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Research Paper

Cyclophilin a represses reactive oxygen species generation and death of hypoxic non-small-cell lung cancer cells by degrading thioredoxin-interacting protein

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Pages 1996-2007 | Received 11 Oct 2021, Accepted 06 May 2022, Published online: 30 May 2022

References

  • DeSantis CE, Miller KD, Dale W, et al. Cancer statistics for adults aged 85 years and older, 2019. CA Cancer J Clin. 2019;69(6):452–467.
  • Cheviron Z, Brumfield R. Genomic insights into adaptation to high-altitude environments. Heredity (Edinb). 2012;108(4):354–361.
  • Chen A, Sceneay J, Gödde N, et al. Intermittent hypoxia induces a metastatic phenotype in breast cancer. Oncogene. 2018;37(31):4214–4225.
  • Ung L, Pattamatta U, Carnt N, et al. Oxidative stress and reactive oxygen species: a review of their role in ocular disease. Clin Sci. 2017;131(24):2865–2883.
  • Bernatoniene J, Kopustinskiene DM. The role of catechins in cellular responses to oxidative stress. Molecules. 2018;23(4):965.
  • Gorrini C, Harris IS, Mak TW. Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 2013 December 01;12(12):931–947.
  • Guo Q, Li F, Duan Y, et al. Oxidative stress, nutritional antioxidants and beyond. Sci China Life Sci. 2020;63(6):866–874.
  • Nigro P, Pompilio G, Capogrossi M. Cyclophilin A: a key player for human disease. Cell Death Dis. 2013;4(10):e888–e888.
  • Kim H, Oh Y, Kim K, et al. Cyclophilin A regulates JNK/p38-MAPK signaling through its physical interaction with ASK1. Biochem Biophys Res Commun. 2015;464(1):112–117.
  • Hsu H-M, Huang Y-H, Aryal S, et al. Endomembrane protein trafficking regulated by a Tv CyP2 Cyclophilin in the Protozoan Parasite, Trichomonas vaginalis. Sci Rep. 2020;10(1):1–18.
  • Doti N, Reuther C, Scognamiglio P, et al. Inhibition of the AIF/CypA complex protects against intrinsic death pathways induced by oxidative stress. Cell Death Dis. 2014;5(1):e993–e993.
  • Ge Q, Tang Y, Luo W, et al. A cyclophilin OsCYP20–2 Interacts with OsSYF2 to regulate Grain Length by Pre-mRNA splicing. Rice. 2020;13(1):1–10.
  • Luan X, Yang W, Bai X, et al. Cyclophilin A is a key positive and negative feedback regulator within interleukin‐6 trans‐signaling pathway. FASEB J. 2021;35(11):e21958.
  • Guo Y, Jiang M, Zhao X, et al. Cyclophilin A promotes non‐small cell lung cancer metastasis via p38 MAPK. Thorac Cancer. 2018;9(1):120–128.
  • Cheng F, Yuan W, Cao M, et al. Cyclophilin A protects cardiomyocytes against hypoxia/reoxygenation-induced apoptosis via the AKT/Nox2 pathway. Oxid Med Cell Longev. 2019;2019:1–11.
  • Tang F-C, Wang H-Y, Ma -M-M, et al. CyPA-CD147-ERK1/2-cyclin D2 signaling pathway is upregulated during rat left ventricular hypertrophy. Sheng li xue bao:[Acta physiologica Sinica].2015;67(4):393–400.
  • Cao M, Yuan W, Peng M, et al. Role of CyPA in cardiac hypertrophy and remodeling. Biosci Rep. 2019;39(12). 10.1042/BSR20193190.
  • Tanaka Y, Sato Y, Sasaki T. Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B. J Gen Virol. 2017;98(2):190.
  • Kim CH, Ko AR, Lee SY, et al. Hypoxia switches glucose depletion-induced necrosis to phosphoinositide 3-kinase/Akt-dependent apoptosis in A549 lung adenocarcinoma cells. Int J Oncol. 2010 Jan;36(1):117–124.
