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Research Paper

Suppression of store-operated Ca2+ entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion

, , , , , & ORCID Icon show all
Pages 3468-3479 | Received 24 Dec 2019, Accepted 25 Oct 2020, Published online: 03 Dec 2020

References

  • Chen R, Smith-Cohn M, Cohen AL, et al. Glioma subclassifications and their clinical significance. Neurotherapeutics. 2017;14:284–297.
  • Heiss W-D. Contribution of PET imaging to clinical management of gliomas. OBM Neurobiol. 2018;2: 1–1.
  • Wirsching HG, Galanis E, Weller M. Glioblastoma. In: Handbook of clinical neurology. Vol. 134; 2016. p. 381–397.
  • Batash R, Asna N, Schaffer P, et al. Glioblastoma multiforme, diagnosis and treatment; Recent literature review. Curr Med Chem. 2017;24:3002–3009.
  • Le AP, Huang Y, Pingle SC, et al. Plexin-B2 promotes invasive growth of malignant glioma. Oncotarget. 2015;6:7293–7304.
  • Prayson RA. Angiocentric glioma: a review of clinicopathologic features. OBM Neurobiol. 2018;2. DOI:10.21926/obm.neurobiol.1804015
  • Berrier AL, Yamada KM. Cell-matrix adhesion. J Cell Physiol. 2007;213:565–573.
  • Berridge MJ, Bootman MD, Roderick HL. Calcium signalling: dynamics, homeostasis and remodelling. Nat Rev Mol Cell Biol. 2003;4:517–529.
  • Putney JW, Steinckwich-Besancon N, Numaga-Tomita T, et al. The functions of store-operated calcium channels. Biochim Biophys Acta Mol Cell Res. 2017;1864:900–906.
  • Xie J, Pan H, Yao J, et al. SOCE and cancer: recent progress and new perspectives. Int J Cancer. 2016;138:2067–2077.
  • Liu H, Hughes JD, Rollins S, et al. Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis. Exp Mol Pathol. 2011;91:753–760.
  • Ambudkar IS, de Souza LB, Ong HL. TRPC1, Orai1, and STIM1 in SOCE: friends in tight spaces. Cell Calcium. 2017;63:33–39.
  • Lacruz RS, Feske S. Diseases caused by mutations in ORAI1 and STIM1. Ann N Y Acad Sci. 2015;1356:45–79.
  • Jha A, The MS. CAR that drives Ca2+ to Orai1. Sci Signal. 2016;9:fs5.
  • Karacicek B, Erac Y, Tosun M. Functional consequences of enhanced expression of STIM1 and Orai1 in Huh-7 hepatocellular carcinoma tumor-initiating cells. BMC Cancer. 2019;19:751.
  • Yang S, Zhang JJ, Huang XY. Orai1 and STIM1 are critical for breast tumor cell migration and metastasis. Cancer Cell. 2009;15:124–134.
  • Merritt JE, Armstrong WP, Benham CD, et al. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem J. 1990;271:515–522.
  • Zhang J, Wei J, He Q, et al. SKF95365 induces apoptosis and cell-cycle arrest by disturbing oncogenic Ca(2+) signaling in nasopharyngeal carcinoma cells. Onco Targets Ther. 2015;8:3123–3133.
  • Tanahashi Y, Wang B, Murakami Y, et al. Inhibitory effects of SKF96365 on the activities of K(+) channels in mouse small intestinal smooth muscle cells. J Vet Med Sci. 2016;78:203–211.
  • Cai R, Ding X, Zhou K, et al. Blockade of TRPC6 channels induced G2/M phase arrest and suppressed growth in human gastric cancer cells. Int J Cancer. 2009;125:2281–2287.
  • Zhu M, Chen L, Zhao P, et al. Store-operated Ca(2+) entry regulates glioma cell migration and invasion via modulation of Pyk2 phosphorylation. J Exp Clin Cancer Res. 2014;33:98.
  • Singh A, Hildebrand ME, Garcia E, et al. The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels. Br J Pharmacol. 2010;160:1464–1475.
  • Jiang Y, Zhou J, Luo P, et al. Prosaposin promotes the proliferation and tumorigenesis of glioma through toll-like receptor 4 (TLR4)-mediated NF-κB signaling pathway. EBioMedicine. 2018;37:78–90.
