Dosing time dependent in vitro pharmacodynamics of Everolimus despite a defective circadian clock

References

• World Health Organization. World Cancer Report 2014; pp. Chapter 1.1. ISBN 92-832-0429-8.
   Google Scholar
• Lumachi F, Brunello A, Maruzzo M, Basso U, Basso SM. Treatment of estrogen receptor-positive breast cancer. Curr Med Chem. 2013;20(5):596–604. doi:10.2174/092986713804999303. PMID:23278394.
   PubMed Web of Science ®Google Scholar
• Steelman LS, Martelli AM, Cocco L, Libra M, Nicoletti F, Abrams SL, McCubrey JA. The therapeutic potential of mTOR inhibitors in breast cancer. Br J Clin Pharmacol. 2016;82(5):1189‐212. doi:10.1111/bcp.12958. PMID:27059645.
   PubMed Web of Science ®Google Scholar
• Hortobagyi GN. Everolimus plus exemestane for the treatment of advanced breast cancer: a review of subanalyses from BOLERO-2. Neoplasia. 2015;17:279‐88. doi:10.1016/j.neo.2015.01.005. PMID:25810012.
   PubMed Web of Science ®Google Scholar
• Piccart M, Hortobagyi GN, Campone M, Pritchard KI, Lebrun F, Ito Y, Noguchi S, Perez A, Rugo HS, Deleu I, et al. Everolimus plus exemestane for hormone-receptor-positive, human epidermal growth factor receptor-2-negative advanced breast cancer: overall survival results from BOLERO-2. Ann Oncol. 2014;25:2357‐62. doi:10.1093/annonc/mdu456. PMID:25231953.
   PubMed Web of Science ®Google Scholar
• Baselga J, Campone M, Piccart M, Burris HA 3rd, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, et al. Everolimus in postmenopausal hormone receptor-positive advanced breast cancer. N Engl J Med. 2012;366:520‐29. doi:10.1056/NEJMoa1109653. PMID:22149876.
   PubMed Web of Science ®Google Scholar
• Xu K, Liu P, Wei W. mTOR signaling in tumorigenesis. Biochimica et Biophysica Acta. 2014;1846(2):638‐54. doi: 10.1016/j.bbcan.2014.10.007. PMID:25450580.
   PubMed Web of Science ®Google Scholar
• Laplante M, Sabatini DM. mTOR signaling at a glance J Cell Sci. 2009;122(Pt 20):3589‐94. doi: 10.1242/jcs.051011. PMID: 19812304.
   PubMedGoogle Scholar
• Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev. 2004;18(16):1926‐45. doi:10.1101/gad.1212704. PMID:15314020.
   PubMed Web of Science ®Google Scholar
• Khapre RV, Patel SA, Kondratova AA, Chaudhary A, Velingkaar N, Antoch MP, Kondratov RV. Metabolic clock generates nutrient anticipation rhythms in mTOR signaling. Aging (Albany NY). 2014;6(8):675‐89. doi:10.18632/aging.100686. PMID:25239872.
   PubMedGoogle Scholar
• Khapre RV, Kondratova AA, Patel S, Dubrovsky Y, Wrobel M, Antoch MP, Kondratov RV BMAL1-dependent regulation of the mTOR signaling pathway delays aging. Aging (Albany NY). 2014;6(1):48‐57. doi:10.18632/aging.100633. PMID:24481314.
   PubMedGoogle Scholar
• Cao R, Robinson B, Xu H, Gkogkas C, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, Sonenberg N. Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron. 2013;79(4):712‐24. doi:10.1016/j.neuron.2013.06.026. PMID:23972597.
   PubMed Web of Science ®Google Scholar
• Cao R, Anderson FE, Jung YJ, Dziema H, Obrietan K. Circadian regulation of mammalian target of rapamycin signaling in the mouse suprachiasmatic nucleus. Neuroscience. 2011;181:79‐88. doi:10.1016/j.neuroscience.2011.03.005. PMID:21382453.
   PubMed Web of Science ®Google Scholar
• Okazaki H, Matsunaga N, Fujioka T, Okazaki F, Akagawa Y, Tsurudome Y, Ono M, Kuwano M, Koyanagi S, Ohdo S. Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma. Cancer Res. 2014;74(2):543‐51. doi:10.1158/0008-5472.CAN-12-3241. PMID:24253377.
   PubMed Web of Science ®Google Scholar
• Drägert K, Bhattacharya I, Hall MN, Humar R, Battegay E, Haas E Basal mTORC2 activity and expression of its components display diurnal variation in mouse perivascular adipose tissue. Biochem Biophys Res Commun. 2016:22;473(1):317‐22. doi:10.1016/j.bbrc.2016.03.102. PMID: 27016480.
   PubMed Web of Science ®Google Scholar
• Stephan FK, Zucker I. Circadian rhythms in drinking behavior and locomotor activity of rats are eliminated by hypothalamic lesions. Proc Natl Acad Sci U S A. 1972;69(6):1583‐6. doi:10.1073/pnas.69.6.1583. PMID:4556464.
