1,266
Views
20
CrossRef citations to date
0
Altmetric
Report

B-cell lymphoma 6 promotes proliferation and survival of trophoblastic cells

, , , , , , & show all
Pages 827-839 | Received 04 Nov 2015, Accepted 21 Jan 2016, Published online: 30 Mar 2016

References

  • Roberts JM, Hubel CA. The two stage model of preeclampsia: variations on the theme. Placenta. 2009; 30 Suppl (A): S32-7; PMID:19070896; http://dx.doi.org/10.1016/j.placenta.2008.11.009
  • Redman CW, Sargent IL. Placental stress and pre-eclampsia: a revised view. Placenta. 2009; 30 Suppl (A): S38-S42; PMID:19138798; http://dx.doi.org/10.1016/j.placenta.2008.11.021
  • Huppertz B. Placental origins of preeclampsia: challenging the current hypothesis. Hypertension. 2008; 51(4): 970-5; PMID:18259009; http://dx.doi.org/10.1161/HYPERTENSIONAHA.107.107607
  • Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009; 33(3): 130-7; PMID:19464502; http://dx.doi.org/10.1053/j.semperi.2009.02.010
  • Louwen F, Muschol-Steinmetz C, Reinhard J, Reitter A, Yuan J. A lesson for cancer research: placental microarray gene analysis in preeclampsia. Oncotarget. 2012; 3(8): 759-73; PMID:22929622; http://dx.doi.org/10.18632/oncotarget.595
  • Louwen F, Muschol-Steinmetz C, Friemel A, Kampf AK, Tottel E, Reinhard J, Yuan J. Targeted gene analysis: increased B-cell lymphoma 6 in preeclamptic placentas. Hum Pathol. 2014; 45(6): 1234-42; PMID:24767250; http://dx.doi.org/10.1016/j.humpath.2014.02.002
  • Muschol-Steinmetz C, Friemel A, Kreis NN, Reinhard J, Yuan J, Louwen F. Function of survivin in trophoblastic cells of the placenta. PLoS One. 2013; 8(9): e73337; PMID:24069188; http://dx.doi.org/10.1371/journal.pone.0073337
  • Shaffer AL, Yu X, He Y, Boldrick J, Chan EP, Staudt LM. BCL-6 represses genes that function in lymphocyte differentiation, inflammation, and cell cycle control. Immunity. 2000; 13(2): 199-212; PMID:10981963; http://dx.doi.org/10.1016/S1074-7613(00)00020-0
  • Basso K, Dalla-Favera R. Roles of BCL6 in normal and transformed germinal center B cells. Immunol Rev. 2012; 247(1): 172-83; PMID:22500840; http://dx.doi.org/10.1111/j.1600-065X.2012.01112.x
  • Baron BW, Nucifora G, McCabe N, Espinosa R, III, Le Beau MM, McKeithan TW. Identification of the gene associated with the recurring chromosomal translocations t(3;14)(q27;q32) and t(3;22)(q27;q11) in B-cell lymphomas. Proc Natl Acad Sci U S A. 1993; 90(11): 5262-6; PMID:8506375; http://dx.doi.org/10.1073/pnas.90.11.5262
  • Ye BH, Lista F, Lo CF, Knowles DM, Offit K, Chaganti RS, Dalla-Favera R. Alterations of a zinc finger-encoding gene, BCL-6, in diffuse large-cell lymphoma. Science. 1993; 262(5134): 747-50; PMID:8235596; http://dx.doi.org/10.1126/science.8235596
  • Lemercier C, Brocard MP, Puvion-Dutilleul F, Kao HY, Albagli O, Khochbin S. Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. J Biol Chem. 2002; 277(24): 22045-52; PMID:11929873; http://dx.doi.org/10.1074/jbc.M201736200
  • Wong CW, Privalsky ML. Components of the SMRT corepressor complex exhibit distinctive interactions with the POZ domain oncoproteins PLZF, PLZF-RARalpha, and BCL-6. J Biol Chem. 1998; 273(42): 27695-702; PMID:9765306; http://dx.doi.org/10.1074/jbc.273.42.27695
  • Ahmad KF, Melnick A, Lax S, Bouchard D, Liu J, Kiang CL, Mayer S, Takahashi S, Licht JD, Prive GG. Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol Cell. 2003; 12(6): 1551-64; PMID:14690607; http://dx.doi.org/10.1016/S1097-2765(03)00454-4
