CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway

References

• Lenis AT, Lec PM, Chamie K, et al. Bladder cancer: a review. JAMA. 2020;324(19):1980–1991.
   PubMed Web of Science ®Google Scholar
• Antoni S, Ferlay J, Soerjomataram I, et al. Bladder cancer incidence and mortality: a global overview and recent trends. Eur Urol. 2017;71(1):96–108.
   PubMed Web of Science ®Google Scholar
• Sung H, Ferlay J, Siegel RL, et al. Global cancer statistics 2020: gLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–249.
   PubMed Web of Science ®Google Scholar
• Tran L, Xiao JF, Agarwal N, et al. Advances in bladder cancer biology and therapy. Nat Rev Cancer. 2021;21(2):104–121.
   PubMed Web of Science ®Google Scholar
• Kamat AM, Hahn NM, Efstathiou JA, et al. Bladder cancer. Lancet. 2016;388(10061):2796–2810.
   PubMed Web of Science ®Google Scholar
• Witjes JA, Bruins HM, Cathomas R, et al. European Association of urology guidelines on muscle-invasive and metastatic bladder cancer: summary of the 2020 guidelines. Eur Urol. 2021;79(1):82–104.
   PubMed Web of Science ®Google Scholar
• Wu Z, Liu J, Dai R, et al. Current status and future perspectives of immunotherapy in bladder cancer treatment. Sci China Life Sci. 2021;64(4):512–533.
   PubMed Web of Science ®Google Scholar
• Cambier S, Sylvester RJ, Collette L, et al. EORTC nomograms and risk groups for predicting recurrence, progression, and disease-specific and overall survival in non–muscle-invasive stage Ta–T1 urothelial bladder cancer patients treated with 1–3 years of maintenance bacillus calmette-guérin. Eur Urol. 2016;69(1):60–69.
   PubMed Web of Science ®Google Scholar
• Yang X, Ye T, Liu H, et al. Expression profiles, biological functions and clinical significance of circRnas in bladder cancer. Mol Cancer. 2021;20(1):4.
   PubMed Web of Science ®Google Scholar
• Li M, Liu Y, Zhang X, et al. Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer. Gene. 2018;677:189–197.
   PubMed Web of Science ®Google Scholar
• Li C, Fu X, He H, et al. The biogenesis, functions, and roles of circrnas in bladder cancer. Cancer Manag Res. 2020;12:3673–3689.
   PubMed Web of Science ®Google Scholar
• Yang Q, Li F, He AT, et al. Circular RNAs: expression, localization, and therapeutic potentials. Mol Ther. 2021;29(5):1683–1702.
   PubMed Web of Science ®Google Scholar
• Huang S, Yang B, Chen BJ, et al. The emerging role of circular RNAs in transcriptome regulation. Genomics. 2017;109(5–6):401–407.
   PubMed Web of Science ®Google Scholar
• Pamudurti NR, Bartok O, Jens M, et al. Translation of CircRnas. Molecular Cell. 2017;66(1):9–21.e7.
   PubMed Web of Science ®Google Scholar
• Li G, Guo BY, Wang HD, et al. CircRNA hsa_circ_0014130 function as a miR-132-3p sponge for playing oncogenic roles in bladder cancer via upregulating KCNJ12 expression. Cell Biol Toxicol. 2021;9. DOI:10.2139/ssrn.3822281.
   Google Scholar
• Zhu J, Luo Y, Zhao Y, et al. circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFβR1/VEGF-D signaling. Mol Ther. 2021;29(5):1838–1852.
   PubMed Web of Science ®Google Scholar
• Chen L, Li W, Li Z, et al. circNUDT21 promotes bladder cancer progression by modulating the miR-16-1-3p/mdm2/p53 axis. Mol Ther Nucleic Acids. 2021;26:625–636.
   PubMedGoogle Scholar
• Qiu F, Liu Q, Xia Y, et al. Circ_0000658 knockdown inhibits epithelial-mesenchymal transition in bladder cancer via miR-498-induced HMGA2 downregulation. J Exp Clin Cancer Res. 2022;41(1):22.
   PubMed Web of Science ®Google Scholar
• Su Y, Feng W, Shi J, et al. circRIP2 accelerates bladder cancer progression via miR-1305/tgf-β2/smad3 pathway. Mol Cancer. 2020;19(1):23.
   PubMed Web of Science ®Google Scholar
• Jin M, Lu S, Wu Y, et al. Hsa_circ_0001944 promotes the growth and metastasis in bladder cancer cells by acting as a competitive endogenous RNA for miR-548. J Exp Clin Cancer Res. 2020;39(1):186.
   PubMed Web of Science ®Google Scholar
• Xia W, Chen C, Zhang MR, et al. LncRNA PCAT6 aggravates the progression of bladder cancer cells by targeting miR-513a-5p. Eur Rev Med Pharmacol Sci. 2020;24(19):9908–9914.
