LncRNA MINCR attenuates osteoarthritis progression via sponging miR-146a-5p to promote BMPR2 expression

References

• Nelson AE. Osteoarthritis year in review 2017: clinical. Osteoarthritis Cartilage. 2018;26(3):319–325.
   PubMed Web of Science ®Google Scholar
• Abramoff B, Caldera FE. Osteoarthritis: pathology, diagnosis, and treatment options. Med Clin North Am. 2020;104(2):293–311.
   PubMed Web of Science ®Google Scholar
• Griffin TM, Scanzello CR. Innate inflammation and synovial macrophages in osteoarthritis pathophysiology. Clin Exp Rheumatol. 2019;37 Suppl 120(5):57–63.
   PubMed Web of Science ®Google Scholar
• Xu X, Li X, Liang Y, et al. Estrogen modulates cartilage and subchondral bone remodeling in an ovariectomized rat model of postmenopausal osteoarthritis. Med Sci Monit. 2019;25:3146–3153.
   PubMed Web of Science ®Google Scholar
• Glyn-Jones S, J R Palmer A, Agricola R, et al. Osteoarthritis. Lancet. 2015;386(9991): 376–387
   PubMed Web of Science ®Google Scholar
• Luo P, Jiang C, Ji P, et al. Exosomes of stem cells from human exfoliated deciduous teeth as an anti-inflammatory agent in temporomandibular joint chondrocytes via miR-100-5p/mTOR. Stem Cell Res Ther. 2019;10(1):216.
   PubMedGoogle Scholar
• Kapoor M, Martel-Pelletier J, Lajeunesse D, et al. Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol. 2011;7(1):33–42.
   PubMed Web of Science ®Google Scholar
• Moussa M, Lajeunesse D, Hilal G, et al. Platelet rich plasma (PRP) induces chondroprotection via increasing autophagy, anti-inflammatory markers, and decreasing apoptosis in human osteoarthritic cartilage. Exp Cell Res. 2017;352(1):146–156.
   PubMed Web of Science ®Google Scholar
• Zhang X, Hamblin MH, Yin KJ. The long noncoding RNA Malat1: its physiological and pathophysiological functions. RNA Biol. 2017;14(12):1705–1714.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Wang F, Chen G, et al. LncRNA MALAT1 promotes osteoarthritis by modulating miR-150-5p/AKT3 axis. Cell Biosci. 2019;9(1):54.
   PubMedGoogle Scholar
• Jiang M, Liu J, Luo T, et al. LncRNA PACER is down-regulated in osteoarthritis and regulates chondrocyte apoptosis and lncRNA HOTAIR expression. Biosci Rep. 2019;39(6). DOI:10.1042/BSR20190404.
   Google Scholar
• Huang T, Wang J, Zhou Y, et al. LncRNA CASC2 is up-regulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis. Biosci Rep. 2019;39(5). DOI:10.1042/BSR20182454.
   Google Scholar
• Shan Y, Ma J, Pan Y, et al. LncRNA SNHG7 sponges miR-216b to promote proliferation and liver metastasis of colorectal cancer through upregulating GALNT1. Cell Death Dis. 2018;9(7):722.
   PubMed Web of Science ®Google Scholar
• Tian F, Junhu W, Zhanhua Z, et al. LncRNA SNHG7/miR-34a-5p/SYVN1 axis plays a vital role in proliferation, apoptosis and autophagy in osteoarthritis. Biol Res. 2020;53(1):9.
   PubMed Web of Science ®Google Scholar
• Liu J, Yao L, Zhang M, et al. Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death. Aging (Albany NY). 2019;11(18):7830–7846.
   PubMedGoogle Scholar
• Wang T, Liu Y, Wang Y, et al. Long non-coding RNA XIST promotes extracellular matrix degradation by functioning as a competing endogenous RNA of miR-1277-5p in osteoarthritis. Int J Mol Med. 2019;44(2):630–642.
   PubMed Web of Science ®Google Scholar
• Zhong Q, Chen Y, Chen Z. LncRNA MINCR regulates irradiation resistance in nasopharyngeal carcinoma cells via the microRNA-223/ZEB1 axis. Cell Cycle. 2020;19(1):53–66.
   PubMed Web of Science ®Google Scholar
• Lyu Q, Jin L, Yang X, et al. LncRNA MINCR activates Wnt/β-catenin signals to promote cell proliferation and migration in oral squamous cell carcinoma. Pathol Res Pract. 2019;215(5):924–930.