  • Huynh KD, Bardwell VJ. The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Oncogene. 1998; 17(19): 2473-84; PMID:9824158; http://dx.doi.org/10.1038/sj.onc.1202197
  • Dent AL, Vasanwala FH, Toney LM. Regulation of gene expression by the proto-oncogene BCL-6. Crit Rev Oncol Hematol. 2002; 41(1): 1-9; PMID:11796228; http://dx.doi.org/10.1016/S1040-8428(01)00164-0
  • Bajalica-Lagercrantz S, Piehl F, Farnebo F, Larsson C, Lagercrantz J. Expression of the BCL6 gene in the pre- and postnatal mouse. Biochem Biophys Res Commun. 1998; 247(2): 357-60; PMID:9642131; http://dx.doi.org/10.1006/bbrc.1998.8551
  • Logarajah S, Hunter P, Kraman M, Steele D, Lakhani S, Bobrow L, Venkitaraman A, Wagner S. BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiation. Oncogene. 2003; 22(36): 5572-8; PMID:12944904; http://dx.doi.org/10.1038/sj.onc.1206689
  • Bos R, van Diest PJ, van der Groep P, Greijer AE, Hermsen MA, Heijnen I, Meijer GA, Baak JP, Pinedo HM, van der Wall E, et al. Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha). Oncogene. 2003; 22(55): 8948-51; PMID:14654791; http://dx.doi.org/10.1038/sj.onc.1206995
  • Walker SR, Liu S, Xiang M, Nicolais M, Hatzi K, Giannopoulou E, Elemento O, Cerchietti L, Melnick A, Frank DA. The transcriptional modulator BCL6 as a molecular target for breast cancer therapy. Oncogene. 2015; 34(9): 1073-82; PMID:24662818; http://dx.doi.org/10.1038/onc.2014.61
  • Winn VD, Gormley M, Paquet AC, Kjaer-Sorensen K, Kramer A, Rumer KK, Haimov-Kochman R, Yeh RF, Overgaard MT, Varki A, et al. Severe preeclampsia-related changes in gene expression at the maternal-fetal interface include sialic acid-binding immunoglobulin-like lectin-6 and pappalysin-2. Endocrinology. 2009; 150(1): 452-62; PMID:18818296; http://dx.doi.org/10.1210/en.2008-0990
  • Nishizawa H, Ota S, Suzuki M, Kato T, Sekiya T, Kurahashi H, Udagawa Y. Comparative gene expression profiling of placentas from patients with severe pre-eclampsia and unexplained fetal growth restriction. Reprod Biol Endocrinol. 2011; 9: 107; PMID:21810232; http://dx.doi.org/10.1186/1477-7827-9-107
  • Tsai S, Hardison NE, James AH, Motsinger-Reif AA, Bischoff SR, Thames BH, Piedrahita JA. Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways. Placenta. 2011; 32(2): 175-82; PMID:21183218; http://dx.doi.org/10.1016/j.placenta.2010.11.014
  • Enquobahrie DA, Meller M, Rice K, Psaty BM, Siscovick DS, Williams MA. Differential placental gene expression in preeclampsia. Am J Obstet Gynecol. 2008; 199(5): 566-11; PMID:18533121; http://dx.doi.org/10.1016/j.ajog.2008.04.020
  • Trifonova EA, Gabidulina TV, Ershov NI, Serebrova VN, Vorozhishcheva AY, Stepanov VA. Analysis of the placental tissue transcriptome of normal and preeclampsia complicated pregnancies. Acta Naturae. 2014; 6(2): 71-83; PMID:25093114
  • Sitras V, Paulssen RH, Gronaas H, Leirvik J, Hanssen TA, Vartun A, Acharya G. Differential placental gene expression in severe preeclampsia. Placenta. 2009; 30(5): 424-33; PMID:19249095; http://dx.doi.org/10.1016/j.placenta.2009.01.012
  • Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Fares C, Arrowsmith CH, et al. A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo. Cancer Cell. 2010; 17(4): 400-11; PMID:20385364; http://dx.doi.org/10.1016/j.ccr.2009.12.050
