Advanced search
Publication Cover
Cell Cycle Volume 21, 2022 - Issue 11
Submit an article Journal homepage
634
Views
2
CrossRef citations to date
0
Altmetric
Research Paper

Compound cellular stress maximizes apoptosis independently of p53 in glioblastoma

Cheng-Jung Hoa Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;b Graduate Institute of Clinical Medicine, Kaohsiung Medical University,Kaohsiung, TaiwanView further author information
,
Cheng-Yu Tsaic Post Baccalaureate Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;d Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanView further author information
,
Wei-Hua Zhue Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, TaiwanView further author information
,
Yu-Hsuan Paoe Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, TaiwanView further author information
,
Hsin-Wen Chene Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, TaiwanView further author information
,
Chieh-Ju Hue Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, TaiwanView further author information
,
Yi-Lin Leee Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, TaiwanView further author information
,
Tzu-Shuo Huange Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, TaiwanView further author information
,
Chung-Hwan Chena Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanView further author information
,
Joon-Khim Lohd Department of Neurosurgery, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanView further author information
,
Yi-Ren Hongf Department of Biochemistry & Graduate Institute of Medicine, Kaohsiung Medical University, Kaohsiung, TaiwanView further author information
&
Chihuei Wange Department of Biotechnology, Kaohsiung Medical University, Kaohsiung, Taiwan;g Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung, TaiwanCorrespondence[email protected]
[email protected]
[email protected]
View further author information
 show all
Pages 1153-1165 | Received 19 May 2021, Accepted 08 Feb 2022, Published online: 20 Mar 2022

References

  • Vazquez A, Bond EE, Levine AJ, et al. The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov. 2008;7(12):979–987.
  • Lavin MF, Gueven N. The complexity of p53 stabilization and activation. Cell Death Differ. 2006;13(6):941–950.
  • Kastenhuber ER, Lowe SW. Putting p53 in context. Cell. 2017;170(6):1062–1078.
  • Brady CA, Attardi LD. p53 at a glance. J Cell Sci. 2010;123(Pt 15):2527–2532.
  • Vousden KH, Lu X. Live or let die: the cell’s response to p53. Nat Rev. 2002;2(8):594–604.
  • Fischer M. Census and evaluation of p53 target genes. Oncogene. 2017;36(28):3943–3956.
  • Murray-Zmijewski F, Slee EA, Lu X. A complex barcode underlies the heterogeneous response of p53 to stress. Nat Rev Mol Cell Biol. 2008;9(9):702–712.
  • Kaeser MD, Iggo RD. Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo. Proc Natl Acad Sci U S A. 2002;99(1):95–100.
  • Szak ST, Mays D, Pietenpol JA. Kinetics of p53 binding to promoter sites in vivo. Mol Cell Biol. 2001;21(10):3375–3386.
  • Robinson M, Jiang P, Cui J, et al. Global genechip profiling to identify genes responsive to p53-induced growth arrest and apoptosis in human lung carcinoma cells. Cancer Biol Ther. 2003;2(4):406–415.
  • Zhao R, Gish K, Murphy M, et al. Analysis of p53-regulated gene expression patterns using oligonucleotide arrays. Genes Dev. 2000;14(8):981–993.
  • Dey P, Strom A, Gustafsson JA. Estrogen receptor beta upregulates FOXO3a and causes induction of apoptosis through PUMA in prostate cancer. Oncogene. 2014;33(33):4213–4225.
  • Yang MC, Lin RW, Huang SB, et al. Bim directly antagonizes Bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53. Cell Cycle. (Georgetown, TX) 2016;15(3):394–402.
  • Lin RW, Ho CJ, Chen HW, et al. P53 enhances apoptosis induced by doxorubicin only under conditions of severe DNA damage. Cell Cycle. 2018;17(17):2175–2186.
  • Paramore A, Frantz S. Bortezomib. Nat Rev Drug Discov. 2003;2(8):611–612.
  • Curran MP, McKeage K. Bortezomib: a review of its use in patients with multiple myeloma. Drugs. 2009;69(7):859–888.
  • Groll M, Berkers CR, Ploegh HL, et al. Crystal structure of the boronic acid-based proteasome inhibitor bortezomib in complex with the yeast 20S proteasome. Structure. 2006;14(3):451–456.
  • Nunes AT, Annunziata CM. Proteasome inhibitors: structure and function. Semin Oncol. 2017;44(6):377–380.
  • Rashid F, Niklison-Chirou MV. Proteasome inhibition-a new target for brain tumours. Cell Death Discov. 2019;5(1):147.
  • Marks PA, Breslow R. Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug. Nat Biotechnol. 2007;25(1):84–90.
  • Grant S, Easley C, Kirkpatrick P. Vorinostat. Nat Rev Drug Discov. 2007;6(1):21–22.
  • Mann BS, Johnson JR, Cohen MH, et al. FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist. 2007;12(10):1247–1252.
  • Bolden JE, Peart MJ, Johnstone RW. Anticancer activities of histone deacetylase inhibitors. Nat Rev Drug Discov. 2006;5(9):769–784.
  • Hirose Y, Berger MS, Pieper RO. p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells. Cancer Res. 2001;61(5):1957–1963.
  • Van Meir EG, Kikuchi T, Tada M, et al. Analysis of the p53 gene and its expression in human glioblastoma cells. Cancer Res. 1994;54(3):649–652.
  • Ho CJ, Lin RW, Zhu WH, et al. Transcription-independent and -dependent p53-mediated apoptosis in response to genotoxic and non-genotoxic stress. Cell Death Discov. 2019;5(1):131.
  • Ho CJ, Ko HJ, Liao TS, et al. Severe cellular stress activates apoptosis independently of p53 in osteosarcoma. Cell Death Discov. 2021;7(1):275.
  • Matkar SS, Wrischnik LA, Hellmann-Blumberg U. Sanguinarine causes DNA damage and p53-independent cell death in human colon cancer cell lines. Chem Biol Interact. 2008;172(1):63–71.
  • Aladjem MI, Spike BT, Rodewald LW, et al. ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage. Curr Biol. 1998;8(3):145–155.
  • Speidel D. Transcription-independent p53 apoptosis: an alternative route to death. Trends Cell Biol. 2010;20(1):14–24.
  • Castrogiovanni C, Waterschoot B, De Backer O, et al. Serine 392 phosphorylation modulates p53 mitochondrial translocation and transcription-independent apoptosis. Cell Death Differ. 2018;25(1):190–203.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.