   PubMedGoogle Scholar
• Cao J, Zhang D, Zeng L, et al. Long noncoding RNA MINCR regulates cellular proliferation, migration, and invasion in hepatocellular carcinoma. Biomed Pharmacother. 2018;102:102–106.
   PubMedGoogle Scholar
• Wang J, Ding M, Zhu H, et al. Up-regulation of long noncoding RNA MINCR promotes non-small cell of lung cancer growth by negatively regulating miR-126/SLC7A5 axis. Biochem Biophys Res Commun. 2019;508(3):780–784.
   PubMedGoogle Scholar
• Mohr AM, Mott JL. Overview of microRNA biology. Semin Liver Dis. 2015;35(1):3–11.
   PubMed Web of Science ®Google Scholar
• Wieczorek E, Reszka E. mRNA, microRNA and lncRNA as novel bladder tumor markers. Clin Chim Acta. 2018;477:141–153.
   PubMed Web of Science ®Google Scholar
• Skrzypa M, Szala D, Gablo N, et al. miRNA-146a-5p is upregulated in serum and cartilage samples of patients with osteoarthritis. Pol Przegl Chir. 2019;91(3):1–5.
   PubMedGoogle Scholar
• Sun T, Li X, Song H, et al. MiR-146a aggravates LPS-induced inflammatory injury by targeting CXCR4 in the articular chondrocytes. Cell Physiol Biochem. 2017;44(4):1282–1294.
   PubMedGoogle Scholar
• Zhang X, Wang C, Zhao J, et al. miR-146a facilitates osteoarthritis by regulating cartilage homeostasis via targeting Camk2d and Ppp3r2. Cell Death Dis. 2017;8(4):e2734.
   PubMedGoogle Scholar
• Schmal H, Mehlhorn AT, Pilz IH, et al. Immunohistological localization of BMP-2, BMP-7, and their receptors in knee joints with focal cartilage lesions. ScientificWorldJournal. 2012;2012:467892.
   PubMedGoogle Scholar
• Chen D, Zhao M, Mundy GR. Bone morphogenetic proteins. Growth Factors. 2004;22(4):233–241.
   PubMed Web of Science ®Google Scholar
• Yang Z, Li R, Ao J, et al. miR-1307-3p suppresses the chondrogenic differentiation of human adipose-derived stem cells by targeting BMPR2. Int J Mol Med. 2018;42(6):3115–3124.
   PubMedGoogle Scholar
• Xiao Y, Yan X, Yang Y, et al. Downregulation of long noncoding RNA HOTAIRM1 variant 1 contributes to osteoarthritis via regulating miR-125b/BMPR2 axis and activating JNK/MAPK/ERK pathway. Biomed Pharmacother. 2019;109:1569–1577.
   PubMed Web of Science ®Google Scholar
• Lin C, Liangliang L, Chun Z, et al. Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12. Bone Res. 2019;7(1):5.
   PubMedGoogle Scholar
• Glasson SS, Chambers MG, Van Den Berg WB, et al. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the mouse. Osteoarthritis Cartilage. 2010;18(3):S17–23.
   PubMedGoogle Scholar
• Hu J, Jinyi Z, Jinting W, et al. Loganin ameliorates cartilage degeneration and osteoarthritis development in an osteoarthritis mouse model through inhibition of NF-κB activity and pyroptosis in chondrocytes. J Ethnopharmacol. 2020;247:112261.
   PubMed Web of Science ®Google Scholar
• Hayami T, Pickarski M, Zhuo Y, et al. Characterization of articular cartilage and subchondral bone changes in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis. Bone. 2006;38(2):234–243.
   PubMed Web of Science ®Google Scholar
• Barnett R. Osteoarthritis. Lancet. 2018;391(10134):1985.
   PubMedGoogle Scholar
• Wang J, Zhu S, Meng N, et al. ncRNA-encoded peptides or proteins and cancer. Mol Ther. 2019;27(10):1718–1725.
   PubMed Web of Science ®Google Scholar
• Chen K, Hao Z, Min-Qian Z, et al. LncRNA MEG3 inhibits the degradation of the extracellular matrix of chondrocytes in osteoarthritis via targeting miR-93/TGFBR2 axis. Cartilage. 2019;13:1947603519855759.