  • Phan RT, Saito M, Basso K, Niu H, Dalla-Favera R. BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells. Nat Immunol. 2005; 6(10): 1054-60; PMID:16142238; http://dx.doi.org/10.1038/ni1245
  • Phan RT, Dalla-Favera R. The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells. Nature. 2004; 432(7017): 635-9; PMID:15577913; http://dx.doi.org/10.1038/nature03147
  • Louwen F, Yuan J. Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy. Oncotarget. 2013; 4(7): 958-71; PMID:23948487; http://dx.doi.org/10.18632/oncotarget.1096
  • Carmena M, Wheelock M, Funabiki H, Earnshaw WC. The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis. Nat Rev Mol Cell Biol. 2012; 13(12): 789-803; PMID:23175282; http://dx.doi.org/10.1038/nrm3474
  • Sanhaji M, Kreis NN, Zimmer B, Berg T, Louwen F, Yuan J. p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors. Cell Cycle. 2012; 11(3): 543-53; PMID:22262171; http://dx.doi.org/10.4161/cc.11.3.19076
  • Sanhaji M, Louwen F, Zimmer B, Kreis NN, Roth S, Yuan J. Polo-like kinase 1 inhibitors, mitotic stress and the tumor suppressor p53. Cell Cycle. 2013; 12(9): 1340-51; PMID:23574746; http://dx.doi.org/10.4161/cc.24573
  • Kreis NN, Sommer K, Sanhaji M, Kramer A, Matthess Y, Kaufmann M, Strebhardt K, Yuan J. Long-term downregulation of Polo-like kinase 1 increases the cyclin-dependent kinase inhibitor p21(WAF1/CIP1). Cell Cycle. 2009; 8(3): 460-472; PMID:19177004; http://dx.doi.org/10.4161/cc.8.3.7651
  • Kreis NN, Sanhaji M, Rieger MA, Louwen F, Yuan J. p21Waf1/Cip1 deficiency causes multiple mitotic defects in tumor cells. Oncogene. 2014; 33(50): 5716-28; PMID:24317508; http://dx.doi.org/10.1038/onc.2013.518
  • Kreis NN, Louwen F, Zimmer B, Yuan J. Loss of p21Cip1/CDKN1A renders cancer cells susceptible to Polo-like kinase 1 inhibition. Oncotarget. 2015; 6(9): 6611-26; PMID:25483104; http://dx.doi.org/10.18632/oncotarget.2844
  • Nigg EA, Stearns T. The centrosome cycle: Centriole biogenesis, duplication and inherent asymmetries. Nat Cell Biol. 2011; 13(10): 1154-60; PMID:21968988; http://dx.doi.org/10.1038/ncb2345
  • Roberts JM, Hubel CA. The two stage model of preeclampsia: variations on the theme. Placenta. 2009; 30 Suppl (A): S32-7; PMID:19070896; http://dx.doi.org/10.1016/j.placenta.2008.11.009
  • Kharfi AA, Leblanc S, Ouellet A, Moutquin JM. Dual action of H2O2 on placental hCG secretion: implications for oxidative stress in preeclampsia. Clin Biochem. 2007; 40(1–2): 94-7; PMID:17150203; http://dx.doi.org/10.1016/j.clinbiochem.2006.10.008
  • Basso K, Dalla-Favera R. BCL6: master regulator of the germinal center reaction and key oncogene in B cell lymphomagenesis. Adv Immunol. 2010; 105: 193-210; PMID:20510734; http://dx.doi.org/10.1016/S0065-2776(10)05007-8
  • Ranuncolo SM, Polo JM, Dierov J, Singer M, Kuo T, Greally J, Green R, Carroll M, Melnick A. Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR. Nat Immunol. 2007; 8(7): 705-14; PMID:17558410; http://dx.doi.org/10.1038/ni1478
  • Redline RW, Patterson P. Pre-eclampsia is associated with an excess of proliferative immature intermediate trophoblast. Hum Pathol. 1995; 26(6): 594-600; PMID:7774887; http://dx.doi.org/10.1016/0046-8177(95)90162-0
