1,875
Views
21
CrossRef citations to date
0
Altmetric
Reports

Inhibition of the mitochondrial unfolded protein response by acetylcholine alleviated hypoxia/reoxygenation-induced apoptosis of endothelial cells

, , , , &
Pages 1331-1343 | Received 05 Feb 2016, Accepted 26 Feb 2016, Published online: 25 Apr 2016

References

  • Feng Y, Hu L, Xu Q, Yuan H, Ba L, He Y, Che H. Cytoprotective role of alpha-1 antitrypsin in vascular endothelial cell under hypoxia/reoxygenation condition. J Cardiovasc Pharmacol 2015; 66:96-107; PMID:25815674; http://dx.doi.org/10.1097/FJC.0000000000000250
  • Scarabelli T, Stephanou A, Rayment N, Pasini E, Comini L, Curello S, Ferrari R, Knight R, Latchman D. Apoptosis of endothelial cells precedes myocyte cell apoptosis in ischemia/reperfusion injury. Circulation 2001; 104:253-6; PMID:11457740; http://dx.doi.org/10.1161/01.CIR.104.3.253
  • Blackstone NW. The impact of mitochondrial endosymbiosis on the evolution of calcium signaling. Cell Calcium 2015; 57:133-9; PMID:25481706; http://dx.doi.org/10.1016/j.ceca.2014.11.006
  • Saraste M. Oxidative phosphorylation at the fin de siecle. Science 1999; 283:1488-93; PMID:10066163; http://dx.doi.org/10.1126/science.283.5407.1488
  • Wang C, Youle RJ. The role of mitochondria in apoptosis. Annu Rev Genetics 2009; 43:95-118; PMID:19659442; http://dx.doi.org/10.1146/annurev-genet-102108-134850
  • Laura Valls-Lacalle IBEM, Marisol Ruiz-Meana MFAR, García-Dorado. Succinate dehydrogenase inhibition with malonate during reperfusion reduces infarct size by preventing mitochondrial permeability transition. Cardiovasc Res 2015; 109: 374-384; PMID:26705364; http://dx.doi.org/10.1093/cvr/cvv279.
  • Davidson SM. Endothelial mitochondria and heart disease. Cardiovasc Res 2010; 88:58-66; PMID:20558442; http://dx.doi.org/10.1093/cvr/cvq195
  • Maity S, Basak T, Bhat A, Bhasin N, Ghosh A, Chakraborty K, Sengupta S. Cross-compartment proteostasis regulation during redox imbalance induced ER stress. Proteomics 2014; 14:1724-36; PMID:24838640; http://dx.doi.org/10.1002/pmic.201300449
  • Yoneda T, Benedetti C, Urano F, Clark SG, Harding HP, Ron D. Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones. J Cell Sci 2004; 117:4055-66; PMID:15280428; http://dx.doi.org/10.1242/jcs.01275
  • Papa L, Germain D. SirT3 Regulates the Mitochondrial Unfolded Protein Response. Mol Cell Biol 2014; 34:699-710; PMID:24324009; http://dx.doi.org/10.1128/MCB.01337-13
  • Sena LA, Chandel NS. Physiological roles of mitochondrial reactive oxygen species. Mol Cell 2012; 48:158-67; PMID:23102266; http://dx.doi.org/10.1016/j.molcel.2012.09.025
  • Haynes CM, Ron D. The mitochondrial UPR - protecting organelle protein homeostasis. J Cell Sci 2010; 123:3849-55; PMID:21048161; http://dx.doi.org/10.1242/jcs.075119
  • Durieux J, Wolff S, Dillin A. The cell-non-autonomous nature of electron transport chain-mediated longevity. Cell 2011; 144:79-91; PMID:21215371; http://dx.doi.org/10.1016/j.cell.2010.12.016
  • Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, Williams RW, Auwerx J. Mitonuclear protein imbalance as a conserved longevity mechanism. Nature 2013; 497:451-7; PMID:23698443; http://dx.doi.org/10.1038/nature12188
  • Moullan N, Mouchiroud L, Wang X, Ryu D, Williams EG, Mottis A, Jovaisaite V, Frochaux MV, Quiros PM, Deplancke B, Houtkooper RH, Auwerx J. Tetracyclines disturb mitochondrial function across eukaryotic models: A call for caution in biomedical research. Cell Rep 2015; 10: 1681-1691; PMID:25772356; http://dx.doi.org/10.1016/j.celrep.2015.02.034
  • Siegelin MD, Dohi T, Raskett CM, Orlowski GM, Powers CM, Gilbert CA, Ross AH, Plescia J, Altieri DC. Exploiting the mitochondrial unfolded protein response for cancer therapy in mice and human cells. J Clin Invest 2011; 121:1349-60; PMID:21364280; http://dx.doi.org/10.1172/JCI44855
  • Sanyal SN, Wada T, Yamabe M, Anai H, Miyamoto S, Shimada T, Ono K. Cardiac autonomic nerve abnormalities in chronic heart failure are associated with presynaptic vagal nerve degeneration. Pathophysiology 2012; 19:253-60; PMID:22921612; http://dx.doi.org/10.1016/j.pathophys.2012.07.004