  • Li Y, Miao LY, Xiao YL, et al. Hypoxia induced high expression of thioredoxin interacting protein (TXNIP) in non-small cell lung cancer and its prognostic effect. Asian Pac J Cancer Prev. 2015;16(7):2953–2958.
  • Zhang C, Wang H, Liu X, et al. Oncogenic microRNA-411 promotes lung carcinogenesis by directly targeting suppressor genes SPRY4 and TXNIP. Oncogene. 2019 Mar;38(11):1892–1904.
  • Brahmer JR, Tykodi SS, Chow LQ, et al. Safety and activity of anti–PD-L1 antibody in patients with advanced cancer. N Engl J Med. 2012;366(26):2455–2465.
  • Topalian SL, Hodi FS, Brahmer JR, et al. Safety, activity, and immune correlates of anti–PD-1 antibody in cancer. N Engl J Med. 2012;366(26):2443–2454.
  • Chu MY, Huang HC, Li EM, et al. CypA: a Potential Target of Tumor Radiotherapy and/or Chemotherapy. Curr Med Chem. 2021;28(19):3787–3802.
  • Liao Y, Luo D, Peng K, et al. Cyclophilin A: a key player for etiological agent infection. Appl Microbiol Biotechnol. 2021 Feb;105(4):1365–1377.
  • Cong L, Bai Z, Du Y, et al. Citron Rho-Interacting serine/threonine kinase promotes HIF1a-CypA signaling and growth of human pancreatic adenocarcinoma. Biomed Res Int. 2020;2020:9210891.
  • Zhang M, Dai C, Zhu H, et al. Cyclophilin A promotes human hepatocellular carcinoma cell metastasis via regulation of MMP3 and MMP9. Mol Cell Biochem. 2011;357(1):387–395.
  • Davra V, Saleh T, Geng K, et al. Cyclophilin A inhibitor Debio-025 targets Crk, reduces metastasis, and induces tumor immunogenicity in breast cancer. Mol Cancer Res. 2020;18(8):1189–1201.
  • Zhang H, Chen J, Liu F, et al. CypA, a gene downstream of HIF-1α, promotes the development of PDAC. PLoS One. 2014;9(3):e92824.
  • Ma Z, Zhang W, Wu Y, et al. Cyclophilin A inhibits A549 cell oxidative stress and apoptosis by modulating the PI3K/Akt/mTOR signaling pathway. Biosci Rep. 2021 Jan 29;41(1). 10.1042/BSR20203219.
  • Yoshioka J, Chutkow WA, Lee S, et al. Deletion of thioredoxin-interacting protein in mice impairs mitochondrial function but protects the myocardium from ischemia-reperfusion injury. J Clin Invest. 2012;122(1):267–279.
  • Zhou J, Chng W-J. Roles of thioredoxin binding protein (TXNIP) in oxidative stress, apoptosis and cancer. Mitochondrion. 2013;13(3):163–169.
  • Polekhina G, Ascher DB, Kok SF, et al. Structure of the N-terminal domain of human thioredoxin-interacting protein. Acta Crystallogr Sect D Biol Crystallog. 2013;69(3):333–344.
  • Yoshihara E. TXNIP/TBP-2: a master regulator for glucose homeostasis. Antioxidants. 2020;9(8):765.
  • Qayyum N, Haseeb M, Kim MS, et al. Role of thioredoxin-interacting protein in diseases and its therapeutic outlook. Int J Mol Sci. 2021 Mar 9 22(5):2754.
  • Karar J, Dolt KS, Mishra MK, et al. Expression and functional activity of pro-oxidants and antioxidants in murine heart exposed to acute hypobaric hypoxia. FEBS Lett. 2007;581(24):4577–4582.
  • Li Y, Miao L-Y, Xiao Y-L, et al. Hypoxia induced high expression of thioredoxin interacting protein (TXNIP) in non-small cell lung cancer and its prognostic effect. Asian Pac J Cancer Prev. 2015;16(7):2953–2958.
  • Zhang P, Wang C, Gao K, et al. The ubiquitin ligase itch regulates apoptosis by targeting thioredoxin-interacting protein for ubiquitin-dependent degradation. J Biol Chem. 2010;285(12):8869–8879.

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