Tumor-derived lactate induces M2 macrophage polarization via the activation of the ERK/STAT3 signaling pathway in breast cancer

References

• Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012 CA Cancer J Clin 2015.65:87–108. doi:10.3322/caac.21262.
   PubMed Web of Science ®Google Scholar
• Choi J, Gyamfi J, Jang H, et al. The role of tumor-associated macrophage in breast cancer biology. Histol Histopathol. 2017;11916;
   Web of Science ®Google Scholar
• Sossey-Alaoui K, Pluskota E, Bialkowska K, et al. Kindlin-2 regulates the growth of breast cancer tumors by activating CSF-1-Mediated macrophage infiltration. Cancer Res. 2017;77:5129–5141. PMID:28687620
   PubMed Web of Science ®Google Scholar
• Boniakowski AE, Kimball AS, Jacobs BN, et al. Macrophage-mediated inflammation in normal and diabetic wound healing. J Immunol. 2017;199:17–24. doi:10.4049/jimmunol.1700223. PMID:28630109
   PubMed Web of Science ®Google Scholar
• Zhang W, Xu W, Xiong S. Macrophage differentiation and polarization via phosphatidylinositol 3-kinase/Akt-ERK signaling pathway conferred by serum amyloid P component. J Immunol. 2011;187:1764–1777. doi:10.4049/jimmunol.1002315. PMID:21753147
   PubMed Web of Science ®Google Scholar
• Sun L, Chen B, Jiang R, et al. Resveratrol inhibits lung cancer growth by suppressing M2-like polarization of tumor associated macrophages. Cell Immunol. 2017;311:86–93. doi:10.1016/j.cellimm.2016.11.002. PMID:27825563
   PubMed Web of Science ®Google Scholar
• Raggi F, Pelassa S, Pierobon D, et al. Regulation of human macrophage M1-M2 polarization balance by hypoxia and the triggering receptor expressed on myeloid cells-1. Front Immunol. 2017;8:1097. doi:10.3389/fimmu.2017.01097. PMID:28936211
   PubMed Web of Science ®Google Scholar
• Rahman K, Vengrenyuk Y, Ramsey SA, et al. Inflammatory Ly6Chi monocytes and their conversion to M2 macrophages drive atherosclerosis regression. J Clin Invest. 2017;127:2904–2915. doi:10.1172/JCI75005. PMID:28650342
   PubMed Web of Science ®Google Scholar
• Shinohara H, Kuranaga Y, Kumazaki M, et al. Regulated polarization of tumor-associated macrophages by miR-145 via colorectal cancer-derived extracellular vesicles. J Immunol. 2017;199:1505–1515. doi:10.4049/jimmunol.1700167. PMID:28696255
   PubMed Web of Science ®Google Scholar
• Mu X, Zhao T, Xu C, et al. Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation. Oncotarget. 2017;8:13174–13185. doi:10.18632/oncotarget.14485. PMID:28061458
   PubMedGoogle Scholar
• Zhao T, Mu X, You Q. Succinate: An initiator in tumorigenesis and progression. Oncotarget. 2017;8:53819–53828. PMID:28881853
   PubMedGoogle Scholar
• Vaitheesvaran B, Xu J, Yee J, et al. The Warburg effect: a balance of flux analysis. Metabolomics. 2015;11:787–796. doi:10.1007/s11306-014-0760-9. PMID:26207106
   PubMed Web of Science ®Google Scholar
• Colegio OR, Chu NQ, Szabo AL, et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature. 2014;513:559–563. doi:10.1038/nature13490. PMID:25043024
   PubMed Web of Science ®Google Scholar
• Faubert B, Li KY, Cai L, et al. Lactate metabolism in human lung tumors. Cell. 2017;171:358–371.e9. doi:10.1016/j.cell.2017.09.019. PMID:28985563
   PubMed Web of Science ®Google Scholar
• Peda JD, Salah SM, Wallace DP, et al. Autocrine IL-10 activation of the STAT3 pathway is required for pathological macrophage differentiation in polycystic kidney disease. Dis Model Mech. 2016;9:1051–1061. doi:10.1242/dmm.024745. PMID:27491076