  • Shinlapawittayatorn K, Chinda K, Palee S, Surinkaew S, Thunsiri K, Weerateerangkul P, Chattipakorn S, KenKnight BH, Chattipakorn N. Low-amplitude, left vagus nerve stimulation significantly attenuates ventricular dysfunction and infarct size through prevention of mitochondrial dysfunction during acute ischemia-reperfusion injury. Heart Rhythm 2013; 10:1700-7; PMID:23933295; http://dx.doi.org/10.1016/j.hrthm.2013.08.009
  • Katare RG, Ando M, Kakinuma Y, Arikawa M, Handa T, Yamasaki F, Sato T. Vagal nerve stimulation prevents reperfusion injury through inhibition of opening of mitochondrial permeability transition pore independent of the bradycardiac effect. J Thorac Cardiovasc Surg 2009; 137:223-31; PMID:19154929; http://dx.doi.org/10.1016/j.jtcvs.2008.08.020
  • Sun L, Zhao M, Yang Y, Xue RQ, Yu X, Liu JK, Zang WJ. Acetylcholine attenuates hypoxia/reoxygenation injury by inducing mitophagy through PINK1/Parkin signal pathway in H9c2 cells. J Cell Physiol 2016:1171-81; PMID:26465230; http://dx.doi.org/10.1002/jcp.25215
  • Mottis A, Jovaisaite V, Auwerx J. The mitochondrial unfolded protein response in mammalian physiology. Mamm Genome 2014; 25:424-33; PMID:24898297; http://dx.doi.org/10.1007/s00335-014-9525-z
  • Strifler G, Tuboly E, Szél E, Kaszonyi E, Cao C, Kaszaki J, Mészáros A, Boros M, Hartmann P. Inhaled methane limits the mitochondrial electron transport chain dysfunction during experimental liver ischemia-reperfusion injury. PLoS One 2016; 11:e146363; PMID:26741361; http://dx.doi.org/10.1371/journal.pone.0146363
  • Aluri HS, Simpson DC, Allegood JC, Hu Y, Szczepanek K, Gronert S, Chen Q, Lesnefsky EJ. Electron flow into cytochrome c coupled with reactive oxygen species from the electron transport chain converts cytochrome c to a cardiolipin peroxidase: role during ischemia-reperfusion. Biochim Biophys Acta 2014; 1840:3199-207; PMID:25092653; http://dx.doi.org/10.1016/j.bbagen.2014.07.017
  • Schleit J, Johnson SC, Bennett CF, Simko M, Trongtham N, Castanza A, Hsieh EJ, Moller RM, Wasko BM, Delaney JR, et al. Molecular mechanisms underlying genotype-dependent responses to dietary restriction. Aging Cell 2013; 12:1050-61; PMID:23837470; http://dx.doi.org/10.1111/acel.12130
  • Runkel ED, Liu S, Baumeister R, Schulze E. Surveillance-activated defenses block the ROS - induced mitochondrial unfolded protein response. PLoS Genet 2013; 9:e1003346; PMID:23516373; http://dx.doi.org/10.1371/journal.pgen.1003364
  • Lin M, Li L, Li L, Pokhrel G, Qi G, Rong R, Zhu T. The protective effect of baicalin against renal ischemia-reperfusion injury through inhibition of inflammation and apoptosis. BMC Complement Altern Med 2014; 14:19; PMID:24417870; http://dx.doi.org/10.1186/1472-6882-14-19
  • Zhao Q, Wang J, Levichkin IV, Stasinopoulos S, Ryan MT, Hoogenraad NJ. A mitochondrial specific stress response in mammalian cells. EMBO J 2002; 21:4411-9; PMID:12198143; http://dx.doi.org/10.1093/emboj/cdf445
  • Hu F, Liu F. Mitochondrial stress: A bridge between mitochondrial dysfunction and metabolic diseases? Cell Signal 2011; 23:1528-33; PMID:21616143; http://dx.doi.org/10.1016/j.cellsig.2011.05.008
  • He L, Lemasters JJ. Regulated and unregulated mitochondrial permeability transition pores: a new paradigm of pore structure and function? FEBS Lett 2002; 512:1-7; PMID:11852041; http://dx.doi.org/10.1016/S0014-5793(01)03314-2
  • Yu E, Mercer J, Bennett M. Mitochondria in vascular disease. Cardiovasc Res 2012; 95:173-82; PMID:22392270; http://dx.doi.org/10.1093/cvr/cvs111
  • Kokoszka JE, Coskun P, Esposito LA, Wallace DC. Increased mitochondrial oxidative stress in the Sod2 (+/−) mouse results in the age-related decline of mitochondrial function culminating in increased apoptosis. Proc Natl Acad Sci U S A 2001; 98:2278-83; PMID:11226230; http://dx.doi.org/10.1073/pnas.051627098
