1,296
Views
0
CrossRef citations to date
0
Altmetric
Perspective

The unveiling of the Warburg effect and the inscribed innovative approach to a radical non toxic anticancer therapy

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 288-297 | Received 22 Aug 2017, Accepted 29 Oct 2017, Published online: 19 Mar 2018

References

  • Clarke MF, Dick JE, Dirks PB, et al. Cancer stem cells-perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006;66:9339–9344. doi:10.1158/0008-5472.CAN-06-3126. PMID:16990346
  • Warburg O. On respiratory impairment in cancer cells. Science. 1956;124:269–270. PMID: 13351639.
  • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science. 2009;324:1029–1033. doi:10.1126/science.1160809. PMID:19460998
  • Del Monte U, Olivotto M. Research on the nature of the substrates of endogenous respiration of Yoshida's ascites hepatoma. Sperimentale. 1965;115:405–422. PMID: 4164352.
  • Olivotto M, Paoletti F. Studies on the kinetic of initial cycle progression in vitro of ascites tumor cells subsequent to isolation from ascites fluid. Cell Tissue Kinet. 1980;13:605–612. doi: 10.1111/j.1365-2184.1980.tb00499.x. PMID:7417977
  • Olivotto M, Paoletti F. The role of respiration in tumor cell transition from the non cycling to the cycling state. J Cell Physiol. 1981;107:243–249. doi:10.1002/jcp.1041070210. PMID:7251682
  • Olivotto M, Caldini R, Chevanne M, et al. The respiration-linked limiting step of tumor cell transition from the non-cycling to the cycling state: its inhibition by oxidizable substrates and its relationships to purine metabolism. J Cell Physiol. 1983;116:149–158. PMID: 6863398. doi:10.1002/jcp.1041160205. PMID:6863398
  • Arcangeli A, Del Bene MR, Ricupero L, et al. Fibronectin hyperpolarizes the plasma membrane potential of murine erythroleukemia cells. Ann NY Acad Sci. 1988;551:242–244. PMID: 3245662. doi:10.1111/j.1749-6632.1988.tb22341.x. PMID:3245662
  • Arcangeli A, Del Bene MR, Poli R, et al. Mutual contact of murine erythroleukemia cells activates depolarizing cation channels, whereas contact with extracellular substrata activates hyperpolarizing Ca2+-dependent K+ channels. J Cell Physiol. 1989;139:1–8. doi:10.1002/jcp.11041390102. PMID:2468677
  • Marzi I, Cipolleschi MG, D'Amico M, et al. The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming. Cell Cycle. 2013;12:353–364. doi:10.4161/cc.23200. PMID:23287475
  • Olivotto M, Dello Sbarba P. Environmental restrictions within tumor ecosystems select for a convergent, hypoxia-resistant phenotype of cancer stem cells. Cell Cycle. 2008;7:176–187. doi:10.4161/cc.7.2.5315. PMID:18256528
  • Folmes CDL, Nelson TJ. Somatic oxidative bioenergetics transition into pluripotency-dependent glycolysis to facilitate nuclear reprogramming. Cell Metabolism. 2011:14;264–271. doi:10.1016/j.cmet.2011.06.011. PMID:21803296
  • Dunwoodie SL. The role of hypoxia in development of the mammalian embryo. Dev Cell. 2009;17:755–773. doi:10.1016/j.devcel.2009.11.008. PMID:20059947
  • Maltepe E, Saugstad OD. Oxygen in health and disease: regulation of oxygen homeostasis-clinical implications. Pediatr Res. 2009;65:261–268. doi:10.1203/PDR.0b013e31818fc83f.
  • Okazaki K, Maltepe E. Oxygen, epigenetics and stem cell fate. Regen Med. 2006;1:71–83. doi:10.2217/17460751.1.1.71. PMID:17465821
