Dephosphorylation of Plk1 occurs through PP2A-B55/ENSA/Greatwall pathway during mitotic DNA damage recovery

References

• Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer. 2003;3:155–168.
   PubMed Web of Science ®Google Scholar
• Zhou BB, Elledge SJ. The DNA damage response: putting checkpoints in perspective. Nature. 2000;408:433–439.
   PubMed Web of Science ®Google Scholar
• Aressy B, Ducommun B. Cell cycle control by the CDC25 phosphatases. Anticancer Agents Med Chem. 2008;8:818–824.
   PubMed Web of Science ®Google Scholar
• Boutros R, Dozier C, Ducommun B. The when and wheres of CDC25 phosphatases. Curr Opin Cell Biol. 2006;18:185–191.
   PubMed Web of Science ®Google Scholar
• Shechter D, Costanzo V, Gautier J. Regulation of DNA replication by ATR: signaling in response to DNA intermediates. DNA Repair (Amst). 2004;3:901–908.
   PubMed Web of Science ®Google Scholar
• Wong PY, Ma HT, Lee HJ, et al. MASTL(Greatwall) regulates DNA damage responses by coordinating mitotic entry after checkpoint recovery and APC/C activation. Sci Rep. 2016;6:22230.
   PubMed Web of Science ®Google Scholar
• Peng A, Yamamoto TM, Goldberg ML, et al. A novel role for greatwall kinase in recovery from DNA damage. Cell Cycle. 2010;9:4364–4369.
   PubMed Web of Science ®Google Scholar
• Glover DM. The overlooked greatwall: a new perspective on mitotic control. Open Biol. 2012;2:120023.
   PubMed Web of Science ®Google Scholar
• Virshup DM, Kaldis P. Cell biology. Enforcing the Greatwall in mitosis. Science. 2010;330:1638–1639.
   PubMed Web of Science ®Google Scholar
• Jang YJ, Ji JH, Choi YC, et al. Regulation of Polo-like kinase 1 by DNA damage in mitosis. Inhibition of mitotic PLK-1 by protein phosphatase 2A. J Biol Chem. 2007;282:2473–2482.
   PubMed Web of Science ®Google Scholar
• Hyun SY, Rosen EM, Jang YJ. Novel DNA damage checkpoint in mitosis: mitotic DNA damage induces re-replication without cell division in various cancer cells. Biochem Biophys Res Commun. 2012;423:593–599.
   PubMed Web of Science ®Google Scholar
• Hyun SY, Jang YJ. p53 activates G(1) checkpoint following DNA damage by doxorubicin during transient mitotic arrest. Oncotarget. 2015;6:4804–4815.
   PubMedGoogle Scholar
• Combes G, Alharbi I, Braga LG, et al. Playing polo during mitosis: PLK1 takes the lead. Oncogene. 2017;36:4819–4827.
   PubMed Web of Science ®Google Scholar
• Petronczki M, Lenart P, Peters JM. Polo on the Rise-from Mitotic Entry to Cytokinesis with Plk1. Dev Cell. 2008;14:646–659.
   PubMed Web of Science ®Google Scholar
• van Vugt MA, Gardino AK, Linding R, et al. A mitotic phosphorylation feedback network connects Cdk1, Plk1, 53BP1, and Chk2 to inactivate the G(2)/M DNA damage checkpoint. PLoS Biol. 2010;8:e1000287.
   PubMed Web of Science ®Google Scholar
• Yoo HY, Kumagai A, Shevchenko A, et al. Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell. 2004;117:575–588.
   PubMed Web of Science ®Google Scholar
• van Vugt MA, Bras A, Medema RH. Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol Cell. 2004;15:799–811.
   PubMed Web of Science ®Google Scholar
• van Vugt MA, Medema RH. Checkpoint adaptation and recovery: back with Polo after the break. Cell Cycle. 2004;3:1383–1386.
   PubMed Web of Science ®Google Scholar
• Lee HJ, Hwang HI, Jang YJ. Mitotic DNA damage response: polo-like kinase-1 is dephosphorylated through ATM-Chk1 pathway. Cell Cycle. 2010;9:2389–2398.
   PubMed Web of Science ®Google Scholar
• Chiyoda T, Sugiyama N, Shimizu T, et al. LATS1/WARTS phosphorylates MYPT1 to counteract PLK1 and regulate mammalian mitotic progression. J Cell Biol. 2012;197:625–641.
   PubMed Web of Science ®Google Scholar
• So S, Davis AJ, Chen DJ. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J Cell Biol. 2009;187:977–990.
   PubMed Web of Science ®Google Scholar
• Kastan MB, Lim DS. The many substrates and functions of ATM. Nat Rev Mol Cell Biol. 2000;1:179–186.
