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Calorie restriction-induced SIRT6 activation delays aging by suppressing NF-κB signaling

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Pages 1009-1018 | Received 12 Oct 2015, Accepted 04 Feb 2016, Published online: 03 Mar 2016

References

  • Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 2015; 14:497-510; PMID:25902704; http://dx.doi.org/10.1111/acel.12338
  • Guarente L. Sirtuins, aging, and metabolism. Cold Spring Harb Symp Quant Biol 2011; 76:81-90; PMID:22114328; http://dx.doi.org/10.1101/sqb.2011.76.010629
  • De Cabo R, Liu L, Ali A, Price N, Zhang J, Wang M, Lakatta E, Irusta PM. Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro. Aging 2015; 7:152-66; PMID:25855056
  • Lin SJ, Defossez PA, Guarente L. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 2000; 289:2126-8; PMID:11000115; http://dx.doi.org/10.1126/science.289.5487.2126
  • Frye RA. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 2000; 273:793-8; PMID:10873683; http://dx.doi.org/10.1006/bbrc.2000.3000
  • Timmers S, Auwerx J, Schrauwen P. The journey of resveratrol from yeast to human. Aging 2012; 4:146-58; PMID:22436213
  • Bordone L, Guarente L. Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat Rev Mol Cell Biol 2005; 6:298-305; PMID:15768047; http://dx.doi.org/10.1038/nrm1616
  • Nakagawa T, Guarente L. SnapShot: sirtuins, NAD, and aging. Cell Metab 2014; 20:192-e1; PMID:24988458; http://dx.doi.org/10.1016/j.cmet.2014.06.001
  • Michishita E, McCord RA, Berber E, Kioi M, Padilla-Nash H, Damian M, Cheung P, Kusumoto R, Kawahara TL, Barrett JC, et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature 2008; 452:492-6; PMID:18337721; http://dx.doi.org/10.1038/nature06736
  • Liszt G, Ford E, Kurtev M, Guarente L. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. J Biol Chem 2005; 280:21313-20; PMID:15795229; http://dx.doi.org/10.1074/jbc.M413296200
  • Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, Liu P, Mostoslavsky G, Franco S, Murphy MM, et al. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell 2006; 124:315-29; PMID:16439206; http://dx.doi.org/10.1016/j.cell.2005.11.044
  • Kanfi Y, Naiman S, Amir G, Peshti V, Zinman G, Nahum L, Bar-Joseph Z, Cohen HY. The sirtuin SIRT6 regulates lifespan in male mice. Nature 2012; 483:218-21; PMID:22367546; http://dx.doi.org/10.1038/nature10815
  • Salminen A, Huuskonen J, Ojala J, Kauppinen A, Kaarniranta K, Suuronen T. Activation of innate immunity system during aging: NF-kB signaling is the molecular culprit of inflamm-aging. Ageing Res Rev 2008; 7:83-105; PMID:17964225; http://dx.doi.org/10.1016/j.arr.2007.09.002
  • Perkins ND. The importance of the p50 NF-kappaB subunit. Cell Cycle 2015; 14:2877-8; PMID:26291483; http://dx.doi.org/10.1080/15384101.2015.1010952
  • Salminen A, Kaarniranta K. NF-kappaB signaling in the aging process. J Clin Immunol 2009; 29:397-405; PMID:19408108; http://dx.doi.org/10.1007/s10875-009-9296-6
  • Kawahara TL, Michishita E, Adler AS, Damian M, Berber E, Lin M, McCord RA, Ongaigui KC, Boxer LD, Chang HY, et al. SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span. Cell 2009; 136:62-74; PMID:19135889; http://dx.doi.org/10.1016/j.cell.2008.10.052
  • Sun H, Wu Y, Fu D, Liu Y, Huang C. SIRT6 regulates osteogenic differentiation of rat bone marrow mesenchymal stem cells partially via suppressing the nuclear factor-kappaB signaling pathway. Stem Cells 2014; 32:1943-55; PMID:24510807; http://dx.doi.org/10.1002/stem.1671
  • Hill GS, Heudes D, Bariety J. Morphometric study of arterioles and glomeruli in the aging kidney suggests focal loss of autoregulation. Kidney Int 2003; 63:1027-36; PMID:12631084; http://dx.doi.org/10.1046/j.1523-1755.2003.00831.x
  • Wang Z, Li H, Xu H, Yue XL, Cheng XQ, Hou WJ, Zhang YY, Chen DF. Beneficial effect of Bupleurum polysaccharides on autoimmune disease induced by Campylobacter jejuni in BALB/c mice. J Ethnopharmacol 2009; 124:481-7; PMID:19467314; http://dx.doi.org/10.1016/j.jep.2009.05.013
  • Teoh SL, Abd Latiff A, Das S. Histological changes in the kidneys of experimental diabetic rats fed with Momordica charantia (bitter gourd) extract. Rom J Morphol Embryol 2010; 51:91-5; PMID:20191126
  • Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 1995; 92:9363-7; PMID:7568133; http://dx.doi.org/10.1073/pnas.92.20.9363
  • Metcalf TU, Cubas RA, Ghneim K, Cartwright MJ, Grevenynghe JV, Richner JM, Olagnier DP, Wilkinson PA, Cameron MJ, Park BS, et al. Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors. Aging Cell 2015; 14:421-32; PMID:25728020; http://dx.doi.org/10.1111/acel.12320
