EXO1 overexpression is associated with poor prognosis of hepatocellular carcinoma patients

References

• Torre LA, Bray F, Siegel RL, et al. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108.
   PubMed Web of Science ®Google Scholar
• Lazarevich NL, Cheremnova OA, Varga EV, et al. Progression of HCC in mice is associated with a downregulation in the expression of hepatocyte nuclear factors. Hepatology. 2004;39:1038–1047.
   PubMed Web of Science ®Google Scholar
• Chen W, Zheng R, Baade PD, et al. Cancer statistics in China, 2015. CA Cancer J Clin. 2016;66:115–132.
   PubMed Web of Science ®Google Scholar
• Bang H, Ha SY, Hwang SH, et al. Expression of PEG10 Is associated with poor survival and tumor recurrence in hepatocellular carcinoma. Cancer Res Treat. 2015;47:844–852.
   PubMedGoogle Scholar
• Wilson DM 3rd, Carney JP, Coleman MA, et al. Hex1: a new human Rad2 nuclease family member with homology to yeast exonuclease 1. Nucleic Acids Res. 1998;26:3762–3768.
   PubMed Web of Science ®Google Scholar
• Schmutte C, Marinescu RC, Sadoff MM, et al. Human exonuclease I interacts with the mismatch repair protein hMSH2. Cancer Res. 1998;58:4537–4542.
   PubMed Web of Science ®Google Scholar
• Keijzers G, Bohr VA, Rasmussen LJ. Human exonuclease 1 (EXO1) activity characterization and its function on flap structures. Biosci Rep. 2015;35(3).
   Web of Science ®Google Scholar
• Orans J, McSweeney EA, Iyer RR, et al. Structures of human exonuclease 1 DNA complexes suggest a unified mechanism for nuclease family. Cell. 2011;145:212–223.
   PubMed Web of Science ®Google Scholar
• Jager AC, Rasmussen M, Bisgaard HC, et al. HNPCC mutations in the human DNA mismatch repair gene hMLH1 influence assembly of hMutLalpha and hMLH1-hEXO1 complexes. Oncogene. 2001;20:3590–3595.
   PubMed Web of Science ®Google Scholar
• Schmutte C, Sadoff MM, Shim KS, et al. The interaction of DNA mismatch repair proteins with human exonuclease I. J Biol Chem. 2001;276:33011–33018.
   PubMed Web of Science ®Google Scholar
• Liberti SE, Andersen SD, Wang J, et al. Bi-directional routing of DNA mismatch repair protein human exonuclease 1 to replication foci and DNA double strand breaks. DNA Repair (Amst). 2011;10:73–86.
   PubMed Web of Science ®Google Scholar
• Chen ZY, Zheng SR, Zhong JH, et al. Association between three exonuclease 1 polymorphisms and cancer risks: a meta-analysis. Onco Targets Ther. 2016;9:899–910.
   PubMed Web of Science ®Google Scholar
• Szankasi P, Smith GR. A role for exonuclease I from S. pombe in mutation avoidance and mismatch correction. Science. 1995;267:1166–1169.
   PubMed Web of Science ®Google Scholar
• Morin I, Ngo HP, Greenall A, et al. Checkpoint-dependent phosphorylation of Exo1 modulates the DNA damage response. Embo J. 2008;27:2400–2410.
   PubMed Web of Science ®Google Scholar
• Tran PT, Erdeniz N, Symington LS, et al. EXO1-A multi-tasking eukaryotic nuclease. DNA Repair (Amst). 2004;3:1549–1559.
   PubMed Web of Science ®Google Scholar
• Bardwell PD, Woo CJ, Wei K, et al. Altered somatic hypermutation and reduced class-switch recombination in exonuclease 1-mutant mice. Nat Immunol. 2004;5:224–229.
   PubMed Web of Science ®Google Scholar
• Tang J, Tang S, Liu J, et al. Genetic risk of lung cancer associated with a single nucleotide polymorphism from EXO1: a meta analysis. Int J Clin Exp Med. 2015;8:11132–11138.
   PubMed Web of Science ®Google Scholar
• Jin G, Wang H, Hu Z, et al. Potentially functional polymorphisms of EXO1 and risk of lung cancer in a Chinese population: a case-control analysis. Lung Cancer. 2008;60:340–346.
   PubMed Web of Science ®Google Scholar
• Hsu NY, Wang HC, Wang CH, et al. Lung cancer susceptibility and genetic polymorphisms of Exo1 gene in Taiwan. Anticancer Res. 2009;29:725–730.
   PubMed Web of Science ®Google Scholar
• Bau DT, Wang HC, Liu CS, et al. Single-nucleotide polymorphism of the Exo1 gene: association with gastric cancer susceptibility and interaction with smoking in Taiwan. Chin J Physiol. 2009;52:411–418.
