ACLY promotes gastric tumorigenesis and accelerates peritoneal metastasis of gastric cancer regulated by HIF-1A

References

• Erratum: global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. Ca A Cancer J Clinicians. 2020;70(4):313. doi: 10.3322/caac.21609
   Web of Science ®Google Scholar
• Ferlay J, Soerjomataram I, Dikshit R, et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015;136(5):E359–86. doi: 10.1002/ijc.29210
   PubMed Web of Science ®Google Scholar
• Van Cutsem E, Ducreux M. Colorectal and gastric cancer in 2015: the development of new agents and molecular classifications. Nat Rev Clin Oncol. 2016;13(2):69–70. doi: 10.1038/nrclinonc.2015.217
   PubMed Web of Science ®Google Scholar
• Rawla P, Barsouk A. Epidemiology of gastric cancer: global trends, risk factors and prevention. Prz Gastroenterol. 2019;14(1):26–38. doi: 10.5114/pg.2018.80001
   PubMed Web of Science ®Google Scholar
• Nie RC, Chen S, Yuan SQ, et al. Significant role of palliative gastrectomy in selective gastric cancer patients with peritoneal dissemination: a propensity score matching analysis. Ann Surg Oncol. 2016;23(12):3956–3963. doi: 10.1245/s10434-016-5223-2
   PubMed Web of Science ®Google Scholar
• Foster JM, Zhang C, Rehman S, et al. The contemporary management of peritoneal metastasis: a journey from the cold past of treatment futility to a warm present and a bright future. Ca A Cancer J Clinicians. 2023;73(1):49–71. doi: 10.3322/caac.21749
   PubMed Web of Science ®Google Scholar
• Chen Y, Zhou Q, Wang H, et al. Predicting peritoneal dissemination of gastric cancer in the era of precision medicine: molecular characterization and biomarkers. Cancers. 2020;12(8):2236. doi: 10.3390/cancers12082236
   PubMed Web of Science ®Google Scholar
• Ikoma N, Chen HC, Wang X, et al. Patterns of initial recurrence in gastric adenocarcinoma in the era of preoperative therapy. Ann Surg Oncol. 2017;24(9):2679–2687. doi: 10.1245/s10434-017-5838-y
   PubMed Web of Science ®Google Scholar
• Braig S. Chemical genetics in tumor lipogenesis. Biotechnol Adv. 2018;36(6):1724–1729. doi: 10.1016/j.biotechadv.2018.02.007
   PubMed Web of Science ®Google Scholar
• Currie E, Schulze A, Zechner R, et al. Cellular fatty acid metabolism and cancer. Cell Metab. 2013;18(2):153–161. doi: 10.1016/j.cmet.2013.05.017
   PubMed Web of Science ®Google Scholar
• Zechner R, Zimmermann R, Eichmann TO, et al. FAT SIGNALS–lipases and lipolysis in lipid metabolism and signaling. Cell Metab. 2012;15(3):279–291. doi: 10.1016/j.cmet.2011.12.018
   PubMed Web of Science ®Google Scholar
• Swinnen JV, Brusselmans K, Verhoeven G. Increased lipogenesis in cancer cells: new players, novel targets. Current Opin Clin Nutr Metab Care. 2006;9(4):358–365. doi: 10.1097/01.mco.0000232894.28674.30
   PubMed Web of Science ®Google Scholar
• Gibson DM, Lyons RT, Scott DF, et al. Synthesis and degradation of the lipogenic enzymes of rat liver. Adv Enzyme Regul. 1972;10:187–204. doi: 10.1016/0065-2571(72)90014-3
   PubMedGoogle Scholar
• Rysman E, Brusselmans K, Scheys K, et al. De Novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res. 2010;70(20):8117–8126. doi: 10.1158/0008-5472.CAN-09-3871
   PubMed Web of Science ®Google Scholar
• Lee JH, Phelan P, Shin M, et al. SREBP-1a-stimulated lipid synthesis is required for macrophage phagocytosis downstream of TLR4-directed mTORC1. Proc Natl Acad Sci USA. 2018;115(52):E12228–e34. doi: 10.1073/pnas.1813458115
   PubMed Web of Science ®Google Scholar
• Zadra G, Ribeiro CF, Chetta P, et al. Inhibition of de novo lipogenesis targets androgen receptor signaling in castration-resistant prostate cancer. Proc Natl Acad Sci USA. 2019;116(2):631–640. doi: 10.1073/pnas.1808834116
   PubMed Web of Science ®Google Scholar
• Pascual G, Avgustinova A, Mejetta S, et al. Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature. 2017;541(7635):41–45. doi: 10.1038/nature20791
   PubMed Web of Science ®Google Scholar
• Husain A, Chiu YT, Sze KM, et al. Ephrin-A3/EphA2 axis regulates cellular metabolic plasticity to enhance cancer stemness in hypoxic hepatocellular carcinoma. J Hepatol. 2022;77(2):383–396. doi: 10.1016/j.jhep.2022.02.018
   PubMed Web of Science ®Google Scholar
• Liu Q, Ge W, Wang T, et al. High-throughput single-cell Mass spectrometry reveals abnormal lipid metabolism in pancreatic ductal adenocarcinoma. Angew Chem (Int Ed In English). 2021;60(46):24534–24542. doi: 10.1002/anie.202107223
   PubMed Web of Science ®Google Scholar
• Fang Z, Meng Q, Xu J, et al. Signaling pathways in cancer-associated fibroblasts: recent advances and future perspectives. Cancer Commun (Lond). 2023;43(1):3–41. doi: 10.1002/cac2.12392