  • Jeschke U, Schiessl B, Mylonas I, Kunze S, Kuhn C, Schulze S, Friese K, Mayr D. Expression of the proliferation marker Ki-67 and of p53 tumor protein in trophoblastic tissue of preeclamptic, HELLP, and intrauterine growth-restricted pregnancies. Int J Gynecol Pathol. 2006; 25(4): 354-60; PMID:16990712; http://dx.doi.org/10.1097/01.pgp.0000225838.29127.6
  • Sharp AN, Heazell AE, Crocker IP, Mor G. Placental apoptosis in health and disease. Am J Reprod Immunol. 2010; 64(3): 159-69; PMID:20367628; http://dx.doi.org/10.1111/j.1600-0897.2010.00837.x
  • Hatzi K, Melnick A. Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis. Trends Mol Med. 2014; 20(6): 343-52; PMID:24698494; http://dx.doi.org/10.1016/j.molmed.2014.03.001
  • Ranuncolo SM, Polo JM, Melnick A. BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells. Blood Cells Mol Dis. 2008; 41(1): 95-9; PMID:18346918; http://dx.doi.org/10.1016/j.bcmd.2008.02.003
  • Lambrus BG, Uetake Y, Clutario KM, Daggubati V, Snyder M, Sluder G, Holland AJ. p53 protects against genome instability following centriole duplication failure. J Cell Biol. 2015; 210(1): 63-77; PMID:26150389; http://dx.doi.org/10.1083/jcb.201502089
  • Petsalaki E, Dandoulaki M, Morrice N, Zachos G. Chk1 protects against chromatin bridges by constitutively phosphorylating BLM serine 502 to inhibit BLM degradation. J Cell Sci. 2014; 127(Pt 18): 3902-8; PMID:25015292; http://dx.doi.org/10.1242/jcs.155176
  • Lawrence KS, Chau T, Engebrecht J. DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity. PLoS Genet. 2015; 11(4): e1005150-; PMID:25898113; http://dx.doi.org/10.1371/journal.pgen.1005150
  • Graham CH. Effect of transforming growth factor-beta on the plasminogen activator system in cultured first trimester human cytotrophoblasts. Placenta. 1997; 18(2–3): 137-43; PMID:9089774; http://dx.doi.org/10.1016/S0143-4004(97)90085-0
  • Yuan J, Sanhaji M, Kramer A, Reindl W, Hofmann M, Kreis NN, Zimmer B, Berg T, Strebhardt K. Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo. Am J Pathol. 2011; 179(4): 2091-9; PMID:21839059; http://dx.doi.org/10.1016/j.ajpath.2011.06.031
  • Ritter A, Sanhaji M, Steinhauser K, Roth S, Louwen F, Yuan J. The activity regulation of the mitotic centromere-associated kinesin by Polo-like kinase 1. Oncotarget. 2015; 6(9): 6641-55; PMID:25504441; http://dx.doi.org/10.18632/oncotarget.2843
  • Sanhaji M, Kreis NN, Zimmer B, Berg T, Louwen F, Yuan J. p53 is not directly relevant to the response of Polo-like kinase 1 inhibitors. Cell Cycle. 2012; 11(3): 543-53; PMID:22262171; http://dx.doi.org/10.4161/cc.11.3.19076
  • Kreis NN, Sanhaji M, Kramer A, Sommer K, Rodel F, Strebhardt K, Yuan J. Restoration of the tumor suppressor p53 by downregulating cyclin B1 in human papillomavirus 16/18-infected cancer cells. Oncogene. 2010; 29(41): 5591-03; PMID:20661218; http://dx.doi.org/10.1038/onc.2010.290
  • Ritter A, Friemel A, Fornoff F, Adjan M, Solbach C, Yuan J, Louwen F. Characterization of adipose-derived stem cells from subcutaneous and visceral adipose tissues and their function in breast cancer cells. Oncotarget. 2015; 6(33): 34475-93; PMID:26439686
  • Ritter A, Sanhaji M, Friemel A, Roth S, Rolle U, Louwen F, Yuan J. Functional analysis of phosphorylation of the mitotic centromere-associated kinesin by Aurora B kinase in human tumor cells. Cell Cycle. 2015; 14(23):3755-67.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.