   PubMed Web of Science ®Google Scholar
• Luo X, Hong XS, Xiong XD, et al. A single nucleotide polymorphism in EXO1 gene is associated with cervical cancer susceptibility in Chinese patients. Int J Gynecol Cancer. 2012;22:220–225.
   PubMed Web of Science ®Google Scholar
• Wang HC, Chiu CF, Tsai RY, et al. Association of genetic polymorphisms of EXO1 gene with risk of breast cancer in Taiwan. Anticancer Res. 2009;29:3897–3901.
   PubMed Web of Science ®Google Scholar
• Tsai MH, Tseng HC, Liu CS, et al. Interaction of Exo1 genotypes and smoking habit in oral cancer in Taiwan. Oral Oncol. 2009;45:e90–4.
   PubMed Web of Science ®Google Scholar
• Kabzinski J, Przybylowska K, Mik M, et al. Association of polymorphism of Lys589Glu Exo1 gene with the risk of colorectal cancer in the Polish population. Pol Przegl Chir. 2014;86:370–373.
   PubMedGoogle Scholar
• Chang JS, Yeh RF, Wiencke JK, et al. Pathway analysis of single-nucleotide polymorphisms potentially associated with glioblastoma multiforme susceptibility using random forests. Cancer Epidemiol Biomarkers Prev. 2008;17:1368–1373.
   PubMed Web of Science ®Google Scholar
• Bayram S, Akkiz H, Bekar A, et al. The significance of Exonuclease 1 K589E polymorphism on hepatocellular carcinoma susceptibility in the Turkish population: a case-control study. Mol Biol Rep. 2012;39:5943–5951.
   PubMed Web of Science ®Google Scholar
• Duan F, Song C, Dai L, et al. The significance of Exo1 K589E polymorphism on cancer susceptibility: evidence based on a meta-analysis. PLoS One. 2014;9:e96764.
   PubMed Web of Science ®Google Scholar
• Bayram S, Akkiz H, Bekar A, et al. No association of the exonuclease 1 T439M polymorphism and risk of hepatocellular carcinoma development in the Turkish population: a case-control study. Asian Pac J Cancer Prev. 2011;12:2455–2460.
   PubMedGoogle Scholar
• Tan S, Qin R, Zhu X, et al. Associations between single-nucleotide polymorphisms of human exonuclease 1 and the risk of hepatocellular carcinoma. Oncotarget. 2016;7:87180–87193.
   PubMedGoogle Scholar
• Zhou J, Wang Y, Wang Y, et al. FOXM1 modulates cisplatin sensitivity by regulating EXO1 in ovarian cancer. PLoS One. 2014;9:e96989.
   PubMed Web of Science ®Google Scholar
• de Sousa JF, Torrieri R, Serafim RB, et al. Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients. Tumour Biol. 2017;39:1010428317694552.
   Google Scholar
• Chochi Y, Kawauchi S, Nakao M, et al. A copy number gain of the 6p arm is linked with advanced hepatocellular carcinoma: an array-based comparative genomic hybridization study. J Pathol. 2009;217:677–684.
   PubMed Web of Science ®Google Scholar
• Zhou C, Zhang W, Chen W, et al. Integrated analysis of copy number variations and gene expression profiling in hepatocellular carcinoma. Sci Rep. 2017;7:10570.
   PubMed Web of Science ®Google Scholar
• Colombo CV, Trovesi C, Menin L, et al. The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1. Nucleic Acids Res. 2017;45:6530–6545.
   PubMed Web of Science ®Google Scholar
• Bologna S, Altmannova V, Valtorta E, et al. Sumoylation regulates EXO1 stability and processing of DNA damage. Cell Cycle. 2015;14:2439–2450.
   PubMed Web of Science ®Google Scholar
• Dai CY, Lin CY, Tsai PC, et al. Impact of tumor size on the prognosis of hepatocellular carcinoma in patients who underwent liver resection. J Chin Med Assoc. 2018;81(2):155-163.
   Web of Science ®Google Scholar
• Anastasov N, Hofig I, Vasconcellos IG, et al. Radiation resistance due to high expression of miR-21 and G2/M checkpoint arrest in breast cancer cells. Radiat Oncol. 2012;7:206.
   PubMed Web of Science ®Google Scholar
• Verslype C, Rosmorduc O, Rougier P. Hepatocellular carcinoma: ESMO-ESDO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2012;23(Suppl 7):vii41–8.
   PubMed Web of Science ®Google Scholar
• Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001;25:402–408.
   PubMed Web of Science ®Google Scholar
• Sun KK, Zhong N, Yang Y, et al. Enhanced radiosensitivity of NSCLC cells by transducer of erbB2.1 (TOB1) through modulation of the MAPK/ERK pathway. Oncol Rep. 2013;29:2385–2391.
   PubMed Web of Science ®Google Scholar