  • Mao Z, Hine C, Tian X, Van Meter M, Au M, Vaidya A, Seluanov A, Gorbunova V. SIRT6 promotes DNA repair under stress by activating PARP1. Science 2011; 332:1443-6; PMID:21680843; http://dx.doi.org/10.1126/science.1202723
  • Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell 2008; 14:661-73; PMID:18477450; http://dx.doi.org/10.1016/j.devcel.2008.02.004
  • Zhang B, Cui S, Bai X, Zhuo L, Sun X, Hong Q, Fu B, Wang J, Chen X, Cai G. SIRT3 overexpression antagonizes high glucose accelerated cellular senescence in human diploid fibroblasts via the SIRT3-FOXO1 signaling pathway. Age 2013; 35:2237-53; PMID:23494737; http://dx.doi.org/10.1007/s11357-013-9520-4
  • Shay JW, Wright WE. Hayflick, his limit, and cellular ageing. Nat Rev Mol Cell Biol 2000; 1:72-6; PMID:11413492; http://dx.doi.org/10.1038/35036093
  • Schafer KA. The cell cycle: a review. Vet Pathol 1998; 35:461-78; PMID:9823588; http://dx.doi.org/10.1177/030098589803500601
  • Kim WY, Sharpless NE. The regulation of INK4/ARF in cancer and aging. Cell 2006; 127:265-75; PMID:17055429; http://dx.doi.org/10.1016/j.cell.2006.10.003
  • Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, Su L, Sharpless NE. Ink4a/Arf expression is a biomarker of aging. J Clin Invest 2004; 114:1299-307; PMID:15520862; http://dx.doi.org/10.1172/JCI22475
  • Salvioli S, Monti D, Lanzarini C, Conte M, Pirazzini C, Bacalini MG, Garagnani P, Giuliani C, Fontanesi E, Ostan R, et al. Immune system, cell senescence, aging and longevity–inflamm-aging reappraised. Curr Pharm Des 2013; 19:1675-9; PMID:23589904
  • Adler AS, Sinha S, Kawahara TL, Zhang JY, Segal E, Chang HY. Motif module map reveals enforcement of aging by continual NF-kappaB activity. Genes Dev 2007; 21:3244-57; PMID:18055696; http://dx.doi.org/10.1101/gad.1588507
  • Stipp D. The transformative promise of aging science. Cell Cycle 2012; 11:3903-4; PMID:22983093; http://dx.doi.org/10.4161/cc.22211
  • Bilinski T, Paszkiewicz T, Zadrag-Tecza R. Energy excess is the main cause of accelerated aging of mammals. Oncotarget 2015; 6:12909-19; PMID:26079722; http://dx.doi.org/10.18632/oncotarget.4271
  • Rogina B, Helfand SL. Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci U S A 2004; 101:15998-6003; PMID:15520384; http://dx.doi.org/10.1073/pnas.0404184101
  • Colman RJ, Anderson RM, Johnson SC, Kastman EK, Kosmatka KJ, Beasley TM, Allison DB, Cruzen C, Simmons HA, Kemnitz JW, et al. Caloric restriction delays disease onset and mortality in rhesus monkeys. Science 2009; 325:201-4; PMID:19590001; http://dx.doi.org/10.1126/science.1173635
  • Ghizzoni M, Haisma HJ, Maarsingh H, Dekker FJ. Histone acetyltransferases are crucial regulators in NF-kappaB mediated inflammation. Drug Discov Today 2011; 16:504-11.
  • Sundaresan NR, Vasudevan P, Zhong L, Kim G, Samant S, Parekh V, Pillai VB, Ravindra PV, Gupta M, Jeevanandam V, et al. The sirtuin SIRT6 blocks IGF-Akt signaling and development of cardiac hypertrophy by targeting c-Jun. Nat Med 2012; 18:1643-50; PMID:23086477; http://dx.doi.org/10.1038/nm.2961
  • Min L, Ji Y, Bakiri L, Qiu Z, Cen J, Chen X, Chen L, Scheuch H, Zheng H, Qin L, et al. Liver cancer initiation is controlled by AP-1 through SIRT6-dependent inhibition of survivin. Nat Cell Biol 2012; 14:1203-11; PMID:23041974; http://dx.doi.org/10.1038/ncb2590
  • Zhong L, D'Urso A, Toiber D, Sebastian C, Henry RE, Vadysirisack DD, Guimaraes A, Marinelli B, Wikstrom JD, Nir T, et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha. Cell 2010; 140:280-93; PMID:20141841; http://dx.doi.org/10.1016/j.cell.2009.12.041
  • Blagosklonny MV. Linking calorie restriction to longevity through sirtuins and autophagy: any role for TOR. Cell Death Dis 2010; 1:e12; PMID:21364614; http://dx.doi.org/10.1038/cddis.2009.17
  • Inoue T, Hiratsuka M, Osaki M, Oshimura M. The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation. Cell Cycle 2007; 6:1011-8; PMID:17457050; http://dx.doi.org/10.4161/cc.6.9.4219
  • Van Meter M, Mao Z, Gorbunova V, Seluanov A. SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells. Cell Cycle 2011; 10:3153-8; PMID:21900744; http://dx.doi.org/10.4161/cc.10.18.17435
  • Kaidi A, Weinert BT, Choudhary C, Jackson SP. Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 2010; 329:1348-53; PMID:20829486; http://dx.doi.org/10.1126/science.1192049
  • Walker JM. The bicinchoninic acid (BCA) assay for protein quantitation. Methods Mol Biol 1994; 32:5-8; PMID:7951748

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