   Google Scholar
• He B, Jiang D. HOTAIR-induced apoptosis is mediated by sponging miR-130a-3p to repress chondrocyte autophagy in knee osteoarthritis. Cell Biol Int. 2020;44(2):524–535.
   PubMedGoogle Scholar
• Zheng J, Li Q. Methylene blue regulates inflammatory response in osteoarthritis by noncoding long chain RNA CILinc02. J Cell Biochem. 2019;120(3):3331–3338.
   PubMedGoogle Scholar
• Wang SH, Yang Y, Wu X-C, et al. Long non-coding RNA MINCR promotes gallbladder cancer progression through stimulating EZH2 expression. Cancer Lett. 2016;380(1):122–133.
   PubMed Web of Science ®Google Scholar
• Jin XL, Lian JR, Guan YH. Overexpression of long non-coding RNA MINCR contributes to progressive clinicopathological features and poor prognosis of human hepatocellular carcinoma. Eur Rev Med Pharmacol Sci. 2018;22(23):8197–8202.
   PubMedGoogle Scholar
• Henriksson M, Lüscher B. Proteins of the Myc network: essential regulators of cell growth and differentiation. Adv Cancer Res. 1996;68:109–182.
   PubMed Web of Science ®Google Scholar
• Quarto R, Dozin B, Tacchetti C, et al. Constitutive myc expression impairs hypertrophy and calcification in cartilage. Dev Biol. 1992;149(1):168–176.
   PubMedGoogle Scholar
• Shi JW, Zhang -T-T, Liu W, et al. Direct conversion of pig fibroblasts to chondrocyte-like cells by c-Myc. Cell Death Discov. 2019;5(1):55.
   PubMedGoogle Scholar
• Hart JR, Weinberg MS, Morris KV, et al. MINCR is not a MYC-induced lncRNA. Proc Natl Acad Sci U S A. 2016;113(5):E496–7.
   PubMedGoogle Scholar
• Doose G, Hoffmann S, Iaccarino I. Reply to Hart et al.: MINCR and MYC: more than expression correlation. Proc Natl Acad Sci U S A. 2016;113(5):E498.
   PubMedGoogle Scholar
• Paraskevopoulou MD, Hatzigeorgiou AG. Analyzing MiRNA-LncRNA Interactions. Methods Mol Biol. 2016;1402:271–286.
   PubMedGoogle Scholar
• Noh JH, Kim KM, McClusky WG, et al. Cytoplasmic functions of long noncoding RNAs. Wiley Interdiscip Rev RNA. 2018;9(3):e1471.
   PubMed Web of Science ®Google Scholar
• Tang LP, Ding JB, Liu ZH, et al. LncRNA TUG1 promotes osteoarthritis-induced degradation of chondrocyte extracellular matrix via miR-195/MMP-13 axis. Eur Rev Med Pharmacol Sci. 2018;22(24):8574–8581.
   PubMed Web of Science ®Google Scholar
• Fan H, Ding L, and Yang Y. lncRNA SNHG16 promotes the occurrence of osteoarthritis by sponging miR‑373‑3p. Mol Med Rep. 2021;23(2):117.
   PubMedGoogle Scholar
• Zhu J, Yu W, Wang Y, et al. lncRNAs: function and mechanism in cartilage development, degeneration, and regeneration. Stem Cell Res Ther. 2019;10(1):344.
   PubMed Web of Science ®Google Scholar
• Kobayashi T, Lyons KM, McMahon AP, et al. BMP signaling stimulates cellular differentiation at multiple steps during cartilage development. Proc Natl Acad Sci U S A. 2005;102(50):18023–18027.
   PubMed Web of Science ®Google Scholar
• Reddi AH. Interplay between bone morphogenetic proteins and cognate binding proteins in bone and cartilage development: noggin, chordin and DAN. Arthritis Res. 2001;3(1):1–5.
   PubMedGoogle Scholar
• Nakase T, Myoui A, Shimada K, et al. Involvement of BMP-2 signaling in a cartilage cap in osteochondroma. J Orthop Res. 2001;19(6):1085–1088.
   PubMedGoogle Scholar
• Cuellar A, Inui A, James MA, et al. Immunohistochemical localization of bone morphogenetic proteins (BMPs) and their receptors in solitary and multiple human osteochondromas. J Histochem Cytochem. 2014;62(7):488–498.
   PubMedGoogle Scholar