   PubMed Web of Science ®Google Scholar
• Takahashi JS Transcriptional architecture of the mammalian circadian clock. Nat Rev Genet. 2017;18(3):164‐79. doi:10.1038/nrg.2016.150. PMID:27990019.
   PubMed Web of Science ®Google Scholar
• Fu L, Kettner NM. The circadian clock in cancer development and therapy. Prog Mol Biol Transl Sci. 2013;119:221‐82. doi:10.1016/B978-0-12-396971-2.00009-9. PMID:23899600.
   PubMed Web of Science ®Google Scholar
• Dallmann R, Okyar A, Lévi F. Dosing-Time Makes the Poison: Circadian Regulation and Pharmacotherapy. Trends Mol Med. 2016;22(5):430‐45. doi:10.1016/j.molmed.2016.03.004. PMID:27066876.
   PubMed Web of Science ®Google Scholar
• Lévi F, Okyar A, Dulong S, Innominato PF, Clairambault J. Circadian timing in cancer treatments. Annu Rev Pharmacol Toxicol. 2010;50:377‐421. doi:10.1146/annurev.pharmtox.48.113006.094626. PMID:20055686.
   PubMed Web of Science ®Google Scholar
• Giacchetti S, Li XM, OZTURK N, Cuvier C, Machowiak J, Arrondeau J, Chang-Marchand Y, Espié M, Okyar A, Lévi F Consistent dosing-time dependent tolerability of everolimus (EV) in a pilot study in women with metastatic breast cancer (MBC) and in a mouse chronopharmacology investigation Abstract of San Antonio Breast Cancer Symposium 2016 Abstract N° 850329.
   Google Scholar
• Rossetti S, Esposito J, Corlazzoli F, Gregorski A, Sacchi N. Entrainment of breast (cancer) epithelial cells detects distinct circadian oscillation patterns for clock and hormone receptor genes. Cell Cycle. 2012;11(2):350‐60. doi:10.4161/cc.11.2.18792. PMID:22193044.
   PubMed Web of Science ®Google Scholar
• Balsalobre A, Damiola F, Schibler U. A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell. 1998;93(6):929‐37. doi:10.1016/S0092-8674(00)81199-X. PMID:9635423.
   PubMed Web of Science ®Google Scholar
• Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156‐9. doi:10.1016/0003-2697(87)90021-2. PMID:2440339.
   PubMed Web of Science ®Google Scholar
• Ballesta A, Dulong S, Abbara C, Cohen B, Okyar A, Clairambault J, Lévi F. A combined experimental and mathematical approach for molecular-based optimization of irinotecan circadian delivery. PLoS Comput Biol. 2011;7:e1002143. doi:10.1371/journal.pcbi.1002143. PMID:21931543.
   PubMed Web of Science ®Google Scholar
• Ramanathan C, Khan SK, Kathale ND, Xu H, Liu AC. Monitoring cell-autonomous circadian clock rhythms of gene expression using luciferase bioluminescence reporters. J Vis Exp. 2012;27(67):pii:4234. doi: 10.3791/4234. PMID: 23052244.
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Blagosklonny MV Gerosuppression by pan-mTOR inhibitors Aging (Albany NY). 2016;30; 8(12):3535‐51. doi:10.18632/aging.101155. PMID:28077803.
   PubMedGoogle Scholar
• Canaple L, Kakizawa T, Laudet V. The days and nights of cancer cells. Cancer Res. 2003;63(22):7545‐52. PMID:14633665.
   PubMed Web of Science ®Google Scholar
• Goldbeter A, Gérard C, Gonze D, Leloup J-C, Dupont G Systems biology of cellular rhythms, FEBS Lett. 2012;586(18):2955‐65. doi:10.1016/j.febslet.2012.07.041. PMID:22841722.
   PubMed Web of Science ®Google Scholar
• Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H Control mechanism of the circadian clock for timing of cell division in vivo. Science. 2003;302:255‐9. doi:10.1126/science.1086271. PMID:12934012.
   PubMed Web of Science ®Google Scholar
• Gréchez-Cassiau A, Rayet B, Guillaumond F, Teboul M, Delaunay F The circadian clock component Bmal1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation. J Biol Chem. 2008;283:4535‐4542. doi:10.1074/jbc.M705576200. PMID:18086663.
   PubMed Web of Science ®Google Scholar
• Fu L, Pelicano H, Liu J, Huang P, Chi Lee C The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell. 2002;111: 41‐50. doi:10.1016/S0092-8674(02)00961-3. PMID:12372299.
   PubMed Web of Science ®Google Scholar
• Pérez-Roger I, Solomon DLC, Sewing A, Land H Myc activation of cyclin E/Cdk2 kinase involves induction of cyclin E gene transcription and inhibition of p27Kip1 binding to newly formed complexes. Oncogene. 1997;14:2373‐81. doi:10.1038/sj.onc.1201197. PMID:9188852.