   PubMed Web of Science ®Google Scholar
• Li R, Hebert JD, Lee TA, et al. Macrophage-Secreted TNFalpha and TGFbeta1 influence migration speed and persistence of cancer cells in 3D tissue culture via independent pathways. Cancer Res. 2017;77:279–290. doi:10.1158/0008-5472.CAN-16-0442. PMID:27872091
   PubMed Web of Science ®Google Scholar
• Zhang J, Cao J, Ma S, et al. Tumor hypoxia enhances non-small cell lung cancer metastasis by selectively promoting macrophage M2 polarization through the activation of ERK signaling. Oncotarget. 2014;5:9664–9677. doi:10.18632/oncotarget.1856. PMID:25313135
   PubMedGoogle Scholar
• Suta S, Maggi F, Nicoletti M, et al. New drugs from old natural compounds: scarcely investigated sesquiterpenes as new possible therapeutic agents. Curr Med Chem. 2018;25:1–18. doi:10.2174/0929867324666170404150351. PMID: 28393689
   PubMed Web of Science ®Google Scholar
• Issa ME, Wijeratne EMK, Gunatilaka AAL, et al. Withanolide D exhibits similar cytostatic effect in drug-resistant and drug-sensitive multiple myeloma cells. Front Pharmacol. 2017;8:610. doi:10.3389/fphar.2017.00610. PMID: 28943850
   PubMed Web of Science ®Google Scholar
• Batista PH, de Lima KS, Pinto F, et al. Withanolides from leaves of cultivated Acnistus arborescens. Phytochemistry. 2016;130:321–327. doi:10.1016/j.phytochem.2016.07.003. PMID: 27498045
   PubMed Web of Science ®Google Scholar
• Hart PC, Mao M, de Abreu AL, et al. MnSOD upregulation sustains the Warburg effect via mitochondrial ROS and AMPK-dependent signalling in cancer. Nat Commun. 2015;6:6053. doi:10.1038/ncomms7053. PMID: 25651975
   PubMed Web of Science ®Google Scholar
• Witkiewicz AK, Whitaker-Menezes D, Dasgupta A, et al. Using the “reverse Warburg effect” to identify high-risk breast cancer patients: stromal MCT4 predicts poor clinical outcome in triple-negative breast cancers. Cell Cycle. 2012;11:1108–1117. doi:10.4161/cc.11.6.19530. PMID: 22313602
   PubMed Web of Science ®Google Scholar
• Liberti MV, Dai Z, Wardell SE, et al. A predictive model for selective targeting of the warburg effect through GAPDH inhibition with a natural product. Cell Metab. 2017;26:648–659.e8. doi:10.1016/j.cmet.2017.08.017. PMID: 28918937
   PubMed Web of Science ®Google Scholar
• Tekade RK, Sun X. The Warburg effect and glucose-derived cancer theranostics. Drug Discov Today. 2017.; doi:10.1016/j.drudis.2017.08.003.
   Web of Science ®Google Scholar
• Romero-Garcia S, Moreno-Altamirano MM, Prado-Garcia H, et al. Lactate contribution to the tumor microenvironment: mechanisms, effects on immune cells and therapeutic relevance. Front Immunol. 2016;7:52. doi:10.3389/fimmu.2016.00052. PMID: 26909082
   PubMed Web of Science ®Google Scholar
• Holm E, Hagmuller E, Staedt U, et al. Substrate balances across colonic carcinomas in humans. Cancer Res. 1995;55:1373–1378. PMID: 7882338
   PubMed Web of Science ®Google Scholar
• Feng J, Yang H, Zhang Y, et al. Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells. Oncogene. 2017;36:5829–5839. doi:10.1038/onc.2017.188. PMID: 28604752
   PubMed Web of Science ®Google Scholar
• Vegran F, Boidot R, Michiels C, et al. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kappaB/IL-8 pathway that drives tumor angiogenesis. Cancer Res. 2011;71:2550–2560. doi:10.1158/0008-5472.CAN-10-2828. PMID: 21300765
   PubMed Web of Science ®Google Scholar
