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ONC201 shows promise in AML treatment

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Page 277 | Received 05 Dec 2017, Accepted 21 Dec 2017, Published online: 10 Jan 2018

References

  • Bose P, Vachhani P, Cortes JE. Treatment of relapsed/refractory acute myeloid leukemia. Curr Treat Options Oncol 2017;18:17. doi:10.1007/s11864-017-0456-2. PMID:28286924
  • Ho TC, LaMere M, Stevens BM, et al. Evolution of acute myelogenous leukemia stem cell properties after treatment and progression. Blood 2016;128:1671–1678. doi:10.1182/blood-2016-02-695312. PMID:27421961
  • Stein MN, Bertino JR, Kaufman HL, et al. First-in-human clinical trial of oral ONC201 in patients with refractory solid tumors. Clin Cancer Res 2017;23:4163–4169. doi:10.1158/1078-0432.CCR-16-2658. PMID:28331050
  • Arrillaga-Romany I, Chi AS, Allen JE, et al. A phase 2 study of the first imipridone ONC201, a selective DRD2 antagonist for oncology, administered every three weeks in recurrent glioblastoma. Oncotarget 2017;8:79298–79304. PMID:29108308
  • Allen JE, Krigsfeld G, Mayes PA, et al. Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects. Sci Transl Med 2013;5:171–117. doi:10.1126/scitranslmed.3004828. PMID:23390247
  • Prabhu VV, Talekar MK, Lulla AR, et al. Single agent and synergistic combniatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies. Cell Cycle 2017. doi:10.1080/15384101.2017.1403689.
  • Ishizawa J, Kojima K, Chachad D, et al. ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies. Sci Signal 2016;9:17. doi:10.1126/scisignal.aac4380. PMID:26884599

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