   PubMed Web of Science ®Google Scholar
• Feillet C, Krusche P, Tamanini F, Janssens RC, Downey MJ, Martin P, Teboul M, Saito S, Lévi F, Bretschneider T, et al. Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle. Proc Natl Acad Sci U S A. 2014;111(27):9828‐33. doi:10.1073/pnas.1320474111. PMID:24958884.
   PubMed Web of Science ®Google Scholar
• Cash E, Sephton SE, Chagpar AB, Spiegel D, Rebholz WN, Zimmaro LA, Tillie JM, Dhabhar FS Circadian disruption and biomarkers of tumor progression in breast cancer patients awaiting surgery. Brain Behav Immun. 2015;48:102‐14. doi:10.1016/j.bbi.2015.02.017. PMID:25728235.
   PubMed Web of Science ®Google Scholar
• Sephton SE, Sapolsky RM, Kraemer HC, Spiegel DJ Diurnal cortisol rhythm as a predictor of breast cancer survival. Natl Cancer Inst. 2000: 21;92(12):994‐1000. doi:10.1093/jnci/92.12.994. PMID:10861311.
   PubMedGoogle Scholar
• Touitou Y, Lévi F, Bogdan A, Benavides M, Bailleul F, Misset JL Rhythm alteration in patients with metastatic breast cancer and poor prognostic factors. J Cancer Res Clin Oncol. 1995;121(3):181‐8. doi:10.1007/BF01198101. PMID:7713990.
   PubMed Web of Science ®Google Scholar
• Blakeman V, Williams JL, Meng QJ, Streuli CH Circadian clocks and breast cancer. Breast Cancer Res. 2016;18(1):89. doi:10.1186/s13058-016-0743-z. PMID:27590298.
   PubMed Web of Science ®Google Scholar
• Reszka E, Przybek M Circadian Genes in Breast Cancer. Adv Clin Chem. 2016;75:53‐70. doi:10.1016/bs.acc.2016.03.005. PMID:27346616.
   PubMed Web of Science ®Google Scholar
• Cadenas C, van de Sandt L, Edlund K, Lohr M, Hellwig B, Marchan R, Schmidt M, Rahnenführer J, Oster H, Hengstler JG Loss of circadian clock gene expression is associated with tumor progression in breast cancer. Cell Cycle. 2014;13(20):3282‐91. doi:10.4161/15384101.2014.954454. PMID:25485508.
   PubMed Web of Science ®Google Scholar
• Gutiérrez-Monreal MA, Treviño V, Moreno-Cuevas JE, Scott SP Identification of circadian-related gene expression profiles in entrained breast cancer cell lines. Chronobiol Int. 2016;33(4):392‐405. doi:10.3109/07420528.2016.1152976. PMID:27010605.
   PubMed Web of Science ®Google Scholar
• Xiang S, Mao L, Duplessis T, Yuan L, Dauchy R, Dauchy E, Blask DE, Frasch T, Hill SM Oscillation of clock and clock controlled genes induced by serum shock in human breast epithelial and breast cancer cells: regulation by melatonin. Breast Cancer (Auckl). 2012;6:137‐50. doi: 10.4137/BCBCR.S9673. PMID:23012497.
   PubMedGoogle Scholar
• Koziczak M, Hynes NE Cooperation between fibroblast growth factor receptor-4 and ERBB2 in regulation of cyclin D1 translation. J Biol Chem. 2004;279(48):50004‐11. doi:10.1074/jbc.M404252200. PMID:15377668.
   PubMed Web of Science ®Google Scholar
• Richter JD, Sonenberg N. Regulation of cap-dependent translation by eIF4E inhibitory proteins. Nature. 2005;433:477‐80. doi:10.1038/nature03205. PMID:15690031.
   PubMed Web of Science ®Google Scholar
• Leontieva OV, Lenzo F, Demidenko ZN, Blagosklonny MV Hyper-mitogenic drive coexists with mitotic incompetence in senescent cells, Cell Cycle. 2012: 11:24:4642‐9; doi:10.4161/cc.22937.
   Web of Science ®Google Scholar
• Edgar RS, Green EW, Zhao Y, van Ooijen G, Olmedo M, Qin X, Xu Y, Pan M, Valekunja UK, Feeney KA, et al. Peroxiredoxins are conserved markers of circadian rhythms. Nature. 2012;485(7399):459‐64. doi: 10.1038/nature11088. PMID:22622569.
   PubMed Web of Science ®Google Scholar
• Zhu B, Zhang Q, Pan Y, Mace EM, York B, Antoulas AC, Dacso CC, O'Malley BW. A Cell-Autonomous Mammalian 12 hr Clock Coordinates Metabolic and Stress Rhythms, Cell Metab. 2017;25(6):1305‐19. e9. doi: 10.1016/j.cmet.2017.05.004.
   PubMed Web of Science ®Google Scholar