  • Lee JV, Berry CT, Kim K, et al. Acetyl-CoA promotes glioblastoma cell adhesion and migration through Ca(2+)-NFAT signaling. Genes Dev. 2018;32:497–511.
  • Liu X, Zhao P, Wang X, et al. Celastrol mediates autophagy and apoptosis via the ROS/JNK and Akt/mTOR signaling pathways in glioma cells. J Exp Clin Cancer Res. 2019;38:184.
  • Chistiakov DA, Chekhonin VP. Circulating tumor cells and their advances to promote cancer metastasis and relapse, with focus on glioblastoma multiforme. Exp Mol Pathol. 2018;105:166–174.
  • Mo P, Yang S. The store-operated calcium channels in cancer metastasis: from cell migration, invasion to metastatic colonization. Front Biosci (Landmark Ed). 2018;23:1241–1256.
  • Zhou Y, Cai X, Nwokonko RM, et al. The STIM-Orai coupling interface and gating of the Orai1 channel. Cell Calcium. 2017;63:8–13.
  • Cui C, Chang Y, Zhang X, et al. Targeting Orai1-mediated store-operated calcium entry by RP4010 for anti-tumor activity in esophagus squamous cell carcinoma. Cancer Lett. 2018;432:169–179.
  • Choi S, Cui C, Luo Y, et al. Selective inhibitory effects of zinc on cell proliferation in esophageal squamous cell carcinoma through Orai1. Faseb J. 2018;32:404–416.
  • Barajas M, Andrade A, Hernandez-Hernandez O, et al. Histamine-induced Ca2+ entry in human astrocytoma U373 MG cells: evidence for involvement of store-operated channels. J Neurosci Res. 2008;86:3456–3468.
  • Motiani RK, Hyzinski-Garcia MC, Zhang X, et al. STIM1 and Orai1 mediate CRAC channel activity and are essential for human glioblastoma invasion. Pflugers Arch. 2013;465:1249–1260.
  • Franzius D, Hoth M, Penner R. Non-specific effects of calcium entry antagonists in mast cells. Pflugers Arch. 1994;428:433–438.
  • Derler I, Fritsch R, Schindl R, et al. CRAC inhibitors: identification and potential. Expert Opin Drug Discov. 2008;3:787–800.
  • Schwarz G, Droogmans G, Nilius B. Multiple effects of SK&F 96365 on ionic currents and intracellular calcium in human endothelial cells. Cell Calcium. 1994;15:45–54.
  • Liu X, Wang T, Wang Y, et al. Orai1 is critical for notch-driven aggressiveness under hypoxic conditions in triple-negative breast cancers. Biochimica Et Biophysica Acta Mol Basis Dis. 2018;1864:975–986.
  • Wang JY, Sun J, Huang MY, et al. STIM1 overexpression promotes colorectal cancer progression, cell motility and COX-2 expression. Oncogene. 2015;34:4358–4367.
  • Hu J, Qin K, Zhang Y, et al. Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. Biochem Biophys Res Commun. 2011;411:786–791.
  • Davis FM, Azimi I, Faville RA, et al. Induction of epithelial-mesenchymal transition (EMT) in breast cancer cells is calcium signal dependent. Oncogene. 2014;33:2307–2316.
  • Mittal V. Epithelial mesenchymal transition in tumor metastasis. Annu Rev Pathol. 2018;13:395–412.
  • Oh SJ, Ahn EJ, Kim O, et al. The Role played by SLUG, an epithelial-mesenchymal transition factor, in invasion and therapeutic resistance of malignant glioma. Cell Mol Neurobiol. 2019;39:769–782.
  • Wolf K, Mazo I, Leung H, et al. Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol. 2003;160:267–277.
  • Torigoe G, Nagao M, Tanabe N, et al. PYK2 mediates BzATP-induced extracellular matrix proteins synthesis. Biochem Biophys Res Commun. 2017;494:663–667.
  • Xu CS, Wang ZF, Dai LM, et al. Induction of proline-rich tyrosine kinase 2 activation-mediated C6 glioma cell invasion after anti-vascular endothelial growth factor therapy. J Transl Med. 2014;12:148.
  • Chen YF, Chiu WT, Chen YT, et al. Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. Proc Natl Acad Sci U S A. 2011;108:15225–15230.

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