   PubMed Web of Science ®Google Scholar
• Zhao H, Piwnica-Worms H. ATR-mediated checkpoint pathways regulate phosphorylation and activation of human Chk1. Mol Cell Biol. 2001;21:4129–4139.
   PubMed Web of Science ®Google Scholar
• Burgess A, Vigneron S, Brioudes E, et al. Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance. Proc Natl Acad Sci U S A. 2010;107:12564–12569.
   PubMed Web of Science ®Google Scholar
• Vigneron S, Brioudes E, Burgess A, et al. Greatwall maintains mitosis through regulation of PP2A. Embo J. 2009;28:2786–2793.
   PubMed Web of Science ®Google Scholar
• Yu J, Zhao Y, Li Z, et al. Greatwall kinase participates in the Cdc2 autoregulatory loop in Xenopus egg extracts. Mol Cell. 2006;22:83–91.
   PubMed Web of Science ®Google Scholar
• Janssens V, Goris J. Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J. 2001;353:417–439.
   PubMed Web of Science ®Google Scholar
• Wlodarchak N, Xing Y. PP2A as a master regulator of the cell cycle. Crit Rev Biochem Mol Biol. 2016;51:162–184.
   PubMed Web of Science ®Google Scholar
• Wang F, Zhu S, Fisher LA, et al. Protein interactomes of protein phosphatase 2A B55 regulatory subunits reveal B55-mediated regulation of replication protein A under replication stress. Sci Rep. 2018;8:2683.
   PubMed Web of Science ®Google Scholar
• Mochida S, Maslen SL, Skehel M, et al. Greatwall phosphorylates an inhibitor of protein phosphatase 2A that is essential for mitosis. Science. 2010;330:1670–1673.
   PubMed Web of Science ®Google Scholar
• Blake-Hodek KA, Williams BC, Zhao Y, et al. Determinants for activation of the atypical AGC kinase Greatwall during M phase entry. Mol Cell Biol. 2012;32:1337–1353.
   PubMed Web of Science ®Google Scholar
• Lorca T, Castro A. The Greatwall kinase: a new pathway in the control of the cell cycle. Oncogene. 2013;32:537–543.
   PubMed Web of Science ®Google Scholar
• Gharbi-Ayachi A, Labbe JC, Burgess A, et al. The substrate of Greatwall kinase, Arpp19, controls mitosis by inhibiting protein phosphatase 2A. Science. 2010;330:1673–1677.
   PubMed Web of Science ®Google Scholar
• Rangone H, Wegel E, Gatt MK, et al. Suppression of scant identifies Endos as a substrate of greatwall kinase and a negative regulator of protein phosphatase 2A in mitosis. PLoS Genet. 2011;7:e1002225.
   PubMed Web of Science ®Google Scholar
• Ma S, Vigneron S, Robert P, et al. Greatwall dephosphorylation and inactivation upon mitotic exit is triggered by PP1. J Cell Sci. 2016;129:1329–1339.
   PubMed Web of Science ®Google Scholar
• Vigneron S, Gharbi-Ayachi A, Raymond AA, et al. Characterization of the mechanisms controlling Greatwall activity. Mol Cell Biol. 2011;31:2262–2275.
   PubMed Web of Science ®Google Scholar
• Manchado E, Guillamot M, de Carcer G, et al. Targeting mitotic exit leads to tumor regression in vivo: modulation by Cdk1, Mastl, and the PP2A/B55alpha,delta phosphatase. Cancer Cell. 2010;18:641–654.
   PubMed Web of Science ®Google Scholar
• Hegarat N, Vesely C, Vinod PK, et al. PP2A/B55 and Fcp1 regulate Greatwall and Ensa dephosphorylation during mitotic exit. PLoS Genet. 2014;10:e1004004.
   PubMed Web of Science ®Google Scholar
• Lorca T, Bernis C, Vigneron S, et al. Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle. J Cell Sci. 2010;123:2281–2291.
   PubMed Web of Science ®Google Scholar
• Furnari B, Rhind N, Russell P. Cdc25 mitotic inducer targeted by chk1 DNA damage checkpoint kinase. Science. 1997;277:1495–1497.
   PubMed Web of Science ®Google Scholar
• Chen MS, Ryan CE, Piwnica-Worms H. Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding. Mol Cell Biol. 2003;23:7488–7497.
   PubMed Web of Science ®Google Scholar
• Lee J, Kumagai A, Dunphy WG. Positive regulation of Wee1 by Chk1 and 14-3-3 proteins. Mol Biol Cell. 2001;12:551–563.
   PubMed Web of Science ®Google Scholar