, Tutt A, Ashworth A, et al. BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. Cell Stem Cell 2010; 7:403-17; PMID:20804975; http://dx.doi.org/10.1016/j.stem.2010.07.010
   PubMed Web of Science ®Google Scholar
• Van Keymeulen A, Lee MY, Ousset M, Brohee S, Rorive S, Giraddi RR, Wuidart A, Bouvencourt G, Dubois C, Salmon I, et al. Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity. Nature 2015; 525:119-23; PMID:26266985; http://dx.doi.org/10.1038/nature14665
   PubMed Web of Science ®Google Scholar
• Koren S, Reavie L, Couto JP, De Silva D, Stadler MB, Roloff T, Britschgi A, Eichlisberger T, Kohler H, Aina O, et al. PIK3CA(H1047R) induces multipotency and multi-lineage mammary tumours. Nature 2015; 525:114-8; PMID:26266975; http://dx.doi.org/10.1038/nature14669
   PubMed Web of Science ®Google Scholar
• Debnath J, Muthuswamy SK, Brugge JS. Morphogenesis and oncogenesis of MCF-10A mammary epithelial acini grown in three-dimensional basement membrane cultures. Methods 2003; 30:256-68; PMID:12798140; http://dx.doi.org/10.1016/S1046-2023(03)00032-X
   PubMed Web of Science ®Google Scholar