   PubMed Web of Science ®Google Scholar
• Wang X, Che X, Yu Y, et al. Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway. J Exper Cli Can Res CR. 2020;39(1):221. doi: 10.1186/s13046-020-01703-x
   PubMed Web of Science ®Google Scholar
• Ebersole JL, Novak MJ, Orraca L, et al. Hypoxia-inducible transcription factors, HIF1A and HIF2A, increase in aging mucosal tissues. Immunology. 2018;154(3):452–464. doi: 10.1111/imm.12894
   PubMed Web of Science ®Google Scholar
• Nagao A, Kobayashi M, Koyasu S, et al. HIF-1-Dependent reprogramming of glucose metabolic pathway of cancer cells and its therapeutic significance. Int J Mol Sci. 2019;20(2):238. doi: 10.3390/ijms20020238
   PubMed Web of Science ®Google Scholar
• Jiang Y, Wu GH, He GD, et al. The effect of silencing HIF-1α gene in BxPC-3 cell line on glycolysis-related gene expression, cell growth, invasion, and apoptosis. Nutr Cancer. 2015;67(8):1314–1323. doi: 10.1080/01635581.2015.1085584
   PubMed Web of Science ®Google Scholar
• Kitajima Y, Miyazaki K. The critical impact of HIF-1a on gastric cancer biology. Cancers. 2013;5(1):15–26. doi: 10.3390/cancers5010015
   PubMedGoogle Scholar
• Huang Y, Hong W, Wei X. The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis. J Hematol Oncol. 2022;15(1):129. doi: 10.1186/s13045-022-01347-8
   PubMed Web of Science ®Google Scholar
• Li J, Gao A, Zhang F, et al. ILT3 promotes tumor cell motility and angiogenesis in non-small cell lung cancer. Cancer Lett. 2021;501:263–276. doi: 10.1016/j.canlet.2020.10.048
   PubMed Web of Science ®Google Scholar
• Fu SH, Lai MC, Zheng YY, et al. MiR-195 inhibits the ubiquitination and degradation of YY1 by Smurf2, and induces EMT and cell permeability of retinal pigment epithelial cells. Cell Death Dis. 2021;12(7):708. doi: 10.1038/s41419-021-03956-6
   PubMed Web of Science ®Google Scholar
• Forristal CE, Winkler IG, Nowlan B, et al. Pharmacologic stabilization of HIF-1α increases hematopoietic stem cell quiescence in vivo and accelerates blood recovery after severe irradiation. Blood. 2013;121(5):759–769. doi: 10.1182/blood-2012-02-408419
   PubMed Web of Science ®Google Scholar
• Wang C, Yang Z, Xu E, et al. Apolipoprotein C-II induces EMT to promote gastric cancer peritoneal metastasis via PI3K/AKT/mTOR pathway. Clin Transl Med. 2021;11(8):e522. doi: 10.1002/ctm2.522
   PubMed Web of Science ®Google Scholar
• Zaidi N, Swinnen JV, Smans K. ATP-citrate lyase: a key player in cancer metabolism. Cancer Res. 2012;72(15):3709–3714. doi: 10.1158/0008-5472.CAN-11-4112
   PubMed Web of Science ®Google Scholar
• Icard P, Wu Z, Fournel L, et al. ATP citrate lyase: A central metabolic enzyme in cancer. Cancer Lett. 2020;471:125–134. doi: 10.1016/j.canlet.2019.12.010
   PubMed Web of Science ®Google Scholar
• Carrer A, Trefely S, Zhao S, et al. Acetyl-CoA Metabolism Supports Multistep Pancreatic Tumorigenesis. Cancer Discovery. 2019;9(3):416–435. doi: 10.1158/2159-8290.CD-18-0567
   PubMed Web of Science ®Google Scholar
• Brabletz T, Kalluri R, Nieto MA, et al. EMT in cancer. Nat Rev Cancer. 2018;18(2):128–134. doi: 10.1038/nrc.2017.118
   PubMed Web of Science ®Google Scholar
• Cortés-Guiral D, Hübner M, Alyami M, et al. Primary and metastatic peritoneal surface malignancies. Nat Rev Dis Primers. 2021;7(1):91. doi: 10.1038/s41572-021-00326-6
   PubMed Web of Science ®Google Scholar
• Miyamoto T, Murphy B, Zhang N. Intraperitoneal metastasis of ovarian cancer: new insights on resident macrophages in the peritoneal cavity. Front Immunol. 2023;14:1104694. doi: 10.3389/fimmu.2023.1104694
   PubMed Web of Science ®Google Scholar
• Liu K, Xu P, Lv J, et al. Peritoneal high-fat environment promotes peritoneal metastasis of gastric cancer cells through activation of NSUN2-mediated ORAI2 m5C modification. Oncogene. 2023;42(24):1980–1993. doi: 10.1038/s41388-023-02707-5
   PubMed Web of Science ®Google Scholar
• Zadoorian A, Du X, Yang H. Lipid droplet biogenesis and functions in health and disease. Nat Rev Endocrinol. 2023;19(8):443–459. doi: 10.1038/s41574-023-00845-0
   PubMed Web of Science ®Google Scholar
• Dong S, Liang S, Cheng Z, et al. ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer. J Exper Cli Can Res CR. 2022;41(1):15. doi: 10.1186/s13046-021-02229-6
   PubMed Web of Science ®Google Scholar
• Du D, Liu C, Qin M, et al. Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma. Acta Pharm Sin B. 2022;12(2):558–580. doi: 10.1016/j.apsb.2021.09.019
   PubMed Web of Science ®Google Scholar