• Chen XW, Yu TJ, Zhang J, et al. CYP4A in tumor-associated macrophages promotes pre-metastatic niche formation and metastasis. Oncogene. 2017;36:5045–5057. doi:10.1038/onc.2017.118. PMID: 28481877
   PubMed Web of Science ®Google Scholar
• Niu Z, Shi Q, Zhang W, et al. Caspase-1 cleaves PPARgamma for potentiating the pro-tumor action of TAMs. Nat Commun. 2017;8:766. doi:10.1038/s41467-017-00523-6. PMID: 28974683
   PubMed Web of Science ®Google Scholar
• Chen P, Zuo H, Xiong H, et al. Gpr132 sensing of lactate mediates tumor-macrophage interplay to promote breast cancer metastasis. Proc Natl Acad Sci U S A. 2017;114:580–585. doi:10.1073/pnas.1614035114. PMID: 28049847
   PubMed Web of Science ®Google Scholar
• He W, Zhu Y, Mu R, et al. A Jak2-selective inhibitor potently reverses the immune suppression by modulating the tumor microenvironment for cancer immunotherapy. Biochem Pharmacol. 2017;145:132–146. doi:10.1016/j.bcp.2017.08.019. PMID: 28859967
   PubMed Web of Science ®Google Scholar
• Veremeyko T, Yung AWY, Dukhinova M, et al. Cyclic AMP pathway suppress autoimmune neuroinflammation by inhibiting functions of encephalitogenic CD4 T cells and enhancing M2 macrophage polarization at the site of inflammation. Front Immunol. 2018;9:50. doi:10.3389/fimmu.2018.00050. PMID: 29422898
   PubMed Web of Science ®Google Scholar
• Zhou J, Zhao T, Ma L, et al. Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling. Oncotarget. 2017;8:103167–103181. doi:10.18632/oncotarget.21704. PMID: 29262554
   PubMedGoogle Scholar
• Ding CP, Guo YJ, Li HN, et al. Red nucleus interleukin-6 participates in the maintenance of neuropathic pain through JAK/STAT3 and ERK signaling pathways. Exp Neurol. 2018;300:212–221. doi:10.1016/j.expneurol.2017.11.012. PMID: 29183675
   PubMed Web of Science ®Google Scholar
• Lawrence T, Natoli G. Transcriptional regulation of macrophage polarization: enabling diversity with identity. Nat Rev Immunol. 2011;11:750–761. doi:10.1038/nri3088. PMID: 22025054
   PubMed Web of Science ®Google Scholar
• Martinez FO, Gordon S. The M1 and M2 paradigm of macrophage activation: time for reassessment. F1000prime Rep. 2014;6:13. doi:10.12703/P6-13. PMID: 24669294
   PubMedGoogle Scholar
• Climaco-Arvizu S, Dominguez-Acosta O, Cabanas-Cortes MA, et al. Aryl hydrocarbon receptor influences nitric oxide and arginine production and alters M1/M2 macrophage polarization. Life Sci. 2016;155:76–84. doi:10.1016/j.lfs.2016.05.001. PMID: 27153778
   PubMed Web of Science ®Google Scholar
• Malik F, Kumar A, Bhushan S, et al. Immune modulation and apoptosis induction: two sides of antitumoural activity of a standardised herbal formulation of Withania somnifera. Eur J Cancer. 2009;45:1494–1509. doi:10.1016/j.ejca.2009.01.034. PMID: 19269163
   PubMed Web of Science ®Google Scholar
• Mondal S, Bhattacharya K, Mallick A, et al. Bak compensated for Bax in p53-null cells to release cytochrome c for the initiation of mitochondrial signaling during Withanolide D-induced apoptosis. PLoS One. 2012;7:e34277. doi:10.1371/journal.pone.0034277. PMID: 22479585
   PubMed Web of Science ®Google Scholar
• Mondal S, Mandal C, Sangwan R, et al. Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Mol Cancer. 2010;9:239. PMID: 20836852
   PubMed Web of Science ®Google Scholar
• Mu X, Shi W, Sun L, et al. Pristimerin, a triterpenoid, inhibits tumor angiogenesis by targeting VEGFR2 activation. Molecules. 2012;17:6854–6868. doi:10.3390/molecules17066854. PMID: 22669041
   PubMed Web of Science ®Google Scholar