  • Abboud FM. The Walter B. Cannon Memorial Award Lecture, 2009. Physiology in perspective: The wisdom of the body. In search of autonomic balance: the good, the bad, and the ugly. Am J Physiol Regul Integr Comp Physiol 2010; 298:R1449-67; PMID:20219871; http://dx.doi.org/10.1152/ajpregu.00130.2010
  • Esler M. The sympathetic nervous system through the ages: from Thomas Willis to resistant hypertension. Exp Physiol 2011; 96:611-22; PMID:21551268; http://dx.doi.org/10.1113/expphysiol.2011.052332
  • He X, Zhao M, Bi X, Sun L, Yu X, Zhao M, Zang W. Novel strategies and underlying protective mechanisms of modulation of vagal activity in cardiovascular diseases. Br J Pharmacol 2015; 172:5489-500; PMID:25378088; http://dx.doi.org/10.1111/bph.13010
  • De Ferrari GM. Vagal Stimulation in Heart Failure. J Cardiovasc Transl Res 2014; 7:310-20; PMID:24500409; http://dx.doi.org/10.1007/s12265-014-9540-1
  • Bi XY, He X, Xu M, Zhao M, Yu XJ, Lu XZ, Zang WJ. Acetylcholine ameliorates endoplasmic reticulum stress in endothelial cells after hypoxia/reoxygenation via M3 AChR-AMPK signaling. Cell Cycle 2015; 14:2461-72; PMID:26066647; http://dx.doi.org/10.1080/15384101.2015.1060383
  • Miao Y, Zhou J, Zhao M, Liu J, Sun L, Yu X, He X, Pan X, Zang W. Acetylcholine attenuates hypoxia/ reoxygenation-induced mitochondrial and cytosolic ROS formation in H9c2 cells via M2 acetylcholine receptor. Cell Physiol Biochem 2013; 31:189-98; PMID:23407103; http://dx.doi.org/10.1159/000343360
  • Lu XZ, Bi XY, He X. Zhao M, Xu M, Yu XJ, Zhao ZH, Zang WJ. Activation of M 3 cholinoceptors attenuates vascular injury ischaemia/reperfusion by inhibiting the Ca+/calmodulin-dependent protein kinase II pathway. Br J Pharmac 2015; 172:5619-33; PMID:25953628; http://dx.doi.org/10.1111/bph.13183
  • He X, Bi XY, Lu XZ, Zhao M, Yu XJ, Sun L, Xu M, Wier WG, Zang WJ. Reduction of mitochondria-endoplasmic reticulum interactions by acetylcholine protects human umbilical vein endothelial cells from hypoxia/reoxygenation injury. Arterioscler Thromb Vasc Biol 2015; 35:1623-34; PMID:25977565; http://dx.doi.org/10.1161/ATVBAHA.115.305469
  • Wang XX, Li YB, Yao HJ, Ju RJ, Zhang Y, Li RJ, Yu Y, Zhang L, Lu WL. The use of mitochondrial targeting resveratrol liposomes modified with a dequalinium polyethylene glycol-distearoylphosphatidyl ethanolamine conjugate to induce apoptosis in resistant lung cancer cells. Biomaterials 2011; 32:5673-87; PMID:21550109; http://dx.doi.org/10.1016/j.biomaterials.2011.04.029
  • Yoshii SR, Kishi C, Ishihara N, Mizushima N. Parkin mediates proteasome-dependent protein degradation and rupture of the outer mitochondrial membrane. J Biol Chem 2011; 286:19630-40; PMID:21454557; http://dx.doi.org/10.1074/jbc.M110.209338
  • Yu L, Li Q, Yu B, Yang Y, Jin Z, Duan W, Zhao G, Zhai M, Liu L, Yi D, Chen M, Yu S. Berberine attenuates myocardial ischemia/reperfusion injury by reducing oxidative stress and inflammation response: role of silent information regulator 1. Oxid Med Cell Longev 2016; 2016:1689602; PMID:26788242; http://dx.doi.org/10.1155/2016/1689602
  • Liu JJ, Huang N, Lu Y, Zhao M, Yu XJ, Yang Y, Yang YH, Zang WJ. Improving vagal activity ameliorates cardiac fibrosis induced by angiotensin II: in vivo and in vitro. Sci Rep 2015; 5:17108; PMID:26596640; http://dx.doi.org/10.1038/srep17108
  • Ghavami S, Kerkhoff C, Chazin WJ, Kadkhoda K, Xiao W, Zuse A, Hashemi M, Eshraghi M, Schulze-Osthoff K, Klonisch T, Los M. S100A8/9 induces cell death via a novel, RAGE-independent pathway that involves selective release of Smac/DIABLO and Omi/HtrA2. Biochim Biophys Acta 2008; 1783:297-311; PMID:10860880; http://dx.doi.org/10.1016/j.bbamcr.2007.10.015
  • Gallerne C, Prola A, Lemaire C. Hsp90 inhibition by PU-H71 induces apoptosis through endoplasmic reticulum stress and mitochondrial pathway in cancer cells and overcomes the resistance conferred by Bcl-2. Biochim Biophy Acta 2013; 1833:1356-66; PMID:23485394; http://dx.doi.org/10.1016/j.bbamcr.2013.02.014

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.