   PubMed Web of Science ®Google Scholar
• Alzahrani AS. PI3K/Akt/mTOR inhibitors in cancer: at the bench and bedside. Semin Cancer Biol. 2019;59:125–132.
   PubMed Web of Science ®Google Scholar
• FT AM. Oncogenic roles of the PI3K/AKT/mTOR axis. Curr Top Microbiol Immunol. 2017;407:153–189.
   PubMed Web of Science ®Google Scholar
• NR SA. Targeting the PI3K/AKT/mTOR pathway in bladder cancer. Methods Mol Biol. 2018;1655:335–350.
   PubMedGoogle Scholar
• Cancer Genome Atlas Research N. Comprehensive molecular characterization of urothelial bladder carcinoma. Nature. 2014;507(7492):315–322.
   PubMed Web of Science ®Google Scholar
• Iyer G, Al-Ahmadie H, Schultz N, et al. Prevalence and co-occurrence of actionable genomic alterations in high-grade bladder cancer. J Clin Oncol. 2013;31(25):3133–3140.
   PubMed Web of Science ®Google Scholar
• Wang Y, Xing QF, Liu XQ, et al. MiR-122 targets VEGFC in bladder cancer to inhibit tumor growth and angiogenesis. Am J Transl Res. 2016;8(7):3056–3066.
   PubMed Web of Science ®Google Scholar
• Patop IL, Wust S, Kadener S. Past, present, and future of circRnas. EMBO J. 2019;38(16):e100836.
   PubMed Web of Science ®Google Scholar
• Jeck WR, Sorrentino JA, Wang K, et al. Circular RNAs are abundant, conserved, and associated with ALU repeats. RNA. 2013;19(2):141–157.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Liang W, Zhang P, et al. Circular RNAs: emerging cancer biomarkers and targets. J Exp Clin Cancer Res. 2017;36(1):152.
   PubMedGoogle Scholar
• Zhang Z, Yang T, Xiao J. Circular RNAs: promising biomarkers for human diseases. EBioMedicine. 2018;34:267–274.
   PubMed Web of Science ®Google Scholar
• Chen L, Shan G. CircRNA in cancer: fundamental mechanism and clinical potential. Cancer Lett. 2021;505:49–57.
   PubMed Web of Science ®Google Scholar
• Goodall GJ, Wickramasinghe VO. RNA in cancer. Nat Rev Cancer. 2021;21(1):22–36.
   PubMed Web of Science ®Google Scholar
• Saliminejad K, Khorram Khorshid HR, Soleymani Fard S, et al. An overview of microRnas: biology, functions, therapeutics, and analysis methods. J Cell Physiol. 2019;234(5):5451–5465.
   PubMed Web of Science ®Google Scholar
• Lu MD, Liu D, Li YX. LINC01436 promotes the progression of gastric cancer via regulating miR-513a-5p/ape1 axis. Onco Targets Ther. 2020;13:10607–10619.
   PubMed Web of Science ®Google Scholar
• Xu W, Li K, Song C, et al. Knockdown of lncRNA LINC01234 suppresses the tumorigenesis of liver cancer via sponging miR-513a-5p. Front Oncol. 2020;10:571565.
   PubMed Web of Science ®Google Scholar
• Li J, Huang C, Zou Y, et al. Circular RNA MYLK promotes tumour growth and metastasis via modulating miR-513a-5p/vegfc signalling in renal cell carcinoma. J Cell Mol Med. 2020;24(12):6609–6621.
   PubMed Web of Science ®Google Scholar
• Zhu K, Miao C, Tian Y, et al. lncRNA MIR4435-2HG promoted clear cell renal cell carcinoma malignant progression via miR-513a-5p/klf6 axis. J Cell Mol Med. 2020;24(17):10013–10026.
   PubMed Web of Science ®Google Scholar
• Lu TX, Rothenberg ME. MicroRNA. J Allergy Clin Immunol. 2018;141(4):1202–1207.
   PubMed Web of Science ®Google Scholar
• Jonas S, Izaurralde E. Towards a molecular understanding of microRNA-mediated gene silencing. Nat Rev Genet. 2015;16(7):421–433.
   PubMed Web of Science ®Google Scholar
• Chen C, Luo Y, He W, et al. Exosomal long noncoding RNA LNMAT2 promotes lymphatic metastasis in bladder cancer. J Clin Invest. 2020;130(1):404–421.
   PubMed Web of Science ®Google Scholar
• Ping Q, Shi Y, Yang M, et al. LncRNA DANCR regulates lymphatic metastasis of bladder cancer via the miR-335/VEGF-C axis. Transl Androl Urol. 2021;10(4):1743–1753.
   PubMed Web of Science ®Google Scholar