  • Anderson JC, Blake AJ, Mills M, et al. A general one-step synthesis of beta-nitronitriles. Org Lett. 2008;10:4141–4143. doi:10.1021/ol801691c. PMID:18722454
  • Seidel S, Garvalov BK, Wirta V, et al. 2010. A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2 alpha. Brain. 133:983–995. doi:10.1093/brain/awq042. PMID:20375133
  • Borovski T, De Sousa E, Melo F, et al. Cancer stem cell niche: the place to be. Cancer Res. 2011;71:634–639. doi:10.1158/0008-5472.CAN-10-3220. PMID:21266356
  • Cipolleschi MG, Dello Sbarba P, Olivotto M. The role of hypoxia in the maintenance of hematopoietic stem cells. Blood. 1993;82:2031–2037. PMID: 8104535. PMID:8104535
  • Cipolleschi MG, D'Ippolito G, Bernabei PA, et al. Severe hypoxia enhances the formation of erythroid bursts from human cord blood cells and the maintenance of BFU-E in vitro. Exp Hematol. 1997;25:1187–1194. PMID: 9328456. PMID:9328456
  • Dello Sbarba P, Cipolleschi MG, Olivotto M. Hemopoietic progenitor cells are sensitive to the cytostatic effect of pyruvate. Exp Hematol. 1987;15:137–142. PMID: 3817047. PMID:3817047
  • Mohyeldin A, Garzón-Muvdi T, Quiñones-Hinojosa A. Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell. 2010;7:150–161. doi:10.1016/j.stem.2010.07.007. PMID:20682444
  • Kubota K, Soeda J, Misawa R, et al. Bone marrow-derived cells fuse with hepatic oval cells but are not involved in hepatic tumorigenesis in the choline-deficient ethionine-supplemented diet rat model. Carcinogenesis. 2008;29:448–454. doi:10.1093/carcin/bgm279. PMID:18174248
  • Visvader JE, Lindeman GJ. Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer. 2008;8:755–768. doi:10.1038/nrc2499. PMID:18784658
  • Cipolleschi MG, Marzi I, Santini R, et al. Hypoxia-resistant profile implies vulnerability of cancer stem cells to physiological agents, which suggests new therapeutic targets. Cell Cycle. 2014:13:268–278. doi:10.4161/cc.27031. PMID:24200964
  • Stivarou T, Cipolleschi MG, D'Amico M, et al. The complex metabolic network gearing the G1/S transition in leukemic stem cells: Hints to a rational use of antineoplastic agents. Oncotarget. 2015;6:31985–31996. doi:10.18632/oncotarget.5155. PMID:26396171
  • Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663–676. doi:10.1016/j.cell.2006.07.024 doi:10.1016/j.cell.2006.07.024. PMID:16904174
  • Abdullah LN, Chow EK. Mechanisms of chemoresistance in cancer stem cells. Clin Transl Med. 2013;23:1–9. doi:10.1186/2001-1326-2-3.
  • Majno G, Joris I. Cells, tissues and diseases. Oxford (UK): Oxford University Press; 2004.
  • Hastak K, Paul RK, Agarwal MK, et al. DNA synthesis from unbalanced nucleotide pools causes limited DNA damage that triggers ATR-CHK1-dependent p53 activation. Proc Natl Acad Sci USA. 2008;105:6314–6319. doi:10.1073/pnas.0802080105. PMID:18434539
  • Koh-Banerjee PK, Ferreira MP, Greenwood M, et al. Effects of calcium pyruvate supplementation during training on body composition, exercise capacity, and metabolic responses to exercise. Nutrition. 2005;21:312–319. doi:10.1016/j.nut.2004.06.026. PMID:15797672
  • Onakpoya I, Hunt K, Wider B, et al. Pyruvate supplementation for weight loss: a systematic review and meta-analysis of randomized clinical trials. Crit Rev Food Sci Nutr. 2014;54:17–23. doi:10.1080/10408398.2011.565890. PMID:24188231